{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:55:44Z","timestamp":1778050544470,"version":"3.51.4"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s00436-019-06568-4","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T09:04:31Z","timestamp":1576659871000},"page":"725-736","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["2\u2032-Hydroxychalcones as an alternative treatment for trichomoniasis in association with metronidazole"],"prefix":"10.1007","volume":"119","author":[{"given":"Raquel Nascimento","family":"das Neves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c2ngela","family":"Sena-Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirna Samara Di\u00e9","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara","family":"da Rocha Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Carapina","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela Maria","family":"Casaril","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucielli","family":"Savegnago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio Martin Pereira","family":"de Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Fernandes","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1774-0059","authenticated-orcid":false,"given":"Sibele","family":"Borsuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"key":"6568_CR1","doi-asserted-by":"publisher","first-page":"484","DOI":"10.3109\/14756366.2014.949255","volume":"30","author":"KRA Abdellatif","year":"2015","unstructured":"Abdellatif KRA, Elshemy HAH, Salama SA, Omar HA (2015) Synthesis, characterization and biological evaluation of novel 4\u2032-fluoro-2\u2032-hydroxy-chalcone derivatives as antioxidant, anti-inflammatory and analgesic agents. J Enzyme Inhib Med Chem 30:484\u2013491. https:\/\/doi.org\/10.3109\/14756366.2014.949255","journal-title":"J Enzyme Inhib Med Chem"},{"key":"6568_CR2","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ejmech.2014.03.076","volume":"79","author":"A Anthwal","year":"2014","unstructured":"Anthwal A, Rajesh UC, Rawat MSM, Kushwaha B, Maikhuri JP, Sharma VL, Gupta G, Rawat DS (2014) Novel metronidazole-chalcone conjugates with potential to counter drug resistance in Trichomonas vaginalis. Eur J Med Chem 79:89\u201394. https:\/\/doi.org\/10.1016\/j.ejmech.2014.03.076","journal-title":"Eur J Med Chem"},{"issue":"10","key":"6568_CR3","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.2174\/1570180813666160711163349","volume":"13","author":"Vishnu N. Badavath","year":"2016","unstructured":"Badavath VN, Jadav SS, Pastorino B, de Lamballerie X, Jayaprakash BNS, (2016) Synthesis and antiviral activity of 2-aryl-4H-chromen-4-one derivatives against Chikungunya virus. Lett Drug Des Discov. https:\/\/doi.org\/10.2174\/1570180813666160711163349","journal-title":"Letters in Drug Design & Discovery"},{"key":"6568_CR4","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.ejmech.2017.11.029","volume":"143","author":"V Bala","year":"2018","unstructured":"Bala V, Chhonker YS (2018) Recent developments in anti-Trichomonas research: an update review. Eur J Med Chem 143:232\u2013243. https:\/\/doi.org\/10.1016\/j.ejmech.2017.11.029","journal-title":"Eur J Med Chem"},{"key":"6568_CR5","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.ejmech.2016.12.017","volume":"126","author":"C Borsari","year":"2017","unstructured":"Borsari C, Santarem N, Torrado J, Ol\u00edas AI, Corral MJ, Baptista C, Gul S, Wolf M, Kuzikov M, Ellinger B, Witt G, Gribbon P, Reinshagen J, Linciano P, Tait A, Costantino L, Freitas-Junior LH, Moraes CB, Bruno dos Santos P, Alc\u00e2ntara LM, Franco CH, Bertolacini CD, Fontana V, Tejera Nevado P, Clos J, Alunda JM, Cordeiro-da-Silva A, Ferrari S, Costi MP (2017) Methoxylated 2\u2032-hydroxychalcones as antiparasitic hit compounds. Eur J Med Chem 126:1129\u20131135. https:\/\/doi.org\/10.1016\/j.ejmech.2016.12.017","journal-title":"Eur J Med Chem"},{"key":"6568_CR6","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1128\/CMR.00109-16","volume":"30","author":"K Bouchemal","year":"2017","unstructured":"Bouchemal K, Bories C, Loiseau PM (2017) Crossm of Trichomonas vaginalis infections. Clin Microbiol Rev 30:811\u2013825","journal-title":"Clin Microbiol Rev"},{"key":"6568_CR7","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/978-3-319-73552-8_4","volume-title":"Increased biodiesel efficiency: alternatives for production, stabilization, characterization and use of coproduct","author":"CC Da Silva","year":"2018","unstructured":"Da Silva CC, Pacheco BS, de Freitas SC, Berneira LM, dos Santos MAZ, Pizzuti L, de Pereira CMP (2018a) Hydroxychalcones: synthetic alternatives to enhance oxidative stability of biodiesel. In: Trindade M (ed) Increased biodiesel efficiency: alternatives for production, stabilization, characterization and use of coproduct. Springer International Publishing, Cham, pp 81\u2013110. https:\/\/doi.org\/10.1007\/978-3-319-73552-8_4"},{"key":"6568_CR8","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/978-3-319-73552-8_4","volume-title":"Green Energy and Technology","author":"Caroline Carapina Da Silva","year":"2018","unstructured":"Da Silva CC, Pacheco BS, de Freitas SC, Berneira LM, dos Santos MAZ, Pizzuti L, de Pereira CMP (2018b) Hydroxychalcones: synthetic alternatives to enhance oxidative stability of biodiesel. Green Energy Technol:81\u2013110. https:\/\/doi.org\/10.1007\/978-3-319-73552-8_4"},{"key":"6568_CR9","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"A Daina","year":"2017","unstructured":"Daina A, Michielin O, Zoete V (2017) SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep 7:42717","journal-title":"Sci Rep"},{"key":"6568_CR10","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1007\/s00436-015-4340-3","volume":"114","author":"P de Brum Vieira","year":"2015","unstructured":"de Brum Vieira P, Giordani RB, Macedo AJ, Tasca T (2015) Natural and synthetic compound anti-Trichomonas vaginalis: an update review. Parasitol Res 114:1249\u20131261. https:\/\/doi.org\/10.1007\/s00436-015-4340-3","journal-title":"Parasitol Res"},{"key":"6568_CR11","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1177\/095632020301400404","volume":"14","author":"N Desideri","year":"2003","unstructured":"Desideri N, Mastromarino P, Conti C (2003) Synthesis and evaluation of antirhinovirus activity of 3-hydroxy and 3-methoxy 2-styrylchromones. Antivir Chem Chemother 14:195\u2013203. https:\/\/doi.org\/10.1177\/095632020301400404","journal-title":"Antivir Chem Chemother"},{"key":"6568_CR12","doi-asserted-by":"publisher","first-page":"488","DOI":"10.2307\/3274682","volume":"43","author":"LS Diamond","year":"1957","unstructured":"Diamond LS (1957) The establishment of various trichomonads of animals and man in axenic cultures. J Parasitol 43:488\u2013490","journal-title":"J Parasitol"},{"key":"6568_CR13","unstructured":"FDA-EUA (n.d) Drug approvals and databases. http:\/\/www.accessdata.fda.gov\/scripts\/cder\/drugsatfda\/index.cfm"},{"key":"6568_CR14","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.tox.2004.11.011","volume":"208","author":"H Forejtn\u00edkov\u00e1","year":"2005","unstructured":"Forejtn\u00edkov\u00e1 H, Lunerov\u00e1 K, Kub\u00ednov\u00e1 R, Jankovsk\u00e1 D, Marek R, Kare\u0161 R, Such\u00fd V, Vondr\u00e1\u010dek J, Machala M (2005) Chemoprotective and toxic potentials of synthetic and natural chalcones and dihydrochalcones in vitro. Toxicology 208:81\u201393. https:\/\/doi.org\/10.1016\/j.tox.2004.11.011","journal-title":"Toxicology"},{"issue":"5","key":"6568_CR15","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1002\/wnan.1334","volume":"7","author":"Luiza A. Frank","year":"2015","unstructured":"Frank LA, Contri RV, Beck RCR, Pohlmann AR, Guterres SS (2015) Improving drug biological effects by encapsulation into polymeric nanocapsules. Wiley Interdiscip Rev Nanomed Nanobiotechnol. https:\/\/doi.org\/10.1002\/wnan.1334","journal-title":"Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology"},{"issue":"5","key":"6568_CR16","doi-asserted-by":"publisher","first-page":"892","DOI":"10.3390\/molecules24050892","volume":"24","author":"M Gajd\u00e1cs","year":"2019","unstructured":"Gajd\u00e1cs M (2019) The concept of an ideal antibiotic: implications for drug design. Molecules 24(5):892. https:\/\/doi.org\/10.3390\/molecules24050892","journal-title":"Molecules"},{"issue":"8","key":"6568_CR17","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.3390\/molecules22081210","volume":"22","author":"Marcelo Gomes","year":"2017","unstructured":"Gomes MN, Muratov EN, Pereira M, Peixoto JC, Rosseto LP, Cravo PVL, Andrade CH, Neves BJ (2017) Chalcone derivatives: promising starting points for drug design. Molecules 22. https:\/\/doi.org\/10.3390\/molecules22081210","journal-title":"Molecules"},{"key":"6568_CR18","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1758-2946-4-17","volume":"4","author":"MD Hanwell","year":"2012","unstructured":"Hanwell MD, Curtis DE, Lonie DC, Vandermeersch T, Zurek E, Hutchison GR (2012) Avogadro: an advanced semantic chemical editor, visualization, and analysis platform. J Cheminform 4:17. https:\/\/doi.org\/10.1186\/1758-2946-4-17","journal-title":"J Cheminform"},{"key":"6568_CR19","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.biopha.2016.09.064","volume":"84","author":"DPG H\u00fcbner","year":"2016","unstructured":"H\u00fcbner DPG, de Brum Vieira P, Frasson AP, Menezes CB, Senger FR, Santos da Silva GN, Baggio Gnoatto SC, Tasca T (2016) Anti-Trichomonas vaginalis activity of betulinic acid derivatives. Biomed Pharmacother 84:476\u2013484. https:\/\/doi.org\/10.1016\/j.biopha.2016.09.064","journal-title":"Biomed Pharmacother"},{"key":"6568_CR20","first-page":"466","volume":"45","author":"YS Jhala","year":"2006","unstructured":"Jhala YS, Dulawat SS, Verma BL (2006) Solvent-free improved syntheses of some substituted 1 , 3-diaryl-propenones and 3 , 5-diaryl-6-carbethoxycyclohexenones under microwave irradiation and their antibacterial activity. Indian J Chem 45:466\u2013469","journal-title":"Indian J Chem"},{"key":"6568_CR21","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/2191-2858-2-20","volume":"2","author":"RC Kamboj","year":"2010","unstructured":"Kamboj RC, Arora R, Sharma G, Kumar D, Sharma C, Joshi R, Aneja KR (2010) Eco-friendly synthesis and antimicrobial activity of chalcones. Der Pharma Chem. 2:157\u2013170. https:\/\/doi.org\/10.1186\/2191-2858-2-20","journal-title":"Der Pharma Chem."},{"key":"6568_CR22","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1186\/s12879-015-1055-0","volume":"15","author":"P Kissinger","year":"2015","unstructured":"Kissinger P (2015) Trichomonas vaginalis: a review of epidemiologic, clinical and treatment issues. BMC Infect Dis 15:307. https:\/\/doi.org\/10.1186\/s12879-015-1055-0","journal-title":"BMC Infect Dis"},{"key":"6568_CR23","doi-asserted-by":"publisher","first-page":"641","DOI":"10.3390\/molecules19010641","volume":"19","author":"YT Lee","year":"2014","unstructured":"Lee YT, Fong TH, Chen HM, Chang CY, Wang YH, Chern CY, Chen YH (2014) Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model. Molecules 19:641\u2013650. https:\/\/doi.org\/10.3390\/molecules19010641","journal-title":"Molecules"},{"key":"6568_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.12688\/f1000research.7594.1","volume":"5","author":"D Leitsch","year":"2016","unstructured":"Leitsch D (2016) Recent advances in the Trichomonas vaginalis field. F1000Res 5:1\u20137. https:\/\/doi.org\/10.12688\/f1000research.7594.1","journal-title":"F1000Res"},{"key":"6568_CR25","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1017\/S0031182015001031","volume":"142","author":"F Ling","year":"2015","unstructured":"Ling F, Jiang C, Liu G, Li M, Wang G (2015) Anthelmintic efficacy of cinnamaldehyde and cinnamic acid from cortex cinnamon essential oil against Dactylogyrus intermedius. Parasitology 142:1744\u20131750. https:\/\/doi.org\/10.1017\/S0031182015001031","journal-title":"Parasitology"},{"issue":"4","key":"6568_CR26","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","volume":"1","author":"CA Lipinski","year":"2004","unstructured":"Lipinski CA (2004) Lead-and drug-like compounds: the rule-of-five revolution. Drug Discovery Today: Technologies 1(4):337\u2013341. https:\/\/doi.org\/10.1016\/j.ddtec.2004.11.007","journal-title":"Drug Discovery Today: Technologies"},{"key":"6568_CR27","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1042\/bj2790675","volume":"279","author":"BC Lockwood","year":"1991","unstructured":"Lockwood BC, Coombs GH (1991) Purification and characterization of methionine y-lyase from. Biochem. J. 279:675\u2013682. https:\/\/doi.org\/10.1042\/bj2790675","journal-title":"Biochem. J."},{"key":"6568_CR28","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ejmech.2015.05.004","volume":"98","author":"DK Mahapatra","year":"2015","unstructured":"Mahapatra DK, Bharti SK, Asati V (2015) Anti-cancer chalcones: structural and molecular target perspectives. Eur J Med Chem 98:69\u2013114. https:\/\/doi.org\/10.1016\/j.ejmech.2015.05.004","journal-title":"Eur J Med Chem"},{"issue":"16","key":"6568_CR29","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"Garrett M. Morris","year":"2009","unstructured":"Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, Olson AJ (2009) AutoDock4 and AutoDockTools4 : automated docking with selective receptor flexibility. J Comput Chem 30:2785-2791 https:\/\/doi.org\/10.1002\/jcc.21256","journal-title":"Journal of Computational Chemistry"},{"key":"6568_CR30","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.2217\/fmb-2017-0062","volume":"12","author":"AC Palanco","year":"2017","unstructured":"Palanco AC, Lacorte S, De J, Costa-Orlandi CB, Gullo FP, Strohmayer Lourencetti NM, Gomes PC, Ayusso GM, Dutra LA, Silva B, Da V, Regasini LO, Soares Mendes-Giannini MJ, Fusco-Almeida AM (2017) Activity of 3\u2032-hydroxychalcone against Cryptococcus gattii and toxicity, and efficacy in alternative animal models. Future Microbiol 12:1123\u20131134. https:\/\/doi.org\/10.2217\/fmb-2017-0062","journal-title":"Future Microbiol"},{"key":"6568_CR31","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1128\/AAC.02370-13","volume":"58","author":"TE Paulish-miller","year":"2014","unstructured":"Paulish-miller TE, Augostini P, Schuyler JA, Smith WL, Mordechai E, Adelson ME, Gygax SE, Secor WE, Hilbert W (2014) Trichomonas vaginalis metronidazole resistance is associated with single nucleotide polymorphisms in the Nitroreductase genes ntr4 Tv and ntr6 Tv. Antimicrob Agents Chemother 58:2938\u20132943. https:\/\/doi.org\/10.1128\/AAC.02370-13","journal-title":"Antimicrob Agents Chemother"},{"key":"6568_CR32","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1128\/CMR.11.2.300","volume":"11","author":"D Petrin","year":"1998","unstructured":"Petrin D, Delgaty K, Bhatt R, Garber G (1998) Clinical and microbiological aspects of Trichomonas vaginalis. Clin Microbiol Rev 11:300\u2013317","journal-title":"Clin Microbiol Rev"},{"key":"6568_CR33","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/jcc.20084","volume":"25","author":"EF Pettersen","year":"2004","unstructured":"Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE (2004) UCSF Chimera - a visualization system for exploratory research and analysis. J Comput Chem 25:1605\u20131612. https:\/\/doi.org\/10.1002\/jcc.20084","journal-title":"J Comput Chem"},{"key":"6568_CR34","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0006-291X(02)00618-6","volume":"295","author":"BM Rezk","year":"2002","unstructured":"Rezk BM, Haenen GRMM, Van der Vijgh WJF, Bast A (2002) The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids. Biochem Biophys Res Commun 295:9\u201313. https:\/\/doi.org\/10.1016\/S0006-291X(02)00618-6","journal-title":"Biochem Biophys Res Commun"},{"key":"6568_CR35","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1021\/bi061515r","volume":"46","author":"A Rinaldo-Matthis","year":"2007","unstructured":"Rinaldo-Matthis A, Wing C, Ghanem M, Deng H, Wu P, Gupta A, Tyler PC, Evans GB, Furneaux RH, Almo SC, Wang CC, Schramm VL (2007) Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues. Biochemistry 46:659\u2013668. https:\/\/doi.org\/10.1021\/bi061515r","journal-title":"Biochemistry"},{"key":"6568_CR36","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.biopha.2017.01.173","volume":"89","author":"\u00c2 Sena-Lopes","year":"2017","unstructured":"Sena-Lopes \u00c2, das Neves RN, Bezerra FSB, de Oliveira Silva MT, Nobre PC, Perin G, Alves D, Savegnago L, Begnini KR, Seixas FK, Collares T, Borsuk S (2017) Antiparasitic activity of 1,3-dioxolanes containing tellurium in Trichomonas vaginalis. Biomed Pharmacother 89:284\u2013287. https:\/\/doi.org\/10.1016\/j.biopha.2017.01.173","journal-title":"Biomed Pharmacother"},{"key":"6568_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/scipharm85010005","volume-title":"Natural products as new treatment options for Trichomoniasis : a molecular docking investigation","author":"MS Setzer","year":"2017","unstructured":"Setzer MS, Byler KG, Ogungbe IV, Setzer WN (2017) Natural products as new treatment options for Trichomoniasis : a molecular docking investigation. https:\/\/doi.org\/10.3390\/scipharm85010005"},{"key":"6568_CR38","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ejmech.2015.11.029","volume":"108","author":"G Singh","year":"2016","unstructured":"Singh G, Arora A, Mangat SS, Rani S, Kaur H, Goyal K, Sehgal R, Maurya IK, Tewari R, Choquesillo-Lazarte D, Sahoo S, Kaur N (2016) Design, synthesis and biological evaluation of chalconyl blended triazole allied organosilatranes as giardicidal and trichomonacidal agents. Eur J Med Chem 108:287\u2013300. https:\/\/doi.org\/10.1016\/j.ejmech.2015.11.029","journal-title":"Eur J Med Chem"},{"key":"6568_CR39","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1002\/pro.2904","volume":"25","author":"PA Steindel","year":"2016","unstructured":"Steindel PA, Chen EH, Wirth JD, Theobald DL (2016) Gradual neofunctionalization in the convergent evolution of trichomonad lactate and malate dehydrogenases. Protein Sci 25:1319\u20131331. https:\/\/doi.org\/10.1002\/pro.2904","journal-title":"Protein Sci"},{"key":"6568_CR40","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1177\/1947601912440575","volume":"2","author":"RJ Tallarida","year":"2011","unstructured":"Tallarida RJ (2011) Quantitative methods for assessing drug synergism. Genes and Cancer 2:1003\u20131008. https:\/\/doi.org\/10.1177\/1947601912440575","journal-title":"Genes and Cancer"},{"issue":"2","key":"6568_CR41","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s00436-018-6164-4","volume":"118","author":"M\u00e1rcia Rodrigues Trein","year":"2018","unstructured":"Trein MR, Rodrigues L, Rigo GV, Aparecida M, Garcia R (2019) Anti-Trichomonas vaginalis activity of chalcone and amino-analogues. Parasitol Res 118:607-615. https:\/\/doi.org\/10.1007\/s00436-018-6164-4","journal-title":"Parasitology Research"},{"key":"6568_CR42","doi-asserted-by":"publisher","unstructured":"Trott O, Olson AJ (2009) AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. https:\/\/doi.org\/10.1002\/jcc.21334","DOI":"10.1002\/jcc.21334"},{"key":"6568_CR43","doi-asserted-by":"publisher","first-page":"3062","DOI":"10.1039\/C3OB42429D","volume":"12","author":"F-W Wang","year":"2014","unstructured":"Wang F-W, Wang S-Q, Zhao B-X, Miao J-Y (2014) Discovery of 2\u2032-hydroxychalcones as autophagy inducer in A549 lung cancer cells. Org Biomol Chem 12:3062\u20133070. https:\/\/doi.org\/10.1039\/C3OB42429D","journal-title":"Org Biomol Chem"},{"key":"6568_CR44","unstructured":"WHO (2012) Global incidence and prevalence of selected curable sexually transmitted infections-2008. World Heal Organ., pp 1\u201328"},{"key":"6568_CR45","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1016\/S0031-9422(00)86646-7","volume":"7","author":"E Wong","year":"1968","unstructured":"Wong E (1968) The role of chalcones and flavanones in flavonoid biosynthesis. Phytochemistry 7:1751\u20131758","journal-title":"Phytochemistry"},{"key":"6568_CR46","doi-asserted-by":"publisher","first-page":"388","DOI":"10.4172\/2161-0444.1000291","volume":"5","author":"B Zhou","year":"2015","unstructured":"Zhou B (2015) Diverse molecular targets for chalcones with varied bioactivities. Med Chem (Los Angeles) 5:388\u2013404. https:\/\/doi.org\/10.4172\/2161-0444.1000291","journal-title":"Med Chem (Los Angeles)"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-019-06568-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-019-06568-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-019-06568-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:18:10Z","timestamp":1608164290000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-019-06568-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,18]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["6568"],"URL":"https:\/\/doi.org\/10.1007\/s00436-019-06568-4","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,18]]},"assertion":[{"value":"22 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}