{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:59:42Z","timestamp":1778705982534,"version":"3.51.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T00:00:00Z","timestamp":1527292800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"EMRO\/TDR Small Grants Scheme for Operational Research in Tropical and Other Communicable Diseases","award":["SGS14\/23"],"award-info":[{"award-number":["SGS14\/23"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Higher Education and Scientific Research of Tunisia"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s00436-018-5939-y","type":"journal-article","created":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T05:32:16Z","timestamp":1527312736000},"page":"2499-2506","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The vector competence of Phlebotomus perniciosus for Leishmania infantum zymodemes of Tunisia"],"prefix":"10.1007","volume":"117","author":[{"given":"Latifa","family":"Remadi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maribel","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najla","family":"Chargui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najoua","family":"Haouas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamouda","family":"Babba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6662-173X","authenticated-orcid":false,"given":"Ricardo","family":"Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,26]]},"reference":[{"key":"5939_CR1","first-page":"101","volume":"93","author":"K Aoun","year":"2000","unstructured":"Aoun K, Bouratbine A, Harrat Z, Guizani I, Mokni M, Belhadj A, Ben Osman A, Belkaied M, Dellagi K, Ben Ismail R (2000) Donn\u00e9es \u00e9pid\u00e9miologiques et parasitologiques concernant la leishmaniose cutan\u00e9e sporadique du nord tunisien. Bull Soc Pathol Exot 93:101\u2013103","journal-title":"Bull Soc Pathol Exot"},{"key":"5939_CR2","first-page":"375","volume":"94","author":"K Aoun","year":"2001","unstructured":"Aoun K, Bouratbine A, Harrat Z, Belkaid M, Belhadj A (2001) Profil particulier des zymodemes de Leishmania infantum causant la leishmaniose visc\u00e9rale en Tunisie. Bull Soc Pathol Exot 94:375\u2013377","journal-title":"Bull Soc Pathol Exot"},{"key":"5939_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.actatropica.2014.10.008","volume":"141","author":"W Barhoumi","year":"2014","unstructured":"Barhoumi W, Qualls WA, Archer RS, Fuller DO, Chelbi I, Cherni S, Derbali M, Arheart KL, Zhioua E, Beier JC (2014) Irrigation in the arid regions of Tunisia impacts the abundance and apparent density of sand fly vectors of Leishmania infantum. Acta Trop 141:73\u201378","journal-title":"Acta Trop"},{"key":"5939_CR4","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3390\/ijerph13030329","volume":"13","author":"W Barhoumi","year":"2016","unstructured":"Barhoumi W, Fares W, Cherni S, Derbali M, Dachraoui K, Chelbi I, Ramalho-Ortigao M, Beier JC, Zhioua E (2016) Changes of sand fly populations and Leishmania infantum infection rates in an Irrigated Village located in arid Central Tunisia. Int J Environ Res Public Health 13:329","journal-title":"Int J Environ Res Public Health"},{"key":"5939_CR5","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0001-706X(02)00255-3","volume":"85","author":"S Belhadj","year":"2003","unstructured":"Belhadj S, Pratlong F, Hammami M, Kallel K, Dedet JP, Chaker E (2003) Human cutaneous leishmaniasis due to Leishmania infantum in the Sidi Bourouis focus (northern Tunisia) epidemiological study and isoenzymatic characterization of the parasites. Acta Trop 85:83\u201386. \n                    https:\/\/doi.org\/10.1016\/S0001-706X(02)00255-3","journal-title":"Acta Trop"},{"key":"5939_CR6","first-page":"91","volume":"70","author":"R Ben Ismail","year":"1993","unstructured":"Ben Ismail R (1993) Incrimination de Phlebotomus perniciosus comme vecteur de Leishmania infantum. Arch Inst Pasteur Tunis 70:91\u2013110","journal-title":"Arch Inst Pasteur Tunis"},{"key":"5939_CR7","first-page":"464","volume":"160","author":"R Benikhlef","year":"2009","unstructured":"Benikhlef R, Aoun K, Bedoui K, Harrat Z, Bouratbine A (2009) First identifications of Leishmania infantum MON-80 in the dog in Algeria and Tunisia. Rev M\u00e9d V\u00e9t 160:464\u2013466","journal-title":"Rev M\u00e9d V\u00e9t"},{"key":"5939_CR8","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/S0399-077X(98)80129-7","volume":"28","author":"A Bouratbine","year":"1998","unstructured":"Bouratbine A, Aoun K, Chahed MK, Ben Ismail R (1998) Donn\u00e9es \u00e9pid\u00e9miologiques sur la leishmaniose visc\u00e9rale infantile en Tunisie en 1993. M\u00e9d Mal Infect 28:446\u2013447","journal-title":"M\u00e9d Mal Infect"},{"key":"5939_CR9","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.actatropica.2013.12.018","volume":"132","author":"D Chaara","year":"2014","unstructured":"Chaara D, Haouas N, Dedet JP, Babba H, Pratlong F (2014) Leishmaniases in Maghreb: an endemic neglected disease. Acta Trop 132:80\u201393. \n                    https:\/\/doi.org\/10.1016\/j.actatropica.2013.12.018","journal-title":"Acta Trop"},{"key":"5939_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1948-7134.2013.12000.x","volume":"38","author":"N Chargui","year":"2013","unstructured":"Chargui N, Haouas N, Slama D, Gorcii M, Jaouadi K, Essabbah-Aguir N, Mezhoud H, Babba H (2013) Transmission of visceral leishmaniasis in a previously non-endemic region of Tunisia: detection of Leishmania DNA in Phlebotomus perniciosus. J Vect. Ecol 38:1\u20135. \n                    https:\/\/doi.org\/10.1111\/j.1948-7134.2013.12000.x","journal-title":"Ecol"},{"key":"5939_CR11","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/1756-3305-5-276","volume":"5","author":"A Dost\u00e1lov\u00e1","year":"2012","unstructured":"Dost\u00e1lov\u00e1 A, Volf P (2012) Leishmania development in sand flies: parasite-vector interactions overview. Parasit Vectors 5:276 \n                    http:\/\/www.parasitesandvectors.com\/content\/5\/1\/276","journal-title":"Parasit Vectors"},{"key":"5939_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005401","volume":"11","author":"E Falc\u00e3o de Oliveira","year":"2017","unstructured":"Falc\u00e3o de Oliveira E, Oshiro ET, Fernandes WS, Murat PG, Medeiros MJ, Souza AI, Oliveira AG, Galati EA (2017) Experimental infection and transmission of Leishmania by Lutzomyia cruzi (Diptera: Psychodidae): Aspects of the ecology of parasite-vector interactions. PLoS Negl Trop Dis 11:e0005401","journal-title":"PLoS Negl Trop Dis"},{"key":"5939_CR13","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.trstmh.2006.07.007","volume":"101","author":"S Guerbouj","year":"2007","unstructured":"Guerbouj S, Chemkhi J, Kaabi B, Rahali A, Ben Ismail R, Guizania I (2007) Natural infection of Phlebotomus (Larroussius) langeroni (Diptera: Psychodidae) with Leishmania infantum in Tunisia. Trans R Soc Trop Med Hyg 101:372\u2013377","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"5939_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1444-2","volume":"9","author":"VCFV Guimar\u00e3es","year":"2016","unstructured":"Guimar\u00e3es VCFV, Pruzinova K, Sadlova J, Volfova V, Myskova J, Filho SPB, Volf P (2016) Lutzomyia migonei is a permissive vector competent for Leishmania infantum. Parasit Vectors 9:159. \n                    https:\/\/doi.org\/10.1186\/s13071-016-1444-2","journal-title":"Parasit Vectors"},{"key":"5939_CR15","doi-asserted-by":"publisher","unstructured":"Haouas N, Babba H (2017) Leishmaniasis in Tunisia: history and new insights into the epidemiology of a neglected disease. In: Claborn D (ed) The epidemiology and ecology of Leishmaniasis. InTech, pp 978\u2013953\u201351-2972-1. \n                    https:\/\/doi.org\/10.5772\/65000","DOI":"10.5772\/65000"},{"key":"5939_CR16","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1051\/parasite\/2007143239","volume":"14","author":"N Haouas","year":"2007","unstructured":"Haouas N, Gorcii M, Chargui N, Aoun K, Bouratbine A, Messaadi Akrout F, Masmoudi A, Zili J, Ben Said M, Pratlong F, Dedet JP, Mezhoud H, Azaiez R, Babba H (2007) Leishmaniasis in central and southern Tunisia: current geographical distribution of zymodemes. Parasite 14:239\u2013246. \n                    https:\/\/doi.org\/10.1051\/parasite\/2007143239","journal-title":"Parasite"},{"key":"5939_CR17","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.actatropica.2012.08.012","volume":"124","author":"N Haouas","year":"2012","unstructured":"Haouas N, Chaker E, Chargui N, Gorciia M, Belhadj S, Kallel K, Aoun K, Messaadi Akrout F, Ben Said M, Pratlong F, Dedet JP, Mezhoud H, Lami P, Zribi M, Azaiez R, Babba H (2012) Geographical distribution updating of Tunisian leishmaniasis foci: about the isoenzymatic analysis of 694 strains. Acta Trop 124:221\u2013228. \n                    https:\/\/doi.org\/10.1016\/j.actatropica.2012.08.012","journal-title":"Acta Trop"},{"key":"5939_CR18","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.vetpar.2014.03.027","volume":"202","author":"M Jim\u00e9nez","year":"2014","unstructured":"Jim\u00e9nez M, Gonz\u00e1lez E, Mart\u00edn-Mart\u00edn I, Hern\u00e1ndez S, Molina R (2014) Could wild rabbits (Oryctolagus cuniculus) be reservoirs for Leishmania infantum in the focus of Madrid, Spain? Vet Parasitol 202:296\u2013300. \n                    https:\/\/doi.org\/10.1016\/j.vetpar.2014.03.027","journal-title":"Vet Parasitol"},{"key":"5939_CR19","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.actatropica.2008.02.006","volume":"160","author":"K Kallel","year":"2008","unstructured":"Kallel K, Pratlong F, Haouas N, Kaouech E, Belhadj S, Anane S, Dedet JP, Babba H, Chaker E (2008) Isoenzymatic variability of Leishmania infantum in Tunisia concerning 254 human strains. Acta Trop 160:132\u2013136. \n                    https:\/\/doi.org\/10.1016\/j.actatropica.2008.02.006","journal-title":"Acta Trop"},{"key":"5939_CR20","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.pt.2006.06.012","volume":"22","author":"S Kamhawi","year":"2006","unstructured":"Kamhawi S (2006) Phlebotomine sand flies and Leishmania parasites: friends or foes? Trends Parasitol 22:439\u2013445. \n                    https:\/\/doi.org\/10.1016\/j.pt.2006.06.012","journal-title":"Trends Parasitol"},{"key":"5939_CR21","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1051\/parasite\/1990651037","volume":"65","author":"R Killick-Kendrick","year":"1990","unstructured":"Killick-Kendrick R (1990) The life-cycle of Leishmania in the sand fly with special reference to the form infective to the vertebrate host. Ann Parasitol Hum Comp 65:37\u201342. \n                    https:\/\/doi.org\/10.1051\/parasite\/1990651037","journal-title":"Ann Parasitol Hum Comp"},{"key":"5939_CR22","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1098\/rspb.1977.0032","volume":"196","author":"R Killick-Kendrick","year":"1977","unstructured":"Killick-Kendrick R, Leaney AJ, Ready PD (1977) Leishmania in phlebotomid sand flies. The transmission of Leishmania mexicana amazonensis to hamsters by the bite of experimentally infected Lutzomyia longipalpis. Proc R Soc Lond B 196:105\u2013115","journal-title":"Proc R Soc Lond B"},{"key":"5939_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001181","volume":"5","author":"C Maia","year":"2011","unstructured":"Maia C, Seblova V, Sadlova J, Votypka J, Volf P (2011) Experimental transmission of Leishmania infantum by two major vectors: a comparison between a viscerotropic and a dermotropic strain. PLoS Negl Trop Dis 5:e1181. \n                    https:\/\/doi.org\/10.1371\/journal.pntd.0001181","journal-title":"PLoS Negl Trop Dis"},{"key":"5939_CR24","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/j.1365-2915.2012.01034.x","volume":"27","author":"M Maroli","year":"2013","unstructured":"Maroli M, Feliciangeli MD, Bichaud L, Charrel RN, Gradoni L (2013) Phlebotomine sandflies and the spreading of leishmaniases and other diseases of public health concern. Med Vet Entomol 27:123\u2013147","journal-title":"Med Vet Entomol"},{"issue":"3","key":"5939_CR25","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/0020-7519(94)90089-2","volume":"24","author":"J Mart\u00edn-S\u00e1nchez","year":"1994","unstructured":"Mart\u00edn-S\u00e1nchez J, Guilvard E, Acedo-S\u00e1nchez C, Wolf-Echeverri M, Sanchiz-Mar\u00edn MC, Morillas-M\u00e1rquez F (1994) Phlebotomus perniciosus Newstead, 1911, infection by various zymodemes of the Leishmania infantum complex in the Granada province (southern Spain). Int J Parasitol 24(3):405\u2013408","journal-title":"Int J Parasitol"},{"key":"5939_CR26","first-page":"87","volume":"51","author":"R Molina","year":"1991","unstructured":"Molina R (1991) Laboratory adaptation of an autochtonous colony of Phlebotomus perniciosus Newstead, 1911 (Diptera: Psychodidae). Res Rev Parasitol 51:87\u201389","journal-title":"Res Rev Parasitol"},{"key":"5939_CR27","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/0035-9203(94)90446-4","volume":"88","author":"R Molina","year":"1994","unstructured":"Molina R, Amela C, Nieto J, San-Andr\u00e9s M, Gonz\u00e1lez F, Castillo JA, Lucientes J, Alvar J (1994) Infectivity of dogs naturally infected with Leishmania infantum to colonized Phlebotomus perniciosus. Trans R Soc Trop Med Hyg 88:491\u2013493","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"5939_CR28","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.vetpar.2012.05.006","volume":"190","author":"R Molina","year":"2012","unstructured":"Molina R, Jim\u00e9nez MI, Cruz I, Iriso A, Mart\u00edn-Mart\u00edn I, Sevillano O, Melero S, Bernal J (2012) The hare (Lepus granatensis) as potential sylvatic reservoir of Leishmania infantum in Spain. Vet Parasitol 190:268\u2013271. \n                    https:\/\/doi.org\/10.1016\/j.vetpar.2012.05.006","journal-title":"Vet Parasitol"},{"key":"5939_CR29","volume-title":"Methods in Sand Fly Research","author":"R Molina","year":"2017","unstructured":"Molina R, Jim\u00e9nez M, Alvar J (2017) Methods in Sand Fly Research, 1st edn. Servicio de Publicaciones Universidad de Alcal\u00e1 de Henares, Madrid","edition":"1"},{"key":"5939_CR30","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1093\/jmedent\/45.1.133","volume":"45","author":"J Myskova","year":"2008","unstructured":"Myskova J, Votypka J, Volf P (2008) Leishmania in sand flies: comparison of quantitative polymerase chain reaction with other techniques to determine the intensity of infection. J Med Entomol 45:133\u2013138. \n                    https:\/\/doi.org\/10.1093\/jmedent\/45.1.133","journal-title":"J Med Entomol"},{"key":"5939_CR31","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13071-018-2613-2","volume":"11","author":"K Pruzinova","year":"2018","unstructured":"Pruzinova K, Sadlova J, Myskova J, Lestinova T, Janda J, Volf P (2018) Leishmania mortality in sand fly blood meal is not species-specific and does not result from direct effect of proteinases. Parasit Vectors 11:37","journal-title":"Parasit Vectors"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-018-5939-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-018-5939-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-018-5939-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T19:22:03Z","timestamp":1558812123000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-018-5939-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,26]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["5939"],"URL":"https:\/\/doi.org\/10.1007\/s00436-018-5939-y","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,26]]},"assertion":[{"value":"27 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}