{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T19:44:45Z","timestamp":1775159085358,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s00436-018-6166-2","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T02:25:18Z","timestamp":1543976718000},"page":"369-376","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["6,7-Dehydroroyleanone diterpene derived from Tetradenia riparia essential oil modulates IL-4\/IL-12 release by macrophages that are infected with Leishmania amazonensis"],"prefix":"10.1007","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9125-6818","authenticated-orcid":false,"given":"Mariana de Souza","family":"Terron-Monich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabel Galhardo","family":"Demarchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pollyanna Rina Ferreira","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1quila Carolina Fernandes Herculano","family":"Ramos-Milar\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zilda Cristiani","family":"Gazim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tha\u00eds Gomes Verzignassi","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Valdrinez Campana","family":"Lonardoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"key":"6166_CR1","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.4049\/jimmunol.1303043","volume":"193","author":"G Arango Duque","year":"2014","unstructured":"Arango Duque G, Fukuda M, Turco SJ, St\u00e4ger S, Descoteaux A (2014) Leishmania promastigotes induce cytokine secretion in macrophages through the degradation of synaptotagmin XI. J Immunol 193:2363\u20132372. \n                    https:\/\/doi.org\/10.4049\/jimmunol.1303043","journal-title":"J Immunol"},{"key":"6166_CR2","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.coi.2014.12.001","volume":"32","author":"RJ Arg\u00fcello","year":"2015","unstructured":"Arg\u00fcello RJ, Rodrigues CR, Gatti E, Pierre P (2015) Protein synthesis regulation, a pillar of strength for innate immunity? Curr Opin Immunol 32:28\u201335. \n                    https:\/\/doi.org\/10.1016\/j.coi.2014.12.001","journal-title":"Curr Opin Immunol"},{"key":"6166_CR3","doi-asserted-by":"publisher","unstructured":"Baldin VP, Bertin De Lima Scodro R, Lopes-Ortiz MA, et al (2018) Anti-Mycobacterium tuberculosis activity of essential oil and 6,7-Dehydroroyleanone isolated from leaves of Tetradenia riparia (Hochst.) Codd (Lamiaceae). Phytomedicine in press. doi: \n                    https:\/\/doi.org\/10.1016\/j.phymed.2018.04.043\n                    \n                  , 47, 34, 39","DOI":"10.1016\/j.phymed.2018.04.043"},{"key":"6166_CR4","unstructured":"Brazil (2017) Manual for surveillance of cutaneous leishmaniasis. Publisher of the Ministry of Health"},{"key":"6166_CR5","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1002\/ffj.3284","volume":"30","author":"IG Demarchi","year":"2015","unstructured":"Demarchi IG, de Souza Terron M, Thomazella MV et al (2015a) Immunomodulatory activity of essential oil from Tetrania riparia (Hochstetter) Codd in murine macrophages. Flavour Fragr J 30:428\u2013438. \n                    https:\/\/doi.org\/10.1002\/ffj.3284","journal-title":"Flavour Fragr J"},{"key":"6166_CR6","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.exppara.2015.06.014","volume":"157","author":"IG Demarchi","year":"2015","unstructured":"Demarchi IG, Thomazella MV, de Souza Terron M, Lopes L, Gazim ZC, Cortez DAG, Donatti L, Aristides SMA, Silveira TGV, Lonardoni MVC (2015b) Antileishmanial activity of essential oil and 6,7-dehydroroyleanone isolated from Tetradenia riparia. Exp Parasitol 157:128\u2013137. \n                    https:\/\/doi.org\/10.1016\/j.exppara.2015.06.014","journal-title":"Exp Parasitol"},{"key":"6166_CR7","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/pim.12297","volume":"38","author":"IG Demarchi","year":"2016","unstructured":"Demarchi IG, de Souza Terron M, Thomazella MV et al (2016) Antileishmanial and immunomodulatory effects of the essential oil from Tetradenia riparia (Hochstetter) Codd. Parasite Immunol 38:64\u201377. \n                    https:\/\/doi.org\/10.1111\/pim.12297","journal-title":"Parasite Immunol"},{"key":"6166_CR8","doi-asserted-by":"publisher","first-page":"5509","DOI":"10.3390\/molecules15085509","volume":"15","author":"ZC Gazim","year":"2010","unstructured":"Gazim ZC, Amorim AC, Hovell AMC et al (2010) Seasonal variation, chemical composition, and analgesic and antimicrobial activities of the essential oil from leaves of Tetradenia riparia (Hochst.) Codd in southern Brazil. Molecules 15:5509\u20135524. \n                    https:\/\/doi.org\/10.3390\/molecules15085509","journal-title":"Molecules"},{"key":"6166_CR9","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3390\/molecules19010514","volume":"19","author":"ZC Gazim","year":"2014","unstructured":"Gazim ZC, Rodrigues F, Amorin ACL, Rezende C, Sokovi\u0107 M, Te\u0161evi\u0107 V, Vu\u010dkovi\u0107 I, Krsti\u0107 G, Cortez L, Colauto N, Linde G, Cortez D (2014) New natural diterpene-type abietane from Tetradenia riparia essential oil with cytotoxic and antioxidant activities. Molecules 19:514\u2013524. \n                    https:\/\/doi.org\/10.3390\/molecules19010514","journal-title":"Molecules"},{"key":"6166_CR10","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/pim.12100","volume":"36","author":"KJ Gollob","year":"2014","unstructured":"Gollob KJ, Viana AG, Dutra WO (2014) Immunoregulation in human American leishmaniasis: balancing pathology and protection. Parasite Immunol 36:367\u2013376. \n                    https:\/\/doi.org\/10.1111\/pim.12100","journal-title":"Parasite Immunol"},{"key":"6166_CR11","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/nri978","volume":"3","author":"S Gordon","year":"2003","unstructured":"Gordon S (2003) Alternative activation of macrophages. Nat Rev Immunol 3:23\u201335. \n                    https:\/\/doi.org\/10.1038\/nri978","journal-title":"Nat Rev Immunol"},{"key":"6166_CR12","doi-asserted-by":"publisher","first-page":"6438","DOI":"10.4049\/jimmunol.0902009","volume":"184","author":"DR Herbert","year":"2010","unstructured":"Herbert DR, Orekov T, Roloson A, Ilies M, Perkins C, O'Brien W, Cederbaum S, Christianson DW, Zimmermann N, Rothenberg ME, Finkelman FD (2010) Arginase I suppresses IL-12\/IL-23 p40-driven intestinal inflammation during acute schistosomiasis. J Immunol 184:6438\u20136446. \n                    https:\/\/doi.org\/10.4049\/jimmunol.0902009","journal-title":"J Immunol"},{"key":"6166_CR13","doi-asserted-by":"publisher","first-page":"6085","DOI":"10.1128\/IAI.73.9.6085-6090.2005","volume":"73","author":"V Iniesta","year":"2005","unstructured":"Iniesta V, Carcel\u00e9n J, Molano I et al (2005) Arginase I induction during Leishmania major infection mediates the development of disease. Infect Immun 73:6085\u20136090. \n                    https:\/\/doi.org\/10.1128\/IAI.73.9.6085","journal-title":"Infect Immun"},{"key":"6166_CR14","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s10886-009-9646-0","volume":"35","author":"N Kusumoto","year":"2009","unstructured":"Kusumoto N, Ashitani T, Hayasaka Y, Murayama T, Ogiyama K, Takahashi K (2009) Antitermitic activities of abietane-type diterpenes from Taxodium distichum cones. J Chem Ecol 35:635\u2013642. \n                    https:\/\/doi.org\/10.1007\/s10886-009-9646-0","journal-title":"J Chem Ecol"},{"key":"6166_CR15","doi-asserted-by":"publisher","first-page":"6355","DOI":"10.1128\/IAI.68.11.6355-6361.2000","volume":"68","author":"MV Lonardoni","year":"2000","unstructured":"Lonardoni MV, Russo M, Jancar S (2000) Essential role of platelet-activating factor in control of Leishmania (Leishmania) amazonensis infection. Infect Immun 68:6355\u20136361. \n                    https:\/\/doi.org\/10.1128\/IAI.68.11.6355-6361.2000","journal-title":"Infect Immun"},{"key":"6166_CR16","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","volume":"23","author":"A Mantovani","year":"2002","unstructured":"Mantovani A, Sozzani S, Locati M et al (2002) Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23:549\u2013555. \n                    https:\/\/doi.org\/10.1016\/S1471-4906(02)02302-5","journal-title":"Trends Immunol"},{"issue":"Suppl 2","key":"6166_CR17","doi-asserted-by":"publisher","first-page":"S359","DOI":"10.1590\/S0102-311X1994000800014","volume":"10","author":"MC d A Marzochi","year":"1994","unstructured":"Marzochi MC d A, Marzochi KBF (1994) Tegumentary and visceral leishmaniases in Brazil: emerging anthropozoonosis and possibilities for their control. Cad Saude Publica 10(Suppl 2):S359\u2013S375. \n                    https:\/\/doi.org\/10.1590\/S0102-311X1994000800014","journal-title":"Cad Saude Publica"},{"key":"6166_CR18","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1080\/20477724.2016.1232042","volume":"110","author":"N Maspi","year":"2016","unstructured":"Maspi N, Abdoli A, Ghaffarifar F (2016) Pro- and anti-inflammatory cytokines in cutaneous leishmaniasis: a review. Pathog Glob Health 110:247\u2013260. \n                    https:\/\/doi.org\/10.1080\/20477724.2016.1232042","journal-title":"Pathog Glob Health"},{"key":"6166_CR19","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1007\/s40265-013-0132-1","volume":"73","author":"B Monge-Maillo","year":"2013","unstructured":"Monge-Maillo B, L\u00f3pez-V\u00e9lez R (2013) Therapeutic options for old world cutaneous leishmaniasis and new world cutaneous and mucocutaneous leishmaniasis. Drugs 73:1889\u20131920. \n                    https:\/\/doi.org\/10.1007\/s40265-013-0132-1","journal-title":"Drugs"},{"key":"6166_CR20","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1084\/jem.189.4.741","volume":"189","author":"HW Murray","year":"1999","unstructured":"Murray HW, Nathan CF (1999) Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani. J Exp Med 189:741\u2013746. \n                    https:\/\/doi.org\/10.1084\/jem.189.4.741","journal-title":"J Exp Med"},{"key":"6166_CR21","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.pt.2004.01.004","volume":"20","author":"W No\u00ebl","year":"2004","unstructured":"No\u00ebl W, Raes G, Ghassabeh GH et al (2004) Alternatively activated macrophages during parasite infections. Trends Parasitol 20:126\u2013133. \n                    https:\/\/doi.org\/10.1016\/j.pt.2004.01.004","journal-title":"Trends Parasitol"},{"key":"6166_CR22","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.cellimm.2016.06.004","volume":"309","author":"I Okwor","year":"2016","unstructured":"Okwor I, Uzonna JE (2016) Pathways leading to interleukin-12 production and protective immunity in cutaneous leishmaniasis. Cell Immunol 309:32\u201336. \n                    https:\/\/doi.org\/10.1016\/j.cellimm.2016.06.004","journal-title":"Cell Immunol"},{"key":"6166_CR23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.actatropica.2011.02.007","volume":"118","author":"LF Oliveira","year":"2011","unstructured":"Oliveira LF, Schubach AO, Martins MM, Passos SL, Oliveira RV, Marzochi MC, Andrade CA (2011) Systematic review of the adverse effects of cutaneous leishmaniasis treatment in the New World. Acta Trop 118:87\u201396. \n                    https:\/\/doi.org\/10.1016\/j.actatropica.2011.02.007","journal-title":"Acta Trop"},{"key":"6166_CR24","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.cyto.2013.12.016","volume":"66","author":"WN Oliveira","year":"2014","unstructured":"Oliveira WN, Ribeiro LE, Schrieffer A, Machado P, Carvalho EM, Bacellar O (2014) The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis. Cytokine 66:127\u2013132. \n                    https:\/\/doi.org\/10.1016\/j.cyto.2013.12.016","journal-title":"Cytokine"},{"key":"6166_CR25","doi-asserted-by":"publisher","unstructured":"Sen R, Chatterjee M (2011) Plant derived therapeutics for the treatment of leishmaniasis. Phytomedicine 18:1056\u20131069. \n                    https:\/\/doi.org\/10.1016\/j.phymed.2011.03.004","DOI":"10.1016\/j.phymed.2011.03.004"},{"key":"6166_CR26","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1016\/j.molimm.2011.05.013","volume":"48","author":"M Shweash","year":"2011","unstructured":"Shweash M, McGachy HA, Schroeder J et al (2011) Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and arginase-1 expression. Mol Immunol 48:1800\u20131808. \n                    https:\/\/doi.org\/10.1016\/j.molimm.2011.05.013","journal-title":"Mol Immunol"},{"key":"6166_CR27","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.3389\/fimmu.2017.01838","volume":"8","author":"D Soulat","year":"2017","unstructured":"Soulat D, Bogdan C (2017) Function of macrophage and parasite phosphatases in leishmaniasis. Front Immunol 8:1838. \n                    https:\/\/doi.org\/10.3389\/fimmu.2017.01838","journal-title":"Front Immunol"},{"key":"6166_CR28","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/j.1574-695X.2007.00311.x","volume":"51","author":"P Tripathi","year":"2007","unstructured":"Tripathi P, Singh V, Naik S (2007) Immune response to Leishmania: paradox rather than paradigm. FEMS Immunol Med Microbiol 51:229\u2013242. \n                    https:\/\/doi.org\/10.1111\/j.1574-695X.2007.00311.x","journal-title":"FEMS Immunol Med Microbiol"},{"key":"6166_CR29","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/j.1365-3083.2007.01950.x","volume":"66","author":"CMV Vendrame","year":"2007","unstructured":"Vendrame CMV, Carvalho MDT, Rios FJO, Manuli ER, Petitto-Assis F, Goto H (2007) Effect of insulin-like growth factor-I on Leishmania amazonensis promastigote arginase activation and reciprocal inhibition of NOS2 pathway in macrophage in vitro. Scand J Immunol 66:287\u2013296. \n                    https:\/\/doi.org\/10.1111\/j.1365-3083.2007.01950.x","journal-title":"Scand J Immunol"},{"key":"6166_CR30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s12026-007-8012-y","volume":"41","author":"N Wanasen","year":"2008","unstructured":"Wanasen N, Soong L (2008) L-arginine metabolism and its impact on host immunity against Leishmania infection. Immunol Res 41:15\u201325. \n                    https:\/\/doi.org\/10.1007\/s12026-007-8012-y","journal-title":"Immunol Res"},{"key":"6166_CR31","unstructured":"World Health Organization (2010) Control of the leishmaniases: report of a meeting of the WHO Expert Committee on the Control of Leishmaniasis. WHO Tech Rep Ser 949:22\u201326. \n                    https:\/\/goo.gl\/6iYa7H\n                    \n                  . Accessed 5 Jan 2018"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-018-6166-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-018-6166-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-018-6166-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T19:06:17Z","timestamp":1575486377000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-018-6166-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,5]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["6166"],"URL":"https:\/\/doi.org\/10.1007\/s00436-018-6166-2","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,5]]},"assertion":[{"value":"7 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Committee of Ethics in Animal Use in Experiments (CEAE) of the State University of Maring\u00e1 (Paran\u00e1, Brazil; opinion nos. 133\/2012 and 079\/2012) to obtain cells from BALB\/c mice.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}