{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:39:02Z","timestamp":1759588742665},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:00:00Z","timestamp":1503273600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s00436-017-5581-0","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T01:43:26Z","timestamp":1503279806000},"page":"2727-2732","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Anti-CD25 monoclonal antibody enhances the protective efficacy of Schistosoma japonicum GST vaccine via inhibition of CD4+CD25+Foxp3+ regulatory T cells"],"prefix":"10.1007","volume":"116","author":[{"given":"Chun-lian","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-yu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan-fang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,8,21]]},"reference":[{"key":"5581_CR1","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.4049\/jimmunol.1102223","volume":"188","author":"S Abel","year":"2012","unstructured":"Abel S, L\u00fcckheide N, Westendorf AM, Geffers R, Roers A, M\u00fcller W, Sparwasser T, Matuschewski K, Buer J, Hansen W (2012) Strong impact of CD4+ Foxp3+ regulatory T cells and limited effect of T cell-derived IL-10 on pathogen clearance during Plasmodium yoelii infection. J Immunol 188:5467\u20135477","journal-title":"J Immunol"},{"issue":"9","key":"5581_CR2","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.4049\/jimmunol.176.9.5374","volume":"176","author":"M Baumgart","year":"2006","unstructured":"Baumgart M, Tompkins F, Leng J, Hesse M (2006) Naturally occurring CD4+Foxp3+ regulatory T cells are an essential, IL-10-independent part of the immunoregulatory network in Schistosoma mansoni egg-induced inflammation. J Immunol 176(9):5374\u20135387","journal-title":"J Immunol"},{"key":"5581_CR3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0001-706X(02)00048-7","volume":"82","author":"R Bergquist","year":"2002","unstructured":"Bergquist R, Al-Sherbiny M, Barakat R, Olds R (2002) Blueprint for schistosomiasis vaccine development. Acta Trop 82:183\u2013192","journal-title":"Acta Trop"},{"key":"5581_CR4","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s00436-008-0880-0","volume":"102","author":"YL Cheng","year":"2008","unstructured":"Cheng YL, Song WJ, Liu WQ, Lei JH, Mo HM, Ruppel A, Li YL (2008) The effects of T cell deficiency on the development of worms and granuloma formation in mice infected with Schistosoma japonicum. Parasitol Res 102:1129\u20131134","journal-title":"Parasitol Res"},{"issue":"8","key":"5581_CR5","doi-asserted-by":"crossref","first-page":"e104627","DOI":"10.1371\/journal.pone.0104627","volume":"9","author":"MR Espinoza Mora","year":"2014","unstructured":"Espinoza Mora MR, Steeg C, Tartz S, Heussler V, Sparwasser T, Link A, Fleischer B, Jacobs T (2014) Depletion of regulatory T cells augments a vaccine-induced T effector cell response against the liver-stage of malaria but fails to increase memory. PLoS One 9(8):e104627","journal-title":"PLoS One"},{"key":"5581_CR6","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.4049\/jimmunol.146.4.1322","volume":"146","author":"JM Grzych","year":"1991","unstructured":"Grzych JM, Pearce E, Cheever A, Caulada ZA, Caspar P, Heiny S, Lewis F, Sher A (1991) Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni. J Immunol 146:1322\u20131327","journal-title":"J Immunol"},{"issue":"4","key":"5581_CR7","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.exppara.2011.05.012","volume":"128","author":"MJ Li","year":"2011","unstructured":"Li MJ, Lei JH, Wang T, Lu SJ, Guan F, Liu WQ, Li YL (2011) Cimetidine enhances the protective effect of GST DNA vaccine against Schistosoma japonicum. Exp Parasitol 128(4):427\u2013432","journal-title":"Exp Parasitol"},{"key":"5581_CR8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.exppara.2007.02.009","volume":"116","author":"HM Mo","year":"2007","unstructured":"Mo HM, Liu WQ, Lei JH, Cheng YL, Wang CZ, Li YL (2007) Schistosoma japonicum eggs modulate the activity of CD4+ CD25+ Tregs and prevent development of colitis in mice. Exp Parasitol 116:385\u2013389","journal-title":"Exp Parasitol"},{"key":"5581_CR9","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1128\/IAI.01028-13","volume":"82","author":"C Onyilagha","year":"2014","unstructured":"Onyilagha C, Okwor I, Kuriakose S, Singh R, Uzonna J (2014) Low-dose intradermal infection with trypanosoma congolense leads to expansion of regulatory T cells and enhanced susceptibility to reinfection. Infect Immun 82:1074\u20131083","journal-title":"Infect Immun"},{"key":"5581_CR10","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1073\/pnas.91.3.999","volume":"91","author":"IP Oswald","year":"1994","unstructured":"Oswald IP, Eltoum I, Wynn TA, Schwartz B, Caspar P, Paulin D, Sher A, James SL (1994) Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni, through the production of nitric oxide. Proc Natl Acad Sci U S A 91:999\u20131003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5581_CR11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1017\/S0031182000079701","volume":"101","author":"A Ruppel","year":"1990","unstructured":"Ruppel A, Shi YE, Moloney NA (1990) Schistosoma mansoni and S. japonicum: comparison of levels of ultraviolet irradiation for vaccination of mice with cercariae. Parasitology 101:23\u201326","journal-title":"Parasitology"},{"key":"5581_CR12","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/ni1102-1041","volume":"3","author":"D Sacks","year":"2002","unstructured":"Sacks D, Sher A (2002) Evasion of innate immunity by parasitic protozoa. Nat Immunol 3:1041\u20131047","journal-title":"Nat Immunol"},{"key":"5581_CR13","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","volume":"155","author":"S Sakaguchi","year":"1995","unstructured":"Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155:1151\u20131164","journal-title":"J Immunol"},{"key":"5581_CR14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1001\/jamadermatol.2014.2233","volume":"151","author":"S Sheik Ali","year":"2015","unstructured":"Sheik Ali S, Goddard AL, Luke JJ, Donahue H, Todd DJ, Werchniak A, Vleugels RA (2015) Drug-associated dermatomyositis following ipilimumab therapy: a novel immune-mediated adverse event associated with cytotoxic T-lymphocyte antigen 4 blockade. JAMA Dermatol 151:195\u2013199","journal-title":"JAMA Dermatol"},{"key":"5581_CR15","doi-asserted-by":"crossref","unstructured":"Stephen-Victor E, Bosschem I, Haesebrouck F, Bayry J (2017) The yin and yang of regulatory T cells in infectious diseases and avenues to target them. Cell Microbiol 19","DOI":"10.1111\/cmi.12746"},{"key":"5581_CR16","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.4049\/jimmunol.175.4.2517","volume":"175","author":"CB Stober","year":"2005","unstructured":"Stober CB, Lange UG, Roberts MT, Alcami A, Blackwell JM (2005) IL-10 from regulatory T cells determines vaccine efficacy in murine Leishmania major infection. J Immunol 175:2517\u20132524","journal-title":"J Immunol"},{"key":"5581_CR17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00436-010-2089-2","volume":"108","author":"CL Tang","year":"2011","unstructured":"Tang CL, Lei JH, Wang T, Lu SJ, Guan F, Liu WQ, Li YL (2011) Effect of CD4+ CD25+ regulatory T cells on the immune evasion of Schistosoma japonicum. Parasitol Res 108:477\u2013480","journal-title":"Parasitol Res"},{"key":"5581_CR18","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.exppara.2013.11.001","volume":"136","author":"CL Tang","year":"2014","unstructured":"Tang CL, Lei JH, Guan F, Li YL, Liu R, Grevelding CG, Jiang MS, Dong HF (2014) Effect of cytotoxic T-lymphocyte-associated protein 4 on CD4(+)CD25(+) regulatory T cells in murine schistosomiasis japonica. Exp Parasitol 136:74\u201378","journal-title":"Exp Parasitol"},{"key":"5581_CR19","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.4049\/jimmunol.179.7.4626","volume":"179","author":"MD Taylor","year":"2007","unstructured":"Taylor MD, Harris A, Babayan SA, Bain O, Culshaw A, Allen JE, Maizels RM (2007) CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo. J Immunol 179:4626\u20134634","journal-title":"J Immunol"},{"key":"5581_CR20","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1186\/s13071-016-1799-4","volume":"9","author":"BM Tebeje","year":"2016","unstructured":"Tebeje BM, Harvie M, You H, Loukas A, McManus DP (2016) Schistosomiasis vaccines: where do we stand? Parasit Vectors 9:528","journal-title":"Parasit Vectors"},{"key":"5581_CR21","doi-asserted-by":"crossref","first-page":"13082","DOI":"10.1128\/JVI.78.23.13082-13089.2004","volume":"78","author":"FN Toka","year":"2004","unstructured":"Toka FN, Suvas S, Rouse BT (2004) CD4+ CD25+ T cells regulate vaccine-generated primary and memory CD8+ T-cell responses against herpes simplex virus type 1. J Virol 78:13082\u201313089","journal-title":"J Virol"},{"key":"5581_CR22","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nature05479","volume":"445","author":"YY Wan","year":"2007","unstructured":"Wan YY, Flavell RA (2007) Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 445:766\u2013770","journal-title":"Nature"},{"issue":"4","key":"5581_CR23","doi-asserted-by":"crossref","first-page":"e2164","DOI":"10.1371\/journal.pntd.0002164","volume":"7","author":"X Wang","year":"2013","unstructured":"Wang X, Dong L, Ni H, Zhou S, Xu Z, Hoellwarth JS, Chen X, Zhang R, Chen Q, Liu F, Wang J, Su C (2013) Combined TLR7\/8 and TLR9 ligands potentiate the activity of a Schistosoma japonicum DNA vaccine. PLoS Negl Trop Dis 7(4):e2164","journal-title":"PLoS Negl Trop Dis"},{"key":"5581_CR24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1017\/S0031182014001310","volume":"142","author":"H You","year":"2015","unstructured":"You H, McManus DP (2015) Vaccines and diagnostics for zoonotic Schistosomiasis japonica. Parasitology 142:271\u2013289","journal-title":"Parasitology"},{"issue":"3","key":"5581_CR25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF02829546","volume":"26","author":"G Yu","year":"2006","unstructured":"Yu G, Song J, Liu W, Long X, Mo H, Li Y, Chen X (2006) Expression of recombinant baculovirus carrying Schistosoma japonicum 26 ku GST in mammalian cells. J Huazhong Univ Sci Technolog Med Sci 26(3):265\u2013268","journal-title":"J Huazhong Univ Sci Technolog Med Sci"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-017-5581-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-017-5581-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-017-5581-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T04:47:24Z","timestamp":1692938844000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-017-5581-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,21]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["5581"],"URL":"https:\/\/doi.org\/10.1007\/s00436-017-5581-0","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,21]]}}}