{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:59:56Z","timestamp":1761490796011},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s00436-019-06318-6","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T06:02:46Z","timestamp":1557295366000},"page":"1943-1952","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["CpG enhances the immunogenicity of heterologous DNA-prime\/protein-boost vaccination with the heavy chain myosin of Brugia malayi in BALB\/c mice"],"prefix":"10.1007","volume":"118","author":[{"given":"Jyoti","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sweta","family":"Misra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailja","family":"Misra-Bhattacharya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,8]]},"reference":[{"key":"6318_CR1","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1128\/CVI.00598-14","volume":"21","author":"R Anuradha","year":"2014","unstructured":"Anuradha R, George PJ, Kumaran P, Nutman TB, Babu S (2014) Interleukin-10- and transforming growth factor beta-independent regulation of CD8(+) T cells expressing type 1 and type 2 cytokines in human lymphatic filariasis. Clin Vaccine Immunol 21:1620\u20131627","journal-title":"Clin Vaccine Immunol"},{"key":"6318_CR2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ijpara.2014.05.003","volume":"44","author":"S Arumugam","year":"2014","unstructured":"Arumugam S, Wei J, Ward D, Abraham D, Lustigman S, Zhan B, Klei TR (2014) Vaccination with a genetically modified Brugia malayi cysteine protease inhibitor-2 reduces adult parasite numbers and affects the fertility of female worms following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae. Int J Parasitol 44:675","journal-title":"Int J Parasitol"},{"key":"6318_CR3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1371\/journal.pntd.0001968","volume":"6","author":"SA Babayan","year":"2012","unstructured":"Babayan SA, Luo H, Gray N, Taylor DW, Allen JE (2012) Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes. PLoS Negl Trop Dis 6:27","journal-title":"PLoS Negl Trop Dis"},{"key":"6318_CR4","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1128\/IAI.68.5.3034-3035.2000","volume":"68","author":"S Babu","year":"2000","unstructured":"Babu S, Ganley LM, Klei TR, Shultz LD, Rajan TV (2000) Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi. Infect Immun 68:3034\u20133035","journal-title":"Infect Immun"},{"key":"6318_CR5","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.4049\/jimmunol.176.7.3885","volume":"176","author":"S Babu","year":"2006","unstructured":"Babu S, Blauvelt CP, Kumaraswami V, Nutman TB (2006) Cutting edge: diminished T cell TLR expression and function modulates the immune response in human filarial infection. J Immunol 176:3885\u20133889","journal-title":"J Immunol"},{"key":"6318_CR6","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1084\/jem.186.10.1621","volume":"186","author":"DA Carson","year":"1997","unstructured":"Carson DA, Raz E (1997) Oligonucleotide adjuvants for T helper 1 (Th1)-specific vaccination. J Exp Med 186:1621\u20131622","journal-title":"J Exp Med"},{"key":"6318_CR7","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1084\/jem.186.10.1623","volume":"186","author":"RS Chu","year":"1997","unstructured":"Chu RS, Targoni OS, Krieg AM, Lehmann PV, Harding CV (1997) CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med 186:1623\u20131631","journal-title":"J Exp Med"},{"key":"6318_CR8","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1097\/01.aids.0000183514.37513.d2","volume":"19","author":"CL Cooper","year":"2005","unstructured":"Cooper CL, Davis HL, Angel JB, Morris ML, Elfer SM, Seguin I, Krieg AM, Cameron DW (2005) CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults. Aids 19:1473\u20131479","journal-title":"Aids"},{"key":"6318_CR9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1371\/journal.pone.0034077","volume":"7","author":"G Dakshinamoorthy","year":"2012","unstructured":"Dakshinamoorthy G, Samykutty AK, Munirathinam G, Shinde GB, Nutman T, Reddy MV, Kalyanasundaram R (2012) Biochemical characterization and evaluation of a Brugia malayi small heat shock protein as a vaccine against lymphatic filariasis. PLoS One 7:5","journal-title":"PLoS One"},{"key":"6318_CR10","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.vaccine.2012.09.055","volume":"31","author":"G Dakshinamoorthy","year":"2013","unstructured":"Dakshinamoorthy G, Samykutty AK, Munirathinam G, Reddy MV, Kalyanasundaram R (2013) Multivalent fusion protein vaccine for lymphatic filariasis. Vaccine 31:1616\u20131622","journal-title":"Vaccine"},{"key":"6318_CR11","first-page":"171","volume":"247","author":"HL Davis","year":"2000","unstructured":"Davis HL (2000) Use of CpG DNA for enhancing specific immune responses. Curr Top Microbiol Immunol 247:171","journal-title":"Curr Top Microbiol Immunol"},{"key":"6318_CR12","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.4049\/jimmunol.140.4.1022","volume":"140","author":"FD Finkelman","year":"1988","unstructured":"Finkelman FD, Katona IM, Mosmann TR, Coffman RL (1988) IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses. J Immunol 140:1022","journal-title":"J Immunol"},{"key":"6318_CR13","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1128\/IAI.68.5.2948-2953.2000","volume":"68","author":"BL Freidag","year":"2000","unstructured":"Freidag BL, Melton GB, Collins F, Klinman DM, Cheever A, Stobie L, Suen W, Seder RA (2000) CpG oligodeoxynucleotides and interleukin-12 improve the efficacy of Mycobacterium bovis BCG vaccination in mice challenged with M. tuberculosis. Infect Immun 68:2948\u20132953","journal-title":"Infect Immun"},{"key":"6318_CR14","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.0818-9641.2004.01271.x","volume":"82","author":"A Gamvrellis","year":"2004","unstructured":"Gamvrellis A, Leong D, Hanley JC, Xiang SD, Mottram P, Plebanski M (2004) Vaccines that facilitate antigen entry into dendritic cells. Immunol Cell Biol 82:506","journal-title":"Immunol Cell Biol"},{"key":"6318_CR15","doi-asserted-by":"crossref","first-page":"e0142548","DOI":"10.1371\/journal.pone.0142548","volume":"10","author":"J Gupta","year":"2015","unstructured":"Gupta J, Pathak M, Misra S, Misra-Bhattacharya S (2015) Immunogenicity and protective efficacy of Brugia malayi heavy chain myosin as homologous DNA, protein and heterologous DNA\/protein prime boost vaccine in rodent model. PLoS One 10:e0142548","journal-title":"PLoS One"},{"key":"6318_CR16","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","volume":"408","author":"H Hemmi","year":"2000","unstructured":"Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S (2000) A toll-like receptor recognizes bacterial DNA. Nature 408:740\u2013745","journal-title":"Nature"},{"key":"6318_CR17","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-3024.2005.00792.x","volume":"27","author":"A Hoerauf","year":"2005","unstructured":"Hoerauf A, Satoguina J, Saeftel M, Specht S (2005) Immunomodulation by filarial nematodes. Parasite Immunol 27:417\u2013429","journal-title":"Parasite Immunol"},{"key":"6318_CR18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/BF00152686","volume":"4","author":"BE Ivins","year":"1988","unstructured":"Ivins BE, Welkos SL (1988) Recent advances in the development of an improved, human anthrax vaccine. Eur J Epidemiol 4:12","journal-title":"Eur J Epidemiol"},{"key":"6318_CR19","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1002\/eji.200636984","volume":"37","author":"W Jiang","year":"2007","unstructured":"Jiang W, Lederman MM, Harding CV, Rodriguez B, Mohner RJ, Sieg SF (2007) TLR9 stimulation drives naive B cells to proliferate and to attain enhanced antigen presenting function. Eur J Immunol 37:2205\u20132213","journal-title":"Eur J Immunol"},{"key":"6318_CR20","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1016\/j.vaccine.2003.12.020","volume":"22","author":"DM Klinman","year":"2004","unstructured":"Klinman DM, Xie H, Little SF, Currie D, Ivins BE (2004) CpG oligonucleotides improve the protective immune response induced by the anthrax vaccination of rhesus macaques. Vaccine 22:2881\u20132886","journal-title":"Vaccine"},{"key":"6318_CR21","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/374546a0","volume":"374","author":"AM Krieg","year":"1995","unstructured":"Krieg AM, Yi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, Koretzky GA, Klinman DM (1995) CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546\u2013549","journal-title":"Nature"},{"key":"6318_CR22","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.micinf.2012.08.006","volume":"14","author":"S Kushwaha","year":"2012","unstructured":"Kushwaha S, Singh PK, Gupta J, Soni VK, Misra-Bhattacharya S (2012) Recombinant trehalose-6-phosphate phosphatase of Brugia malayi cross-reacts with human Wuchereria bancrofti immune sera and engenders a robust protective outcome in mice. Microbes Infect 14:1330\u20131339","journal-title":"Microbes Infect"},{"key":"6318_CR23","doi-asserted-by":"crossref","first-page":"e72585","DOI":"10.1371\/journal.pone.0072585","volume":"8","author":"S Kushwaha","year":"2013","unstructured":"Kushwaha S, Singh PK, Rana AK, Misra-Bhattacharya S (2013) Immunization of Mastomys coucha with Brugia malayi recombinant trehalose-6-phosphate phosphatase results in significant protection against homologous challenge infection. PLoS One 8:e72585","journal-title":"PLoS One"},{"key":"6318_CR24","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1002\/eji.1830270931","volume":"27","author":"GB Lipford","year":"1997","unstructured":"Lipford GB, Bauer M, Blank C, Reiter R, Wagner H, Heeg K (1997) CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur J Immunol 27:2340\u20132344","journal-title":"Eur J Immunol"},{"key":"6318_CR25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"6318_CR26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.0105-2896.2004.00191.x","volume":"201","author":"RM Maizels","year":"2004","unstructured":"Maizels RM, Balic A, Gomez-Escobar N, Nair M, Taylor MD, Allen JE (2004) Helminth parasites\u2014masters of regulation. Immunol Rev 201:89\u2013116","journal-title":"Immunol Rev"},{"key":"6318_CR27","doi-asserted-by":"crossref","first-page":"0000544","DOI":"10.1371\/journal.pntd.0000544","volume":"3","author":"BL Makepeace","year":"2009","unstructured":"Makepeace BL, Jensen SA, Laney SJ, Nfon CK, Njongmeta LM, Tanya VN, Williams SA, Bianco AE, Trees AJ (2009) Immunisation with a multivalent, subunit vaccine reduces patent infection in a natural bovine model of onchocerciasis during intense field exposure. PLoS Negl Trop Dis 3:0000544","journal-title":"PLoS Negl Trop Dis"},{"key":"6318_CR28","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/S0264-410X(98)80122-9","volume":"16","author":"Z Moldoveanu","year":"1998","unstructured":"Moldoveanu Z, Love-Homan L, Huang WQ, Krieg AM (1998) CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus. Vaccine 16:1216\u20131224","journal-title":"Vaccine"},{"key":"6318_CR29","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1152\/ajpregu.00738.2001","volume":"283","author":"TS Olson","year":"2002","unstructured":"Olson TS, Ley K (2002) Chemokines and chemokine receptors in leukocyte trafficking. Am J Physiol Regul Integr Comp Physiol 283:R7\u2013R28","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"6318_CR30","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/imm.12364","volume":"144","author":"M Pathak","year":"2015","unstructured":"Pathak M, Verma M, Srivastava M, Misra-Bhattacharya S (2015) Wolbachia endosymbiont of Brugia malayi elicits a T helper type 17-mediated pro-inflammatory immune response through Wolbachia surface protein. Immunology 144:231\u2013244","journal-title":"Immunology"},{"key":"6318_CR31","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.4049\/jimmunol.175.3.1827","volume":"175","author":"B Rajan","year":"2005","unstructured":"Rajan B, Ramalingam T, Rajan TV (2005) Critical role for IgM in host protection in experimental filarial infection. J Immunol 175:1827\u20131833","journal-title":"J Immunol"},{"key":"6318_CR32","first-page":"26","volume":"181690","author":"L Ramirez","year":"2010","unstructured":"Ramirez L, Iborra S, Cortes J, Bonay P, Alonso C, Barral-Netto M, Soto M (2010) BALB\/c mice vaccinated with Leishmania major ribosomal proteins extracts combined with CpG oligodeoxynucleotides become resistant to disease caused by a secondary parasite challenge. J Biomed Biotechnol 181690:26","journal-title":"J Biomed Biotechnol"},{"key":"6318_CR33","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nm0897-849","volume":"3","author":"M Roman","year":"1997","unstructured":"Roman M, Martin-Orozco E, Goodman JS, Nguyen MD, Sato Y, Ronaghy A, Kornbluth RS, Richman DD, Carson DA, Raz E (1997) Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat Med 3:849\u2013854","journal-title":"Nat Med"},{"key":"6318_CR34","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1086\/589881","volume":"198","author":"BR Sahu","year":"2008","unstructured":"Sahu BR, Mohanty MC, Sahoo PK, Satapathy AK, Ravindran B (2008) Protective immunity in human filariasis: a role for parasite-specific IgA responses. J Infect Dis 198:434\u2013443","journal-title":"J Infect Dis"},{"key":"6318_CR35","doi-asserted-by":"crossref","first-page":"6377","DOI":"10.1016\/j.vaccine.2014.06.065","volume":"32","author":"J Scheiermann","year":"2014","unstructured":"Scheiermann J, Klinman DM (2014) Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer. Vaccine 32:6377\u20136389","journal-title":"Vaccine"},{"key":"6318_CR36","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1128\/IAI.69.9.5813-5822.2001","volume":"69","author":"RT Semnani","year":"2001","unstructured":"Semnani RT, Sabzevari H, Iyer R, Nutman TB (2001) Filarial antigens impair the function of human dendritic cells during differentiation. Infect Immun 69:5813\u20135822","journal-title":"Infect Immun"},{"key":"6318_CR37","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1128\/IAI.01106-05","volume":"74","author":"RT Semnani","year":"2006","unstructured":"Semnani RT, Keiser PB, Coulibaly YI, Keita F, Diallo AA, Traore D, Diallo DA, Doumbo OK, Traore SF, Kubofcik J, Klion AD, Nutman TB (2006) Filaria-induced monocyte dysfunction and its reversal following treatment. Infect Immun 74:4409\u20134417","journal-title":"Infect Immun"},{"key":"6318_CR38","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.cimid.2013.05.003","volume":"36","author":"N Shrivastava","year":"2013","unstructured":"Shrivastava N, Singh PK, Nag JK, Kushwaha S, Misra-Bhattacharya S (2013) Immunization with a multisubunit vaccine considerably reduces establishment of infective larvae in a rodent model of Brugia malayi. Comp Immunol Microbiol Infect Dis 36:507\u2013519","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"6318_CR39","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jbiotec.2011.12.003","volume":"157","author":"M Singh","year":"2012","unstructured":"Singh M, Singh PK, Misra-Bhattacharya S (2012) RNAi mediated silencing of ATPase RNA helicase gene in adult filarial parasite Brugia malayi impairs in vitro microfilaria release and adult parasite viability. J Biotechnol 157:351\u2013358","journal-title":"J Biotechnol"},{"key":"6318_CR40","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1002\/(SICI)1521-4141(199806)28:06<2045::AID-IMMU2045>3.0.CO;2-8","volume":"28","author":"T Sparwasser","year":"1998","unstructured":"Sparwasser T, Koch ES, Vabulas RM, Heeg K, Lipford GB, Ellwart JW, Wagner H (1998) Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 28:2045\u20132054","journal-title":"Eur J Immunol"},{"key":"6318_CR41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/cimm.2000.1735","volume":"206","author":"S Takeshita","year":"2000","unstructured":"Takeshita S, Takeshita F, Haddad DE, Ishii KJ, Klinman DM (2000) CpG oligodeoxynucleotides induce murine macrophages to up-regulate chemokine mRNA expression. Cell Immunol 206:101\u2013106","journal-title":"Cell Immunol"},{"key":"6318_CR42","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4161\/hv.22950","volume":"9","author":"T Tougan","year":"2013","unstructured":"Tougan T, Aoshi T, Coban C, Katakai Y, Kai C, Yasutomi Y, Ishii KJ, Horii T (2013) TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36\/AHG malaria vaccine in nonhuman primate models. Hum Vaccin Immunother 9:283\u2013290","journal-title":"Hum Vaccin Immunother"},{"key":"6318_CR43","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.4049\/jimmunol.181.8.5785","volume":"181","author":"D Tross","year":"2008","unstructured":"Tross D, Klinman DM (2008) Effect of CpG oligonucleotides on vaccine-induced B cell memory. J Immunol 181:5785\u20135790","journal-title":"J Immunol"},{"key":"6318_CR44","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.4049\/jimmunol.164.5.2372","volume":"164","author":"RM Vabulas","year":"2000","unstructured":"Vabulas RM, Pircher H, Lipford GB, Hacker H, Wagner H (2000) CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses. J Immunol 164:2372\u20132378","journal-title":"J Immunol"},{"key":"6318_CR45","doi-asserted-by":"crossref","first-page":"5997","DOI":"10.1016\/j.vaccine.2008.08.073","volume":"26","author":"S Vedi","year":"2008","unstructured":"Vedi S, Dangi A, Hajela K, Misra-Bhattacharya S (2008) Vaccination with 73kDa recombinant heavy chain myosin generates high level of protection against Brugia malayi challenge in jird and mastomys models. Vaccine 26:5997\u20136005","journal-title":"Vaccine"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-019-06318-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-019-06318-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-019-06318-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T10:12:31Z","timestamp":1694859151000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-019-06318-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,8]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["6318"],"URL":"https:\/\/doi.org\/10.1007\/s00436-019-06318-6","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,8]]},"assertion":[{"value":"26 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}