{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:29:02Z","timestamp":1774618142783,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"crossref","award":["Project PAPIIT IT201018"],"award-info":[{"award-number":["Project PAPIIT IT201018"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s00436-020-06705-4","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T02:02:17Z","timestamp":1591668137000},"page":"2687-2693","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficiency comparison of experimental fosfatriclaben with three commercial fasciolicides in experimentally infected sheep"],"prefix":"10.1007","volume":"119","author":[{"given":"Rosa","family":"Arias-Garc\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Vera-Montenegro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Flores-Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Hern\u00e1ndez-Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5529-4702","authenticated-orcid":false,"given":"Froyl\u00e1n","family":"Ibarra-Velarde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"6705_CR1","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.vetpar.2014.07.017","volume":"205","author":"K Ashrafi","year":"2014","unstructured":"Ashrafi K, Mas-Coma S (2014) Fasciola gigantica transmission in the zoonotic fascioliasis endemic lowlands of Guilan, Iran: experimental assessment. Vet Parasitol 205:96\u2013106. https:\/\/doi.org\/10.1016\/j.vetpar.2014.07.017","journal-title":"Vet Parasitol"},{"key":"6705_CR2","unstructured":"Ates Alagoz Z, Adejare A (2012) Prodrugs. In: Loyd VAJ (ed) Remington, the science and practice of pharmacy, 22nd edn, Philadelphia, pp 175\u2013194"},{"key":"6705_CR3","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1021\/op010064","volume":"6","author":"A Bentley","year":"2002","unstructured":"Bentley A, Butters M, Green SP, Learmonth WJ, MacRae JA, Morland MC, O\u2019Conno G, Skuse J (2002) The discovery and process development of a commercial route to the water soluble prodrug, Fosfluconazole. Org Process Res Dev 6:109\u2013112. https:\/\/doi.org\/10.1021\/op010064","journal-title":"Org Process Res Dev"},{"key":"6705_CR4","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1136\/vr.113.14.315","volume":"113","author":"JC Boray","year":"1983","unstructured":"Boray JC, Crowfoot PD, Strong MB, Allison J, Schellenbaum M, von Orelli M, Sarasin G (1983) Treatment of immature and mature Fasciola hepatica infections in sheep with triclabendazole. Vet Rec 113:315\u2013317. https:\/\/doi.org\/10.1136\/vr.113.14.315","journal-title":"Vet Rec"},{"key":"6705_CR5","unstructured":"CDC - Centers for Disease Control and Prevention (2019) CDC - Fasciola - Biology. https:\/\/www.cdc.gov\/parasites\/fasciola\/biology.html. Accessed 21 Jan 2020"},{"key":"6705_CR6","volume-title":"Fasciolosis","year":"1999","unstructured":"Dalton JP (ed) (1999) Fasciolosis. CAB International, Wallingford"},{"key":"6705_CR7","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.vetpar.2015.02.014","volume":"209","author":"TP Elliott","year":"2015","unstructured":"Elliott TP, Kelley JM, Rawlin G, Spithill TW (2015) High prevalence of fasciolosis and evaluation of drug efficacy against Fasciola hepatica in dairy cattle in the Maffra and Bairnsdale districts of Gippsland, Victoria, Australia. Vet Parasitol 209:117\u2013124. https:\/\/doi.org\/10.1016\/j.vetpar.2015.02.014","journal-title":"Vet Parasitol"},{"key":"6705_CR8","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1053\/tvjl.1999.0377","volume":"158","author":"I Fairweather","year":"1999","unstructured":"Fairweather I, Boray JC (1999) Fasciolicides: efficacy, actions, resistance and its management. Vet J 158:81\u2013112. https:\/\/doi.org\/10.1053\/tvjl.1999.0377","journal-title":"Vet J"},{"key":"6705_CR9","unstructured":"FAO\/WHO Expert Committee on Food Additives (2012) Triclabendazole. Addendum to the monographs prepared by the 40th, 66th and 70th Meetings of the Committee. FAO JECFA Monographs 2 and 6, Rome"},{"key":"6705_CR10","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2165\/00003088-200342010-00002","volume":"42","author":"JH Fischer","year":"2003","unstructured":"Fischer JH, Patel TV, Fischer PA (2003) Fosphenytoin. Clin Pharmacokinet 42:33\u201358. https:\/\/doi.org\/10.2165\/00003088-200342010-00002","journal-title":"Clin Pharmacokinet"},{"key":"6705_CR11","doi-asserted-by":"publisher","first-page":"5814","DOI":"10.1016\/j.bmcl.2014.10.017","volume":"24","author":"M Flores","year":"2014","unstructured":"Flores M, Ibarra F, Hern\u00e1ndez A, Vera Y, Jung H, Cant\u00f3 GJ, Del Rivero LM, Castillo R (2014) A highly water soluble benzimidazole derivative useful for the treatment of fasciolosis. Bioorg Med Chem Lett 24:5814\u20135817. https:\/\/doi.org\/10.1016\/j.bmcl.2014.10.017","journal-title":"Bioorg Med Chem Lett"},{"key":"6705_CR12","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.bmcl.2016.12.004","volume":"27","author":"M Flores","year":"2017","unstructured":"Flores M, Ibarra F, Jung H, Hern\u00e1ndez A, Vera Y, Castillo R (2017) Novel triclabendazole prodrug: a highly water soluble alternative for the treatment of fasciolosis. Bioorg Med Chem Lett 27:616\u2013619. https:\/\/doi.org\/10.1016\/j.bmcl.2016.12.004","journal-title":"Bioorg Med Chem Lett"},{"key":"6705_CR13","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1248\/cpb.50.649","volume":"50","author":"A Hern\u00e1ndez","year":"2002","unstructured":"Hern\u00e1ndez A, Ibarra F, Vera Y, Rivera N, Castillo R (2002) Synthesis and fasciolicidal activity of 5-chloro-2-methylthio-6-(1-naphthyloxy)-1 H-benzimidazole. Chem Pharm Bull 50:649\u2013652","journal-title":"Chem Pharm Bull"},{"key":"6705_CR14","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.vetpar.2003.12.005","volume":"120","author":"F Ibarra","year":"2004","unstructured":"Ibarra F, Vera Y, Quiroz H, Cant\u00f3 GJ, Castillo R, Hern\u00e1ndez A, Ochoa P (2004) Determination of the effective dose of an experimental fasciolicide in naturally and experimentally infected cattle. Vet Parasitol 120:65\u201374","journal-title":"Vet Parasitol"},{"key":"6705_CR15","first-page":"253","volume-title":"Estudios de la Fasciolosis en M\u00e9xico de 1879 a 2006","author":"F Ibarra-Velarde","year":"2010","unstructured":"Ibarra-Velarde F (2010) Quimioterapia y estudios terap\u00e9uticos sobre fasciolosis en M\u00e9xico. In: Quiroz H, Figueroa JA (eds) Estudios de la Fasciolosis en M\u00e9xico de 1879 a 2006, 1st edn. UNAM, M\u00e9xico, pp 253\u2013271","edition":"1"},{"key":"6705_CR16","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.pt.2016.03.002","volume":"32","author":"JM Kelley","year":"2016","unstructured":"Kelley JM, Elliott TP, Beddoe T, Anderson G, Skuce P, Spithill TW (2016) Current threat of triclabendazole resistance in Fasciola hepatica. Trends Parasitol 32:458\u2013469. https:\/\/doi.org\/10.1016\/j.pt.2016.03.002","journal-title":"Trends Parasitol"},{"key":"6705_CR17","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.ejpb.2004.03.001","volume":"58","author":"M Lindenberg","year":"2004","unstructured":"Lindenberg M, Kopp S, Dressman JB (2004) Classification of orally administered drugs on the World Health Organization Model list of Essential Medicines according to the biopharmaceutics classification system. Eur J Pharm Biopharm 58:265\u2013278. https:\/\/doi.org\/10.1016\/j.ejpb.2004.03.001","journal-title":"Eur J Pharm Biopharm"},{"key":"6705_CR18","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.vetpar.2009.02.004","volume":"162","author":"M McConville","year":"2009","unstructured":"McConville M, Brennan GP, Flanagan A, Edgar HWJ, Hanna REB, McCoy M, Gordon AW, Castillo R, Hern\u00e1ndez A, Fairweather I (2009) An evaluation of the efficacy of compound alpha and triclabendazole against two isolates of Fasciola hepatica. Vet Parasitol 162:75\u201388. https:\/\/doi.org\/10.1016\/j.vetpar.2009.02.004","journal-title":"Vet Parasitol"},{"key":"6705_CR19","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.vetpar.2011.12.028","volume":"187","author":"M McConville","year":"2012","unstructured":"McConville M, Hanna REB, Brennan GP, Edgar HWJ, McConnell S, McCoy M, Castillo R, Hern\u00e1ndez A, Fairweather I (2012) Impact of compound alpha treatment in vivo on egg production by the liver fluke, Fasciola hepatica. Vet Parasitol 187:183\u2013195. https:\/\/doi.org\/10.1016\/j.vetpar.2011.12.028","journal-title":"Vet Parasitol"},{"key":"6705_CR20","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.micpath.2017.06.006","volume":"109","author":"K Mehmood","year":"2017","unstructured":"Mehmood K, Zhang H, Sabir AJ, Abbas RZ, Ijaz M, Durrani AZ, Saleem MH, Ur Rehman M, Iqbal MK, Wang Y, Ahmad HI, Abbas T, Hussain R, Ghori MT, Ali S, Khan AU, Li J (2017) A review on epidemiology, global prevalence and economical losses of fasciolosis in ruminants. Microb Pathog 109:253\u2013262. https:\/\/doi.org\/10.1016\/j.micpath.2017.06.006","journal-title":"Microb Pathog"},{"key":"6705_CR21","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1365-2885.2008.01014.x","volume":"32","author":"N Ram\u00edrez","year":"2009","unstructured":"Ram\u00edrez N, Mayet L, Del Rivero L, Ibarra F, Castillo R, Hernandez A, Jung H (2009) Pharmacokinetic behavior in sheep and cattle of 5-chloro-2-(methylthio)-6-(1-naphthyloxy)-1H-benzimidazole, a new fasciolicide agent. J Vet PharmacolTher 32:154\u2013159. https:\/\/doi.org\/10.1111\/j.1365-2885.2008.01014.x","journal-title":"J Vet PharmacolTher"},{"key":"6705_CR22","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s00436-004-1127-3","volume":"93","author":"N Rivera","year":"2004","unstructured":"Rivera N, Ibarra F, Zepeda A, Fortoul T, Hern\u00e1ndez A, Castillo R, Cant\u00f3 GJ (2004) Tegumental surface changes in adult Fasciola hepatica following treatment in vitro and in vivo with an experimental fasciolicide. Parasitol Res 93:283\u2013286. https:\/\/doi.org\/10.1007\/s00436-004-1127-3","journal-title":"Parasitol Res"},{"key":"6705_CR23","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s00436-005-1304-z","volume":"95","author":"N Rivera","year":"2005","unstructured":"Rivera N, Ibarra F, Zepeda A, Fortoul T, Cant\u00f3 GJ, Hern\u00e1ndez A, Castillo R (2005) The effect of the 5-chloro-2-methylthio-6-(1-naphtyloxy)-1H-benzimidazole on the tegument of immature Fasciola hepatica in their natural host. Parasitol Res 95:379\u2013382. https:\/\/doi.org\/10.1007\/s00436-005-1304-z","journal-title":"Parasitol Res"},{"key":"6705_CR24","first-page":"300","volume":"77","author":"L Savioli","year":"1999","unstructured":"Savioli L, Chitsulo L, Montresor A (1999) New opportunities for the control of fascioliasis. Bull World Health Organ 77:300","journal-title":"Bull World Health Organ"},{"key":"6705_CR25","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/j.1751-0813.1983.tb02833.x","volume":"60","author":"MG Smeal","year":"1983","unstructured":"Smeal MG, Hall CA (1983) The activity of triclabendazole against immature and adult Fasciola hepatica infections in sheep. Aust Vet J 60:329\u2013331. https:\/\/doi.org\/10.1111\/j.1751-0813.1983.tb02833.x","journal-title":"Aust Vet J"},{"key":"6705_CR26","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1177\/0091270003262799","volume":"44","author":"S Sobue","year":"2004","unstructured":"Sobue S, Sekiguchi K, Shimatani K, Tan K (2004) Pharmacokinetics and safety of fosfluconazole after single intravenous bolus injection in healthy male Japanese volunteers. J ClinPharmacol 44:284\u2013292. https:\/\/doi.org\/10.1177\/0091270003262799","journal-title":"J ClinPharmacol"},{"key":"6705_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/9781119073680","volume-title":"Veterinary parasitology","author":"M Taylor","year":"2015","unstructured":"Taylor M, Coop R, Wall R (2015) Veterinary parasitology, 4th edn. Wiley-Blackwell, Hoboken","edition":"4"},{"key":"6705_CR28","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1136\/vr.114.2.41","volume":"114","author":"K Turner","year":"1984","unstructured":"Turner K, Armour J, Richards RJ (1984) Anthelmintic efficacy of triclabendazole against Fasciola hepatica in sheep. Vet Rec 114:41\u201342. https:\/\/doi.org\/10.1136\/vr.114.2.41","journal-title":"Vet Rec"},{"key":"6705_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00436-003-0901-y","volume":"91","author":"Y Vera","year":"2003","unstructured":"Vera Y, Ibarra F, Quiroz H, Hern\u00e1ndez A, Castillo R (2003) Field trial on the efficacy of an experimental fasciolicide compared with some commercial compounds in naturally infected cattle. Parasitol Res 91:1\u20134. https:\/\/doi.org\/10.1007\/s00436-003-0901-y","journal-title":"Parasitol Res"},{"key":"6705_CR30","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0304-4017(83)90074-2","volume":"13","author":"K Wolff","year":"1983","unstructured":"Wolff K, Eckert J, Schneiter G, Lutz H (1983) Efficacy of triclabendazole against Fasciola hepatica in sheep and goats. Vet Parasitol 13:145\u2013150. https:\/\/doi.org\/10.1016\/0304-4017(83)90074-2","journal-title":"Vet Parasitol"},{"key":"6705_CR31","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/0304-4017(95)00806-2","volume":"58","author":"IB Wood","year":"1995","unstructured":"Wood IB, Amaral NK, Bairden K, Duncan JL, Kassai T, Malone JB Jr, Pankavich JA, Reinecke RK, Slocombe O, Taylor SM, Vercruysse J (1995) World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) second edition of guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine, ovine, caprine). Vet Parasitol 58:181\u2013213. https:\/\/doi.org\/10.1016\/0304-4017(95)00806-2","journal-title":"Vet Parasitol"},{"key":"6705_CR32","unstructured":"WORLD HEALTH ORGANIZATION (2019) Food borne trematode infection\u2013fascioliasis, retrieved from: www.who.int\/foodborne_trematode_infections\/fascioliasis\/en\/"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-020-06705-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-020-06705-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-020-06705-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T23:33:02Z","timestamp":1623195182000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-020-06705-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,9]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["6705"],"URL":"https:\/\/doi.org\/10.1007\/s00436-020-06705-4","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,9]]},"assertion":[{"value":"5 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All procedures performed in this work are in agreement with the ethical standards of institutional guidelines on the care and use of animals. This experimental protocol was approved by the Comit\u00e9 Interno para el Cuidado y Uso de Animales (CICUA) of the Facultad de Medicina Veterinaria y Zootecnia of the Universidad Nacional Aut\u00f3noma de M\u00e9xico, with the number of protocol MC-2017\/2-2.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}]}}