{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T12:48:41Z","timestamp":1750682921962,"version":"3.37.3"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Ferrer International SA"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Head lice (<jats:italic>Pediculus humanus capitis<\/jats:italic>) are worldwide obligate human ectoparasites, with high implications in pediatrics. In Europe, first-line topical neurotoxic insecticidal therapeutic strategies are being replaced by topical physically acting agents as the first-choice treatment. Safety of the active ingredients and high efficacy in a one-time single-dose treatment with a brief treatment application time are key issues for consumer use and effective compliance. The aim of this study was to assess the in vitro efficacy of a newly developed squalane and dimethicone-based pediculicidal formula, against motile head lice and eggs after 2 and 5 min immersion in the product, as well as its skin tolerance and acceptability under dermatological and pediatric expert control in children with atopic skin. The results indicate that at both time points, 100% mortality rate of head lice crawling stages and late-stage eggs was achieved. The formula was well tolerated and suitable for children with atopic skin from 12 months of age. Showing high in vitro efficacy and good skin acceptability, this solution is presented as a new safe alternative therapy for treatment of head lice infestations.<\/jats:p>","DOI":"10.1007\/s00436-021-07113-y","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T08:02:41Z","timestamp":1617350561000},"page":"1883-1890","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness and tolerability of a squalane and dimethicone-based treatment for head lice"],"prefix":"10.1007","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4624-6204","authenticated-orcid":false,"given":"Leticia","family":"Mart\u00ednez de Murgu\u00eda Fern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Puig Algora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Bajona Roig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3923-3656","authenticated-orcid":false,"given":"Gabriela","family":"Bacchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,2]]},"reference":[{"key":"7113_CR1","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00436-009-1680-x","volume":"106","author":"F Abdel-Ghaffar","year":"2010","unstructured":"Abdel-Ghaffar F, Semmler M, Al-Rasheid K, Klimpel S, Mehlhorn H (2010) Comparative in vitro tests on the efficacy and safety of 13 anti-head-lice products. Parasitol Res 106:423\u2013429. https:\/\/doi.org\/10.1007\/s00436-009-1680-x","journal-title":"Parasitol Res"},{"key":"7113_CR2","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00436-011-2484-3","volume":"110","author":"F Abdel-Ghaffar","year":"2012","unstructured":"Abdel-Ghaffar F, Al-Quraishy S, Al-Rasheid KAS, Mehlhorn H (2012) Efficacy of a single treatment of head lice with a neem seed extract: an in vivo and in vitro study on nits and motile stages. Parasitol Res 110:277\u2013280. https:\/\/doi.org\/10.1007\/s00436-011-2484-3","journal-title":"Parasitol Res"},{"key":"7113_CR3","doi-asserted-by":"publisher","unstructured":"Amanzougaghene N, Fenollar F, Raoult D, Mediannikov O (2020) Where are we with human lice? A review of the current state of knowledge. Front Cell Infect Microbiol 9. https:\/\/doi.org\/10.3389\/fcimb.2019.00474","DOI":"10.3389\/fcimb.2019.00474"},{"key":"#cr-split#-7113_CR4.1","unstructured":"Bacchini GS, Puig Algora G (2018) inventors"},{"key":"#cr-split#-7113_CR4.2","unstructured":"Ferrer International SA, assignee. Compounds, compositions thereof and methods for treating ectoparasite infestation. World patent application WO 2019\/008116"},{"key":"7113_CR5","unstructured":"Bajona Roig M, Bacchini GS, Puig Algora G 2018. Pediculicidal efficacy of two products against Pediculus humanus capitis adults, nymphs and nits. Poster 48. Presented at the 30th Meeting of the Spanish Group of Aesthetic and Therapeutic Dermatology of the Spanish Academy of Dermatology and Venereology (GEDET), San Sebastian Spain"},{"key":"7113_CR6","unstructured":"Bajona Roig M, Bacchini GS, Puig Algora G 2019a. Mechanism of action of a new pediculicide in motile forms (adults and late nymphs) and eggs (nits) of the head louse, Pediculus humanus capitis. Poster A66. Presented at the 31st INFARMA - European Meeting of Pharmacy, Barcelone Spain"},{"key":"7113_CR7","unstructured":"Bajona Roig M, Bacchini GS, Puig Algora G 2019b. Evaluation of the compatibility and skin acceptability of a new pediculicide in atopic children from 6 months of age. Poster A65. Presented at the 31st INFARMA - European Meeting of Pharmacy, Barcelone Spain"},{"key":"7113_CR8","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1111\/j.1365-4632.2011.05446.x","volume":"51","author":"SC Barker","year":"2012","unstructured":"Barker SC, Burgess I, Meinking TL, Mumcuoglu KY (2012) International guidelines for clinical trials with pediculicides. Int J Dermatol 51:853\u2013858. https:\/\/doi.org\/10.1111\/j.1365-4632.2011.05446.x","journal-title":"Int J Dermatol"},{"key":"7113_CR9","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1471-5945-12-15","volume":"12","author":"E Barnett","year":"2012","unstructured":"Barnett E, Palma KG, Clayton B, Ballard T (2012) Effectiveness of isopropyl myristate\/cyclomethicone D5 solution of removing cuticular hydrocarbons from human head lice (Pediculus humanus capitis). BMC Dermatol 12:15. https:\/\/doi.org\/10.1186\/1471-5945-12-15","journal-title":"BMC Dermatol"},{"key":"7113_CR10","doi-asserted-by":"publisher","first-page":"65S","DOI":"10.1177\/1091581814524963","volume":"33","author":"LC Becker","year":"2014","unstructured":"Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA (2014) Safety assessment of dimethicone crosspolymers as used in cosmetics. Int J Toxicol 33:65S\u2013115S. https:\/\/doi.org\/10.1177\/1091581814524963","journal-title":"Int J Toxicol"},{"key":"7113_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1471-2210-9-3","volume":"9","author":"IF Burgess","year":"2009","unstructured":"Burgess IF (2009) The mode of action of dimeticone 4% lotion against head lice. Pediculus capitis BMC Pharmacol 9:3. https:\/\/doi.org\/10.1186\/1471-2210-9-3","journal-title":"Pediculus capitis BMC Pharmacol"},{"key":"7113_CR12","unstructured":"Burgess IF, 2016. Current approaches to head louse treatment \u2013 a global update [WWW Document]. SelfCare J. URL https:\/\/selfcarejournal.com\/article\/current-approaches-head-louse-treatment-global-update\/ (accessed 1.10.21)"},{"key":"7113_CR13","doi-asserted-by":"publisher","unstructured":"Burgess IF 2018 Physically acting products for head lice \u2013 the end of the beginning (No. e27412v1). PeerJ Inc. doi:https:\/\/doi.org\/10.7287\/peerj.preprints.27412v1","DOI":"10.7287\/peerj.preprints.27412v1"},{"key":"7113_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1756-0500-4-15","volume":"4","author":"IF Burgess","year":"2011","unstructured":"Burgess IF, Burgess NA (2011) Dimeticone 4% liquid gel found to kill all lice and eggs with a single 15 minute application. BMC Res Notes 4:15. https:\/\/doi.org\/10.1186\/1756-0500-4-15","journal-title":"BMC Res Notes"},{"key":"7113_CR15","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1136\/bmj.38497.506481.8F","volume":"330","author":"IF Burgess","year":"2005","unstructured":"Burgess IF, Brown CM, Lee PN (2005) Treatment of head louse infestation with 4% dimeticone lotion: randomised controlled equivalence trial. BMJ 330:1423. https:\/\/doi.org\/10.1136\/bmj.38497.506481.8F","journal-title":"BMJ"},{"key":"7113_CR16","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/s0140-6736(99)09458-1","volume":"355","author":"O Chosidow","year":"2000","unstructured":"Chosidow O (2000) Scabies and pediculosis. Lancet Lond Engl 355:819\u2013826. https:\/\/doi.org\/10.1016\/s0140-6736(99)09458-1","journal-title":"Lancet Lond Engl"},{"key":"7113_CR17","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.pestbp.2013.03.008","volume":"106","author":"JM Clark","year":"2013","unstructured":"Clark JM, Yoon KS, Lee SH, Pittendrigh BR (2013) Human lice: Past, present and future control. Pestic Biochem Physiol 106:162\u2013171. https:\/\/doi.org\/10.1016\/j.pestbp.2013.03.008","journal-title":"Pestic Biochem Physiol"},{"key":"7113_CR18","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.pestbp.2014.11.008","volume":"120","author":"JM Clark","year":"2015","unstructured":"Clark JM, Yoon KS, Kim JH, Lee SH, Pittendrigh BR (2015) Utilization of the human louse genome to study insecticide resistance and innate immune response. Pestic Biochem Physiol 120:125\u2013132. https:\/\/doi.org\/10.1016\/j.pestbp.2014.11.008","journal-title":"Pestic Biochem Physiol"},{"key":"7113_CR19","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.jaad.2019.05.110","volume":"82","author":"SJ Coates","year":"2020","unstructured":"Coates SJ, Thomas C, Chosidow O, Engelman D, Chang AY (2020) Ectoparasites: pediculosis and tungiasis. J Am Acad Dermatol 82:551\u2013569. https:\/\/doi.org\/10.1016\/j.jaad.2019.05.110","journal-title":"J Am Acad Dermatol"},{"key":"7113_CR20","unstructured":"Colas A, DowCorning SA, Rafidison P, (2005) Silicones in new pharmaceutical developments, from formulations to manufacturing processes [WWW Document]. URL \/paper\/Silicones-in-new-pharmaceutical-developments-%2C-from-Colas-DowCorning\/b4dc093b3f348ace499f8b0b6762a09c2470babd (accessed 1.10.21)"},{"key":"7113_CR21","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1007\/s13670-018-0255-z","volume":"7","author":"A Dietrich","year":"2018","unstructured":"Dietrich A, Joshi K, Sayed C (2018) Infestations in the Geriatric Patient. Curr Geriatr Rep 7:210\u2013215. https:\/\/doi.org\/10.1007\/s13670-018-0255-z","journal-title":"Curr Geriatr Rep"},{"key":"7113_CR22","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/j.1469-0691.2012.03806.x","volume":"18","author":"R Durand","year":"2012","unstructured":"Durand R, Bouvresse S, Berdjane Z, Izri A, Chosidow O, Clark JM (2012) Insecticide resistance in head lice: clinical, parasitological and genetic aspects. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis 18:338\u2013344. https:\/\/doi.org\/10.1111\/j.1469-0691.2012.03806.x","journal-title":"Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis"},{"key":"7113_CR23","unstructured":"Ecocert Group (n.d.) COSMOS certification (organic or natural cosmetics) | Ecocert [WWW Document]. URL https:\/\/www.ecocert.com\/en\/certification-detail\/natural-and-organic-cosmetics-cosmos (accessed 2.17.21)"},{"key":"7113_CR24","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.3201\/eid1409.080368","volume":"14","author":"ME Falagas","year":"2008","unstructured":"Falagas ME, Matthaiou DK, Rafailidis PI, Panos G, Pappas G (2008) Worldwide prevalence of head lice. Emerg Infect Dis 14:1493\u20131494. https:\/\/doi.org\/10.3201\/eid1409.080368","journal-title":"Emerg Infect Dis"},{"key":"7113_CR25","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1007\/s10096-012-1575-0","volume":"31","author":"H Feldmeier","year":"2012","unstructured":"Feldmeier H (2012) Pediculosis capitis: new insights into epidemiology, diagnosis and treatment. Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol 31:2105\u20132110. https:\/\/doi.org\/10.1007\/s10096-012-1575-0","journal-title":"Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol"},{"key":"7113_CR26","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s40257-014-0094-4","volume":"15","author":"H Feldmeier","year":"2014","unstructured":"Feldmeier H (2014) Treatment of pediculosis capitis: a critical appraisal of the current literature. Am J Clin Dermatol 15:401\u2013412. https:\/\/doi.org\/10.1007\/s40257-014-0094-4","journal-title":"Am J Clin Dermatol"},{"key":"7113_CR27","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/pde.14016","volume":"37","author":"RNS Flores-Genuino","year":"2020","unstructured":"Flores-Genuino RNS, Gnilo CMS, Dofitas BL (2020) Occlusive versus neurotoxic agents for topical treatment of head lice infestation: A systematic review and meta-analysis. Pediatr Dermatol 37:86\u201392. https:\/\/doi.org\/10.1111\/pde.14016","journal-title":"Pediatr Dermatol"},{"key":"7113_CR28","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1007\/s00436-011-2668-x","volume":"110","author":"A Gallardo","year":"2012","unstructured":"Gallardo A, Mougabure-Cueto G, Vassena C, Picollo MI, Toloza AC (2012) Comparative efficacy of new commercial pediculicides against adults and eggs of Pediculus humanus capitis (head lice). Parasitol Res 110:1601\u20131606. https:\/\/doi.org\/10.1007\/s00436-011-2668-x","journal-title":"Parasitol Res"},{"key":"7113_CR29","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1093\/jme\/tjw023","volume":"53","author":"KJ Gellatly","year":"2016","unstructured":"Gellatly KJ, Krim S, Palenchar DJ, Shepherd K, Yoon KS, Rhodes CJ, Lee SH, Marshall Clark J (2016) Expansion of the knockdown resistance frequency map for human head lice (Phthiraptera: Pediculidae) in the United States using quantitative sequencing. J Med Entomol 53:653\u2013659. https:\/\/doi.org\/10.1093\/jme\/tjw023","journal-title":"J Med Entomol"},{"key":"7113_CR30","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1177\/10598405070230050701","volume":"23","author":"SC Gordon","year":"2007","unstructured":"Gordon SC (2007) Shared vulnerability: a theory of caring for children with persistent head lice. J Sch Nurs Off Publ Natl Assoc Sch Nurses 23:283\u2013292. https:\/\/doi.org\/10.1177\/10598405070230050701","journal-title":"J Sch Nurs Off Publ Natl Assoc Sch Nurses"},{"key":"7113_CR31","unstructured":"Hammer \u00d8 (n.d.) PAST: PAleontological Statistics Version 4.02. 1999-2020. Reference Manual. Natural History Museum. University of Oslo [WWW Document]. URL http:\/\/priede.bf.lu.lv\/ftp\/pub\/TIS\/datu_analiize\/PAST\/4.xx\/past-4.02-manual.pdf (accessed 1.10.21)"},{"key":"7113_CR32","unstructured":"Hammer \u00d8, Harper D, Ryan P, 2001. PAST: Paleontological statistics software package for education and data analysis [WWW Document]. Palaeontol. Electron. URL https:\/\/palaeo-electronica.org\/2001_1\/past\/issue1_01.htm (accessed 1.10.21)."},{"key":"7113_CR33","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1177\/000992280404300603","volume":"43","author":"RC Hansen","year":"2004","unstructured":"Hansen RC, O\u2019Haver J (2004) Economic considerations associated with Pediculus humanus capitis infestation. Clin Pediatr (Phila) 43:523\u2013527. https:\/\/doi.org\/10.1177\/000992280404300603","journal-title":"Clin Pediatr (Phila)"},{"key":"7113_CR34","first-page":"67","volume":"2","author":"J Heukelbach","year":"2007","unstructured":"Heukelbach J, Canyon D, Speare R (2007) The effect of natural products on head lice: in vitro tests and clinical evidence. J Pediatr Infect Dis 2:67\u201376","journal-title":"J Pediatr Infect Dis"},{"key":"7113_CR35","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.1016\/j.jaad.2010.04.003","volume":"64","author":"J Heukelbach","year":"2011","unstructured":"Heukelbach J, Sonnberg S, Becher H, Melo I, Speare R, Oliveira FA (2011) Ovicidal efficacy of high concentration dimeticone: a new era of head lice treatment. J Am Acad Dermatol 64:e61\u2013e62. https:\/\/doi.org\/10.1016\/j.jaad.2010.04.003","journal-title":"J Am Acad Dermatol"},{"key":"7113_CR36","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12895-019-0094-4","volume":"19","author":"J Heukelbach","year":"2019","unstructured":"Heukelbach J, Wolf D, Clark JM, Dautel H, Roeschmann K (2019) High efficacy of a dimeticone-based pediculicide following a brief application: in vitro assays and randomized controlled investigator-blinded clinical trial. BMC Dermatol 19:14. https:\/\/doi.org\/10.1186\/s12895-019-0094-4","journal-title":"BMC Dermatol"},{"key":"7113_CR37","unstructured":"International Organization for Standardization (n.d.-a). ISO 16128-1:2016(en), Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products \u2014 Part 1: Definitions for ingredients [WWW Document]. URL https:\/\/www.iso.org\/obp\/ui\/#iso:std:iso:16128:-1:ed-1:v1:en (accessed 2.17.21)"},{"key":"7113_CR38","unstructured":"International Organization for Standardization (n.d.-b) ISO 16128-2:2017(en), Cosmetics \u2014 guidelines on technical definitions and criteria for natural and organic cosmetic ingredients \u2014 Part 2: Criteria for ingredients and products [WWW Document]. URL https:\/\/www.iso.org\/obp\/ui\/#iso:std:iso:16128:-2:ed-1:v1:en (accessed 2.17.21)"},{"key":"7113_CR39","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1080\/10837450.2018.1469150","volume":"24","author":"R Kantipakala","year":"2019","unstructured":"Kantipakala R, Bonam SR, Vemireddy S, Miryala S, Halmuthur MSK (2019) Squalane-based emulsion vaccine delivery system: composition with murabutide activate Th1 response. Pharm Dev Technol 24:269\u2013275. https:\/\/doi.org\/10.1080\/10837450.2018.1469150","journal-title":"Pharm Dev Technol"},{"key":"7113_CR40","first-page":"29","volume":"4","author":"GS Kelly","year":"1999","unstructured":"Kelly GS (1999) Squalene and its potential clinical uses. Altern Med Rev J Clin Ther 4:29\u201336","journal-title":"Altern Med Rev J Clin Ther"},{"key":"7113_CR41","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1542\/peds.2006-3087","volume":"119","author":"M Lebwohl","year":"2007","unstructured":"Lebwohl M, Clark L, Levitt J (2007) Therapy for head lice based on life cycle, resistance, and safety considerations. Pediatrics 119:965\u2013974. https:\/\/doi.org\/10.1542\/peds.2006-3087","journal-title":"Pediatrics"},{"key":"7113_CR42","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s00436-011-2374-8","volume":"109","author":"H Mehlhorn","year":"2011","unstructured":"Mehlhorn H, Abdel-Ghaffar F, Al-Rasheid KAS, Schmidt J, Semmler M (2011) Ovicidal effects of a neem seed extract preparation on eggs of body and head lice. Parasitol Res 109:1299\u20131302. https:\/\/doi.org\/10.1007\/s00436-011-2374-8","journal-title":"Parasitol Res"},{"key":"7113_CR43","doi-asserted-by":"publisher","first-page":"763","DOI":"10.3238\/arztebl.2016.0763","volume":"113","author":"L Meister","year":"2016","unstructured":"Meister L, Ochsendorf F (2016) Head Lice Dtsch Arzteblatt Int 113:763\u2013772. https:\/\/doi.org\/10.3238\/arztebl.2016.0763","journal-title":"Head Lice Dtsch Arzteblatt Int"},{"key":"7113_CR44","first-page":"10","volume":"8","author":"G Mougabure Cueto","year":"2000","unstructured":"Mougabure Cueto G, Vassena C, Gonz\u00e1lez Audino P, Picollo M, Zerba E (2000) Efectividad de lociones capilares sobre poblaciones de Pediculus capitis resistentes a insecticidas. Acta Toxicol Argent 8:10\u201312","journal-title":"Acta Toxicol Argent"},{"key":"7113_CR45","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1603\/0022-2585-39.3.457","volume":"39","author":"G Mougabure Cueto","year":"2002","unstructured":"Mougabure Cueto G, Gonzalez Audino P, Vassena CV, Picollo MI, Zerba EN (2002) Toxic effect of aliphatic alcohols against susceptible and permethrin-resistant Pediculus humanus capitis (Anoplura: Pediculidae). J Med Entomol 39:457\u2013460. https:\/\/doi.org\/10.1603\/0022-2585-39.3.457","journal-title":"J Med Entomol"},{"key":"7113_CR46","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1111\/j.1468-3083.2007.02258.x","volume":"21","author":"FAS Oliveira","year":"2007","unstructured":"Oliveira FAS, Speare R, Heukelbach J (2007) High in vitro efficacy of Nyda L, a pediculicide containing dimeticone. J Eur Acad Dermatol Venereol JEADV 21:1325\u20131329. https:\/\/doi.org\/10.1111\/j.1468-3083.2007.02258.x","journal-title":"J Eur Acad Dermatol Venereol JEADV"},{"key":"7113_CR47","first-page":"840","volume":"62","author":"I Popa","year":"2014","unstructured":"Popa I, B\u0103beanu N, Ni\u021b\u0103 S, Popa O (2014) Squalene-natural resources and applications. Farmacia 62:840\u2013862","journal-title":"Farmacia"},{"key":"7113_CR48","doi-asserted-by":"publisher","first-page":"8962685","DOI":"10.1155\/2016\/8962685","volume":"2016","author":"AK Sangar\u00e9","year":"2016","unstructured":"Sangar\u00e9 AK, Doumbo OK, Raoult D (2016) Management and treatment of human lice. Biomed Res Int 2016:8962685. https:\/\/doi.org\/10.1155\/2016\/8962685","journal-title":"Biomed Res Int"},{"key":"7113_CR49","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1007\/s00436-017-5461-7","volume":"116","author":"M Semmler","year":"2017","unstructured":"Semmler M, Abdel-Ghaffar F, Gestmann F, Abdel-Aty M, Rizk I, Al-Quraishy S, Lehmacher W, Hoff N-P (2017) Randomized, investigator-blinded, controlled clinical study with lice shampoo (Licener\u00ae) versus dimethicone (Jacutin\u00ae Pedicul Fluid) for the treatment of infestations with head lice. Parasitol Res 116:1863\u20131870. https:\/\/doi.org\/10.1007\/s00436-017-5461-7","journal-title":"Parasitol Res"},{"key":"7113_CR50","doi-asserted-by":"publisher","first-page":"82","DOI":"10.2174\/1874372201004030082","volume":"4","author":"S Sonnberg","year":"2010","unstructured":"Sonnberg S, Oliveira F, Melo I, De M, Soares M, Becher H, Heukelbach J (2010) Ex Vivo Development of Eggs from Head Lice (Pediculus humanus capitis). Open Dermatol J 4:82\u201389. https:\/\/doi.org\/10.2174\/1874372201004030082","journal-title":"Open Dermatol J"},{"key":"7113_CR51","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1603\/ME11178","volume":"49","author":"J Strycharz","year":"2012","unstructured":"Strycharz J, Lao A, Alves A, Clark J (2012) Ovicidal response of NYDA formulations on the human head louse (Anoplura: Pediculidae) using a hair tuft bioassay. J Med Entomol 49:336\u2013342","journal-title":"J Med Entomol"},{"issue":"5","key":"7113_CR52","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1603\/0022-2585-40.5.628","volume":"40","author":"M Takano-Lee","year":"2003","unstructured":"Takano-Lee M, Yoon KS, Edman JD, Mullens BA, Clark JM (2003) In vivo and in vitro rearing of Pediculus humanus capitis (Anoplura: Pediculidae). J Med Entomol 40(5):628\u2013635. https:\/\/doi.org\/10.1603\/0022-2585-40.5.628","journal-title":"J Med Entomol"},{"key":"7113_CR53","doi-asserted-by":"publisher","first-page":"493","DOI":"10.5281\/zenodo.2605743","volume":"9","author":"A Tytu\u0142a","year":"2019","unstructured":"Tytu\u0142a A, Bartosik K, Jasztal-Knia\u017cuk A, Buczek W, B\u0142aszkiewicz A, Borz\u0119cka-Sapko A (2019) Analysis of the prevalence of pediculosis and scabies in orphanages and refugee shelters in south-eastern Poland. J Educ Health Sport 9:493\u2013500. https:\/\/doi.org\/10.5281\/zenodo.2605743","journal-title":"J Educ Health Sport"},{"key":"7113_CR54","unstructured":"United States Department of Agriculture (n.d.). BioPreferred|Catalog [WWW Document]. BioPreferred\u00ae Program. URL https:\/\/www.biopreferred.gov\/BioPreferred\/faces\/catalog\/Catalog.xhtml (accessed 2.17.21)"},{"key":"7113_CR55","first-page":"S277","volume":"10","author":"D West","year":"2004","unstructured":"West D (2004) Head lice treatment costs and the impact on managed care. Am J Manag Care 10:S277\u2013S282","journal-title":"Am J Manag Care"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-021-07113-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-021-07113-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-021-07113-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T14:26:41Z","timestamp":1619706401000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-021-07113-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,2]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["7113"],"URL":"https:\/\/doi.org\/10.1007\/s00436-021-07113-y","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"type":"print","value":"0932-0113"},{"type":"electronic","value":"1432-1955"}],"subject":[],"published":{"date-parts":[[2021,4,2]]},"assertion":[{"value":"18 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Head lice collection for the in vitro study followed the protocol approved by the Clinical Research Ethics Committee of the Hospital of Donostia (Gipuzkoa, Spain) and was performed in accordance with the ethical standards of Declaration of Helsinki. Clinical use test followed the corresponding protocol according to Good Clinical Practice guidelines in San Ferm\u00edn Clinic (Pamplona, Spain) and was performed in accordance with the ethical standards of Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all individual participants included in the studies or from parents or legal guardians when applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"L. Mart\u00ednez de Murgu\u00eda Fern\u00e1ndez is a scientific consultant of Ferrer International S.A. The company has not participated in the protocol design, performance, or interpretation of the laboratory and clinical studies. Neither the principal author nor Tecnalia has commercial interests in the tested product. G. Bacchini, G. Puig Algora, and M. Bajona Roig are employees of Ferrer International S.A.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}