{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:58:31Z","timestamp":1777417111949,"version":"3.51.4"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,5,4]],"date-time":"2019-05-04T00:00:00Z","timestamp":1556928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s00436-019-06316-8","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T13:26:47Z","timestamp":1557149207000},"page":"1849-1863","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Troponin 1 of human filarial parasite Brugia malayi: cDNA cloning, expression, purification, and its immunoprophylactic potential"],"prefix":"10.1007","volume":"118","author":[{"given":"Vikas","family":"Kushwaha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prachi","family":"Tewari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payal","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anurag","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Kalpana","family":"Murthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,4]]},"reference":[{"key":"6316_CR1","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1084\/jem.190.7.953","volume":"190","author":"D Artis","year":"1999","unstructured":"Artis D, Humphreys NE, Bancroft AJ, Rothwell NJ, Potten CS, Grencis RK (1999) Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection. J Exp Med 190:953\u2013962","journal-title":"J Exp Med"},{"key":"6316_CR2","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.ijpara.2006.04.013","volume":"36","author":"SA Babayan","year":"2006","unstructured":"Babayan SA, Attout T, Harris A, Taylor MD, Le Goff L, Vuong PN, R\u00e9nia L, Allen JE, Bain O (2006) Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stages. Int J Parasitol 36:903\u2013914","journal-title":"Int J Parasitol"},{"key":"6316_CR3","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/pim.12081","volume":"36","author":"S Babu","year":"2014","unstructured":"Babu S, Nutman TB (2014) Immunology of lymphatic filariasis. Parasite Immunol 36:338\u2013346","journal-title":"Parasite Immunol"},{"key":"6316_CR4","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00281-012-0346-4","volume":"34","author":"S Babu","year":"2012","unstructured":"Babu S, Nutman TB (2012) Immunopathogenesis of lymphatic filarial disease. Semin Immunopathol 34:847\u2013861","journal-title":"Semin Immunopathol"},{"key":"6316_CR5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"6316_CR6","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0020-7519(90)90005-8","volume":"20","author":"R Chandrashekar","year":"1990","unstructured":"Chandrashekar R, Rao UR, Subrahmanyam D (1990) Antibody-mediated cytotoxic effects in vitro and in vivo of rat cells on infective larvae of Brugia malayi. Int J Parasitol 20:725\u2013730","journal-title":"Int J Parasitol"},{"key":"6316_CR7","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.3389\/fimmu.2018.01520","volume":"9","author":"N Chauhan","year":"2018","unstructured":"Chauhan N, Khatri V, Banerjee P, Kalyanasundaram R (2018) Evaluating the vaccine potential of a tetravalent fusion protein (rBmHAXT) vaccine antigen against lymphatic filariasis in a mouse model. Front Immunol 9:1520. \nhttps:\/\/doi.org\/10.3389\/fimmu.2018.01520","journal-title":"Front Immunol"},{"key":"6316_CR8","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/35038103","volume":"407","author":"Q Chen","year":"2000","unstructured":"Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407:916\u2013920","journal-title":"Nature"},{"key":"6316_CR9","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.vaccine.2012.09.055","volume":"31","author":"G Dakshinamoorthy","year":"2013","unstructured":"Dakshinamoorthy G, Samykutty AK, Munirathinam G, Reddy MV, Kalyanasundaram R (2013) Multivalent fusion protein vaccine for lymphatic filariasis. Vaccine 31:1616\u20131622","journal-title":"Vaccine"},{"key":"6316_CR10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112982","volume":"9","author":"G Dakshinamoorthy","year":"2014","unstructured":"Dakshinamoorthy G, von Gegerfelt A, Andersen H, Lewis M, Kalyanasundaram R (2014) Evaluation of a multivalent vaccine against lymphatic filariasis in rhesus macaque model. PLoS One 9:e112982","journal-title":"PLoS One"},{"key":"6316_CR11","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1128\/IAI.64.8.2962-2967.1996","volume":"64","author":"KA Dimock","year":"1996","unstructured":"Dimock KA, Eberhard ML, Lammie PJ (1996) Th1-like antifilarial immune responses predominate in antigen-negative persons. Infect Immun 64:2962\u20132967","journal-title":"Infect Immun"},{"key":"6316_CR12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.0141-9838.2004.00725.x","volume":"26","author":"S Dixit","year":"2004","unstructured":"Dixit S, Gaur RL, Khan MA, Saxena JK, Murthy PS, Murthy PK (2004) Inflammatory antigens of Brugia malayi and their effect on rodent host Mastomys coucha. Parasite Immunol 26:397\u2013407","journal-title":"Parasite Immunol"},{"key":"6316_CR13","doi-asserted-by":"crossref","first-page":"5824","DOI":"10.1016\/j.vaccine.2006.05.003","volume":"24","author":"S Dixit","year":"2006","unstructured":"Dixit S, Gaur RL, Sahoo MK, Joseph SK, Murthy PS, Murthy PK (2006) Protection against L3 induced Brugia malayi infection in Mastomys coucha pre-immunized with BmAFII fraction of the filarial adult worm. Vaccine 24:5824\u20135831","journal-title":"Vaccine"},{"key":"6316_CR14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/intimm\/12.5.623","volume":"12","author":"A Doetze","year":"2000","unstructured":"Doetze A, Satoguina J, Burchard G, Rau T, Loliger C, Fleischer B, Hoerauf A (2000) Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by T(h)3\/T(r)1-type cytokines IL-10 and transforming growth factor-beta but not by a T(h)1 to T(h)2 shift. Int Immunol 12:623\u2013630","journal-title":"Int Immunol"},{"key":"6316_CR15","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/infdis\/171.3.652","volume":"171","author":"LH Elson","year":"1995","unstructured":"Elson LH, Calvopina M, Paredes W, Araujo E, Bradley JE, Guderian RH, Nutman TB (1995) Immunity to onchocerciasis: putative immune persons produce a Th1-like response to Onchocerca volvulus. J Infect Dis 171:652\u2013658","journal-title":"J Infect Dis"},{"key":"6316_CR16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1023\/A:1020537506008","volume":"19","author":"RF Furchgott","year":"1999","unstructured":"Furchgott RF (1999) Endothelium-derived relaxing factor: discovery, early studies, and identification as nitric oxide. Biosci Rep 19:235\u2013251","journal-title":"Biosci Rep"},{"key":"6316_CR17","doi-asserted-by":"crossref","first-page":"864","DOI":"10.2174\/0929866511320080004","volume":"20","author":"VS Gomase","year":"2013","unstructured":"Gomase VS, Chitlange NR, Changbhale SS, Kale KV (2013) Prediction of Brugia malayi antigenic peptides: candidates for synthetic vaccine design against lymphatic filariasis. Protein Pept Lett 20:864\u2013887","journal-title":"Protein Pept Lett"},{"key":"6316_CR18","volume":"10","author":"J Gupta","year":"2015","unstructured":"Gupta J, Pathak M, Misra S, Misra-Bhattacharya S (2015) Immunogenicity and protective efficacy of Brugia malayi heavy chain myosin as homologous DNA, protein and heterologous DNA\/protein prime boost vaccine in rodent model. PLoS One 10:e0142548","journal-title":"PLoS One"},{"key":"6316_CR19","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0264-410X(99)00274-1","volume":"18","author":"RA Harrison","year":"1999","unstructured":"Harrison RA, Wu Y, Egerton G, Bianco AE (1999) DNA immunisation with Onchocerca volvulus chitinase induces partial protection against challenge infection with L3 larvae in mice. Vaccine 18:647\u2013655","journal-title":"Vaccine"},{"key":"6316_CR20","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.1016\/j.vaccine.2012.07.084","volume":"30","author":"SK Joseph","year":"2012","unstructured":"Joseph SK, Sambanthamoorthy S, Dakshinamoorthy G, Munirathinam G, Ramaswamy K (2012) Protective immune responses to biolistic DNA vaccination of Brugia malayi abundant larval transcript-2. Vaccine 30:6477\u20136482","journal-title":"Vaccine"},{"key":"6316_CR21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.actatropica.2011.08.005","volume":"120","author":"SK Joseph","year":"2011","unstructured":"Joseph SK, Verma SK, Sahoo MK, Dixit S, Verma AK, Kushwaha V, Saxena K, Sharma A, Saxena JK, Murthy PK (2011) Sensitization with anti-inflammatory BmAFI of Brugia malayi allows L3 development in the hostile peritoneal cavity of Mastomys coucha. Acta Trop 120:191\u2013205","journal-title":"Acta Trop"},{"key":"6316_CR22","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/micr.20342","volume":"27","author":"N Kanai","year":"2007","unstructured":"Kanai N, Min WP, Ichim TE, Wang H, Zhong R (2007) Th1\/Th2 xenogenic antibody responses are associated with recipient dendritic cells. Microsurgery 27:234\u2013239","journal-title":"Microsurgery"},{"key":"6316_CR23","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.ijpara.2018.04.002","volume":"48","author":"V Khatri","year":"2018","unstructured":"Khatri V, Chauhan N, Vishnoi K, von Gegerfelt A, Gittens C, Kalyanasundaram R (2018) Prospects of developing a prophylactic vaccine against human lymphatic filariasis - evaluation of protection in non-human primates. Int J Parasitol 48:773\u2013783. \nhttps:\/\/doi.org\/10.1016\/j.ijpara.2018.04.002","journal-title":"Int J Parasitol"},{"key":"6316_CR24","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.vaccine.2014.01.064","volume":"32","author":"V Kushwaha","year":"2014","unstructured":"Kushwaha V, Kumar V, Verma SK, Sharma R, Siddiqi MI, Murthy PK (2014) Disorganized muscle protein-1 (DIM-1) of filarial parasite Brugia malayi: cDNA cloning, expression, purification, structural modeling and its potential as vaccine candidate for human filarial infection. Vaccine 32:1693\u20131699","journal-title":"Vaccine"},{"key":"6316_CR25","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0166-6851(91)90075-H","volume":"49","author":"BW Li","year":"1991","unstructured":"Li BW, Chandrashekar R, Alvarez RM, Liftis F, Weil GJ (1991) Identification of paramyosin as a potential protective antigen against Brugia malayi infection in jirds. Mol Biochem Parasitol 49:315\u2013323","journal-title":"Mol Biochem Parasitol"},{"key":"6316_CR26","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0020-7519(94)00164-J","volume":"25","author":"BW Li","year":"1995","unstructured":"Li BW, Hoppe PE, Weil GJ (1995) Cloning of an early immunodominant filarial antigen: a member of the Brugia malayi myosin heavy chain gene family. Int J Parasitol 25:611\u2013619","journal-title":"Int J Parasitol"},{"key":"6316_CR27","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0264-410X(99)00182-6","volume":"18","author":"BW Li","year":"1999","unstructured":"Li BW, Zhang S, Curtis KC, Weil GJ (1999) Immune responses to Brugia malayi paramyosin in rodents after DNA vaccination. Vaccine 18:76\u201381","journal-title":"Vaccine"},{"key":"6316_CR28","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.0105-2896.2004.00191.x","volume":"201","author":"RM Maizels","year":"2004","unstructured":"Maizels RM, Balic A, Gomez-Escobar N, Nair M, Taylor MD, Allen JE (2004) Helminth parasites--masters of regulation. Immunol Rev 201:89\u2013116","journal-title":"Immunol Rev"},{"key":"6316_CR29","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0140-6736(16)30171-4","volume":"389","author":"DH Molyneux","year":"2017","unstructured":"Molyneux DH, Savioli L, Engels D (2017) Neglected tropical diseases: progress towards addressing the chronic pandemic. Lancet 389:312\u2013325","journal-title":"Lancet"},{"key":"6316_CR30","volume-title":"Role of interleukin-6 during infection with the filarial nematode Litomosoides sigmodontis","author":"Muhsin","year":"2013","unstructured":"Muhsin (2013) Role of interleukin-6 during infection with the filarial nematode Litomosoides sigmodontis. Universit\u00e4ts-und Landesbibliothek, Bonn"},{"key":"6316_CR31","doi-asserted-by":"crossref","first-page":"6663","DOI":"10.1128\/IAI.68.12.6663-6669.2000","volume":"68","author":"PK Murthy","year":"2000","unstructured":"Murthy PK, Dennis VA, Lasater BL, Philipp MT (2000) Interleukin-10 modulates proinflammatory cytokines in the human monocytic cell line THP-1 stimulated with Borrelia burgdorferi lipoproteins. Infect Immun 68:6663\u20136669","journal-title":"Infect Immun"},{"key":"6316_CR32","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1574-695X.2007.00353.x","volume":"52","author":"MG Netea","year":"2007","unstructured":"Netea MG, Van De Veerdonk F, Verschueren I, Van Der Meer JW, Kullberg BJ (2007) Role of TLR1 and TLR6 in the host defense against disseminated candidiasis. FEMS Immunol Med Microbiol 52:118\u2013123","journal-title":"FEMS Immunol Med Microbiol"},{"key":"6316_CR33","volume":"11","author":"RU Rao","year":"2017","unstructured":"Rao RU, Samarasekera SD, Nagodavithana KC, Dassanayaka TDM, Punchihewa MW, Ranasinghe USB, Weil GJ (2017) Reassessment of areas with persistent lymphatic Filariasis nine years after cessation of mass drug administration in Sri Lanka. PLoS Negl Trop Dis 11:e0006066","journal-title":"PLoS Negl Trop Dis"},{"key":"6316_CR34","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1166\/jbn.2011.1226","volume":"7","author":"R Roy","year":"2011","unstructured":"Roy R, Tripathi A, Das M, Dwivedi PD (2011) Cytotoxicity and uptake of zinc oxide nanoparticles leading to enhanced inflammatory cytokines levels in murine macrophages: comparison with bulk zinc oxide. J Biomed Nanotechnol 7:110\u2013111","journal-title":"J Biomed Nanotechnol"},{"key":"6316_CR35","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.tiv.2013.12.004","volume":"28","author":"R Roy","year":"2014","unstructured":"Roy R, Parashar V, Chauhan L, Shanker R, Das M, Tripathi A, Dwivedi PD (2014) Mechanism of uptake of ZnO nanoparticles and inflammatory responses in macrophages require PI3K mediated MAPKs signaling. Toxicol in Vitro 28:457\u2013467","journal-title":"Toxicol in Vitro"},{"key":"6316_CR36","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1016\/j.vaccine.2009.05.015","volume":"27","author":"MK Sahoo","year":"2009","unstructured":"Sahoo MK, Sisodia BS, Dixit S, Joseph SK, Gaur RL, Verma SK, Verma AK, Shasany AK, Dowle AA, Murthy PK (2009) Immunization with inflammatory proteome of Brugia malayi adult worm induces a Th1\/Th2-immune response and confers protection against the filarial infection. Vaccine 27:4263\u20134271","journal-title":"Vaccine"},{"key":"6316_CR37","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4103\/0022-3859.68650","volume":"56","author":"S Sabesan","year":"2010","unstructured":"Sabesan S, Vanamail P, Raju K, Jambulingam P (2010) Lymphatic filariasis in India: epidemiology and control measures. J Postgrad Med 56:232\u2013238","journal-title":"J Postgrad Med"},{"key":"6316_CR38","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.provac.2010.11.003","volume":"3","author":"A Samykutty","year":"2010","unstructured":"Samykutty A, Dakshinamoorthy G, Kalyanasundaram R (2010) Multivalent vaccine for lymphatic Filariasis. Procedia Vaccinol 3:12\u201318","journal-title":"Procedia Vaccinol"},{"key":"6316_CR39","volume-title":"Fundamental Immunology","author":"C Snapper","year":"1999","unstructured":"Snapper C, Finkelman F (1999) In: Paul WE (ed) Fundamental Immunology. Lippincott, Philadelphia"},{"issue":"Pt 3","key":"6316_CR40","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1017\/S0031182000065835","volume":"112","author":"MJ Taylor","year":"1996","unstructured":"Taylor MJ, Cross HF, Mohammed AA, Trees AJ, Bianco AE (1996) Susceptibility of Brugia malayi and Onchocerca lienalis microfilariae to nitric oxide and hydrogen peroxide in cell-free culture and from IFN gamma-activated macrophages. Parasitology 112(Pt 3):315\u2013322","journal-title":"Parasitology"},{"key":"6316_CR41","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0140-6736(10)60586-7","volume":"376","author":"MJ Taylor","year":"2010","unstructured":"Taylor MJ, Hoerauf A, Bockarie M (2010) Lymphatic filariasis and onchocerciasis. Lancet 376:1175\u20131185","journal-title":"Lancet"},{"key":"6316_CR42","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.toxlet.2017.05.008","volume":"276","author":"P Tewari","year":"2017","unstructured":"Tewari P, Mandal P, Roy R, Asthana S, Dwivedi PD, Das M, Tripathi A (2017) A novel function of TLR4 in mediating the immunomodulatory effect of Benzanthrone, an environmental pollutant. Toxicol Lett 276:69\u201384","journal-title":"Toxicol Lett"},{"key":"6316_CR43","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.exppara.2007.02.017","volume":"116","author":"S Thirugnanam","year":"2007","unstructured":"Thirugnanam S, Pandiaraja P, Ramaswamy K, Murugan V, Gnanasekar M, Nandakumar K, Reddy MV, Kaliraj P (2007) Brugia malayi: comparison of protective immune responses induced by Bm-alt-2 DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird model. Exp Parasitol 116:483\u2013491","journal-title":"Exp Parasitol"},{"key":"6316_CR44","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1128\/IAI.65.7.2732-2739.1997","volume":"65","author":"GR Thomas","year":"1997","unstructured":"Thomas GR, McCrossan M, Selkirk ME (1997) Cytostatic and cytotoxic effects of activated macrophages and nitric oxide donors on Brugia malayi. Infect Immun 65:2732\u20132739","journal-title":"Infect Immun"},{"key":"6316_CR45","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4269\/ajtmh.2009.80.319","volume":"80","author":"U Vanam","year":"2009","unstructured":"Vanam U, Pandey V, Prabhu PR, Dakshinamurthy G, Reddy MV, Kaliraj P (2009) Evaluation of immunoprophylactic efficacy of Brugia malayi transglutaminase (BmTGA) in single and multiple antigen vaccination with BmALT-2 and BmTPX for human lymphatic filariasis. Am J Trop Med Hyg 80:319\u2013324","journal-title":"Am J Trop Med Hyg"},{"key":"6316_CR46","doi-asserted-by":"crossref","first-page":"e457","DOI":"10.1371\/journal.pntd.0000457","volume":"3","author":"A Veerapathran","year":"2009","unstructured":"Veerapathran A, Dakshinamoorthy G, Gnanasekar M, Reddy MV, Kalyanasundaram R (2009) Evaluation of Wuchereria bancrofti GST as a vaccine candidate for lymphatic filariasis. PLoS Negl Trop Dis 3:e457","journal-title":"PLoS Negl Trop Dis"},{"key":"6316_CR47","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1016\/j.vaccine.2017.07.105","volume":"35","author":"SK Verma","year":"2017","unstructured":"Verma SK, Arora A, Murthy PK (2017) Recombinant Calponin of human filariid Brugia malayi: secondary structure and immunoprophylactic potential. Vaccine 35:5201\u20135208","journal-title":"Vaccine"},{"key":"6316_CR48","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.vaccine.2014.11.041","volume":"33","author":"SK Verma","year":"2015","unstructured":"Verma SK, Joseph SK, Verma R, Kushwaha V, Parmar N, Yadav PK, Thota JR, Kar S, Murthy PK (2015) Protection against filarial infection by 45-49 kDa molecules of Brugia malayi via IFN-gamma-mediated iNOS induction. Vaccine 33:527\u2013534","journal-title":"Vaccine"},{"key":"6316_CR49","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00430-002-0155-9","volume":"192","author":"L Volkmann","year":"2003","unstructured":"Volkmann L, Bain O, Saeftel M, Specht S, Fischer K, Brombacher F, Matthaei KI, Hoerauf A (2003) Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages. Med Microbiol Immunol 192:23\u201331","journal-title":"Med Microbiol Immunol"},{"key":"6316_CR50","first-page":"489","volume":"90","author":"WHO","year":"2014","unstructured":"WHO (2014) Global Programme to eliminate lymphatic Filariasis: progress report. WHO Wkly Epidemiol Rec 90:489\u2013504","journal-title":"WHO Wkly Epidemiol Rec"},{"key":"6316_CR51","volume-title":"Alternative mass drug administration regimens to eliminate lymphatic filariasis","author":"WHO","year":"2017","unstructured":"WHO (2017) Alternative mass drug administration regimens to eliminate lymphatic filariasis. World Health Organization, Geneva Licence: CC BY-NC-SA 3.0 IGO"},{"key":"6316_CR52","unstructured":"WHO (2018) Three more countries eliminate lymphatic filariasis. World Health Organization. \nhttps:\/\/www.who.int\/westernpacific\/news\/detail\/08-10-2018-three-more-countries-eliminate-lymphatic-filariasis"},{"key":"6316_CR53","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.toxlet.2012.12.016","volume":"217","author":"A Yadav","year":"2013","unstructured":"Yadav A, Kumar A, Tripathi A, Das M (2013) Sunset yellow FCF, a permitted food dye, alters functional responses of splenocytes at non-cytotoxic dose. Toxicol Lett 217:197\u2013204","journal-title":"Toxicol Lett"},{"key":"6316_CR54","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.toxlet.2011.11.014","volume":"208","author":"A Yadav","year":"2012","unstructured":"Yadav A, Kumar A, Dwivedi PD, Tripathi A, Das M (2012) In vitro studies on immunotoxic potential of Orange II in splenocytes. Toxicol Lett 208:239\u2013245","journal-title":"Toxicol Lett"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-019-06316-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-019-06316-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-019-06316-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,2]],"date-time":"2020-05-02T23:10:26Z","timestamp":1588461026000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-019-06316-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,4]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["6316"],"URL":"https:\/\/doi.org\/10.1007\/s00436-019-06316-8","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,4]]},"assertion":[{"value":"5 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The animal study protocol was approved by the National Laboratory Animal Centre (NLAC), CSIR-Central Drug Research Institute (CDRI), Lucknow, India, following the rules and guidelines of the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Ministry of Environments and Forests, Govt. of India, New Delhi, for use and handling of animals. The animals used in the study were housed in climatically controlled pathogen-free animal quarters (Temp.: 23\u2009\u00b1\u20092\u00a0\u00b0C; RH: 60%; and photoperiod: 12\u00a0h light\u2013dark cycles) at NALC, CSIR-CDRI, Lucknow, India, and they were fed standard rodent maintenance diet (prepared in-house) and water ad libitum. The animal study protocol was approved (approval number: IAEC\/2011\/145 renewed dated 03\/07\/2014).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}