{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:46:26Z","timestamp":1791585986735,"version":"4.3.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s00436-021-07283-9","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T01:03:08Z","timestamp":1629248588000},"page":"3335-3339","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Antitumor effects of a Toxoplasma mutant lacking lactate dehydrogenases"],"prefix":"10.1007","volume":"120","author":[{"given":"Yaqiong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningbo","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taifang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0103-271X","authenticated-orcid":false,"given":"Bang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"issue":"1","key":"7283_CR1","doi-asserted-by":"publisher","first-page":"469","DOI":"10.4049\/jimmunol.1201209","volume":"190","author":"JR Baird","year":"2013","unstructured":"Baird JR et al (2013) Immune-mediated regression of established B16F10 melanoma by intratumoral injection of attenuated Toxoplasma gondii protects against rechallenge. J Immunol 190(1):469\u2013478. https:\/\/doi.org\/10.4049\/jimmunol.1201209","journal-title":"J Immunol"},{"key":"7283_CR2","doi-asserted-by":"publisher","unstructured":"Edner NM, Carlesso G, Rush J, Walker L (2020) Targeting co-stimulatory molecules in autoimmune disease. Nature Reviews Drug Discovery:1\u201324. https:\/\/doi.org\/10.1038\/s41573-020-0081-9","DOI":"10.1038\/s41573-020-0081-9"},{"issue":"6","key":"7283_CR3","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00005-010-0097-7","volume":"58","author":"NK Egilmez","year":"2010","unstructured":"Egilmez NK, Kilinc MO (2010) Tumor-resident CD8+ T-cell: the critical catalyst in IL-12-mediated reversal of tumor immune suppression. Arch Immunol Ther Exp 58(6):399\u2013405. https:\/\/doi.org\/10.1007\/s00005-010-0097-7","journal-title":"Arch Immunol Ther Exp"},{"issue":"9","key":"7283_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006523","volume":"13","author":"BA Fox","year":"2017","unstructured":"Fox BA, Butler KL, Guevara RB, Bzik DJ (2017) Cancer therapy in a microbial bottle: uncorking the novel biology of the protozoan Toxoplasma gondii. PLoS Pathog 13(9):e1006523. https:\/\/doi.org\/10.1371\/journal.ppat.1006523","journal-title":"PLoS Pathog"},{"issue":"6874","key":"7283_CR5","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/415926a","volume":"415","author":"BA Fox","year":"2002","unstructured":"Fox BA, Bzik DJ (2002) De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii. Nature 415(6874):926\u2013929. https:\/\/doi.org\/10.1038\/415926a","journal-title":"Nature"},{"issue":"9","key":"7283_CR6","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.pt.2013.07.001","volume":"29","author":"BA Fox","year":"2013","unstructured":"Fox BA, Sanders KL, Chen S, Bzik DJ (2013) Targeting tumors with nonreplicating Toxoplasma gondii uracil auxotroph vaccines. Trends Parasitol 29(9):431\u2013437. https:\/\/doi.org\/10.1016\/j.pt.2013.07.001","journal-title":"Trends Parasitol"},{"issue":"2","key":"7283_CR7","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.tmrv.2019.01.005","volume":"33","author":"EJM Grigor","year":"2019","unstructured":"Grigor EJM et al (2019) Risks and benefits of chimeric antigen receptor T-cell (CAR-T) therapy in cancer: a systematic review and meta-analysis. Transfus Med Rev 33(2):98\u2013110. https:\/\/doi.org\/10.1016\/j.tmrv.2019.01.005","journal-title":"Transfus Med Rev"},{"issue":"6","key":"7283_CR8","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1093\/infdis\/124.6.587","volume":"124","author":"JB Hibbs Jr","year":"1971","unstructured":"Hibbs JB Jr, Lambert LH Jr, Remington JS (1971) Resistance to murine tumors conferred by chronic infection with intracellular protozoa, Toxoplasma gondii and Besnoitia jellisoni. J Infect Dis 124(6):587\u2013592. https:\/\/doi.org\/10.1093\/infdis\/124.6.587","journal-title":"J Infect Dis"},{"issue":"2","key":"7283_CR9","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1054\/mehy.2001.1469","volume":"58","author":"SA Hoption Cann","year":"2002","unstructured":"Hoption Cann SA, van Netten JP, van Netten C, Glover DW (2002) Spontaneous regression: a hidden treasure buried in time. Med Hypotheses 58(2):115\u2013119. https:\/\/doi.org\/10.1054\/mehy.2001.1469","journal-title":"Med Hypotheses"},{"issue":"4","key":"7283_CR10","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1097\/CAD.0000000000000337","volume":"27","author":"P Kucerova","year":"2016","unstructured":"Kucerova P, Cervinkova M (2016) Spontaneous regression of tumour and the role of microbial infection\u2014possibilities for cancer treatment. Anticancer Drugs 27(4):269\u2013277. https:\/\/doi.org\/10.1097\/CAD.0000000000000337","journal-title":"Anticancer Drugs"},{"issue":"6","key":"7283_CR11","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.3390\/cancers12061416","volume":"12","author":"Z Li","year":"2020","unstructured":"Li Z, Jiang Z, Zhang Y, Huang X, Liu Q (2020) Efficacy and safety of oncolytic viruses in randomized controlled trials: a systematic review and meta-analysis. Cancers 12(6):1416. https:\/\/doi.org\/10.3390\/cancers12061416","journal-title":"Cancers"},{"issue":"7378","key":"7283_CR12","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/nature10673","volume":"480","author":"I Mellman","year":"2011","unstructured":"Mellman I, Coukos G, Dranoff G (2011) Cancer immunotherapy comes of age. Nature 480(7378):480\u2013489. https:\/\/doi.org\/10.1038\/nature10673","journal-title":"Nature"},{"issue":"1","key":"7283_CR13","doi-asserted-by":"publisher","first-page":"6","DOI":"10.2144\/000114624","volume":"64","author":"K Nybo","year":"2018","unstructured":"Nybo K (2018) Part I: fighting cancer with deadly bacteria. Biotechniques 64(1):6\u20138. https:\/\/doi.org\/10.2144\/000114624","journal-title":"Biotechniques"},{"key":"7283_CR14","first-page":"37","volume":"34","author":"T Pizzi","year":"1963","unstructured":"Pizzi T, Diaz M (1963) Biological interactions between parasitic infections and tumoral growth. I. Effect of Toxoplasma gondii infections on the early growth phase of an ascites tumor of mice. Biologica 34:37\u201349","journal-title":"Biologica"},{"issue":"8","key":"7283_CR15","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1158\/2326-6066.CIR-14-0235","volume":"3","author":"KL Sanders","year":"2015","unstructured":"Sanders KL, Fox BA, Bzik DJ (2015) Attenuated Toxoplasma gondii stimulates immunity to pancreatic cancer by manipulation of myeloid cell populations. Cancer Immunol Res 3(8):891\u2013901. https:\/\/doi.org\/10.1158\/2326-6066.CIR-14-0235","journal-title":"Cancer Immunol Res"},{"issue":"6024","key":"7283_CR16","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1126\/science.1203486","volume":"331","author":"RD Schreiber","year":"2011","unstructured":"Schreiber RD, Old LJ, Smyth MJ (2011) Cancer immunoediting: integrating immunity\u2019s roles in cancer suppression and promotion. Science 331(6024):1565\u20131570. https:\/\/doi.org\/10.1126\/science.1203486","journal-title":"Science"},{"issue":"12\u201313","key":"7283_CR17","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","volume":"30","author":"AM Tenter","year":"2000","unstructured":"Tenter AM, Heckeroth AR, Weiss LM (2000) Toxoplasma gondii: from animals to humans. Int J Parasitol 30(12\u201313):1217\u20131258. https:\/\/doi.org\/10.1016\/S0020-7519(00)00124-7","journal-title":"Int J Parasitol"},{"key":"7283_CR18","doi-asserted-by":"publisher","first-page":"8086","DOI":"10.1002\/cam4.3410","volume":"9","author":"Z Wang","year":"2020","unstructured":"Wang Z, Wu X (2020) Study and analysis of antitumor resistance mechanism of PD1\/PD-L1 immune checkpoint blocker. Cancer Med 9:8086\u20138121. https:\/\/doi.org\/10.1002\/cam4.3410","journal-title":"Cancer Med"},{"key":"7283_CR19","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12794","volume":"20","author":"N Xia","year":"2018","unstructured":"Xia N et al (2018a) Functional analysis of Toxoplasma lactate dehydrogenases suggests critical roles of lactate fermentation for parasite growth in vivo. Cell Microbiol 20:e12794. https:\/\/doi.org\/10.1111\/cmi.12794","journal-title":"Cell Microbiol"},{"key":"7283_CR20","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.3389\/fimmu.2018.01814","volume":"9","author":"N Xia","year":"2018","unstructured":"Xia N et al (2018b) A lactate fermentation mutant of Toxoplasma stimulates protective immunity against acute and chronic toxoplasmosis. Front Immunol 9:1814. https:\/\/doi.org\/10.3389\/fimmu.2018.01814","journal-title":"Front Immunol"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-021-07283-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-021-07283-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-021-07283-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T04:13:39Z","timestamp":1630037619000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-021-07283-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,18]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["7283"],"URL":"https:\/\/doi.org\/10.1007\/s00436-021-07283-9","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,18]]},"assertion":[{"value":"17 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments, as well as the procedures for animal care and treatments, were approved by the ethics committee of Huazhong Agricultural University (Permit # HZAUMO-2017\u2013045). All institutional and governmental regulations concerning the use of experimental animals were followed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}