{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:07:12Z","timestamp":1770448032081,"version":"3.49.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T00:00:00Z","timestamp":1468368000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["14\/00302-0"],"award-info":[{"award-number":["14\/00302-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["15\/06809-1"],"award-info":[{"award-number":["15\/06809-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Coordination for the Improvement of Higher Level (CAPES)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1007\/s00436-016-5183-2","type":"journal-article","created":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T05:49:10Z","timestamp":1468388950000},"page":"4107-4114","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Early developmental stages of Ascaris lumbricoides featured by high-resolution mass spectrometry"],"prefix":"10.1007","volume":"115","author":[{"given":"Carlos Fernando Odir Rodrigues","family":"Melo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cibele Zanardi","family":"Esteves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosimeire Nunes","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiane Melina","family":"Guerreiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diogo Noin","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estela de Oliveira","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falio C\u00e9sar","family":"Min\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silmara Marques","family":"Allegretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Ramos","family":"Catharino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,7,13]]},"reference":[{"key":"5183_CR1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/387489a0","volume":"387","author":"AMA Aguinaldo","year":"1997","unstructured":"Aguinaldo AMA, Turbeville JM, Linford LS, Rivera MC, Garey JR, Raff RA, Lake JA (1997) Evidence for a clade of nematodes, arthropods and other moulting animals. Nature 387:489\u2013493","journal-title":"Nature"},{"key":"5183_CR2","first-page":"89","volume":"14","author":"P Araujo","year":"1972","unstructured":"Araujo P (1972) Observacoes pertinentes as primeiras ecdises de larvas de Ascaris lumbricoides, A. suum e Toxocara canis. Rev Inst Med Trop Sao Paulo 14:89\u201390","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"5183_CR3","first-page":"15","volume":"51","author":"PT Artigas","year":"1989","unstructured":"Artigas PT, Ueta MT (1989) Sobre a evolu\u00e7\u00e4o de Ascaris lumbricoides linnaeus, 1758, na fase larvar endovular. Mem Inst Butantan 51:15\u201324","journal-title":"Mem Inst Butantan"},{"key":"5183_CR4","unstructured":"Barbara MIHMP, Escoubas LTP (1991) Cuticular Hydrocarbons: Species and Population-Level Discrimination in Termites1 on Current Research on Wood-Destroying Organisms and Future Prospects for Protecting Wood in Use:15"},{"key":"5183_CR5","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S0140-6736(06)68653-4","volume":"367","author":"J Bethony","year":"2006","unstructured":"Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, Diemert D, Hotez PJ (2006) Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet 367:1521\u20131532","journal-title":"Lancet"},{"key":"5183_CR6","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1126\/science.282.5396.2041","volume":"282","author":"M Blaxter","year":"1998","unstructured":"Blaxter M (1998) Caenorhabditis elegans is a nematode. Science 282:2041\u20132046","journal-title":"Science"},{"key":"5183_CR7","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.675256","volume":"201","author":"D Carlson","year":"1978","unstructured":"Carlson D, Langley P, Huyton P (1978) Sex pheromone of the tsetse fly: isolation, identification, and synthesis of contact aphrodisiacs. Science 201:750\u2013753","journal-title":"Science"},{"key":"5183_CR8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mad.2014.11.002","volume":"143","author":"RG Cutler","year":"2014","unstructured":"Cutler RG, Thompson KW, Camandola S, Mack KT, Mattson MP (2014) Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans. Mech Ageing Dev 143:9\u201318","journal-title":"Mech Ageing Dev"},{"key":"5183_CR9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1046\/j.1365-3156.1997.d01-320.x","volume":"2","author":"N Silva De","year":"1997","unstructured":"De Silva N, Chan M, Bundy D (1997) Morbidity and mortality due to ascariasis: re\u2010estimation and sensitivity analysis of global numbers at risk. Tropical Med Int Health 2:513\u2013518","journal-title":"Tropical Med Int Health"},{"key":"5183_CR10","doi-asserted-by":"crossref","first-page":"6245","DOI":"10.1038\/onc.2008.301","volume":"27","author":"DN Dhanasekaran","year":"2008","unstructured":"Dhanasekaran DN, Reddy EP (2008) JNK signaling in apoptosis. Oncogene 27:6245\u20136251","journal-title":"Oncogene"},{"key":"5183_CR11","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.micinf.2010.09.012","volume":"13","author":"C Dold","year":"2011","unstructured":"Dold C, Holland CV (2011) Ascaris and ascariasis. Microbes Infect 13:632\u2013637","journal-title":"Microbes Infect"},{"key":"5183_CR12","doi-asserted-by":"crossref","unstructured":"Entchev EV, Kurzchalia TV Requirement of sterols in the life cycle of the nematode Caenorhabditis elegans. In: Seminars in cell & developmental biology, 2005. Elsevier, pp 175-182","DOI":"10.1016\/j.semcdb.2005.01.004"},{"key":"5183_CR13","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1002\/jms.3308","volume":"49","author":"MS Ferreira","year":"2014","unstructured":"Ferreira MS, de Oliveira DN, de Oliveira RN, Allegretti SM, Vercesi AE, Catharino RR (2014) Mass spectrometry imaging: a new vision in differentiating Schistosoma mansoni strains. J Mass Spectrom 49:86\u201392. doi: 10.1002\/jms.3308","journal-title":"J Mass Spectrom"},{"key":"5183_CR14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ijpara.2014.12.008","volume":"45","author":"MS Ferreira","year":"2015","unstructured":"Ferreira MS, de Oliveira RN, de Oliveira DN, Esteves CZ, Allegretti SM, Catharino RR (2015) Revealing praziquantel molecular targets using mass spectrometry imaging: an expeditious approach applied to Schistosoma mansoni. Int J Parasitol 45:385\u2013391","journal-title":"Int J Parasitol"},{"issue":"4","key":"5183_CR15","doi-asserted-by":"crossref","first-page":"616","DOI":"10.2307\/3285733","volume":"85","author":"P Geenen","year":"1999","unstructured":"Geenen P, Bresciani J, Boes J, Pedersen A, Eriksen L, Fagerholm H-P, Nansen P (1999) The morphogenesis of Ascaris suum to the infective third-stage larvae within the egg. J Parasitol 85(4):616\u2013622","journal-title":"J Parasitol"},{"key":"5183_CR16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ydbio.2003.10.014","volume":"266","author":"CR Gissendanner","year":"2004","unstructured":"Gissendanner CR, Crossgrove K, Kraus KA, Maina CV, Sluder AE (2004) Expression and function of conserved nuclear receptor genes in Caenorhabditis elegans. Dev Biol 266:399\u2013416","journal-title":"Dev Biol"},{"key":"5183_CR17","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1126\/science.6896933","volume":"218","author":"JW Golden","year":"1982","unstructured":"Golden JW, Riddle DL (1982) A pheromone influences larval development in the nematode Caenorhabditis elegans. Science 218:578\u2013580","journal-title":"Science"},{"key":"5183_CR18","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1073\/pnas.81.3.819","volume":"81","author":"JW Golden","year":"1984","unstructured":"Golden JW, Riddle DL (1984) A pheromone-induced developmental switch in Caenorhabditis elegans: temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc Natl Acad Sci 81:819\u2013823","journal-title":"Proc Natl Acad Sci"},{"key":"5183_CR19","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.devcel.2012.11.012","volume":"24","author":"XL Guan","year":"2013","unstructured":"Guan XL et al (2013) Biochemical membrane lipidomics during Drosophila development. Dev Cell 24:98\u2013111","journal-title":"Dev Cell"},{"issue":"5","key":"5183_CR20","first-page":"546","volume":"68","author":"NF Hadley","year":"1980","unstructured":"Hadley NF (1980) Surface waxes and integumentary permeability: lipids deposited on or associated with the surface of terrestrial plants and animals help protect them from a lethal rate of desiccation. Am Sci 68(5):546\u2013553","journal-title":"Am Sci"},{"key":"5183_CR21","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1126\/science.160.3829.778","volume":"160","author":"W Hieb","year":"1968","unstructured":"Hieb W, Rothstein M (1968) Sterol requirement for reproduction of a free-living nematode. Science 160:778\u2013780","journal-title":"Science"},{"key":"5183_CR22","unstructured":"Hoffman W, Poxs J, JA J (1934) Schistosomiasis, due to infestations of Schistosoma man-soni, is not unimportant in certain regions of Puerto Rico, but its distribution and incidence still remain to be definitely determined. The method usually relied upon for diagnosis is that of"},{"key":"5183_CR23","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1242\/dev.129.1.221","volume":"129","author":"K Jia","year":"2002","unstructured":"Jia K, Albert PS, Riddle DL (2002) DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity. Development 129:221\u2013231","journal-title":"Development"},{"key":"5183_CR24","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S1473-3099(14)71004-7","volume":"15","author":"D-A Karagiannis-Voules","year":"2015","unstructured":"Karagiannis-Voules D-A et al (2015) Spatial and temporal distribution of soil-transmitted helminth infection in sub-Saharan Africa: a systematic review and geostatistical meta-analysis. Lancet Infect Dis 15:74\u201384","journal-title":"Lancet Infect Dis"},{"key":"5183_CR25","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/QCO.0b013e32833de06a","volume":"23","author":"J Keiser","year":"2010","unstructured":"Keiser J, Duthaler U, Utzinger J (2010) Update on the diagnosis and treatment of food-borne trematode infections. Curr Opin Infect Dis 23:513\u2013520","journal-title":"Curr Opin Infect Dis"},{"key":"5183_CR26","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0020-7519(97)00016-7","volume":"27","author":"K Kita","year":"1997","unstructured":"Kita K, Hirawake H, Takamiya S (1997) Cytochromes in the respiratory chain of helminth mitochondria. Int J Parasitol 27:617\u2013630","journal-title":"Int J Parasitol"},{"key":"5183_CR27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF00987535","volume":"6","author":"J Klun","year":"1980","unstructured":"Klun J et al (1980) Sex pheromone chemistry of female corn earworm moth, Heliothis zea. J Chem Ecol 6:165\u2013175","journal-title":"J Chem Ecol"},{"key":"5183_CR28","unstructured":"K\u00fchbandner S (2015) Cuticular lipids of the parasitoid Lariophagus distinguendus (Hymenoptera: Pteromalidae): Chemistry and behavioural function."},{"key":"5183_CR29","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.cellsig.2011.02.009","volume":"23","author":"A Kumar","year":"2011","unstructured":"Kumar A, Byun H-S, Bittman R, Saba JD (2011) The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cell Signal 23:1144\u20131152","journal-title":"Cell Signal"},{"key":"5183_CR30","first-page":"641","volume":"53","author":"A Ligocka","year":"2009","unstructured":"Ligocka A, Paluszak Z (2009) Effectiveness of different sanitisation technologies on the inactivation of Ascaris suum eggs in organic waste. Bull Vet Inst Pulawy 53:641\u2013644","journal-title":"Bull Vet Inst Pulawy"},{"key":"5183_CR31","doi-asserted-by":"publisher","first-page":"3585","DOI":"10.1021\/acs.analchem.5b00097","volume":"87","author":"EO Lima","year":"2015","unstructured":"Lima EO et al (2015) Skin imprinting in silica plates: a potential diagnostic methodology for leprosy using high-resolution mass spectrometry. Anal Chem 87:3585\u20133592. doi: 10.1021\/acs.analchem.5b00097","journal-title":"Anal Chem"},{"key":"5183_CR32","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1046\/j.1474-9728.2002.00014.x","volume":"1","author":"A Lin","year":"2002","unstructured":"Lin A, Dibling B (2002) The true face of JNK activation in apoptosis. Aging Cell 1:112\u2013116","journal-title":"Aging Cell"},{"key":"5183_CR33","doi-asserted-by":"crossref","unstructured":"Matyash V et al. (2004) Sterol-derived hormone (s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16","DOI":"10.1371\/journal.pbio.0020280"},{"key":"5183_CR34","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1080\/09168451.2014.942250","volume":"78","author":"R Niwa","year":"2014","unstructured":"Niwa R, Niwa YS (2014) Enzymes for ecdysteroid biosynthesis: their biological functions in insects and beyond. Biosci Biotechnol Biochem 78:1283\u20131292","journal-title":"Biosci Biotechnol Biochem"},{"key":"5183_CR35","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s10886-013-0272-5","volume":"39","author":"OA Olaniran","year":"2013","unstructured":"Olaniran OA, Sudhakar AV, Drijfhout FP, Dublon IA, Hall DR, Hamilton JG, Kirk WD (2013) A male-predominant cuticular hydrocarbon, 7-methyltricosane, is used as a contact pheromone in the western flower thrips Frankliniella occidentalis. J Chem Ecol 39:559\u2013568","journal-title":"J Chem Ecol"},{"key":"5183_CR36","unstructured":"Organization WH (1967) Control of ascariasis: report of a WHO expert committee. World Health Organization"},{"key":"5183_CR37","first-page":"1951","volume":"7","author":"Z Qu","year":"2015","unstructured":"Qu Z et al (2015) How did arthropod sesquiterpenoids and ecdysteroids arise? Comparison of hormonal pathway genes in noninsect arthropod genomes. Genome Biol Evol 7:1951\u20131959","journal-title":"Genome Biol Evol"},{"key":"5183_CR38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0083-6729(00)60016-X","volume":"60","author":"LM Riddiford","year":"2000","unstructured":"Riddiford LM, Cherbas P, Truman JW (2000) Ecdysone receptors and their biological actions. Vitamins & Hormones 60:1\u201373","journal-title":"Vitamins & Hormones"},{"key":"5183_CR39","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0163-7827(00)00005-9","volume":"39","author":"M Schlame","year":"2000","unstructured":"Schlame M, Rua D, Greenberg ML (2000) The biosynthesis and functional role of cardiolipin. Prog Lipid Res 39:257\u2013288","journal-title":"Prog Lipid Res"},{"key":"5183_CR40","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.advenzreg.2009.10.024","volume":"50","author":"M Serra","year":"2010","unstructured":"Serra M, Saba JD (2010) Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. Adv Enzym Regul 50:349\u2013362","journal-title":"Adv Enzym Regul"},{"key":"5183_CR41","doi-asserted-by":"crossref","unstructured":"Steiger S, Schmitt T, Schaefer HM (2010) The origin and dynamic evolution of chemical information transfer Proceedings of the Royal Society of London B: Biological Sciences:rspb20102285","DOI":"10.1098\/rspb.2010.2285"},{"key":"5183_CR42","doi-asserted-by":"crossref","first-page":"bcr2015209839","DOI":"10.1136\/bcr-2015-209839","volume":"2015","author":"R Swain","year":"2015","unstructured":"Swain R, Behera C, Mridha AR, Gupta SK (2015) Massive hepatobiliary ascariasis at autopsy. BMJ case reports 2015:bcr2015209839","journal-title":"BMJ case reports"},{"key":"5183_CR43","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0005-2728(93)90190-Q","volume":"1141","author":"S Takamiya","year":"1993","unstructured":"Takamiya S, Kita K, Wang H, Weinstein PP, Hiraishi A, Oya H, Aoki T (1993) Developmental changes in the respiratory chain of Ascaris mitochondria. Biochimica et Biophysica Acta (BBA)-Bioenergetics 1141:65\u201374","journal-title":"Biochimica et Biophysica Acta (BBA)-Bioenergetics"},{"key":"5183_CR44","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1017\/S0031182000058029","volume":"95","author":"D Taren","year":"1987","unstructured":"Taren D et al (1987) Contributions of ascariasis to poor nutritional status in children from Chiriqui Province, Republic of Panama. Parasitology 95:603\u2013613","journal-title":"Parasitology"},{"key":"5183_CR45","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1021\/jf0616255","volume":"54","author":"L Wang","year":"2006","unstructured":"Wang L, Wang T, Fehr WR (2006) Effect of seed development stage on sphingolipid and phospholipid contents in soybean seeds. J Agric Food Chem 54:7812\u20137816","journal-title":"J Agric Food Chem"},{"key":"5183_CR46","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/S0022-2275(20)32186-6","volume":"39","author":"SM Watkins","year":"1998","unstructured":"Watkins SM, Carter LC, German JB (1998) Docosahexaenoic acid accumulates in cardiolipin and enhances HT-29 cell oxidant production. J Lipid Res 39:1583\u20131588","journal-title":"J Lipid Res"},{"key":"5183_CR47","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1093\/jn\/121.7.956","volume":"121","author":"S Yamaoka-Koseki","year":"1991","unstructured":"Yamaoka-Koseki S, Urade R, Kito M (1991) Cardiolipins from rats fed different dietary lipids affect bovine heart cytochrome c oxidase activity. J Nutr 121:956\u2013958","journal-title":"J Nutr"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-016-5183-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-016-5183-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-016-5183-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T01:03:43Z","timestamp":1656810223000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-016-5183-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,13]]},"references-count":47,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["5183"],"URL":"https:\/\/doi.org\/10.1007\/s00436-016-5183-2","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,13]]}}}