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It has been proposed that \u201cparakines\u201d secreted by <jats:italic>Trichinella<\/jats:italic> larvae serve as messengers to implement communication between the parasite and the muscle cells through a molecular cross-talk to ensure permanent coexistence within the host. The <jats:italic>Ts-<\/jats:italic>NBL1 protein is considered to be a potential key \u201cparakine\u201d involved in the early invasion of the muscle fiber and its transformation into a feeder cell during <jats:italic>Trichinella spiralis<\/jats:italic> infection. This study used for the first time yeast two-hybrid (Y2H) technology in <jats:italic>Trichinella<\/jats:italic> to identify <jats:italic>Ts-<\/jats:italic>NBL1 interacting proteins. GST co-affinity purification experiments confirmed vimentin as an important interactor. The discovery of the new host proteins interacting with <jats:italic>Ts-<\/jats:italic>NBL1 will help to suggest that <jats:italic>Ts-<\/jats:italic>NBL1 contributes to participate in the capsule formation of feeder cells and provide ideas for understanding the molecular and cellular mechanisms involved in the survival of <jats:italic>Trichinella<\/jats:italic> in the host.<\/jats:p>","DOI":"10.1007\/s00436-022-07479-7","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T05:02:30Z","timestamp":1648011750000},"page":"1369-1378","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Trichinella spiralis new born larvae-specific protein, Ts-NBL1, interacts with host\u2019s cell vimentin"],"prefix":"10.1007","volume":"121","author":[{"given":"A.","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Heckmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Caignard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Vitour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Hirchaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Boireau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Karadjian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Vall\u00e9e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"7479_CR1","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s13071-020-04010-8","volume":"13","author":"AMI Abuzeid","year":"2020","unstructured":"Abuzeid AMI, Zhou X, Huang Y, Li G (2020) Twenty-five-year research progress in hookworm excretory\/secretory products. 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