{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T10:32:28Z","timestamp":1749033148868,"version":"3.37.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH-17-1-0175"],"award-info":[{"award-number":["W81XWH-17-1-0175"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AR068436","R21AI138135","R21HD097472"],"award-info":[{"award-number":["R01AR068436","R21AI138135","R21HD097472"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s00436-020-06712-5","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T04:06:26Z","timestamp":1590033986000},"page":"2227-2235","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Proteomic analysis reveals pathogen-derived biomarkers of acute babesiosis in erythrocytes, plasma, and urine of infected hamsters"],"prefix":"10.1007","volume":"119","author":[{"given":"Ruben","family":"Magni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Luchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance","family":"Liotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4357-8940","authenticated-orcid":false,"given":"Robert E.","family":"Molestina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"issue":"6","key":"6712_CR1","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/ki.2011.184","volume":"80","author":"S Blum","year":"2011","unstructured":"Blum S, Gattringer R, Haschke E, Walochnik J, Tschurtschenthaler G, Lang F, Oberbauer R (2011) The case: hemolysis and acute renal failure. Babesiosis Kidney Int 80(6):681\u2013683. https:\/\/doi.org\/10.1038\/ki.2011.184","journal-title":"Babesiosis Kidney Int"},{"key":"6712_CR2","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/1471-2180-13-295","volume":"13","author":"K Chan","year":"2013","unstructured":"Chan K, Marras SA, Parveen N (2013) Sensitive multiplex PCR assay to differentiate Lyme spirochetes and emerging pathogens Anaplasma phagocytophilum and Babesia microti. BMC Microbiol 13:295. https:\/\/doi.org\/10.1186\/1471-2180-13-295","journal-title":"BMC Microbiol"},{"issue":"5","key":"6712_CR3","first-page":"640","volume":"37","author":"JM Cullen","year":"1987","unstructured":"Cullen JM, Levine JF (1987) Pathology of experimental Babesia microti infection in the Syrian hamster. Lab Anim Sci 37(5):640\u2013643","journal-title":"Lab Anim Sci"},{"issue":"4","key":"6712_CR4","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/j.biomaterials.2010.10.004","volume":"32","author":"TA Douglas","year":"2011","unstructured":"Douglas TA, Tamburro D, Fredolini C, Espina BH, Lepene BS, Ilag L, Espina V, Petricoin EF, Liotta LA, Luchini A (2011) The use of hydrogel microparticles to sequester and concentrate bacterial antigens in a urine test for Lyme disease. Biomaterials 32(4):1157\u20131166. https:\/\/doi.org\/10.1016\/j.biomaterials.2010.10.004","journal-title":"Biomaterials"},{"issue":"1","key":"6712_CR5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0736-4679(00)00289-4","volume":"20","author":"MR Filbin","year":"2001","unstructured":"Filbin MR, Mylonakis EE, Callegari L, Legome E (2001) Babesiosis. J Emerg Med 20(1):21\u201324","journal-title":"J Emerg Med"},{"issue":"6","key":"6712_CR6","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1007\/s12274-008-8054-z","volume":"1","author":"C Fredolini","year":"2008","unstructured":"Fredolini C, Meani F, Reeder KA, Rucker S, Patanarut A, Botterell PJ, Bishop B, Longo C, Espina V, Petricoin EF, Liotta LA, Luchini A (2008) Concentration and preservation of very low abundance biomarkers in urine, such as human growth hormone (hGH), by Cibacron blue F3G-A loaded hydrogel harticles. Nano Res 1(6):502\u2013518. https:\/\/doi.org\/10.1007\/s12274-008-8054-z","journal-title":"Nano Res"},{"issue":"4","key":"6712_CR7","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1128\/JCM.40.4.1259-1263.2002","volume":"40","author":"J Gray","year":"2002","unstructured":"Gray J, von Stedingk LV, Gurtelschmid M, Granstrom M (2002) Transmission studies of Babesia microti in Ixodes ricinus ticks and gerbils. J Clin Microbiol 40(4):1259\u20131263","journal-title":"J Clin Microbiol"},{"unstructured":"Gray EB, Niknafs AM, Herwaldt BL (2019) Surveillance for Babesiosis - United States, 2017. Annual Summary. https:\/\/www.cdc.gov\/parasites\/babesiosis\/resources\/babesiosis_surveillance_summary_2017b.pdf. Accessed 5 Jan 2020","key":"6712_CR8"},{"issue":"4","key":"6712_CR9","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1080\/14789450.2018.1450631","volume":"15","author":"B Kim","year":"2018","unstructured":"Kim B, Araujo R, Howard M, Magni R, Liotta LA, Luchini A (2018) Affinity enrichment for mass spectrometry: improving the yield of low abundance biomarkers. Expert Rev Proteomics 15(4):353\u2013366. https:\/\/doi.org\/10.1080\/14789450.2018.1450631","journal-title":"Expert Rev Proteomics"},{"issue":"2","key":"6712_CR10","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.ijpara.2018.11.007","volume":"49","author":"PJ Krause","year":"2019","unstructured":"Krause PJ (2019) Human babesiosis. Int J Parasitol 49(2):165\u2013174. https:\/\/doi.org\/10.1016\/j.ijpara.2018.11.007","journal-title":"Int J Parasitol"},{"issue":"7","key":"6712_CR11","doi-asserted-by":"publisher","first-page":"e1003387","DOI":"10.1371\/journal.ppat.1003387","volume":"9","author":"CA Lobo","year":"2013","unstructured":"Lobo CA, Cursino-Santos JR, Alhassan A, Rodrigues M (2013) Babesia: an emerging infectious threat in transfusion medicine. PLoS Pathog 9(7):e1003387. https:\/\/doi.org\/10.1371\/journal.ppat.1003387","journal-title":"PLoS Pathog"},{"issue":"3","key":"6712_CR12","doi-asserted-by":"publisher","first-page":"e4763","DOI":"10.1371\/journal.pone.0004763","volume":"4","author":"C Longo","year":"2009","unstructured":"Longo C, Patanarut A, George T, Bishop B, Zhou W, Fredolini C, Ross MM, Espina V, Pellacani G, Petricoin EF, Liotta LA (2009) Core-shell hydrogel particles harvest, concentrate and preserve labile low abundance biomarkers. PLoS One 4(3):e4763. https:\/\/doi.org\/10.1371\/journal.pone.0004763","journal-title":"PLoS One"},{"key":"6712_CR13","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1186\/s12967-015-0701-z","volume":"13","author":"R Magni","year":"2015","unstructured":"Magni R, Espina BH, Shah K, Lepene B, Mayuga C, Douglas TA, Espina V, Rucker S, Dunlap R, Petricoin EF, Kilavos MF, Poretz DM, Irwin GR, Shor SM, Liotta LA, Luchini A (2015) Application of Nanotrap technology for high sensitivity measurement of urinary outer surface protein a carboxyl-terminus domain in early stage Lyme borreliosis. J Transl Med 13:346. https:\/\/doi.org\/10.1186\/s12967-015-0701-z","journal-title":"J Transl Med"},{"issue":"2","key":"6712_CR14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.ijpara.2018.08.004","volume":"49","author":"R Magni","year":"2019","unstructured":"Magni R, Luchini A, Liotta L, Molestina RE (2019) Analysis of the Babesia microti proteome in infected red blood cells by a combination of nanotechnology and mass spectrometry. Int J Parasitol 49(2):139\u2013144. https:\/\/doi.org\/10.1016\/j.ijpara.2018.08.004","journal-title":"Int J Parasitol"},{"issue":"10","key":"6712_CR15","first-page":"1969","volume":"63","author":"E Mylonakis","year":"2001","unstructured":"Mylonakis E (2001) When to suspect and how to monitor babesiosis. Am Fam Physician 63(10):1969\u20131974","journal-title":"Am Fam Physician"},{"issue":"6","key":"6712_CR16","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/0020-7519(96)00022-7","volume":"26","author":"HS Oz","year":"1996","unstructured":"Oz HS, Hughes WT (1996) Acute fulminating babesiosis in hamsters infected with Babesia microti. Int J Parasitol 26(6):667\u2013670","journal-title":"Int J Parasitol"},{"issue":"4","key":"6712_CR17","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/0020-7519(86)90118-9","volume":"16","author":"J Piesman","year":"1986","unstructured":"Piesman J, Karakashian SJ, Lewengrub S, Rudzinska MA, Spielmank A (1986) Development of Babesia microti sporozoites in adult Ixodes dammini. Int J Parasitol 16(4):381\u2013385","journal-title":"Int J Parasitol"},{"key":"6712_CR18","doi-asserted-by":"publisher","first-page":"35284","DOI":"10.1038\/srep35284","volume":"6","author":"JC Silva","year":"2016","unstructured":"Silva JC, Cornillot E, McCracken C, Usmani-Brown S, Dwivedi A, Ifeonu OO, Crabtree J, Gotia HT, Virji AZ, Reynes C, Colinge J, Kumar V, Lawres L, Pazzi JE, Pablo JV, Hung C, Brancato J, Kumari P, Orvis J, Tretina K, Chibucos M, Ott S, Sadzewicz L, Sengamalay N, Shetty AC, Su Q, Tallon L, Fraser CM, Frutos R, Molina DM, Krause PJ, Ben Mamoun C (2016) Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions. Sci Rep 6:35284. https:\/\/doi.org\/10.1038\/srep35284","journal-title":"Sci Rep"},{"issue":"1","key":"6712_CR19","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.molbiopara.2004.05.009","volume":"137","author":"CJ Tonkin","year":"2004","unstructured":"Tonkin CJ, van Dooren GG, Spurck TP, Struck NS, Good RT, Handman E, Cowman AF, McFadden GI (2004) Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method. Mol Biochem Parasitol 137(1):13\u201321. https:\/\/doi.org\/10.1016\/j.molbiopara.2004.05.009","journal-title":"Mol Biochem Parasitol"},{"doi-asserted-by":"publisher","unstructured":"Tonnetti L, Young C, Kessler DA, Williamson PC, Reik R, Proctor MC, Bres V, Deisting B, Bakkour S, Schneider W, Diner S, Busch MP, Stramer SL, Linnen JM (2019) Transcription-mediated amplification blood donation screening for Babesia. Transfusion. https:\/\/doi.org\/10.1111\/trf.15630","key":"6712_CR20","DOI":"10.1111\/trf.15630"},{"issue":"2","key":"6712_CR21","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.idc.2015.02.008","volume":"29","author":"EG Vannier","year":"2015","unstructured":"Vannier EG, Diuk-Wasser MA, Ben Mamoun C, Krause PJ (2015) Babesiosis. Infect Dis Clin N Am 29(2):357\u2013370. https:\/\/doi.org\/10.1016\/j.idc.2015.02.008","journal-title":"Infect Dis Clin N Am"},{"issue":"2","key":"6712_CR22","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.diagmicrobio.2015.03.010","volume":"82","author":"G Wang","year":"2015","unstructured":"Wang G, Villafuerte P, Zhuge J, Visintainer P, Wormser GP (2015) Comparison of a quantitative PCR assay with peripheral blood smear examination for detection and quantitation of Babesia microti infection in humans. Diagn Microbiol Infect Dis 82(2):109\u2013113. https:\/\/doi.org\/10.1016\/j.diagmicrobio.2015.03.010","journal-title":"Diagn Microbiol Infect Dis"},{"key":"6712_CR23","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.exppara.2014.12.003","volume":"149","author":"M Wilson","year":"2015","unstructured":"Wilson M, Glaser KC, Adams-Fish D, Boley M, Mayda M, Molestina RE (2015) Development of droplet digital PCR for the detection of Babesia microti and Babesia duncani. Exp Parasitol 149:24\u201331. https:\/\/doi.org\/10.1016\/j.exppara.2014.12.003","journal-title":"Exp Parasitol"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-020-06712-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-020-06712-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-020-06712-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T23:27:14Z","timestamp":1621553234000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-020-06712-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,21]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["6712"],"URL":"https:\/\/doi.org\/10.1007\/s00436-020-06712-5","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"type":"print","value":"0932-0113"},{"type":"electronic","value":"1432-1955"}],"subject":[],"published":{"date-parts":[[2020,5,21]]},"assertion":[{"value":"14 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}