{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:16:46Z","timestamp":1761581806687},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T00:00:00Z","timestamp":1551484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s00436-019-06271-4","type":"journal-article","created":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T17:53:29Z","timestamp":1551549209000},"page":"1581-1592","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cathepsin L\u2014a novel cysteine protease from Haemaphysalis flava Neumann, 1897"],"prefix":"10.1007","volume":"118","author":[{"given":"Yali","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junlong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,3,2]]},"reference":[{"issue":"7","key":"6271_CR1","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.ibmb.2004.03.019","volume":"34","author":"EG Abraham","year":"2004","unstructured":"Abraham EG, Jacobslorena M (2004) Mosquito midgut barriers to malaria parasite development. Insect Biochem Mol Biol 34(7):667\u2013671","journal-title":"Insect Biochem Mol Biol"},{"key":"6271_CR2","doi-asserted-by":"crossref","unstructured":"Akov S (1982) Blood digestion in ticks. Physiology of Ticks 1982:197-211","DOI":"10.1016\/B978-0-08-024937-7.50011-1"},{"key":"6271_CR3","unstructured":"Aksenova AS, Kupriianova ES, Anufrieva VN, Ermakova RM, Shlenova MF (1976) Comparative characteristics of blood digestion stages in the mosquitoes Anopheles Meig., Culex pipiens L. and four species of Aedes Meig. (Aedes cantans Meig., Aedes caspius Pall., Aedes cinereus Meig., and Aedes communis De Geer). Meditsinskaia Parazitologiia I Parazitarnye Bolezni"},{"issue":"1","key":"6271_CR4","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/1756-3305-6-276","volume":"6","author":"H AM","year":"2013","unstructured":"AM H et al (2013) The ovarian transcriptome of the cattle tick, Rhipicephalus (Boophilus) microplus, feeding upon a bovine host infected with Babesia bovis. Parasit Vectors 6(1):276","journal-title":"Parasit Vectors"},{"issue":"1","key":"6271_CR5","first-page":"1","volume":"244","author":"AJ Barrett","year":"1994","unstructured":"Barrett AJ (1994) Classification of peptidases. Methods Enzymol 244(1):1\u201315","journal-title":"Methods Enzymol"},{"issue":"1","key":"6271_CR6","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.phytochem.2003.09.005","volume":"65","author":"EP Beers","year":"2004","unstructured":"Beers EP, Jones AM, Dickerman AW (2004) The S8 serine, C1A cysteine and A1 aspartic protease families in Arabidopsis. Phytochemistry 65(1):43\u201358","journal-title":"Phytochemistry"},{"issue":"4","key":"6271_CR7","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1139\/O08-071","volume":"86","author":"D Boldbaatar","year":"2008","unstructured":"Boldbaatar D, Battsetseg B, Matsuo T, Hatta T, Umemiya-Shirafuji R, Xuan X, Fujisaki K (2008) Tick vitellogenin receptor reveals critical role in oocyte development and transovarial transmission of Babesia parasite. Biochem Cell Biol-biochim Et Biol Cell 86(4):331\u2013344","journal-title":"Biochem Cell Biol-biochim Et Biol Cell"},{"issue":"2","key":"6271_CR8","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1006\/expr.1999.4478","volume":"94","author":"CP Brady","year":"2000","unstructured":"Brady CP, Brindley PJ, Dowd AJ, Dalton JP (2000) Schistosoma mansoni: differential expression of cathepsins L1 and L2 suggests discrete biological functions for each enzyme. Exp Parasitol 94(2):75\u201383","journal-title":"Exp Parasitol"},{"issue":"4","key":"6271_CR9","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/BF00539454","volume":"74","author":"G B\u00fcscher","year":"1988","unstructured":"B\u00fcscher G, Friedhoff KT, Elallawy TA (1988) Quantitative description of the development of Babesia ovis in Rhipicephalus bursa (hemolymph, ovary, eggs). Parasitol Res 74(4):331\u2013339","journal-title":"Parasitol Res"},{"issue":"2","key":"6271_CR10","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1182\/blood-2010-06-293241","volume":"117","author":"J Chmelar","year":"2011","unstructured":"Chmelar J, Oliveira CJ, Rezacova P, Francischetti IMB, Kovarova Z, Pejler G, Kopacek P, Ribeiro JMC, Mares M, Kopecky J, Kotsyfakis M (2011) A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation. Blood 117(2):736\u2013744","journal-title":"Blood"},{"issue":"19","key":"6271_CR11","doi-asserted-by":"publisher","first-page":"13311","DOI":"10.1074\/jbc.274.19.13311","volume":"274","author":"WL Cho","year":"1999","unstructured":"Cho WL, Tsao SM, Hays AR, Walter R, Chen JS, Snigirevskaya ES, Raikhel AS (1999) Mosquito cathepsin B-like protease involved in embryonic degradation of vitellin is produced as a latent extraovarian precursor. J Biol Chem 274(19):13311\u201313321","journal-title":"J Biol Chem"},{"issue":"20","key":"6271_CR12","doi-asserted-by":"publisher","first-page":"5492","DOI":"10.1002\/j.1460-2075.1996.tb00934.x","volume":"15","author":"R Coulombe","year":"1996","unstructured":"Coulombe R, Grochulski P, Sivaraman J, M\u00e9nard R, Mort JS, Cygler M (1996) Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment. EMBO J 15(20):5492\u20135503","journal-title":"EMBO J"},{"issue":"51","key":"6271_CR13","doi-asserted-by":"publisher","first-page":"39316","DOI":"10.1074\/jbc.M607128200","volume":"281","author":"M Delcroix","year":"2006","unstructured":"Delcroix M, Sajid M, Caffrey CR, Lim KC, Dvo\u0159\u00e1k J, Hsieh I, Bahgat M, Dissous C, McKerrow JH (2006) A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite. J Biol Chem 281(51):39316\u201339329","journal-title":"J Biol Chem"},{"issue":"5145","key":"6271_CR14","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/218929a0","volume":"218","author":"J Drenth","year":"1968","unstructured":"Drenth J, Jansonius JN, Koekoek R, Swen HM, Wolthers BG (1968) Structure of papain. Nature 218(5145):929\u2013932","journal-title":"Nature"},{"issue":"6","key":"6271_CR15","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1128\/JCM.40.6.2176-2181.2002","volume":"40","author":"PE Fournier","year":"2002","unstructured":"Fournier PE, Fujita H, Takada N, Raoult D (2002) Genetic identification of rickettsiae isolated from ticks in Japan. J Clin Microbiol 40(6):2176\u20132181","journal-title":"J Clin Microbiol"},{"issue":"14","key":"6271_CR16","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.2741\/3363","volume":"14","author":"IM Francischetti","year":"2009","unstructured":"Francischetti IM, Sanunes A, Mans BJ, Santos IM, Ribeiro JM (2009) The role of saliva in tick feeding. Front Biosci 14(14):2051\u20132088","journal-title":"Front Biosci"},{"issue":"1","key":"6271_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-3305-3-119","volume":"3","author":"Z Franta","year":"2010","unstructured":"Franta Z et al (2010) Dynamics of digestive proteolytic system during blood feeding of the hard tick Ixodes ricinus. Parasit Vectors 3(1):1\u201311","journal-title":"Parasit Vectors"},{"key":"6271_CR18","unstructured":"Fuente JDL et al (2017) Tick-pathogen interactions and vector competence: identification of molecular drivers for tick-borne diseases. Front Cell Infect Microbiol 7:114"},{"key":"6271_CR19","first-page":"147","volume":"25","author":"O Grandjean","year":"1984","unstructured":"Grandjean O (1984) Blood digestion in Ornithodorus moubata Murray sensu stricto Walton (Ixodoidea: Argasidae) females. I. Biochemical changes in the midgut lumen and ultrastructure of the midgut cell, related to intracellular digestion. Acarologia 25:147\u2013165","journal-title":"Acarologia"},{"issue":"10","key":"6271_CR20","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.chembiol.2009.09.009","volume":"16","author":"M Horn","year":"2009","unstructured":"Horn M, Nussbaumerov\u00e1 M, \u0160anda M, Kov\u00e1\u0159ov\u00e1 Z, Srba J, Franta Z, Sojka D, Bogyo M, Caffrey CR, Kop\u00e1\u010dek P, Mare\u0161 M (2009) Hemoglobin digestion in blood-feeding ticks: mapping a multipeptidase pathway by functional proteomics. Chem Biol 16(10):1053\u20131063. \n                    https:\/\/doi.org\/10.1016\/j.chembiol.2009.09.009","journal-title":"Chem Biol"},{"issue":"9","key":"6271_CR21","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.pt.2007.07.001","volume":"23","author":"JW Hovius","year":"2007","unstructured":"Hovius JW, van Dam AP, Fikrig E (2007) Tick-host-pathogen interactions in Lyme borreliosis. Trends Parasitol 23(9):434\u2013438","journal-title":"Trends Parasitol"},{"issue":"11","key":"6271_CR22","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/j.ijpara.2008.03.001","volume":"38","author":"KP Hunfeld","year":"2008","unstructured":"Hunfeld KP, Hildebrandt A, Gray JS (2008) Babesiosis: recent insights into an ancient disease. Int J Parasitol 38(11):1219\u20131237","journal-title":"Int J Parasitol"},{"issue":"6","key":"6271_CR23","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.ijpara.2014.01.010","volume":"44","author":"AMG Ibelli","year":"2014","unstructured":"Ibelli AMG, Kim TK, Hill CC, Lewis LA, Bakshi M, Miller S, Porter L, Mulenga A (2014) A blood meal-induced Ixodes scapularis tick saliva serpin inhibits trypsin and thrombin, and interferes with platelet aggregation and blood clotting. Int J Parasitol 44(6):369\u2013379","journal-title":"Int J Parasitol"},{"issue":"10","key":"6271_CR24","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1089\/vbz.2010.0197","volume":"11","author":"A Kern","year":"2011","unstructured":"Kern A, Collin E, Barthel C, Michel C, Jaulhac B, Boulanger N (2011) Tick saliva represses innate immunity and cutaneous inflammation in a murine model of Lyme disease. Vector Borne Zoonotic Dis 11(10):1343\u20131350","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"2","key":"6271_CR25","doi-asserted-by":"publisher","first-page":"e3984","DOI":"10.7717\/peerj.3984","volume":"5","author":"D Kim","year":"2017","unstructured":"Kim D, Maldonado-Ruiz P, Zurek L, Park Y (2017) Water absorption through salivary gland type I acini in the blacklegged tick, Ixodes scapularis. Peerj 5(2):e3984","journal-title":"Peerj"},{"issue":"12\u201313","key":"6271_CR26","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/S0020-7519(00)00137-5","volume":"30","author":"AM Kjemtrup","year":"2000","unstructured":"Kjemtrup AM, Conrad PA (2000) Human babesiosis: an emerging tick-borne disease. Int J Parasitol 30(12\u201313):1323\u20131337","journal-title":"Int J Parasitol"},{"issue":"10","key":"6271_CR27","doi-asserted-by":"publisher","first-page":"3621","DOI":"10.1007\/s00436-014-4027-1","volume":"113","author":"P Liang","year":"2014","unstructured":"Liang P, He L, Xu Y, Chen X, Huang Y, Ren M, Liang C, Li X, Xu J, Lu G, Yu X (2014) Identification, immunolocalization, and characterization analyses of an exopeptidase of papain superfamily, (cathepsin C) from Clonorchis sinensis. Parasitol Res 113(10):3621\u20133629","journal-title":"Parasitol Res"},{"issue":"1","key":"6271_CR28","first-page":"30","volume":"29","author":"UG Moltmann","year":"1982","unstructured":"Moltmann UG, Mehlhorn H, Friedhoff KT (1982) Ultrastructural study of the development of Babesia ovis (Piroplasmia) in the ovary of the vector tick Rhipicephalus bursa. J Eukaryot Microbiol 29(1):30\u201338","journal-title":"J Eukaryot Microbiol"},{"issue":"1","key":"6271_CR29","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.phrp.2012.12.001","volume":"4","author":"S Moon","year":"2013","unstructured":"Moon S et al (2013) Autochthonous lyme borreliosis in humans and ticks in Korea. Osong Public Health Res Perspect 4(1):52","journal-title":"Osong Public Health Res Perspect"},{"issue":"1","key":"6271_CR30","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.chom.2013.12.001","volume":"15","author":"S Narasimhan","year":"2014","unstructured":"Narasimhan S, Rajeevan N, Liu L, Zhao YO, Heisig J, Pan J, Eppler-Epstein R, DePonte K, Fish D, Fikrig E (2014) Gut microbiota of the tick vector Ixodes scapularis modulate colonization of the Lyme disease spirochete. Cell Host Microbe 15(1):58\u201371","journal-title":"Cell Host Microbe"},{"key":"6271_CR31","unstructured":"Otsuka H (1976) Studies on transmission of Babesia gibsoni Patton (1910) by Haemaphysalis flava Neumann (1897). Bulletin of the Faculty of Agriculture\u2014Miyazaki University (Japan)"},{"issue":"1","key":"6271_CR32","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ttbdis.2010.01.002","volume":"1","author":"VA Rar","year":"2010","unstructured":"Rar VA, Livanova NN, Panov VV, Doroschenko EK, Pukhovskaya NM, Vysochina NP, Ivanov LI (2010) Genetic diversity of Anaplasma and Ehrlichia in the Asian part of Russia. Ticks Tick-borne Dis 1(1):57\u201365","journal-title":"Ticks Tick-borne Dis"},{"issue":"13\u201314","key":"6271_CR33","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1016\/j.ijpara.2004.10.003","volume":"34","author":"PJ Rosenthal","year":"2004","unstructured":"Rosenthal PJ (2004) Cysteine proteases of malaria parasites. Int J Parasitol 34(13\u201314):1489\u20131499","journal-title":"Int J Parasitol"},{"issue":"1","key":"6271_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0166-6851(01)00438-8","volume":"120","author":"M Sajid","year":"2002","unstructured":"Sajid M, Mckerrow JH (2002) Cysteine proteases of parasitic organisms. Mol Biochem Parasitol 120(1):1\u201321","journal-title":"Mol Biochem Parasitol"},{"issue":"3","key":"6271_CR35","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1590\/S0103-84782000000300014","volume":"30","author":"TRBD Santos","year":"2000","unstructured":"Santos TRBD, Gonzales JC, Chies JM, Rosa Farias NAD (2000) Babesia bovis transovarian transmission in Boophilus microplus: obtention of a Babesia free tick strain. Ci\u00eanc Rural 30(3):455\u2013459","journal-title":"Ci\u00eanc Rural"},{"issue":"5602","key":"6271_CR36","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/266536a0","volume":"266","author":"JD Smit","year":"1977","unstructured":"Smit JD, Grandjean O, Guggenheim R, Winterhalter KH (1977) Haemoglobin crystals in the midgut of the tick Ornithodorus moubata Murray. Nature 266(5602):536\u2013538","journal-title":"Nature"},{"issue":"7","key":"6271_CR37","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.ijpara.2006.12.020","volume":"37","author":"D Sojka","year":"2007","unstructured":"Sojka D, Hajdu\u0161ek O, Dvo\u0159\u00e1k J, Sajid M, Franta Z, Schneider EL, Craik CS, Vancov\u00e1 M, Bure\u0161ov\u00e1 V, Bogyo M, Sexton KB, McKerrow JH, Caffrey CR, Kop\u00e1\u010dek P (2007) IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus. Int J Parasitol 37(7):713\u2013724","journal-title":"Int J Parasitol"},{"issue":"25","key":"6271_CR38","doi-asserted-by":"publisher","first-page":"21152","DOI":"10.1074\/jbc.M112.347922","volume":"287","author":"D Sojka","year":"2012","unstructured":"Sojka D, Franta Z, Frantov\u00e1 H, Barto\u0161ov\u00e1 P, Horn M, V\u00e1chov\u00e1 J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey CR, McKerrow JH, Mare\u0161 M, Kop\u00e1\u010dek P (2012) Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). J Biol Chem 287(25):21152\u201321163","journal-title":"J Biol Chem"},{"issue":"6","key":"6271_CR39","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.pt.2013.04.002","volume":"29","author":"D Sojka","year":"2013","unstructured":"Sojka D, Franta Z, Horn M, Caffrey CR, Mare\u0161 M, Kop\u00e1\u010dek P (2013) New insights into the machinery of blood digestion by ticks. Trends Parasitol 29(6):276\u2013285","journal-title":"Trends Parasitol"},{"key":"6271_CR40","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ibmb.2016.01.004","volume":"71","author":"L Tirloni","year":"2016","unstructured":"Tirloni L, Kim TK, Coutinho ML, Ali A, Seixas A, Termignoni C, Mulenga A, da Silva Vaz I Jr (2016) The putative role of Rhipicephalus microplus salivary serpins in the tick-host relationship. Insect Biochem Mol Biol 71:12\u201328","journal-title":"Insect Biochem Mol Biol"},{"key":"6271_CR41","unstructured":"Tsuji N, Miyoshi T, Battsetseg B, etal (2008) A cysteine protease is critical for Babesia spp. Transmission in Haemaphysalis Ticks PLoS Pathogens 4(5):e1000062"},{"issue":"1","key":"6271_CR42","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1006\/dbio.2001.0357","volume":"237","author":"K Uchida","year":"2001","unstructured":"Uchida K, Ohmori D, Ueno T, Nishizuka M, Eshita Y, Fukunaga A, Kominami E (2001) Preoviposition activation of cathepsin-like proteinases in degenerating ovarian follicles of the mosquito Culex pipiens pallens. Dev Biol 237(1):68\u201378","journal-title":"Dev Biol"},{"issue":"3","key":"6271_CR43","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1128\/JCM.02929-12","volume":"51","author":"M Villar","year":"2013","unstructured":"Villar M et al (2013) Identification and characterization of Anaplasma phagocytophilum proteins involved in infection of the tick vector, Ixodes scapularis. Infection of immature Ixodes scapularis (Acari: Ixodidae) by membrane feeding. Two Anaplasma phagocytophilum strain. J Clin Microbiol 51(3):954\u2013958","journal-title":"J Clin Microbiol"},{"issue":"9","key":"6271_CR44","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S1471-4922(03)00189-2","volume":"19","author":"AL Williamson","year":"2003","unstructured":"Williamson AL, Brindley PJ, Knox DP, Hotez PJ, Loukas A (2003) Digestive proteases of blood-feeding nematodes. Trends Parasitol 19(9):417\u2013423","journal-title":"Trends Parasitol"},{"issue":"1","key":"6271_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3347\/kjp.1997.35.1.1","volume":"35","author":"L WonKoo","year":"1997","unstructured":"WonKoo L, JaeWon L, SoYoung L, InYong L (1997) Redescription of Haemaphysalis flava and Ixodes tanuki collected from a raccoon dog in Korea. Korean J Parasitol 35(1):1","journal-title":"Korean J Parasitol"},{"issue":"1","key":"6271_CR46","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.meegid.2015.12.005","volume":"38","author":"XL Xu","year":"2016","unstructured":"Xu XL, Cheng TY, Yang H, Liao ZH (2016) De novo assembly and analysis of midgut transcriptome of Haemaphysalis flava and identification of genes involved in blood digestion, feeding and defending from pathogens. Infect Genet Evol 38(1):62\u201372","journal-title":"Infect Genet Evol"},{"issue":"2","key":"6271_CR47","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.meegid.2013.01.018","volume":"16","author":"K Yamaji","year":"2013","unstructured":"Yamaji K, Miyoshi T, Hatta T, Matsubayashi M, Alim MA, Anisuzzaman, Kushibiki S, Fujisaki K, Tsuji N (2013) HlCPL-A, a cathepsin L-like cysteine protease from the ixodid tick Haemaphysalis longicornis, modulated midgut proteolytic enzymes and their inhibitors during blood meal digestion. Infect Genet Evol 16(2):206\u2013211","journal-title":"Infect Genet Evol"},{"key":"6271_CR48","unstructured":"Yoon SY, et al. (1996) A case of tick bite caused by Haemaphysalis flava 34:326\u2013330"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-019-06271-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-019-06271-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-019-06271-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T19:04:42Z","timestamp":1583003082000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-019-06271-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,2]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["6271"],"URL":"https:\/\/doi.org\/10.1007\/s00436-019-06271-4","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,2]]},"assertion":[{"value":"25 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The care and maintenance of experimental rabbit, mice, and dog in this study was approved by the Institutional Animal Care and Use Committee of Huazhong Agricultural University, and all experiments were performed according to the regulations for the administration of affairs concerning experimental animals of Hubei Province, P.R. China consent for publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"<i>HfCL<\/i> mRNA sequence was available in GenBank (accession no. MG914066).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}}]}}