{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T05:41:06Z","timestamp":1744263666038},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"CNPQ","award":["306993\/2015-5"],"award-info":[{"award-number":["306993\/2015-5"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s00436-020-06674-8","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T01:02:31Z","timestamp":1586912551000},"page":"1989-1995","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chronic Toxoplasma gondii infection contributes to decreasing of perineuronal nets surrounding neurons in the Corpus striatum of mice"],"prefix":"10.1007","volume":"119","author":[{"given":"Ramayana Morais","family":"de Medeiros Brito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ywlliane","family":"da Silva Rodrigues Meurer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidiane","family":"da Silva Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenna Marceliane","family":"de Melo Marcelino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valter Ferreira","family":"de Andrade-Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"6674_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032489","volume":"7","author":"C Afonso","year":"2012","unstructured":"Afonso C, Paix\u00e3o VB, Costa RM (2012) Chronic Toxoplasma infection modifies the structure and risk of host behaviour. PLoS One 7:e32489","journal-title":"PLoS One"},{"key":"6674_CR2","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1111\/j.1462-5822.2005.00486.x","volume":"7","author":"A Barragan","year":"2005","unstructured":"Barragan A, Brossier F, Sibley LD (2005) Transepithelial migration of Toxoplasma gondii involves an interaction of intracellular adhesion molecule 1 (ICAM-1) with the parasite adhesion MIC2. Cell Microbiol 7:561\u2013568","journal-title":"Cell Microbiol"},{"key":"6674_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0028925","volume":"6","author":"M Berenreiterov\u00e1","year":"2011","unstructured":"Berenreiterov\u00e1 M, Flegr J, Kubena AA, Nemec P (2011) The distribution of Toxoplasma gondii cyst in the brain of a mouse with latent toxoplasmosis: implications for behavioral manipulation hypothesis. PLoS One 6:1\u201314","journal-title":"PLoS One"},{"key":"6674_CR4","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/ni.1629","volume":"9","author":"N Blanchard","year":"2008","unstructured":"Blanchard N, Gonzalez F, Schaeffer M, Joncker NT, Cheng T, Shastri AJ, Robey EA, Shastri N (2008) Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum. Nat Immunol 9:937\u2013944","journal-title":"Nat Immunol"},{"key":"6674_CR5","first-page":"419","volume":"85","author":"CR Brown","year":"1995","unstructured":"Brown CR, Hunter CA, Estes RG, Beckmann E, Forman J, David C (1995) Definitive identification of a gene that confers resistance against Toxoplasma gondii cyst burden and encephalitis. Immunol 85:419\u2013428","journal-title":"Immunol"},{"key":"6674_CR6","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/0165-0173(94)90006-X","volume":"19","author":"MR Celio","year":"1994","unstructured":"Celio MR, Blumcke I (1994) Perineuronal nets \u2013 a specialized form of extracellular matrix in the adult nervous system. Brain Res Rev 19:128\u2013145","journal-title":"Brain Res Rev"},{"key":"6674_CR7","first-page":"309","volume":"107","author":"N Courret","year":"2006","unstructured":"Courret N, Darche S, Sonigo P, Milon G, Buzoni-Gatel D, Tardieux I (2006) CD11c- and CD11bexpressing mouse leukocytes transport single Toxoplasma gondii tachyzoites to the brain. Am Soc Hematol 107:309\u2013316","journal-title":"Am Soc Hematol"},{"issue":"7","key":"6674_CR8","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1007\/s11064-016-1876-2","volume":"41","author":"Ciro De Luca","year":"2016","unstructured":"De Luca C, Papa M (2016) Looking inside the matrix: perineuronal nets in plasticity, maladaptive plasticity and neurological disorders. Neurochem Res 41(7):1507\u20131515","journal-title":"Neurochemical Research"},{"key":"6674_CR9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.clineuro.2016.08.014","volume":"150","author":"GB De Oliveira","year":"2016","unstructured":"De Oliveira GB, da Silva MA, Wanderley LB, da Cunha CC, Ferreira EC, de Medeiros ZM, Filho JL, de Melo FL, de Ara\u00fajo OS, Santos AH (2016) Cerebral toxoplasmosis in patients with acquired immune deficiency syndrome in the neurological department of a tertiary hospital. Clin Neurol Neurosurg 150:23\u201326","journal-title":"Clin Neurol Neurosurg"},{"issue":"5","key":"6674_CR10","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1002\/dneu.20361","volume":"67","author":"Alexander Dityatev","year":"2007","unstructured":"Dityatev A, Br\u00fcckner G, Dityateva G, Grosche J, Kleene R, Schachner M (2007) Activity-dependent formation and functions of chondroitin sulfate-rich extracellular matrix of perineuronal nets. Dev Neurobiol 67(5):570\u2013588","journal-title":"Developmental Neurobiology"},{"key":"6674_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S0031182011001673","volume":"139","author":"JP Dubey","year":"2012","unstructured":"Dubey JP, Ferreira LR, Martin J, Mcleod R (2012) Oral oocyst induced model of toxoplasmosis: effect of infection with Toxoplasma gondii strains of different genotypes, dose, and mouse strains (transgenic, outbred, inbred) on pathogenesis and mortality. Parasitology 139:1\u201313","journal-title":"Parasitology"},{"key":"6674_CR12","doi-asserted-by":"publisher","first-page":"e0156255","DOI":"10.1371\/journal.pone.0156255","volume":"11","author":"JP Dubey","year":"2016","unstructured":"Dubey JP, Ferreira LR, Alsaad M, Verma SK, Alves DA, Holland GN, McConkey GA (2016) Experimental toxoplasmosis in rats induced orally with eleven strains of Toxoplasma gondii of seven genotypes: tissue tropism, tissue cyst size, neural lesions, tissue cyst rupture without reactivation and ocular lesions. PLoS One 11:e0156255","journal-title":"PLoS One"},{"key":"6674_CR13","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1016\/j.ajpath.2018.07.007","volume":"188","author":"V Estato","year":"2018","unstructured":"Estato V, Stipursky J, Gomes F, Mergener TC, Fraz\u00e3o-Teixeira W, Allodi S, Tibiri\u00e7\u00e1 E, Barbosa HS, Adesse D (2018) The neurotropic parasite Toxoplasma gondii induces sustained neuroinflammation with microvascular dysfunction in infected mice. Am J Pathol 188:2674\u20132687","journal-title":"Am J Pathol"},{"key":"6674_CR14","doi-asserted-by":"publisher","first-page":"e90203","DOI":"10.1371\/journal.pone.0090203","volume":"9","author":"J Flegr","year":"2014","unstructured":"Flegr J, Prandota J, Sovickova M, Israili ZH (2014) Toxoplasmosis \u2013 a global threat: correlation of latent toxoplasmosis with specific disease burden in a set of 83 countries. PLoS One 9:e90203","journal-title":"PLoS One"},{"key":"6674_CR15","unstructured":"Franklin KBJ, Paxinos G (2007) The mouse brain in stereotaxic coordinates, 3a edn. Elsevier Science Academic Press, 351 pages"},{"key":"6674_CR16","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00436-011-2800-y","volume":"111","author":"J Gatkowska","year":"2012","unstructured":"Gatkowska J, Wieczorek M, Dziadek B, Dzitko K, Dlugonska H (2012) Behavioral changes in mice caused by Toxoplasma gondii invasion of brain. Parasitol Res 111:53\u201358","journal-title":"Parasitol Res"},{"issue":"5945","key":"6674_CR17","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1126\/science.1174146","volume":"325","author":"N. Gogolla","year":"2009","unstructured":"Gogolla N, Caroni P, Luthi A, Herry C (2009) Perineuronal nets protect fear memories from erasure. Science 325(5945):1258\u20131261","journal-title":"Science"},{"key":"6674_CR18","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.bbr.2006.11.012","volume":"177","author":"LE Gonzalez","year":"2007","unstructured":"Gonzalez LE, Rojnik B, Urrea F, Urdaneta H, Petrosino P, Colasante C, Pino S, Hernandez L (2007) Toxoplasma gondii infection lower anxiety as measured in the plus-maze and social interaction test in rats: a behavioral analysis. Behav Brain Res 177:70\u201379","journal-title":"Behav Brain Res"},{"key":"6674_CR19","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/j.1462-5822.2009.01417.x","volume":"12","author":"H Lambert","year":"2010","unstructured":"Lambert H, Barragan A (2010) Microreview modeling parasite dissemination: host cell subversion and immune evasion by Toxoplasma gondii. Cell Microbiol 12:292\u2013300","journal-title":"Cell Microbiol"},{"key":"6674_CR20","doi-asserted-by":"publisher","first-page":"e32747","DOI":"10.1371\/journal.pone.0032747","volume":"7","author":"H Lee","year":"2012","unstructured":"Lee H, Leamey CA, Sawatari A (2012) Perineuronal nets play a role in regulating striatal function in the mouse. PLoS One 7:e32747","journal-title":"PLoS One"},{"key":"6674_CR21","doi-asserted-by":"publisher","unstructured":"Liu J, Huang S, Lu F (2018) Galectin-3 and Galectin-9 may differently regulate the expressions of microglial M1\/M2 markers and T helper 1\/Th2 cytokines in the brain of genetically susceptible C57BL\/6 and resistant Balb\/c mice following peroral infection with Toxoplasma gondii. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2018.01648","DOI":"10.3389\/fimmu.2018.01648"},{"key":"6674_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4303\/jnp\/N100505","volume":"1","author":"T. C. Melzer","year":"2010","unstructured":"Melzer TC, Cranston HJ, Weiss LM, Halonen SK (2010) Host cell preference of Toxoplasma gondii cysts in murine brain: a confocal study. J Neuroparasitol. https:\/\/doi.org\/10.4303\/jnp\/N100505","journal-title":"Journal of Neuroparasitology"},{"key":"6674_CR23","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.micinf.2008.04.001","volume":"10","author":"S Morisset","year":"2008","unstructured":"Morisset S, Peyron F, Lobry JR, Garweg J, Ferrandiz J, Musset K, Gomez-Marin JE, de la Torre A, Demar M, Carme B, Mercier C, Garin JF, Cesbron-Delauw M (2008) Serotyping of Toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America. Microbes Infect 10:742\u2013747","journal-title":"Microbes Infect"},{"key":"6674_CR24","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.brainres.2008.11.022","volume":"1252","author":"M Nakamura","year":"2009","unstructured":"Nakamura M, Nakano K, Morita S, Nakashima T, Oohira A, Miyata S (2009) Expression of chondroitin sulfate proteoglycans in barrel field of mouse and rat somatosensory cortex. Brain Res 1252:117\u2013129","journal-title":"Brain Res"},{"issue":"1","key":"6674_CR25","doi-asserted-by":"publisher","first-page":"e496","DOI":"10.1038\/tp.2014.128","volume":"5","author":"H Pantazopoulos","year":"2015","unstructured":"Pantazopoulos H, Markota M, Jaquet F, Ghosh D, Wallin A, Santos A, Caterson B, Berretta S (2015) Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala. Transl Psychiatry 5(1):e496","journal-title":"Translational Psychiatry"},{"key":"6674_CR26","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/j.ijpara.2009.04.003","volume":"39","author":"G Pappas","year":"2009","unstructured":"Pappas G, Roussos N, Falagas ME (2009) Toxoplasmosis snapshots: global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis. Int J Parasitol 39:1385\u20131394","journal-title":"Int J Parasitol"},{"key":"6674_CR27","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1590\/S0001-37652008000100005","volume":"80","author":"MG Resende","year":"2008","unstructured":"Resende MG, Fux B, Caetano BC, Mendes EA, Silva NM, Ferreira AM, Melo MN, Vitor RWA, Gazzinelli RT (2008) The role of MHC haplotypes H2d\/H2b in mouse resistance\/susceptibility to cyst formation is influenced by the lineage of infective Toxoplasma gondii strain. An Acad Bras Cienc 80:85\u201399","journal-title":"An Acad Bras Cienc"},{"key":"6674_CR28","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.tins.2007.11.001","volume":"31","author":"LS Sherman","year":"2008","unstructured":"Sherman LS, Back SA (2008) A \u201cGAG\u201d reflex prevents repair of the damaged CNS. Trends Neurosci 31:44\u201352","journal-title":"Trends Neurosci"},{"key":"6674_CR29","doi-asserted-by":"publisher","unstructured":"Tan D, Soh LJT, Lim LW, Daniel TCW, Zhang X, Vyas A (2015) Infection of male rats with Toxoplasma gondii results in enhanced delay aversion and neuronal changes in the nucleus accumbens core. Proc Biol Sci. https:\/\/doi.org\/10.1095\/rspb.2015.0042","DOI":"10.1095\/rspb.2015.0042"},{"key":"6674_CR30","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0020-7519(00)00124-7","volume":"30","author":"A Tenter","year":"2000","unstructured":"Tenter A, Heckeroth AR, Weiss LM (2000) Toxoplasma gondii: from animals to humans. Int J Parasitol 30:217\u20131258","journal-title":"Int J Parasitol"},{"key":"6674_CR31","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.conb.2004.10.003","volume":"14","author":"JM Tepper","year":"2004","unstructured":"Tepper JM, Bolam JP (2004) Functional diversity and specificity of neostriatal interneurons. Curr Opin Neurobiol 14:685\u2013692","journal-title":"Curr Opin Neurobiol"},{"key":"6674_CR32","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.ibror.2018.01.002","volume":"4","author":"N Ueno","year":"2018","unstructured":"Ueno N, Fujii K, Suemitsu S, Shinji M, Kitamura N, Wani K, Aoki S, Okamoto M, Ishihara T, Takao K (2018) Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex. IBRO Rep 4:22\u201337","journal-title":"IBRO Rep"},{"key":"6674_CR33","doi-asserted-by":"publisher","first-page":"6442","DOI":"10.1073\/pnas.0608310104","volume":"104","author":"A Vyas","year":"2007","unstructured":"Vyas A, Kim SK, Giacomini N, Boothroyd JC, Sapolsky RM (2007) Behavioral changes induced by Toxoplasma gondii infection of rodents are highly specific to aversion of cat odors. PNAS 104:6442\u20136447","journal-title":"PNAS"},{"key":"6674_CR34","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S2352-3018(17)30005-X","volume":"4","author":"ZD Wang","year":"2017","unstructured":"Wang ZD, Wang SC, Liu HH, Ma HY, Li ZY, Wei F, Zhu XQ, Liu Q (2017) Prevalence and burden of Toxoplasma gondii infection in HIV-infected people: a systematic review and meta-analysis. Lancet HIV 4:177\u2013188","journal-title":"Lancet HIV"},{"key":"6674_CR35","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.bbr.2018.09.011","volume":"359","author":"Ting Wang","year":"2019","unstructured":"Wang T, Sun X, Qin W, Zhang X, Wu L, Li Y, Zhou C, Zhou H, He S, Cong H (2018) From inflammatory reactions to neurotransmitter changes: implications for understanding the neurobehavioral changes in mice chronically infected with Toxoplasma gondii. Behav Brain Res. https:\/\/doi.org\/10.1016\/j.bbr.2018.09.011","journal-title":"Behavioural Brain Research"},{"key":"6674_CR36","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.exppara.2018.12.003","volume":"196","author":"GF Watson","year":"2019","unstructured":"Watson GF, Davis PH (2019) Experimental parasitology systematic review and meta-analysis of variation in Toxoplasma gondii cyst burden in murine model. Exp Parasitol 196:55\u201362","journal-title":"Exp Parasitol"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-020-06674-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-020-06674-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-020-06674-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T08:18:38Z","timestamp":1618474718000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-020-06674-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,15]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["6674"],"URL":"https:\/\/doi.org\/10.1007\/s00436-020-06674-8","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,15]]},"assertion":[{"value":"30 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This project was performed in accordance with the norms issued by the National Council for the Control of Animal Experimentation (CONCEA), approved by the Committee on Ethics in the Use of Animals of the Federal University of Rio Grande do Norte (CEUA\/UFRN), under protocol 048\/2018, certificate number 124.048\/2018.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}