{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:48:29Z","timestamp":1790477309027,"version":"4.1.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T00:00:00Z","timestamp":1604793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T00:00:00Z","timestamp":1604793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Fapemig","doi-asserted-by":"crossref","award":["PPM 00296\/16, APQ 03536-16"],"award-info":[{"award-number":["PPM 00296\/16, APQ 03536-16"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s00436-020-06963-2","type":"journal-article","created":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T23:02:20Z","timestamp":1604876540000},"page":"1321-1333","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["In vitro and in vivo evaluation of cnicin from blessed thistle (Centaurea benedicta) and its inclusion complexes with cyclodextrins against Schistosoma mansoni"],"prefix":"10.1007","volume":"120","author":[{"given":"Lucas S.","family":"Queiroz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Everton Allan","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Mengarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayla das C.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila de F.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine S.","family":"Coimbra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josu\u00e9","family":"de Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ngelo M. L.","family":"Denadai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9096-1336","authenticated-orcid":false,"given":"Ademar A.","family":"Da Silva Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,8]]},"reference":[{"key":"6963_CR1","doi-asserted-by":"publisher","first-page":"12523","DOI":"10.1021\/la100705d","volume":"26","author":"L Aberkane","year":"2010","unstructured":"Aberkane L, Jasniewski J, Gaiani C et al (2010) Thermodynamic characterization of acacia gum\u2212\u03b2-lactoglobulin complex coacervation. Langmuir 26:12523\u201312533. https:\/\/doi.org\/10.1021\/la100705d","journal-title":"Langmuir"},{"key":"6963_CR2","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1177\/1934578X1100600202","volume":"6","author":"SM Bach","year":"2011","unstructured":"Bach SM, Fortuna MA, Attarian R, de Trimarco JT, Catal\u00e1n CAN, Av-Gay Y, Bach H (2011) Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin. Nat Prod Commun 6:163\u2013166. https:\/\/doi.org\/10.1177\/1934578X1100600202","journal-title":"Nat Prod Commun"},{"key":"6963_CR3","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1016\/j.lwt.2015.07.060","volume":"64","author":"C Barba","year":"2015","unstructured":"Barba C, Eguinoa A, Mat\u00e9 JI (2015) Preparation and characterization of \u03b2-cyclodextrin inclusion complexes as a tool of a controlled antimicrobial release in whey protein edible films. LWT - Food Sci Technol 64:1362\u20131369. https:\/\/doi.org\/10.1016\/j.lwt.2015.07.060","journal-title":"LWT - Food Sci Technol"},{"key":"6963_CR4","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/S0367-326X(99)00122-7","volume":"71","author":"AF Barrero","year":"2000","unstructured":"Barrero AF, Oltra JE, \u00c1lvarez M et al (2000) New sources and antifungal activity of sesquiterpene lactones. Fitoterapia 71:60\u201364. https:\/\/doi.org\/10.1016\/S0367-326X(99)00122-7","journal-title":"Fitoterapia"},{"key":"6963_CR5","doi-asserted-by":"publisher","first-page":"e02013","DOI":"10.1016\/j.heliyon.2019.e02013","volume":"5","author":"VCE Bittencourt","year":"2019","unstructured":"Bittencourt VCE, dos Moreira AMS, da Silva JG et al (2019) Hydrophobic nanoprecipitates formed by benzoylphenylureas and \u03b2-cyclodextrin inclusion compounds: synthesis, characterization and toxicity against Aedes aegypti larvae. Heliyon 5:e02013. https:\/\/doi.org\/10.1016\/j.heliyon.2019.e02013","journal-title":"Heliyon"},{"key":"6963_CR6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jconrel.2005.09.045","volume":"110","author":"SL Borgia","year":"2005","unstructured":"Borgia SL, Regehly M, Sivaramakrishnan R et al (2005) Lipid nanoparticles for skin penetration enhancement-correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy. J Control Release 110:151\u2013163. https:\/\/doi.org\/10.1016\/j.jconrel.2005.09.045","journal-title":"J Control Release"},{"key":"6963_CR7","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1155\/2004\/727869","volume":"18","author":"I Bratu","year":"2004","unstructured":"Bratu I, Veiga F, Fernandes C, Hernanz A, Gavira JM (2004) Infrared spectroscopic study of triacetyl\u2013 \u03b2 \u2013cyclodextrin and its inclusion complex with nicardipine. Spectroscopy 18:459\u2013467. https:\/\/doi.org\/10.1155\/2004\/727869","journal-title":"Spectroscopy"},{"key":"6963_CR8","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.addr.2007.05.012","volume":"59","author":"ME Brewster","year":"2007","unstructured":"Brewster ME, Loftsson T (2007) Cyclodextrins as pharmaceutical solubilizers. Adv Drug Deliv Rev 59:645\u2013666. https:\/\/doi.org\/10.1016\/j.addr.2007.05.012","journal-title":"Adv Drug Deliv Rev"},{"key":"6963_CR9","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1016\/j.xphs.2020.02.002","volume":"109","author":"V Buchter","year":"2020","unstructured":"Buchter V, Priotti J, Leonardi D, Lamas MC, Keiser J (2020) Activity of novel oral formulations of albendazole and mebendazole against Heligmosomoides polygyrus in vitro and in vivo. J Pharm Sci 109:1819\u20131826. https:\/\/doi.org\/10.1016\/j.xphs.2020.02.002","journal-title":"J Pharm Sci"},{"key":"6963_CR10","doi-asserted-by":"publisher","first-page":"642","DOI":"10.3390\/ijms20030642","volume":"20","author":"S Carneiro","year":"2019","unstructured":"Carneiro S, Costa Duarte F, Heimfarth L, Siqueira Quintans J, Quintans-J\u00fanior L, Veiga J\u00fanior V, Neves de Lima \u00c1 (2019) Cyclodextrin\u2013drug inclusion complexes: in vivo and in vitro approaches. Int J Mol Sci 20:642. https:\/\/doi.org\/10.3390\/ijms20030642","journal-title":"Int J Mol Sci"},{"key":"6963_CR11","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.phymed.2015.06.009","volume":"22","author":"CCB Castro","year":"2015","unstructured":"Castro CCB, Costa PS, Laktin GT et al (2015) Cardamonin, a schistosomicidal chalcone from Piper aduncum L. (Piperaceae) that inhibits Schistosoma mansoni ATP diphosphohydrolase. Phytomedicine 22:921\u2013928. https:\/\/doi.org\/10.1016\/j.phymed.2015.06.009","journal-title":"Phytomedicine"},{"key":"6963_CR12","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.molstruc.2014.02.057","volume":"1065\u20131066","author":"F Chain","year":"2014","unstructured":"Chain F, Romano E, Leyton P, Paipa C, Catal\u00e1n CAN, Fortuna MA, Brand\u00e1n SA (2014) An experimental study of the structural and vibrational properties of sesquiterpene lactone cnicin using FT-IR, FT-Raman, UV\u2013visible and NMR spectroscopies. J Mol Struct 1065\u20131066:160\u2013169. https:\/\/doi.org\/10.1016\/j.molstruc.2014.02.057","journal-title":"J Mol Struct"},{"key":"6963_CR13","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.ejmech.2018.08.033","volume":"157","author":"LA Chibli","year":"2018","unstructured":"Chibli LA, Schmidt TJ, Nonato MC, Calil FA, da Costa FB (2018) Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase. Eur J Med Chem 157:852\u2013866. https:\/\/doi.org\/10.1016\/j.ejmech.2018.08.033","journal-title":"Eur J Med Chem"},{"key":"6963_CR14","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s00436-018-6188-9","volume":"118","author":"SAP Corr\u00eaa","year":"2019","unstructured":"Corr\u00eaa SAP, Oliveira RN, Mendes TMF et al (2019) In vitro and in vivo evaluation of six artemisinin derivatives against Schistosoma mansoni. Parasitol Res 118:505\u2013516. https:\/\/doi.org\/10.1007\/s00436-018-6188-9","journal-title":"Parasitol Res"},{"key":"6963_CR15","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jpba.2017.01.025","volume":"137","author":"M Cugov\u010dan","year":"2017","unstructured":"Cugov\u010dan M, Jablan J, Lovri\u0107 J, Cin\u010di\u0107 D, Gali\u0107 N, Jug M (2017) Biopharmaceutical characterization of praziquantel cocrystals and cyclodextrin complexes prepared by grinding. J Pharm Biomed Anal 137:42\u201353. https:\/\/doi.org\/10.1016\/j.jpba.2017.01.025","journal-title":"J Pharm Biomed Anal"},{"key":"6963_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/7909137","volume":"2019","author":"LSA de Carvalho","year":"2019","unstructured":"de Carvalho LSA, Queiroz LS, Alves Junior IJ et al (2019) In vitro schistosomicidal activity of the alkaloid-rich fraction from Ruta graveolens L. (Rutaceae) and its characterization by UPLC-QTOF-MS. Evidence-Based Complement Altern Med 2019:1\u20138. https:\/\/doi.org\/10.1155\/2019\/7909137","journal-title":"Evidence-Based Complement Altern Med"},{"key":"6963_CR17","doi-asserted-by":"publisher","first-page":"689","DOI":"10.2217\/nnm-2017-0308","volume":"13","author":"LI de Lima","year":"2018","unstructured":"de Lima LI, Py-Daniel KR, Guimar\u00e3es MA, Muehlmann LA, Mafud AC, Mascarenhas YP, Moraes J, de Souza de Almeida Leite JR, Jiang CS, Azevedo RB, Figueir\u00f3 Longo JP (2018) Self-nanoemulsifying drug-delivery systems improve oral absorption and antischistosomal activity of epiisopiloturine. Nanomedicine 13:689\u2013702. https:\/\/doi.org\/10.2217\/nnm-2017-0308","journal-title":"Nanomedicine"},{"key":"6963_CR18","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.molstruc.2019.02.033","volume":"1184","author":"TM de Miranda","year":"2019","unstructured":"de Miranda TM, de Oliveira AR, Pereira JR, da Silva JG, Lula IS, Nascimento CS Jr, Denadai \u00c2ML (2019) Inclusion vs. micellization in the cethylpyridine chloride \/ \u03b2-cyclodextrin system: a structural and thermodynamic approach. J Mol Struct 1184:289\u2013297. https:\/\/doi.org\/10.1016\/j.molstruc.2019.02.033","journal-title":"J Mol Struct"},{"key":"6963_CR19","doi-asserted-by":"publisher","unstructured":"de Moraes J, Geary TG (2020) FDA-approved antiparasitic drugs in the 21st century: a success for helminthiasis? Trends Parasitol. 6, S1471\u20134922(20)30102\u20131. https:\/\/doi.org\/10.1016\/j.pt.2020.04.005","DOI":"10.1016\/j.pt.2020.04.005"},{"key":"6963_CR20","doi-asserted-by":"publisher","first-page":"e2617","DOI":"10.1371\/journal.pntd.0002617","volume":"8","author":"J de Moraes","year":"2014","unstructured":"de Moraes J, de Oliveira RN, Costa JP, Junior ALG, de Sousa DP, Freitas RM, Allegretti SM, Pinto PLS (2014) Phytol, a diterpene alcohol from chlorophyll, as a drug against neglected tropical disease Schistosomiasis mansoni. PLoS Negl Trop Dis 8:e2617. https:\/\/doi.org\/10.1371\/journal.pntd.0002617","journal-title":"PLoS Negl Trop Dis"},{"key":"6963_CR21","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1128\/AAC.01900-13","volume":"58","author":"EF de Santiago","year":"2014","unstructured":"de Santiago EF, de Oliveira SA, de Oliveira Filho GB et al (2014) Evaluation of the anti-Schistosoma mansoni activity of thiosemicarbazones and thiazoles. Antimicrob Agents Chemother 58:352\u2013363. https:\/\/doi.org\/10.1128\/AAC.01900-13","journal-title":"Antimicrob Agents Chemother"},{"key":"6963_CR22","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1590\/S0100-40422008000200032","volume":"31","author":"CG de Venturini","year":"2008","unstructured":"de Venturini CG, Nicolini J, Machado C, Machado VG (2008) Propriedades e aplica\u00e7\u00f5es recentes das ciclodextrinas. Quim Nova 31:360\u2013368. https:\/\/doi.org\/10.1590\/S0100-40422008000200032","journal-title":"Quim Nova"},{"key":"6963_CR23","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/0924-2031(90)80041-2","volume":"1","author":"O Egyed","year":"1990","unstructured":"Egyed O (1990) Spectroscopic studies on \u03b2-cyclodextrin. Vib Spectrosc 1:225\u2013227. https:\/\/doi.org\/10.1016\/0924-2031(90)80041-2","journal-title":"Vib Spectrosc"},{"key":"6963_CR24","doi-asserted-by":"publisher","first-page":"840","DOI":"10.3109\/13880209.2010.551538","volume":"49","author":"SB Erel","year":"2011","unstructured":"Erel SB, Karaalp C, Bedir E, Kaehlig H, Glasl S, Khan S, Krenn L (2011) Secondary metabolites of Centaurea calolepis and evaluation of cnicin for anti-inflammatory, antioxidant, and cytotoxic activities. Pharm Biol 49:840\u2013849. https:\/\/doi.org\/10.3109\/13880209.2010.551538","journal-title":"Pharm Biol"},{"key":"6963_CR25","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.indcrop.2018.06.027","volume":"122","author":"M Ghiasy-Oskoee","year":"2018","unstructured":"Ghiasy-Oskoee M, AghaAlikhani M, Sefidkon F, Mokhtassi-Bidgoli A, Ayyari M (2018) Blessed thistle agronomic and phytochemical response to nitrogen and plant density. Ind Crop Prod 122:566\u2013573. https:\/\/doi.org\/10.1016\/j.indcrop.2018.06.027","journal-title":"Ind Crop Prod"},{"key":"6963_CR26","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1016\/j.fct.2005.03.007","volume":"43","author":"S Gould","year":"2005","unstructured":"Gould S, Scott RC (2005) 2-Hydroxypropyl-\u03b2-cyclodextrin (HP-\u03b2-CD): a toxicology review. Food Chem Toxicol 43:1451\u20131459. https:\/\/doi.org\/10.1016\/j.fct.2005.03.007","journal-title":"Food Chem Toxicol"},{"key":"6963_CR27","doi-asserted-by":"publisher","first-page":"e01722","DOI":"10.1128\/AAC.01722-18","volume":"63","author":"RA Guerra","year":"2019","unstructured":"Guerra RA, Silva MP, Silva TC, Salvadori MC, Teixeira FS, de Oliveira RN, Rocha JA, Pinto PLS, de Moraes J (2019) In vitro and in vivo studies of spironolactone as an antischistosomal drug capable of clinical repurposing. Antimicrob Agents Chemother 63:e01722\u2013e01718. https:\/\/doi.org\/10.1128\/AAC.01722-18","journal-title":"Antimicrob Agents Chemother"},{"key":"6963_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003656","volume":"9","author":"MA Guimar\u00e3es","year":"2015","unstructured":"Guimar\u00e3es MA, de Oliveira RN, V\u00e9ras LMC, Lima DF, Campelo YDM, Campos SA, Kuckelhaus SAS, Pinto PLS, Eaton P, Mafud AC, Mascarenhas YP, Allegretti SM, de Moraes J, Loli\u0107 A, Verbi\u0107 T, Leite JRSA (2015) Anthelmintic activity in vivo of epiisopiloturine against juvenile and adult worms of Schistosoma mansoni. PLoS Negl Trop Dis 9:e0003656. https:\/\/doi.org\/10.1371\/journal.pntd.0003656","journal-title":"PLoS Negl Trop Dis"},{"key":"6963_CR29","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1021\/cr970014w","volume":"98","author":"AR Hedges","year":"1998","unstructured":"Hedges AR (1998) Industrial applications of cyclodextrins. Chem Rev 98:2035\u20132044. https:\/\/doi.org\/10.1021\/cr970014w","journal-title":"Chem Rev"},{"key":"6963_CR30","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1093\/infdis\/139.6.659","volume":"139","author":"RA Hiatt","year":"1979","unstructured":"Hiatt RA, Sotomayor ZR, Sanchez G, Zambrana M, Knight WB (1979) Factors in the pathogenesis of acute Schistosomiasis mansoni. J Infect Dis 139:659\u2013666. https:\/\/doi.org\/10.1093\/infdis\/139.6.659","journal-title":"J Infect Dis"},{"key":"6963_CR31","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1021\/js960213f","volume":"86","author":"T Irie","year":"1997","unstructured":"Irie T, Uekama K (1997) Pharmaceutical applications of cyclodextrins. III Toxicological Issues and Safety Evaluation J Pharm Sci 86:147\u2013162. https:\/\/doi.org\/10.1021\/js960213f","journal-title":"III Toxicological Issues and Safety Evaluation J Pharm Sci"},{"key":"6963_CR32","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3109\/10611860903131677","volume":"18","author":"MB Jesus","year":"2010","unstructured":"Jesus MB, de Pinto LMA, Fraceto LF et al (2010) Improvement of the oral praziquantel anthelmintic effect by cyclodextrin complexation. J Drug Target 18:21\u201326. https:\/\/doi.org\/10.3109\/10611860903131677","journal-title":"J Drug Target"},{"key":"6963_CR33","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s00109-011-0848-x","volume":"90","author":"K J\u00f6hrer","year":"2012","unstructured":"J\u00f6hrer K, Obkircher M, Neureiter D, Parteli J, Zelle-Rieser C, Maizner E, Kern J, Hermann M, Hamacher F, Merkel O, Wacht N, Zidorn C, Scheideler M, Greil R (2012) Antimyeloma activity of the sesquiterpene lactone cnicin: impact on Pim-2 kinase as a novel therapeutic target. J Mol Med 90:681\u2013693. https:\/\/doi.org\/10.1007\/s00109-011-0848-x","journal-title":"J Mol Med"},{"key":"6963_CR34","doi-asserted-by":"publisher","first-page":"5899","DOI":"10.1016\/j.tetlet.2016.11.067","volume":"57","author":"M Kurita","year":"2016","unstructured":"Kurita M, Tanigawa M, Narita S, Usuki T (2016) Synthetic study of cnicin: synthesis of the side chain and its esterification. Tetrahedron Lett 57:5899\u20135901. https:\/\/doi.org\/10.1016\/j.tetlet.2016.11.067","journal-title":"Tetrahedron Lett"},{"key":"6963_CR35","doi-asserted-by":"publisher","first-page":"89","DOI":"10.4155\/fmc-2017-0112","volume":"10","author":"EM Lago","year":"2018","unstructured":"Lago EM, Xavier RP, Teixeira TR, Silva LM, da Silva Filho AA, de Moraes J (2018) Antischistosomal agents: state of art and perspectives. Future Med Chem 10:89\u2013120. https:\/\/doi.org\/10.4155\/fmc-2017-0112","journal-title":"Future Med Chem"},{"key":"6963_CR36","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s10847-016-0624-1","volume":"85","author":"EG Lanna","year":"2016","unstructured":"Lanna EG, Bittencourt VCE, Moreira AMS, da Silva JG, Sousa OV, Denadai \u00c2ML (2016) Physicochemical characterization and biological activities of the ethanol extract of Bryophyllum pinnatum (Lam.) Oken incorporated in \u03b2-cyclodextrin. J Incl Phenom Macrocycl Chem 85:247\u2013259. https:\/\/doi.org\/10.1007\/s10847-016-0624-1","journal-title":"J Incl Phenom Macrocycl Chem"},{"key":"6963_CR37","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1002\/bdd.2005","volume":"37","author":"J-Y Lee","year":"2016","unstructured":"Lee J-Y, Kim S-B, Chun J, Song KH, Kim YS, Chung SJ, Cho HJ, Yoon IS, Kim DD (2016) High body clearance and low oral bioavailability of alantolactone, isolated from Inula helenium, in rats: extensive hepatic metabolism and low stability in gastrointestinal fluids. Biopharm Drug Dispos 37:156\u2013167. https:\/\/doi.org\/10.1002\/bdd.2005","journal-title":"Biopharm Drug Dispos"},{"key":"6963_CR38","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0305-1978(87)90005-6","volume":"15","author":"LJ Locken","year":"1987","unstructured":"Locken LJ, Kelsey RG (1987) Cnicin concentrations in Centaurea maculosa, spotted knapweed. Biochem Syst Ecol 15:313\u2013320. https:\/\/doi.org\/10.1016\/0305-1978(87)90005-6","journal-title":"Biochem Syst Ecol"},{"key":"6963_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tiv.2018.02.012","volume":"50","author":"AC Mafud","year":"2018","unstructured":"Mafud AC, Silva MPN, Nunes GBL, de Oliveira MAR, Batista LF, Rubio TI, Mengarda AC, Lago EM, Xavier RP, Gutierrez SJC, Pinto PLS, da Silva Filho AA, Mascarenhas YP, de Moraes J (2018) Antiparasitic, structural, pharmacokinetic, and toxicological properties of riparin derivatives. Toxicol Vitr 50:1\u201310. https:\/\/doi.org\/10.1016\/j.tiv.2018.02.012","journal-title":"Toxicol Vitr"},{"key":"6963_CR40","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.foodchem.2013.12.067","volume":"153","author":"CS Mangolim","year":"2014","unstructured":"Mangolim CS, Moriwaki C, Nogueira AC, Sato F, Baesso ML, Neto AM, Matioli G (2014) Curcumin\u2013\u03b2-cyclodextrin inclusion complex: stability, solubility, characterisation by FT-IR, FT-Raman, X-ray diffraction and photoacoustic spectroscopy, and food application. Food Chem 153:361\u2013370. https:\/\/doi.org\/10.1016\/j.foodchem.2013.12.067","journal-title":"Food Chem"},{"key":"6963_CR41","doi-asserted-by":"publisher","first-page":"105350","DOI":"10.1016\/j.actatropica.2020.105350","volume":"205","author":"AC Mengarda","year":"2020","unstructured":"Mengarda AC, Mendon\u00e7a PS, Morais CS, Cogo RM, Mazloum SF, Salvadori MC, Teixeira FS, Morais TR, Antar GM, Lago JHG, Moraes J (2020) Antiparasitic activity of piplartine (piperlongumine) in a mouse model of schistosomiasis. Acta Trop 205:105350. https:\/\/doi.org\/10.1016\/j.actatropica.2020.105350","journal-title":"Acta Trop"},{"key":"6963_CR42","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1017\/S0022149X08070235","volume":"83","author":"Y Mitsui","year":"2009","unstructured":"Mitsui Y, Miura M, Aoki Y (2009) In vitro effects of artesunate on the survival of worm pairs and egg production of Schistosoma mansoni. J Helminthol 83:7\u201311. https:\/\/doi.org\/10.1017\/S0022149X08070235","journal-title":"J Helminthol"},{"key":"6963_CR43","doi-asserted-by":"publisher","first-page":"7275","DOI":"10.1021\/acs.jafc.8b01300","volume":"66","author":"AMS Moreira","year":"2018","unstructured":"Moreira AMS, Bittencourt VCE, Costa FLS et al (2018) Hydrophobic nanoprecipitates of \u03b2-cyclodextrin\/avermectins inclusion compounds reveal insecticide activity against Aedes aegypti larvae and low toxicity against fibroblasts. J Agric Food Chem 66:7275\u20137285. https:\/\/doi.org\/10.1021\/acs.jafc.8b01300","journal-title":"J Agric Food Chem"},{"key":"6963_CR44","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55\u201363. https:\/\/doi.org\/10.1016\/0022-1759(83)90303-4","journal-title":"J Immunol Methods"},{"issue":"3","key":"6963_CR45","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00436-017-5740-3","volume":"117","author":"PA Pacheco","year":"2018","unstructured":"Pacheco PA, Rodrigues LNC, Ferreira JFS, Gomes ACP, Ver\u00edssimo CJ, Louvandini H, Costa RLD, Katiki LM (2018) Inclusion complex and nanoclusters of cyclodextrin to increase the solubility and efficacy of albendazole. Parasitol Res 117(3):705\u2013712. https:\/\/doi.org\/10.1007\/s00436-017-5740-3","journal-title":"Parasitol Res"},{"key":"6963_CR46","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1590\/S0074-02761994000400017","volume":"89","author":"MLO Penido","year":"1994","unstructured":"Penido MLO, Nelson DL, Vieira LQ, Coelho PMZ (1994) Schistosomicidal activity of alkylaminoctanethiosulfuric acids. Mem Inst Oswaldo Cruz 89:595\u2013602. https:\/\/doi.org\/10.1590\/S0074-02761994000400017","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"6963_CR47","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1021\/js960075u","volume":"85","author":"RA Rajewski","year":"1996","unstructured":"Rajewski RA, Stella VJ (1996) Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery. J Pharm Sci 85:1142\u20131169. https:\/\/doi.org\/10.1021\/js960075u","journal-title":"J Pharm Sci"},{"key":"6963_CR48","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1208\/s12249-008-9143-8","volume":"9","author":"A Ribeiro","year":"2008","unstructured":"Ribeiro A, Figueiras A, Santos D, Veiga F (2008) Preparation and solid-state characterization of inclusion complexes formed between miconazole and methyl-\u03b2-cyclodextrin. AAPS PharmSciTech 9:1102\u20131109. https:\/\/doi.org\/10.1208\/s12249-008-9143-8","journal-title":"AAPS PharmSciTech"},{"key":"6963_CR49","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1021\/np058042u","volume":"68","author":"V Saroglou","year":"2005","unstructured":"Saroglou V, Karioti A, Demetzos C, Dimas K, Skaltsa H (2005) Sesquiterpene lactones from Centaurea spinosa and their antibacterial and cytotoxic activities. J Nat Prod 68:1404\u20131407. https:\/\/doi.org\/10.1021\/np058042u","journal-title":"J Nat Prod"},{"key":"6963_CR50","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nm1737","volume":"14","author":"AA Sayed","year":"2008","unstructured":"Sayed AA, Simeonov A, Thomas CJ, Inglese J, Austin CP, Williams DL (2008) Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nat Med 14:407\u2013412. https:\/\/doi.org\/10.1038\/nm1737","journal-title":"Nat Med"},{"key":"6963_CR51","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1080\/13880209.2016.1255980","volume":"55","author":"A Sen","year":"2017","unstructured":"Sen A, Ozbas Turan S, Bitis L (2017) Bioactivity-guided isolation of anti-proliferative compounds from endemic Centaurea kilaea. Pharm Biol 55:541\u2013546. https:\/\/doi.org\/10.1080\/13880209.2016.1255980","journal-title":"Pharm Biol"},{"key":"6963_CR52","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.ijantimicag.2017.06.005","volume":"50","author":"MP Silva","year":"2017","unstructured":"Silva MP, de Oliveira RN, Mengarda AC, Roquini DB, Allegretti SM, Salvadori MC, Teixeira FS, de Sousa DP, Pinto PLS, da Silva Filho AA, de Moraes J (2017) Antiparasitic activity of nerolidol in a mouse model of schistosomiasis. Int J Antimicrob Agents 50:467\u2013472. https:\/\/doi.org\/10.1016\/j.ijantimicag.2017.06.005","journal-title":"Int J Antimicrob Agents"},{"key":"6963_CR53","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.colsurfb.2014.01.028","volume":"118","author":"DF Su\u00e1rez","year":"2014","unstructured":"Su\u00e1rez DF, Consuegra J, Trajano VC, Gontijo SML, Guimar\u00e3es PPG, Cort\u00e9s ME, Denadai \u00c2L, Sinisterra RD (2014) Structural and thermodynamic characterization of doxycycline\/\u03b2-cyclodextrin supramolecular complex and its bacterial membrane interactions. Colloids Surfaces B Biointerfaces 118:194\u2013201. https:\/\/doi.org\/10.1016\/j.colsurfb.2014.01.028","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"6963_CR54","first-page":"126","volume":"16","author":"I Szab\u00f3","year":"2009","unstructured":"Szab\u00f3 I, Pallag A, Blidar CF (2009) The antimicrobial activity of the Cnicus benedictus L. extracts. Analele Univ din Oradea, Fasc Biol 16:126\u2013128","journal-title":"Analele Univ din Oradea, Fasc Biol"},{"key":"6963_CR55","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.3390\/molecules23051228","volume":"23","author":"L Szente","year":"2018","unstructured":"Szente L, Singhal A, Domokos A, Song B (2018) Cyclodextrins: assessing the impact of cavity size, occupancy, and substitutions on cytotoxicity and cholesterol homeostasis. Molecules 23:1228. https:\/\/doi.org\/10.3390\/molecules23051228","journal-title":"Molecules"},{"key":"6963_CR56","doi-asserted-by":"publisher","first-page":"444","DOI":"10.3109\/10717544.2013.879679","volume":"22","author":"KIR Teixeira","year":"2015","unstructured":"Teixeira KIR, Denadai AML, Sinisterra RD, Cort\u00e9s ME (2015) Cyclodextrin modulates the cytotoxic effects of chlorhexidine on microrganisms and cells in vitro. Drug Deliv 22:444\u2013453. https:\/\/doi.org\/10.3109\/10717544.2013.879679","journal-title":"Drug Deliv"},{"key":"6963_CR57","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.2298\/JSC0712275T","volume":"72","author":"V Tesevic","year":"2007","unstructured":"Tesevic V, Milosavljevic S, Vajs V, Janackovic P, Djordjevic I, Jadranin M, Vuckovic I (2007) Quantitative analysis of sesquiterpene lactone cnicin in seven Centaurea species wild-growing in Serbia and Montenegro using 1H-NMR spectroscopy. J Serbian Chem Soc 72:1275\u20131280. https:\/\/doi.org\/10.2298\/JSC0712275T","journal-title":"J Serbian Chem Soc"},{"key":"6963_CR58","doi-asserted-by":"publisher","unstructured":"Vale N, Gouveia MJ, Rinaldi G, Brindley PJ, G\u00e4rtner F, Correia da Costa JM (2017) Praziquantel for schistosomiasis: single-drug metabolism revisited, mode of action, and resistance. Antimicrob Agents Chemother 61. https:\/\/doi.org\/10.1128\/AAC.02582-16","DOI":"10.1128\/AAC.02582-16"},{"key":"6963_CR59","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/j.1600-065X.1982.tb00377.x","volume":"61","author":"KS Warren","year":"1982","unstructured":"Warren KS (1982) The secret of the immunopathogenesis of schistosomiasis: in vivo models. Immunol Rev 61:189\u2013213. https:\/\/doi.org\/10.1111\/j.1600-065X.1982.tb00377.x","journal-title":"Immunol Rev"},{"key":"6963_CR60","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1080\/10717540701829267","volume":"15","author":"HS Woldum","year":"2008","unstructured":"Woldum HS, Larsen KL, Madsen F (2008) Cyclodextrin controlled release of poorly water-soluble drugs from hydrogels. Drug Deliv 15:69\u201380. https:\/\/doi.org\/10.1080\/10717540701829267","journal-title":"Drug Deliv"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-020-06963-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00436-020-06963-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-020-06963-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T06:05:55Z","timestamp":1615183555000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00436-020-06963-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,8]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["6963"],"URL":"https:\/\/doi.org\/10.1007\/s00436-020-06963-2","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,8]]},"assertion":[{"value":"7 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experiments were conducted in conformity with the Brazilian Law for Guidelines for Care and Use of Laboratory Animals (Law 11790\/2008). The protocol for experimental design was approved by the Comiss\u00e3o de \u00c9tica no Uso de Animais (CEUA), Brazil (Protocols \u2260 CEUA 031\/2017 and \u2260 CEUA 007\/2018). Animal studies are reported in compliance with the ARRIVE guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}]}}