{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T22:26:03Z","timestamp":1781562363427,"version":"3.54.5"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2009\/07815-4"],"award-info":[{"award-number":["2009\/07815-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"name":"FAPESP, Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2009\/11687-1"],"award-info":[{"award-number":["2009\/11687-1"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s00436-018-5868-9","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T08:18:42Z","timestamp":1524039522000},"page":"1819-1827","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Expression of matrix metalloproteinase-2 and metalloproteinase-9 in the skin of dogs with visceral leishmaniasis"],"prefix":"10.1007","volume":"117","author":[{"given":"Ana Paula Prudente","family":"Jacintho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme D.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele F.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Henrique Leal","family":"Bertolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela Rodrigues Reina","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Momo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago A.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemeri de Oliveira","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,18]]},"reference":[{"key":"5868_CR1","first-page":"153","volume-title":"Pathologic basis of veterinary disease","author":"MR Ackermann","year":"2011","unstructured":"Ackermann MR (2011) Chronic inflammation and wound healing. In: McGavin MD, Zachary JF (eds) Pathologic basis of veterinary disease, 5th edn. Elsevier, St Louis, pp 153\u2013191","edition":"5"},{"key":"5868_CR2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/j.1365-3024.2006.00840.x","volume":"28","author":"CL Barbi\u00e9ri","year":"2006","unstructured":"Barbi\u00e9ri CL (2006) Immunology of canine leishmaniasis. Parasite Immunol 28:329\u2013337. https:\/\/doi.org\/10.1111\/j.1365-3024.2006.00840.x","journal-title":"Parasite Immunol"},{"key":"5868_CR3","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.1002\/eji.200940115","volume":"40","author":"VS Boaventura","year":"2010","unstructured":"Boaventura VS, Santos CS, Cardoso CR, Andrade J, Santos WLC, Clar\u00eancio J, Silva JS, Borges VM, Barral-Netto M, Brodskyn CI, Barral A (2010) Human mucosal leishmaniasis: neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines. Eur J Immunol 40:2830\u20132836. https:\/\/doi.org\/10.1002\/eji.200940115","journal-title":"Eur J Immunol"},{"key":"5868_CR4","unstructured":"Brasil (2014) Minist\u00e9rio da Sa\u00fade. Secretaria de Vigil\u00e2ncia em Sa\u00fade. Departamento de Vigil\u00e2ncia Epidemiol\u00f3gica. Manual de vigil\u00e2ncia e controle da leishmaniose visceral. Minist\u00e9rio da Sa\u00fade, Bras\u00edlia, pp 120"},{"issue":"11","key":"5868_CR5","doi-asserted-by":"publisher","first-page":"e3282","DOI":"10.1371\/journal.pntd.0003282","volume":"8","author":"TM Campos","year":"2014","unstructured":"Campos TM, Passos ST, Novais FO, Beiting DP, Costa RS, Queiroz A, Mosser D, Scott P, Carvalho EM, Carvalho LP (2014) Matrix metalloproteinase 9 production by monocytes is enhanced by TNF and participates in the pathology of human cutaneous leishmaniasis. PLoS Negl Trop Dis 8(11):e3282. https:\/\/doi.org\/10.1371\/journal.pntd.0003282","journal-title":"PLoS Negl Trop Dis"},{"key":"5868_CR6","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.vetpar.2017.05.028","volume":"243","author":"JMO Cardoso","year":"2017","unstructured":"Cardoso JMO, Ker HG, Aguiar-Soares RDO, Moreira ND, Mathias FAZ, Reis LES, Roatt BM, Vieira PMA, Coura-Vital W, Carneiro CM, Reis AB (2017) Association between mast cells, tissue remodelation and parasite burden in the skin of dogs with visceral leishmaniasis. Vet Parasitol 243:260\u2013266. https:\/\/doi.org\/10.1016\/j.vetpar.2017.05.028","journal-title":"Vet Parasitol"},{"key":"5868_CR7","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.berh.2006.06.007","volume":"20","author":"TE Cawston","year":"2006","unstructured":"Cawston TE, Wilson AJ (2006) Understanding the role of tissue degrading enzymes and their inhibitors in development and disease. Best Pract Res Clin Rheumatol 20:983\u20131002. https:\/\/doi.org\/10.1016\/j.berh.2006.06.007","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"5868_CR8","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.febslet.2004.03.070","volume":"567","author":"J Dzwonek","year":"2004","unstructured":"Dzwonek J, Rylski M, Kaczmarek L (2004) Matrix metalloproteinases and their endogenous inhibitors in neuronal physiology of the adult brain. FEBS Lett 567:129\u2013135. https:\/\/doi.org\/10.1016\/j.febslet.2004.03.070","journal-title":"FEBS Lett"},{"key":"5868_CR9","first-page":"36","volume":"5","author":"MM Feitosa","year":"2000","unstructured":"Feitosa MM, Ikeda FA, Luvizotto MCR, Perri SHV (2000) Aspectos cl\u00ednicos de c\u00e3es com leishmaniose visceral no munic\u00edpio de Ara\u00e7atuba\u2014S\u00e3o Paulo (Brasil). Clin Vet 5:36\u201344","journal-title":"Clin Vet"},{"key":"5868_CR10","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.jcpa.2006.06.005","volume":"135","author":"RC Giunchetti","year":"2006","unstructured":"Giunchetti RC, Mayrink W, Genaro O, Carneiro CM, Corr\u00eaa-Oliveira R, Martins-Filho OA, Marques MJ, Tafuri WL, Reis AB (2006) Relationship between canine visceral leishmaniosis and the Leishmania (Leishmania) chagasi burden in dermal foci. J Comp Pathol 135:100\u2013107","journal-title":"J Comp Pathol"},{"key":"5868_CR11","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1086\/587487","volume":"197","author":"FRS Gutierrez","year":"2008","unstructured":"Gutierrez FRS, Lalu MM, Mariano FS, Milanezi CM, Cena J, Gerlach RF, Santos JET, Torres-Due\u00f1as D, Cunha FQ, Schulz R, Silva JS (2008) Increased activities of cardiac matrix metalloproteinases MMP-2 and MMP-9 are associated with mortality during the acute phase of experimental Trypanosoma cruzi infection. J Infect Dis 197:1468\u20131476","journal-title":"J Infect Dis"},{"key":"5868_CR12","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1097\/00004647-200107000-00008","volume":"21","author":"M Ihara","year":"2001","unstructured":"Ihara M, Tomimoto H, Kinoshita M, Oh J, Noda M, Wakita H, Akiguchi I, Shibasaki H (2001) Chronic cerebral hypoperfusion induces MMP-2 but not MMP-9 expression in the microglia and vascular endothelium of white matter. J Cereb Blood Flow Metab 21:828\u2013834","journal-title":"J Cereb Blood Flow Metab"},{"key":"5868_CR13","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1590\/S0100-736X2009000800003","volume":"29","author":"KRJ Kondo","year":"2009","unstructured":"Kondo KRJ, Fonseca CC, Matta SLP, Viloria MIV (2009) An\u00e1lise histomorfom\u00e9trica da matriz extracelular do linfonodo popl\u00edteo de c\u00e3es naturalmente infectados por Leishmania (L.) chagasi. Pesq Vet Bras 29:610\u2013616","journal-title":"Pesq Vet Bras"},{"key":"5868_CR14","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.vascn.2010.02.011","volume":"65","author":"K Kupai","year":"2010","unstructured":"Kupai K, Szucs G, Cseh S, Hajdu I, Csonka C, Csont T, Ferdinandy P (2010) Matrix metalloproteinases activity assays: importance of zymography. J Pharmacol Toxicol Methods 65:205\u2013209","journal-title":"J Pharmacol Toxicol Methods"},{"key":"5868_CR15","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.actatropica.2004.04.007","volume":"92","author":"WG Lima","year":"2004","unstructured":"Lima WG, Michalick MSM, Melo MN, Tafuri WL, Tafuri WL (2004) Canine visceral leishmaniasis: a histopathological study of lymph nodes. Acta Trop 92:43\u201353","journal-title":"Acta Trop"},{"issue":"4","key":"5868_CR16","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1590\/S0100-736X2005000400005","volume":"25","author":"VMF Lima","year":"2005","unstructured":"Lima VMF, Biazzono L, Silva AC, Correa APFL, Luvizotto MCR (2005) Serological diagnosis of visceral leishmaniasis by an enzyme immunoassay using protein A in naturally infected dogs. Pesq Vet Bras 25(4):215\u2013218","journal-title":"Pesq Vet Bras"},{"key":"5868_CR17","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1006\/expr.1996.4127","volume":"85","author":"R Lira","year":"1997","unstructured":"Lira R, Rosales-Encina JL, Arguelos C (1997) Leishmania mexicana: binding of promastigotes to type I collagen. Exp Parasitol 85:149\u2013157","journal-title":"Exp Parasitol"},{"key":"5868_CR18","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1354\/vp.40-4-382","volume":"40","author":"P Loukopoulos","year":"2003","unstructured":"Loukopoulos P, Mungall BA, Straw RC, Thornton JR, Robinson WF (2003) Matrix metalloproteinase-2 and -9 involvement in canine tumors. Vet Pathol 40:382\u2013394","journal-title":"Vet Pathol"},{"key":"5868_CR19","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.vetimm.2010.03.024","volume":"136","author":"GF Machado","year":"2010","unstructured":"Machado GF, Melo GD, Moraes OC, Souza MS, Marcondes M, Perri SHV, Vasconcelos RO (2010) Differential alterations in the activity of matrix metalloproteinases within the nervous tissue of dogs in distinct manifestations of visceral leishmaniasis. Vet Immunol Immunopathol 136:340\u2013345","journal-title":"Vet Immunol Immunopathol"},{"key":"5868_CR20","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.rvsc.2009.03.008","volume":"87","author":"MF Madeira","year":"2009","unstructured":"Madeira MF, Figueiredo FB, Pinto AG, Nascimento LD, Furtado M, Mouta-Confort E, Paula CC, Bogio A, Gomes MCA, Bessa AMS, Passos SRL (2009) Parasitological diagnosis of canine visceral leishmaniasis: is intact skin a good target? Res Vet Sci 87:260\u2013262","journal-title":"Res Vet Sci"},{"issue":"33","key":"5868_CR21","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/j.1365-3024.2011.01285.x","volume":"11","author":"NR Marangoni","year":"2011","unstructured":"Marangoni NR, Melo GD, Moraes OC, Souza MS, Perri SHV, Machado GF (2011) Levels of matrix metalloproteinase-2 and metalloproteinase-9 in the cerebrospinal fluid of dogs with visceral leishmaniasis. Parasite Immunol 11(33):330\u2013334","journal-title":"Parasite Immunol"},{"key":"5868_CR22","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s00436-010-1902-2","volume":"107","author":"PRR Moreira","year":"2010","unstructured":"Moreira PRR, Vieira LM, Andrade MMC, Bandarra MB, Machado GF, Munari DP, Vasconcelos RO (2010) Immune response pattern of the popliteal lymph nodes of dogs with visceral leishmaniasis. Parasitol Res 107:605\u2013613. https:\/\/doi.org\/10.1007\/s00436-010-1902-2","journal-title":"Parasitol Res"},{"key":"5868_CR23","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.vetpar.2012.09.029","volume":"192","author":"PRR Moreira","year":"2013","unstructured":"Moreira PRR, Bandarra MB, Magalh\u00e3es GM, Munari DP, Machado GF, Prandini MM, Alessi AC, Vasconcelos RO (2013) Influence of apoptosis on the cutaneous and peripheral lymph node inflammatory response in dogs with visceral leishmaniasis. Vet Parasitol 192:149\u2013157. https:\/\/doi.org\/10.1016\/j.vetpar.2012.09.029","journal-title":"Vet Parasitol"},{"key":"5868_CR24","doi-asserted-by":"publisher","first-page":"21491","DOI":"10.1074\/jbc.274.31.21491","volume":"274","author":"H Nagase","year":"1999","unstructured":"Nagase H, Woessner Jr JF (1999) Matrix metalloproteinases. J Biol Chem 274:21491\u201321494","journal-title":"J Biol Chem"},{"key":"5868_CR25","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1590\/S1984-29612008000100002","volume":"17","author":"TMFS Oliveira","year":"2008","unstructured":"Oliveira TMFS, Furuta PI, Carvalho D, Machado RZ (2008) A study of cross-reactivity in serum samples from dogs positive for Leishmania sp, Babesia canis and Ehrlichia canis in enzyme-linked immunosorbent assay and indirect fluorescent antibody test. Ver Bras Parasitol Vet 17:7\u201311","journal-title":"Ver Bras Parasitol Vet"},{"key":"5868_CR26","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1189\/jlb.69.6.851","volume":"69","author":"G Opdenakker","year":"2001","unstructured":"Opdenakker G, Van den Steen PE, Dubois B, Nelissen I, Coillie EV, Masure S, Proost P, Van Damme J (2001a) Gelatinase B functions as regulator and effector in leukocyte biology. J Leukoc Biol 69:851\u2013859","journal-title":"J Leukoc Biol"},{"key":"5868_CR27","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S1471-4906(01)02023-3","volume":"22","author":"G Opdenakker","year":"2001","unstructured":"Opdenakker G, Van den Steen PE, Van Damme J (2001b) Gelatinase B: a tuner and amplifier of immune functions. Trends Immunol 22:571\u2013579","journal-title":"Trends Immunol"},{"key":"5868_CR28","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.vetimm.2008.10.307","volume":"128","author":"AB Reis","year":"2009","unstructured":"Reis AB, Martins-Filho OA, Teixeira-Carvalho A, Giunchetti RC, Carneiro CM, Mayrink W, Tafuri WL, Corr\u00eaa-Oliveira R (2009) Systemic and compartmentalized immune response in canine visceral leishmaniasis. Vet Immunol Immunopathol 128:87\u201395","journal-title":"Vet Immunol Immunopathol"},{"key":"5868_CR29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S0021-9975(03)00063-X","volume":"130","author":"L Solano-Gallego","year":"2004","unstructured":"Solano-Gallego L, Fern\u00e1ndez-Bellon H, Morrell P, Fondevila D, Alberola J, Ramis A, Ferrer L (2004) Histological and immunohistochemical study of clinically normal skin of Leishmania infantum-infected dogs. J Comp Pathol 130:7\u201312","journal-title":"J Comp Pathol"},{"key":"5868_CR30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jim.2004.05.009","volume":"292","author":"WL Tafuri","year":"2004","unstructured":"Tafuri WL, Santos RL, Arantes RME, Gon\u00e7alves R, Melo MN, Michalick MSM, Tafuri WL (2004) An alternative immunohistochemical method for detecting Leishmania amastigotes in paraffin-embedded canine tissues. J Immunol Methods 292:17\u201323","journal-title":"J Immunol Methods"},{"issue":"6","key":"5868_CR31","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1590\/S0102-09352006000600004","volume":"58","author":"SC Xavier","year":"2006","unstructured":"Xavier SC, Chiarelli IM, Lima WG, Gon\u00e7alves R, Tafuri WL (2006) Canine visceral leishmaniasis: a remarkable histopathological picture of one asymptomatic animal reported from Belo Horizonte, Minas Gerais, Brazil. Arq Bras Med Vet Zootec 58(6):994\u20131000","journal-title":"Arq Bras Med Vet Zootec"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-018-5868-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-018-5868-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-018-5868-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T05:11:20Z","timestamp":1693631480000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-018-5868-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,18]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["5868"],"URL":"https:\/\/doi.org\/10.1007\/s00436-018-5868-9","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,18]]},"assertion":[{"value":"6 September 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The design for this study was approved by the Ethics and Animal Welfare Committee (CEBEA no. 020373\/09) of FCAV\/UNESP, Jaboticabal, state of S\u00e3o Paulo, Brazil.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}