{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:11:54Z","timestamp":1740107514468,"version":"3.37.3"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s00436-022-07510-x","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T06:02:41Z","timestamp":1650261761000},"page":"1699-1707","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recombinant dynein light intermediate chain of Haemonchus contortus affects the functions of goat immune cells in vitro"],"prefix":"10.1007","volume":"121","author":[{"given":"Kalibixiati","family":"Aimulajiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohai","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiz Muhammad","family":"Khand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambreen","family":"Leghari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaokai","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangrui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8347-3097","authenticated-orcid":false,"given":"Ruofeng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"7510_CR1","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/1756-3305-6-243","volume":"6","author":"AJ Abbar","year":"2013","unstructured":"Abbar AJ, Campbell AJ, Charles JA, Gasser RB (2013) First report of anthelmintic resistance in Haemonchus contortus in alpacas in Australia. Parasit Vectors 6:243. https:\/\/doi.org\/10.1186\/1756-3305-6-243","journal-title":"Parasit Vectors"},{"key":"7510_CR2","doi-asserted-by":"publisher","unstructured":"Aimulajiang K et al (2020) Unveiling the immunomodulatory characteristics of Haemonchus contortus ephrin domain containing protein in the parasite-host interactions. Animals : an open access journal from MDPI 10(11). https:\/\/doi.org\/10.3390\/ani10112137","DOI":"10.3390\/ani10112137"},{"issue":"12","key":"7510_CR3","doi-asserted-by":"publisher","first-page":"e12895","DOI":"10.1111\/pim.12895","volume":"43","author":"K Aimulajiang","year":"2021","unstructured":"Aimulajiang K et al (2021) Characteristics of biotin lipoyl attachment and 2-oxoacid dehydrogenase acyltransferase of the parasitic nematode Haemonchus contortus and its modulatory functions on goat PBMCs in vitro. Parasite Immunol 43(12):e12895. https:\/\/doi.org\/10.1111\/pim.12895","journal-title":"Parasite Immunol"},{"key":"7510_CR4","doi-asserted-by":"publisher","first-page":"329438","DOI":"10.1155\/2013\/329438","volume":"2013","author":"C Aranzamendi","year":"2013","unstructured":"Aranzamendi C, Sofronic-Milosavljevic L, Pinelli E (2013) Helminths: immunoregulation and inflammatory diseases-which side are Trichinella spp. and Toxocara spp. on? J Parasitol Res 2013:329438. https:\/\/doi.org\/10.1155\/2013\/329438","journal-title":"J Parasitol Res"},{"issue":"5","key":"7510_CR5","doi-asserted-by":"publisher","first-page":"a025817","DOI":"10.1101\/cshperspect.a025817","volume":"9","author":"K Barlan","year":"2017","unstructured":"Barlan K, Gelfand VI (2017) Microtubule-based transport and the distribution, tethering, and organization of organelles. Cold Spring Harb Perspect Biol 9(5):a025817","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"7510_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceb.2017.01.008","volume":"47","author":"JS Boni Fa Cino","year":"2017","unstructured":"Boni Fa Cino JS, Neefjes J (2017) Moving and positioning the endolysosomal system - ScienceDirect. Curr Opin Cell Biol 47:1\u20138","journal-title":"Curr Opin Cell Biol"},{"key":"7510_CR7","doi-asserted-by":"publisher","unstructured":"Cao L, Fetterer R, Qu G, Zhang X, Tuo W (2018) Neospora caninum cytoplasmic dynein LC8 light chain 2 (NcDYNLL2) is differentially produced by pathogenically distinct isolates and regulates the host immune response. Parasitology 1\u20138. https:\/\/doi.org\/10.1017\/s003118201800207x","DOI":"10.1017\/s003118201800207x"},{"key":"7510_CR8","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.sbi.2015.12.003","volume":"37","author":"AP Carter","year":"2016","unstructured":"Carter AP, Diamant AG, Urnavicius L (2016) How dynein and dynactin transport cargos: a structural perspective. Curr Opin Struct Biol 37:62\u201370","journal-title":"Curr Opin Struct Biol"},{"issue":"4","key":"7510_CR9","first-page":"271","volume":"51","author":"K Donskow-Schmelter","year":"2005","unstructured":"Donskow-Schmelter K, Doligalska M (2005) Apoptosis, a protective mechanism for pathogens and their hosts. Wiad Parazytol 51(4):271\u2013280","journal-title":"Wiad Parazytol"},{"key":"7510_CR10","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.3389\/fimmu.2018.01627","volume":"9","author":"M Ehsan","year":"2018","unstructured":"Ehsan M et al (2018) The serine\/threonine-protein phosphatase 1 from Haemonchus contortus is actively involved in suppressive regulatory roles on immune functions of goat peripheral blood mononuclear cells. Front Immunol 9:1627. https:\/\/doi.org\/10.3389\/fimmu.2018.01627","journal-title":"Front Immunol"},{"key":"7510_CR11","doi-asserted-by":"publisher","unstructured":"Ehsan M et al (2020) Characterization of Haemonchus contortus excretory\/secretory antigen (ES-15) and its modulatory functions on goat immune cells in vitro. Pathogens (Basel, Switzerland) 9(3). https:\/\/doi.org\/10.3390\/pathogens9030162","DOI":"10.3390\/pathogens9030162"},{"issue":"1\u20133","key":"7510_CR12","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.vetpar.2012.11.014","volume":"193","author":"LC Falzon","year":"2013","unstructured":"Falzon LC et al (2013) Anthelmintic resistance in sheep flocks in Ontario, Canada. Vet Parasitol 193(1\u20133):150\u2013162","journal-title":"Vet Parasitol"},{"issue":"7","key":"7510_CR13","doi-asserted-by":"publisher","first-page":"e0159796","DOI":"10.1371\/journal.pone.0159796","volume":"11","author":"JA Gadahi","year":"2016","unstructured":"Gadahi JA et al (2016a) Proteomic analysis of the excretory and secretory proteins of Haemonchus contortus (HcESP) binding to goat PBMCs in vivo revealed stage-specific binding profiles. PLoS ONE 11(7):e0159796. https:\/\/doi.org\/10.1371\/journal.pone.0159796","journal-title":"PLoS ONE"},{"issue":"24","key":"7510_CR14","doi-asserted-by":"publisher","first-page":"35670","DOI":"10.18632\/oncotarget.9589","volume":"7","author":"JA Gadahi","year":"2016","unstructured":"Gadahi JA et al (2016b) Haemonchus contortus excretory and secretory proteins (HcESPs) suppress functions of goat PBMCs in vitro. Oncotarget 7(24):35670\u201335679","journal-title":"Oncotarget"},{"key":"7510_CR15","doi-asserted-by":"publisher","unstructured":"Gazzinelli-Guimaraes PH, Nutman TB (2018) Helminth parasites and immune regulation. F1000Research 7. https:\/\/doi.org\/10.12688\/f1000research.15596.1","DOI":"10.12688\/f1000research.15596.1"},{"key":"7510_CR16","doi-asserted-by":"crossref","unstructured":"Gilleard JS, Redman EJAiP (2016) Genetic diversity and population structure of Haemonchus contortus. 93:31","DOI":"10.1016\/bs.apar.2016.02.009"},{"issue":"6","key":"7510_CR17","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.immuni.2011.05.012","volume":"34","author":"A Hashimoto-Tane","year":"2011","unstructured":"Hashimoto-Tane A et al (2011) Dynein-driven transport of T cell receptor microclusters regulates immune synapse formation and T cell activation. Immunity 34(6):919\u2013931. https:\/\/doi.org\/10.1016\/j.immuni.2011.05.012","journal-title":"Immunity"},{"issue":"5","key":"7510_CR18","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.tcb.2016.01.001","volume":"26","author":"CC Hoogenraad","year":"2016","unstructured":"Hoogenraad CC, Akhmanova A (2016) Bicaudal D family of motor adaptors: linking dynein motility to cargo binding. Trends Cell Biol 26(5):327\u2013340","journal-title":"Trends Cell Biol"},{"issue":"1","key":"7510_CR19","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jaci.2003.10.050","volume":"113","author":"AD Klion","year":"2004","unstructured":"Klion AD, Nutman TB (2004) The role of eosinophils in host defense against helminth parasites. J Allergy Clin Immunol 113(1):30\u201337. https:\/\/doi.org\/10.1016\/j.jaci.2003.10.050","journal-title":"J Allergy Clin Immunol"},{"key":"7510_CR20","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/bs.apar.2016.02.012","volume":"93","author":"AC Kotze","year":"2016","unstructured":"Kotze AC, Prichard RK (2016) Anthelmintic resistance in Haemonchus contortus: history, mechanisms and diagnosis - ScienceDirect. Adv Parasitol 93:397\u2013428","journal-title":"Adv Parasitol"},{"issue":"1","key":"7510_CR21","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1038\/s41467-018-03412-8","volume":"9","author":"IG Lee","year":"2018","unstructured":"Lee IG, Olenick MA, Boczkowska M, Franzini-Armstrong C, Holzbaur ELF, Dominguez R (2018) A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity. Nat Commun 9(1):986. https:\/\/doi.org\/10.1038\/s41467-018-03412-8","journal-title":"Nat Commun"},{"issue":"Suppl","key":"7510_CR22","doi-asserted-by":"publisher","first-page":"S123","DOI":"10.1017\/S0031182000086017","volume":"96","author":"MW Lightowlers","year":"1988","unstructured":"Lightowlers MW, Rickard MD (1988) Excretory\u2013secretory products of helminth parasites: effects on host immune responses. Parasitology 96(Suppl):S123-66","journal-title":"Parasitology"},{"key":"7510_CR23","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2174\/1573395509666131217000000","volume":"9","author":"KE McGovern","year":"2013","unstructured":"McGovern KE, Wilson EH (2013) Role of chemokines and trafficking of immune cells in parasitic infections. Curr Immunol Rev 9:157\u2013168. https:\/\/doi.org\/10.2174\/1573395509666131217000000","journal-title":"Curr Immunol Rev"},{"issue":"1","key":"7510_CR24","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s13071-020-04025-1","volume":"13","author":"MA Naqvi","year":"2020","unstructured":"Naqvi MA et al (2020) Haemonchus contortus: siRNA mediated knockdown of matrix metalloproteinase 12A (MMP-12) results in reduction of infectivity. Parasit Vectors 13(1):151. https:\/\/doi.org\/10.1186\/s13071-020-04025-1","journal-title":"Parasit Vectors"},{"issue":"1","key":"7510_CR25","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jim.2005.07.005","volume":"305","author":"IC Nicholson","year":"2005","unstructured":"Nicholson IC et al (2005) Characterisation of the protein composition of peripheral blood mononuclear cell microsomes by SDS-PAGE and mass spectrometry. J Immunol Methods 305(1):84\u201393. https:\/\/doi.org\/10.1016\/j.jim.2005.07.005","journal-title":"J Immunol Methods"},{"issue":"5203","key":"7510_CR26","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1126\/science.7878463","volume":"267","author":"H Steller","year":"1995","unstructured":"Steller H (1995) Mechanisms and genes of cellular suicide. Science (New York, NY) 267(5203):1445\u20131449. https:\/\/doi.org\/10.1126\/science.7878463","journal-title":"Science (New York, NY)"},{"issue":"3","key":"7510_CR27","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s10989-006-9045-0","volume":"13","author":"Y Sun","year":"2007","unstructured":"Sun Y, Yan R, Muleke CI, Zhao G, Xu L, Li X (2007) Recombinant galectins of Haemonchus contortus parasite induces apoptosis in the peripheral blood lymphocytes of goat. Int J Peptide Res Ther 13(3):387\u2013392. https:\/\/doi.org\/10.1007\/s10989-006-9045-0","journal-title":"Int J Peptide Res Ther"},{"issue":"1","key":"7510_CR28","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.vetpar.2012.03.037","volume":"189","author":"J Torres-Acosta","year":"2012","unstructured":"Torres-Acosta J, Mendoza-De-Gives P, Aguilar-Caballero AJ (2012) Anthelmintic resistance in sheep farms: update of the situation in the American continent. Vet Parasitol 189(1):89\u201396","journal-title":"Vet Parasitol"},{"issue":"1\u20132","key":"7510_CR29","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.vetimm.2007.11.002","volume":"122","author":"DG Turner","year":"2008","unstructured":"Turner DG, Wildblood LA, Inglis NF, Jones DG (2008) Characterization of a galectin-like activity from the parasitic nematode, Haemonchus contortus, which modulates ovine eosinophil migration in vitro. Vet Immunol Immunopathol 122(1\u20132):138\u2013145. https:\/\/doi.org\/10.1016\/j.vetimm.2007.11.002","journal-title":"Vet Immunol Immunopathol"},{"issue":"10","key":"7510_CR30","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1007\/s00436-017-5589-5","volume":"116","author":"N Viseshakul","year":"2017","unstructured":"Viseshakul N, Dechkhajorn W, Benjathummarak S, Nuamtanong S, Maneerat Y (2017) Excretory-secretory product of third-stage Gnathostoma spinigerum larvae induces apoptosis in human peripheral blood mononuclear cells. Parasitol Res 116(10):2783\u20132794. https:\/\/doi.org\/10.1007\/s00436-017-5589-5","journal-title":"Parasitol Res"},{"issue":"1","key":"7510_CR31","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s13071-019-3375-1","volume":"12","author":"Q Wang","year":"2019","unstructured":"Wang Q et al (2019) Hepatocellular carcinoma-associated antigen 59 of Haemonchus contortus modulates the functions of PBMCs and the differentiation and maturation of monocyte-derived dendritic cells of goats in vitro. Parasit Vectors 12(1):105. https:\/\/doi.org\/10.1186\/s13071-019-3375-1","journal-title":"Parasit Vectors"},{"issue":"1","key":"7510_CR32","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1186\/s13071-020-04333-6","volume":"13","author":"Y Wang","year":"2020","unstructured":"Wang Y et al (2020a) Characterization of a rhodanese homologue from Haemonchus contortus and its immune-modulatory effects on goat immune cells in vitro. Parasit Vectors 13(1):454. https:\/\/doi.org\/10.1186\/s13071-020-04333-6","journal-title":"Parasit Vectors"},{"issue":"14","key":"7510_CR33","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/j.ijpara.2020.07.004","volume":"50","author":"Y Wang","year":"2020","unstructured":"Wang Y et al (2020b) Characterization of a phosphotyrosyl phosphatase activator homologue of the parasitic nematode Haemonchus contortus and its immunomodulatory effect on goat peripheral blood mononuclear cells in vitro. Int J Parasitol 50(14):1157\u20131166. https:\/\/doi.org\/10.1016\/j.ijpara.2020.07.004","journal-title":"Int J Parasitol"},{"issue":"19","key":"7510_CR34","doi-asserted-by":"publisher","first-page":"16941","DOI":"10.1074\/jbc.M212453200","volume":"278","author":"AP Yatsuda","year":"2003","unstructured":"Yatsuda AP, Krijgsveld J, Cornelissen A, Heck A, Vries ED (2003) Comprehensive analysis of the secreted proteins of the parasite Haemonchus contortus reveals extensive sequence variation and differential immune recognition. J Biol Chem 278(19):16941\u201316951","journal-title":"J Biol Chem"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-022-07510-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-022-07510-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-022-07510-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T12:14:13Z","timestamp":1652357653000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-022-07510-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,18]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["7510"],"URL":"https:\/\/doi.org\/10.1007\/s00436-022-07510-x","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"type":"print","value":"0932-0113"},{"type":"electronic","value":"1432-1955"}],"subject":[],"published":{"date-parts":[[2022,4,18]]},"assertion":[{"value":"13 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}