{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:46:06Z","timestamp":1784616366908,"version":"3.55.0"},"reference-count":129,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R03AI107431-01A1"],"award-info":[{"award-number":["1R03AI107431-01A1"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s00436-022-07514-7","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T07:03:24Z","timestamp":1650265404000},"page":"1559-1571","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["IFN-induced cell-autonomous immune mechanisms in the control of intracellular protozoa"],"prefix":"10.1007","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9125-1889","authenticated-orcid":false,"given":"Sini","family":"Skariah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-5231","authenticated-orcid":false,"given":"Ali A.","family":"Sultan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6721-0684","authenticated-orcid":false,"given":"Dana G.","family":"Mordue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"issue":"5","key":"7514_CR1","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.chom.2018.10.005","volume":"24","author":"BH Abuaita","year":"2018","unstructured":"Abuaita BH, Schultz TL, O\u2019Riordan MX (2018) Mitochondria-derived vesicles deliver antimicrobial reactive oxygen species to control phagosome-localized Staphylococcus aureus. Cell Host Microbe 24(5):625-636 e5. https:\/\/doi.org\/10.1016\/j.chom.2018.10.005","journal-title":"Cell Host Microbe"},{"issue":"7","key":"7514_CR2","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.4049\/jimmunol.144.7.2725","volume":"144","author":"LB Adams","year":"1990","unstructured":"Adams LB, Hibbs JB Jr, Taintor RR, Krahenbuhl JL (1990) Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine. J immunol 144(7):2725\u20139","journal-title":"J immunol"},{"issue":"8","key":"7514_CR3","doi-asserted-by":"publisher","first-page":"6627","DOI":"10.1074\/jbc.M110.167247","volume":"286","author":"MN Alvarez","year":"2011","unstructured":"Alvarez MN, Peluffo G, Piacenza L, Radi R (2011) Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity. J Biol Chem 286(8):6627\u20136640. https:\/\/doi.org\/10.1074\/jbc.M110.167247","journal-title":"J Biol Chem"},{"issue":"5","key":"7514_CR4","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1084\/jem.139.5.1154","volume":"139","author":"SE Anderson Jr","year":"1974","unstructured":"Anderson SE Jr, Remington JS (1974) Effect of normal and activated human macrophages on Toxoplasma gondii. J Exp Med 139(5):1154\u20131174","journal-title":"J Exp Med"},{"issue":"9","key":"7514_CR5","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1084\/jem.20041408","volume":"200","author":"LO Andrade","year":"2004","unstructured":"Andrade LO, Andrews NW (2004) Lysosomal fusion is essential for the retention of Trypanosoma cruzi inside host cells. J Exp Med 200(9):1135\u20131143. https:\/\/doi.org\/10.1084\/jem.20041408","journal-title":"J Exp Med"},{"issue":"Suppl 1","key":"7514_CR6","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1590\/s0074-02761988000500045","volume":"83","author":"NW Andrews","year":"1988","unstructured":"Andrews NW, Schenkman S, Ley V, Whitlow MB, Robbins ES, Nussenzweig V (1988) Trypanosoma cruzi: mechanisms of cell-invasion and intracellular survival. Mem Inst Oswaldo Cruz 83(Suppl 1):452\u2013455. https:\/\/doi.org\/10.1590\/s0074-02761988000500045","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"1","key":"7514_CR7","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.gene.2007.04.010","volume":"396","author":"HJ Ball","year":"2007","unstructured":"Ball HJ et al (2007) Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Gene 396(1):203\u2013213. https:\/\/doi.org\/10.1016\/j.gene.2007.04.010","journal-title":"Gene"},{"issue":"3","key":"7514_CR8","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.biocel.2008.01.005","volume":"41","author":"HJ Ball","year":"2009","unstructured":"Ball HJ, Yuasa HJ, Austin CJ, Weiser S, Hunt NH (2009) Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway. Int J Biochem Cell Biol 41(3):467\u2013471. https:\/\/doi.org\/10.1016\/j.biocel.2008.01.005","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"7514_CR9","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1038\/s41467-020-16143-6","volume":"11","author":"KS Beckwith","year":"2020","unstructured":"Beckwith KS et al (2020) Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection. Nat Commun 11(1):2270. https:\/\/doi.org\/10.1038\/s41467-020-16143-6","journal-title":"Nat Commun"},{"issue":"1","key":"7514_CR10","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1152\/physrev.00044.2005","volume":"87","author":"K Bedard","year":"2007","unstructured":"Bedard K, Krause KH (2007) The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87(1):245\u2013313. https:\/\/doi.org\/10.1152\/physrev.00044.2005","journal-title":"Physiol Rev"},{"issue":"12","key":"7514_CR11","doi-asserted-by":"publisher","first-page":"6562","DOI":"10.1016\/S0021-9258(19)39184-7","volume":"265","author":"PA Berman","year":"1990","unstructured":"Berman PA, Human L (1990) Regulation of 5-phosphoribosyl 1-pyrophosphate and of hypoxanthine uptake and release in human erythrocytes by oxypurine cycling. J Biol Chem 265(12):6562\u20136568","journal-title":"J Biol Chem"},{"key":"7514_CR12","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/978-1-4899-2638-8_37","volume":"309A","author":"PA Berman","year":"1991","unstructured":"Berman PA, Human L (1991) Hypoxanthine depletion induced by xanthine oxidase inhibits malaria parasite growth in vitro. Adv Exp Med Biol 309A:165\u2013168. https:\/\/doi.org\/10.1007\/978-1-4899-2638-8_37","journal-title":"Adv Exp Med Biol"},{"issue":"6","key":"7514_CR13","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1172\/JCI115506","volume":"88","author":"PA Berman","year":"1991","unstructured":"Berman PA, Human L, Freese JA (1991) Xanthine oxidase inhibits growth of Plasmodium falciparum in human erythrocytes in vitro. J Clin Invest 88(6):1848\u20131855. https:\/\/doi.org\/10.1172\/JCI115506","journal-title":"J Clin Invest"},{"key":"7514_CR14","doi-asserted-by":"publisher","unstructured":"Bhushan J, et al (2020) ISG15 connects autophagy and IFN-gamma-dependent control of Toxoplasma gondii infection in human cells. mBio 11(5) https:\/\/doi.org\/10.1128\/mBio.00852-20","DOI":"10.1128\/mBio.00852-20"},{"issue":"5","key":"7514_CR15","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1002\/eji.200323825","volume":"33","author":"M Blos","year":"2003","unstructured":"Blos M, Schleicher U, Soares Rocha FJ, Meissner U, Rollinghoff M, Bogdan C (2003) Organ-specific and stage-dependent control of Leishmania major infection by inducible nitric oxide synthase and phagocyte NADPH oxidase. Eur J Immunol 33(5):1224\u20131234. https:\/\/doi.org\/10.1002\/eji.200323825","journal-title":"Eur J Immunol"},{"key":"7514_CR16","doi-asserted-by":"publisher","first-page":"101882","DOI":"10.1016\/j.redox.2021.101882","volume":"41","author":"M Bortolotti","year":"2021","unstructured":"Bortolotti M, Polito L, Battelli MG, Bolognesi A (2021) Xanthine oxidoreductase: one enzyme for multiple physiological tasks. Redox Biol 41:101882. https:\/\/doi.org\/10.1016\/j.redox.2021.101882","journal-title":"Redox Biol"},{"issue":"2","key":"7514_CR17","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0171-2985(99)80062-X","volume":"201","author":"D Bout","year":"1999","unstructured":"Bout D, Moretto M, Dimier-Poisson I, Gatel DB (1999) Interaction between Toxoplasma gondii and enterocyte. Immunobiology 201(2):225\u2013228","journal-title":"Immunobiology"},{"issue":"2","key":"7514_CR18","doi-asserted-by":"publisher","first-page":"e0148084","DOI":"10.1371\/journal.pone.0148084","volume":"11","author":"PP Carneiro","year":"2016","unstructured":"Carneiro PP, Conceicao J, Macedo M, Magalhaes V, Carvalho EM, Bacellar O (2016) The role of nitric oxide and reactive oxygen species in the killing of Leishmania braziliensis by monocytes from patients with cutaneous Leishmaniasis. PLoS ONE 11(2):e0148084. https:\/\/doi.org\/10.1371\/journal.pone.0148084","journal-title":"PLoS ONE"},{"issue":"5","key":"7514_CR19","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1128\/IAI.67.5.2233-2240.1999","volume":"67","author":"IP Ceravolo","year":"1999","unstructured":"Ceravolo IP, Chaves AC, Bonjardim CA, Sibley D, Romanha AJ, Gazzinelli RT (1999) Replication of Toxoplasma gondii, but not Trypanosoma cruzi, is regulated in human fibroblasts activated with gamma interferon: requirement of a functional JAK\/STAT pathway. Infect Immun 67(5):2233\u20132240","journal-title":"Infect Immun"},{"issue":"2","key":"7514_CR20","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/1521-4141(200102)31:2<333::AID-IMMU333>3.0.CO;2-X","volume":"31","author":"AC Chaves","year":"2001","unstructured":"Chaves AC, Ceravolo IP, Gomes JA, Zani CL, Romanha AJ, Gazzinelli RT (2001) IL-4 and IL-13 regulate the induction of indoleamine 2,3-dioxygenase activity and the control of Toxoplasma gondii replication in human fibroblasts activated with IFN-gamma. Eur J Immunol 31(2):333\u2013344. https:\/\/doi.org\/10.1002\/1521-4141(200102)31:2%3c333::AID-IMMU333%3e3.0.CO;2-X","journal-title":"Eur J Immunol"},{"issue":"6","key":"7514_CR21","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.immuni.2014.05.006","volume":"40","author":"J Choi","year":"2014","unstructured":"Choi J et al (2014) The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy. Immunity 40(6):924\u2013935. https:\/\/doi.org\/10.1016\/j.immuni.2014.05.006","journal-title":"Immunity"},{"issue":"9","key":"7514_CR22","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1111\/j.1462-5822.2009.01336.x","volume":"11","author":"N Choudhry","year":"2009","unstructured":"Choudhry N, Korbel DS, Edwards LA, Bajaj-Elliott M, McDonald V (2009) Dysregulation of interferon-gamma-mediated signalling pathway in intestinal epithelial cells by Cryptosporidium parvum infection. Cell Microbiol 11(9):1354\u20131364. https:\/\/doi.org\/10.1111\/j.1462-5822.2009.01336.x","journal-title":"Cell Microbiol"},{"issue":"11","key":"7514_CR23","doi-asserted-by":"publisher","first-page":"e1006027","DOI":"10.1371\/journal.ppat.1006027","volume":"12","author":"B Clough","year":"2016","unstructured":"Clough B et al (2016) K63-linked ubiquitination targets Toxoplasma gondii for endo-lysosomal destruction in IFNgamma-stimulated human cells. PLoS Pathog 12(11):e1006027. https:\/\/doi.org\/10.1371\/journal.ppat.1006027","journal-title":"PLoS Pathog"},{"issue":"9","key":"7514_CR24","doi-asserted-by":"publisher","first-page":"e1003538","DOI":"10.1371\/journal.ppat.1003538","volume":"9","author":"J Coers","year":"2013","unstructured":"Coers J (2013) Self and non-self discrimination of intracellular membranes by the innate immune system. PLoS Pathog 9(9):e1003538. https:\/\/doi.org\/10.1371\/journal.ppat.1003538","journal-title":"PLoS Pathog"},{"issue":"7","key":"7514_CR25","doi-asserted-by":"publisher","first-page":"4081","DOI":"10.1128\/IAI.72.7.4081-4089.2004","volume":"72","author":"KL Cummings","year":"2004","unstructured":"Cummings KL, Tarleton RL (2004) Inducible nitric oxide synthase is not essential for control of Trypanosoma cruzi infection in mice. Infect Immun 72(7):4081\u20134089. https:\/\/doi.org\/10.1128\/IAI.72.7.4081-4089.2004","journal-title":"Infect Immun"},{"issue":"6","key":"7514_CR26","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1089\/jir.1994.14.313","volume":"14","author":"W Dai","year":"1994","unstructured":"Dai W, Pan H, Kwok O, Dubey JP (1994) Human indoleamine 2,3-dioxygenase inhibits Toxoplasma gondii growth in fibroblast cells. J Interferon Res 14(6):313\u2013317","journal-title":"J Interferon Res"},{"issue":"10","key":"7514_CR27","doi-asserted-by":"publisher","first-page":"6527","DOI":"10.1128\/IAI.69.10.6527-6531.2001","volume":"69","author":"W Daubener","year":"2001","unstructured":"Daubener W et al (2001) Restriction of Toxoplasma gondii growth in human brain microvascular endothelial cells by activation of indoleamine 2,3-dioxygenase. Infect Immun 69(10):6527\u20136531. https:\/\/doi.org\/10.1128\/IAI.69.10.6527-6531.2001","journal-title":"Infect Immun"},{"issue":"12","key":"7514_CR28","doi-asserted-by":"publisher","first-page":"e186","DOI":"10.1371\/journal.ppat.0030186","volume":"3","author":"AS Davis","year":"2007","unstructured":"Davis AS, Vergne I, Master SS, Kyei GB, Chua J, Deretic V (2007) Mechanism of inducible nitric oxide synthase exclusion from mycobacterial phagosomes. PLoS Pathog 3(12):e186. https:\/\/doi.org\/10.1371\/journal.ppat.0030186","journal-title":"PLoS Pathog"},{"issue":"11","key":"7514_CR29","doi-asserted-by":"publisher","first-page":"7729","DOI":"10.4049\/jimmunol.179.11.7729","volume":"179","author":"D Degrandi","year":"2007","unstructured":"Degrandi D et al (2007) Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J Immunol 179(11):7729\u20137740","journal-title":"J Immunol"},{"issue":"4","key":"7514_CR30","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1046\/j.1365-2567.1998.00553.x","volume":"94","author":"IH Dimier","year":"1998","unstructured":"Dimier IH, Bout DT (1998) Interferon-gamma-activated primary enterocytes inhibit Toxoplasma gondii replication: a role for intracellular iron. Immunology 94(4):488\u2013495","journal-title":"Immunology"},{"issue":"1","key":"7514_CR31","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1093\/infdis\/jir621","volume":"205","author":"S Divanovic","year":"2012","unstructured":"Divanovic S et al (2012) Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. J Infect Dis 205(1):152\u2013161. https:\/\/doi.org\/10.1093\/infdis\/jir621","journal-title":"J Infect Dis"},{"issue":"6","key":"7514_CR32","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/S0092-8674(00)81071-5","volume":"84","author":"JM Dobrowolski","year":"1996","unstructured":"Dobrowolski JM, Sibley LD (1996) Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite. Cell 84(6):933\u2013939","journal-title":"Cell"},{"issue":"2","key":"7514_CR33","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.immuni.2012.08.005","volume":"37","author":"CD Dupont","year":"2012","unstructured":"Dupont CD, Hunter CA (2012) Guanylate-binding proteins: niche recruiters for antimicrobial effectors. Immunity 37(2):191\u2013193. https:\/\/doi.org\/10.1016\/j.immuni.2012.08.005","journal-title":"Immunity"},{"issue":"4","key":"7514_CR34","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1128\/IAI.68.4.2315-2322.2000","volume":"68","author":"DA Elliott","year":"2000","unstructured":"Elliott DA, Clark DP (2000) Cryptosporidium parvum induces host cell actin accumulation at the host-parasite interface. Infect Immun 68(4):2315\u20132322. https:\/\/doi.org\/10.1128\/IAI.68.4.2315-2322.2000","journal-title":"Infect Immun"},{"issue":"9","key":"7514_CR35","doi-asserted-by":"publisher","first-page":"5940","DOI":"10.1128\/IAI.69.9.5940-5942.2001","volume":"69","author":"DA Elliott","year":"2001","unstructured":"Elliott DA, Coleman DJ, Lane MA, May RC, Machesky LM, Clark DP (2001) Cryptosporidium parvum infection requires host cell actin polymerization. Infect Immun 69(9):5940\u20135942. https:\/\/doi.org\/10.1128\/IAI.69.9.5940-5942.2001","journal-title":"Infect Immun"},{"issue":"5","key":"7514_CR36","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.chom.2014.04.002","volume":"15","author":"RD Etheridge","year":"2014","unstructured":"Etheridge RD, Alaganan A, Tang K, Lou HJ, Turk BE, Sibley LD (2014) The toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice. Cell Host Microbe 15(5):537\u2013550. https:\/\/doi.org\/10.1016\/j.chom.2014.04.002","journal-title":"Cell Host Microbe"},{"issue":"9","key":"7514_CR37","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/bies.201100054","volume":"33","author":"SJ Fentress","year":"2011","unstructured":"Fentress SJ, Sibley LD (2011) The secreted kinase ROP18 defends Toxoplasma\u2019s border. BioEssays news and reviews in molecular cellular and developmental biology 33(9):693\u2013700","journal-title":"BioEssays news and reviews in molecular cellular and developmental biology"},{"issue":"6","key":"7514_CR38","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.chom.2010.11.005","volume":"8","author":"SJ Fentress","year":"2010","unstructured":"Fentress SJ et al (2010) Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. Cell Host Microbe 8(6):484\u2013495. https:\/\/doi.org\/10.1016\/j.chom.2010.11.005","journal-title":"Cell Host Microbe"},{"issue":"13","key":"7514_CR39","doi-asserted-by":"publisher","first-page":"e100926","DOI":"10.15252\/embj.2018100926","volume":"38","author":"D Fisch","year":"2019","unstructured":"Fisch D et al (2019) Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis. EMBO J 38(13):e100926. https:\/\/doi.org\/10.15252\/embj.2018100926","journal-title":"EMBO J"},{"issue":"6","key":"7514_CR40","doi-asserted-by":"publisher","first-page":"108008","DOI":"10.1016\/j.celrep.2020.108008","volume":"32","author":"D Fisch","year":"2020","unstructured":"Fisch D et al (2020) Human GBP1 differentially targets Salmonella and toxoplasma to license recognition of microbial ligands and caspase-mediated death. Cell Rep 32(6):108008. https:\/\/doi.org\/10.1016\/j.celrep.2020.108008","journal-title":"Cell Rep"},{"issue":"7","key":"7514_CR41","doi-asserted-by":"publisher","first-page":"e1001358","DOI":"10.1371\/journal.pbio.1001358","volume":"10","author":"MC Fleckenstein","year":"2012","unstructured":"Fleckenstein MC, Reese ML, Konen-Waisman S, Boothroyd JC, Howard JC, Steinfeldt T (2012) A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins. PLoS Biol 10(7):e1001358. https:\/\/doi.org\/10.1371\/journal.pbio.1001358","journal-title":"PLoS Biol"},{"issue":"1","key":"7514_CR42","doi-asserted-by":"publisher","first-page":"5209","DOI":"10.1038\/s41598-017-05487-7","volume":"7","author":"C Foltz","year":"2017","unstructured":"Foltz C, Napolitano A, Khan R, Clough B, Hirst EM, Frickel EM (2017) TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles. Sci Rep 7(1):5209. https:\/\/doi.org\/10.1038\/s41598-017-05487-7","journal-title":"Sci Rep"},{"issue":"34","key":"7514_CR43","doi-asserted-by":"publisher","first-page":"30542","DOI":"10.1074\/jbc.M414126200","volume":"280","author":"G Forget","year":"2005","unstructured":"Forget G, Gregory DJ, Olivier M (2005) Proteasome-mediated degradation of STAT1alpha following infection of macrophages with Leishmania donovani. J Biol Chem 280(34):30542\u201330549. https:\/\/doi.org\/10.1074\/jbc.M414126200","journal-title":"J Biol Chem"},{"issue":"9","key":"7514_CR44","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1084\/jem.20160340","volume":"213","author":"G Gay","year":"2016","unstructured":"Gay G et al (2016) Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-gamma-mediated host defenses. J Exp Med 213(9):1779\u20131798. https:\/\/doi.org\/10.1084\/jem.20160340","journal-title":"J Exp Med"},{"issue":"10","key":"7514_CR45","doi-asserted-by":"publisher","first-page":"e2469","DOI":"10.1371\/journal.pntd.0002469","volume":"7","author":"VM Goncalves","year":"2013","unstructured":"Goncalves VM et al (2013) NLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production. PLoS Negl Trop Dis 7(10):e2469. https:\/\/doi.org\/10.1371\/journal.pntd.0002469","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"7514_CR46","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","volume":"20","author":"T Gong","year":"2020","unstructured":"Gong T, Liu L, Jiang W, Zhou R (2020) DAMP-sensing receptors in sterile inflammation and inflammatory diseases. Nat Rev Immunol 20(2):95\u2013112. https:\/\/doi.org\/10.1038\/s41577-019-0215-7","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"7514_CR47","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1053\/j.gastro.2013.07.011","volume":"145","author":"H Grasberger","year":"2013","unstructured":"Grasberger H, El-Zaatari M, Dang DT, Merchant JL (2013) Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice. Gastroenterology 145(5):1045\u20131054. https:\/\/doi.org\/10.1053\/j.gastro.2013.07.011","journal-title":"Gastroenterology"},{"issue":"4","key":"7514_CR48","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1600-0854.2006.00531.x","volume":"8","author":"A Haas","year":"2007","unstructured":"Haas A (2007) The phagosome: compartment with a license to kill. Traffic 8(4):311\u2013330. https:\/\/doi.org\/10.1111\/j.1600-0854.2006.00531.x","journal-title":"Traffic"},{"issue":"6","key":"7514_CR49","doi-asserted-by":"publisher","first-page":"e1003414","DOI":"10.1371\/journal.ppat.1003414","volume":"9","author":"AK Haldar","year":"2013","unstructured":"Haldar AK et al (2013) IRG and GBP host resistance factors target aberrant, \u201cnon-self\u201d vacuoles characterized by the missing of \u201cself\u201d IRGM proteins. PLoS Pathog 9(6):e1003414. https:\/\/doi.org\/10.1371\/journal.ppat.1003414","journal-title":"PLoS Pathog"},{"key":"7514_CR50","doi-asserted-by":"publisher","unstructured":"Haldar AK, Nigam U, Yamamoto M, Coers J, Goyal N (2020) Guanylate binding proteins restrict Leishmania donovani growth in nonphagocytic cells independent of parasitophorous vacuolar targeting. mBio 11(4) https:\/\/doi.org\/10.1128\/mBio.01464-20","DOI":"10.1128\/mBio.01464-20"},{"key":"7514_CR51","doi-asserted-by":"publisher","first-page":"641495","DOI":"10.3389\/fimmu.2021.641495","volume":"12","author":"R Hatinguais","year":"2021","unstructured":"Hatinguais R, Pradhan A, Brown GD, Brown AJP, Warris A, Shekhova E (2021) Mitochondrial reactive oxygen species regulate immune responses of macrophages to Aspergillus fumigatus. Front Immunol 12:641495. https:\/\/doi.org\/10.3389\/fimmu.2021.641495","journal-title":"Front Immunol"},{"key":"7514_CR52","doi-asserted-by":"publisher","unstructured":"Herb M, Schramm M (2021) Functions of ROS in macrophages and antimicrobial immunity. Antioxidants (Basel) 10(2) https:\/\/doi.org\/10.3390\/antiox10020313","DOI":"10.3390\/antiox10020313"},{"issue":"3","key":"7514_CR53","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1128\/IAI.66.3.1208-1215.1998","volume":"66","author":"C Holscher","year":"1998","unstructured":"Holscher C, Kohler G, Muller U, Mossmann H, Schaub GA, Brombacher F (1998) Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase. Infect Immun 66(3):1208\u20131215. https:\/\/doi.org\/10.1128\/IAI.66.3.1208-1215.1998","journal-title":"Infect Immun"},{"key":"7514_CR54","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.coi.2019.04.017","volume":"60","author":"S Huang","year":"2019","unstructured":"Huang S, Meng Q, Maminska A, MacMicking JD (2019) Cell-autonomous immunity by IFN-induced GBPs in animals and plants. Curr Opin Immunol 60:71\u201380. https:\/\/doi.org\/10.1016\/j.coi.2019.04.017","journal-title":"Curr Opin Immunol"},{"issue":"4","key":"7514_CR55","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41590-019-0323-3","volume":"20","author":"P Hubel","year":"2019","unstructured":"Hubel P et al (2019) A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nat Immunol 20(4):493\u2013502. https:\/\/doi.org\/10.1038\/s41590-019-0323-3","journal-title":"Nat Immunol"},{"issue":"19","key":"7514_CR56","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1038\/emboj.2008.176","volume":"27","author":"JP Hunn","year":"2008","unstructured":"Hunn JP et al (2008) Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii. EMBO J 27(19):2495\u20132509. https:\/\/doi.org\/10.1038\/emboj.2008.176","journal-title":"EMBO J"},{"issue":"1\u20132","key":"7514_CR57","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00335-010-9293-3","volume":"22","author":"JP Hunn","year":"2011","unstructured":"Hunn JP, Feng CG, Sher A, Howard JC (2011) The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens. Mammalian Genome\u202f: Official Journal of the International Mammalian Genome Society 22(1\u20132):43\u201354. https:\/\/doi.org\/10.1007\/s00335-010-9293-3","journal-title":"Mammalian Genome : Official Journal of the International Mammalian Genome Society"},{"issue":"9","key":"7514_CR58","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/s41577-018-0029-z","volume":"18","author":"LB Ivashkiv","year":"2018","unstructured":"Ivashkiv LB (2018) IFNgamma: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy. Nat Rev Immunol 18(9):545\u2013558. https:\/\/doi.org\/10.1038\/s41577-018-0029-z","journal-title":"Nat Rev Immunol"},{"issue":"8","key":"7514_CR59","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1080\/15548627.2020.1788890","volume":"16","author":"J Jia","year":"2020","unstructured":"Jia J et al (2020) AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system. Autophagy 16(8):1550\u20131552. https:\/\/doi.org\/10.1080\/15548627.2020.1788890","journal-title":"Autophagy"},{"issue":"5","key":"7514_CR60","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.molcel.2019.12.028","volume":"77","author":"J Jia","year":"2020","unstructured":"Jia J et al (2020) AMPK, a regulator of metabolism and autophagy, is activated by lysosomal damage via a novel galectin-directed ubiquitin signal transduction system. Mol Cell 77(5):951-969 e9. https:\/\/doi.org\/10.1016\/j.molcel.2019.12.028","journal-title":"Mol Cell"},{"key":"7514_CR61","doi-asserted-by":"publisher","unstructured":"Johannes L, Jacob R, Leffler H (2018) Galectins at a glance. J Cell Sci 131(9) https:\/\/doi.org\/10.1242\/jcs.208884","DOI":"10.1242\/jcs.208884"},{"issue":"6030","key":"7514_CR62","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1126\/science.1201711","volume":"332","author":"BH Kim","year":"2011","unstructured":"Kim BH, Shenoy AR, Kumar P, Das R, Tiwari S, MacMicking JD (2011) A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection. Science 332(6030):717\u2013721. https:\/\/doi.org\/10.1126\/science.1201711","journal-title":"Science"},{"issue":"4","key":"7514_CR63","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.chom.2012.09.007","volume":"12","author":"BH Kim","year":"2012","unstructured":"Kim BH, Shenoy AR, Kumar P, Bradfield CJ, MacMicking JD (2012) IFN-inducible GTPases in host cell defense. Cell Host Microbe 12(4):432\u2013444. https:\/\/doi.org\/10.1016\/j.chom.2012.09.007","journal-title":"Cell Host Microbe"},{"issue":"8","key":"7514_CR64","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.1096\/fj.09-150920","volume":"24","author":"CP Knubel","year":"2010","unstructured":"Knubel CP et al (2010) Indoleamine 2,3-dioxigenase (IDO) is critical for host resistance against Trypanosoma cruzi. FASEB J 24(8):2689\u20132701. https:\/\/doi.org\/10.1096\/fj.09-150920","journal-title":"FASEB J"},{"issue":"10","key":"7514_CR65","doi-asserted-by":"publisher","first-page":"e26550","DOI":"10.1371\/journal.pone.0026550","volume":"6","author":"CP Knubel","year":"2011","unstructured":"Knubel CP et al (2011) 3-Hydroxy kynurenine treatment controls T. cruzi replication and the inflammatory pathology preventing the clinical symptoms of chronic Chagas disease. PLoS One 6(10):e26550. https:\/\/doi.org\/10.1371\/journal.pone.0026550","journal-title":"PLoS One"},{"issue":"7","key":"7514_CR66","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1021\/acsmedchemlett.7b00169","volume":"8","author":"CP Knubel","year":"2017","unstructured":"Knubel CP et al (2017) 3-Hydroxykynurenine, a tryptophan metabolite generated during the infection, is active against Trypanosoma cruzi. ACS Med Chem Lett 8(7):757\u2013761. https:\/\/doi.org\/10.1021\/acsmedchemlett.7b00169","journal-title":"ACS Med Chem Lett"},{"key":"7514_CR67","doi-asserted-by":"publisher","unstructured":"Kravets E, et al (2016) Guanylate binding proteins directly attack Toxoplasma gondii via supramolecular complexes. Elife 5https:\/\/doi.org\/10.7554\/eLife.11479","DOI":"10.7554\/eLife.11479"},{"issue":"20","key":"7514_CR68","doi-asserted-by":"publisher","first-page":"5826","DOI":"10.1111\/febs.15662","volume":"288","author":"M Kutsch","year":"2021","unstructured":"Kutsch M, Coers J (2021) Human guanylate binding proteins: nanomachines orchestrating host defense. FEBS J 288(20):5826\u20135849. https:\/\/doi.org\/10.1111\/febs.15662","journal-title":"FEBS J"},{"issue":"5","key":"7514_CR69","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1172\/JCI110545","volume":"69","author":"RM Locksley","year":"1982","unstructured":"Locksley RM, Wilson CB, Klebanoff SJ (1982) Role for endogenous and acquired peroxidase in the toxoplasmacidal activity of murine and human mononuclear phagocytes. J Clin Investig 69(5):1099\u20131111","journal-title":"J Clin Investig"},{"issue":"1","key":"7514_CR70","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/s0167-4889(99)00112-3","volume":"1452","author":"R Lofgren","year":"1999","unstructured":"Lofgren R, Serrander L, Forsberg M, Wilsson A, Wasteson A, Stendahl O (1999) CR3, FcgammaRIIA and FcgammaRIIIB induce activation of the respiratory burst in human neutrophils: the role of intracellular Ca(2+), phospholipase D and tyrosine phosphorylation. Biochim Biophys Acta 1452(1):46\u201359. https:\/\/doi.org\/10.1016\/s0167-4889(99)00112-3","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"7514_CR71","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.it.2004.08.010","volume":"25","author":"JD MacMicking","year":"2004","unstructured":"MacMicking JD (2004) IFN-inducible GTPases and immunity to intracellular pathogens. Trends Immunol 25(11):601\u2013609. https:\/\/doi.org\/10.1016\/j.it.2004.08.010","journal-title":"Trends Immunol"},{"issue":"5","key":"7514_CR72","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/nri3210","volume":"12","author":"JD MacMicking","year":"2012","unstructured":"MacMicking JD (2012) Interferon-inducible effector mechanisms in cell-autonomous immunity. Nat Rev Immunol 12(5):367\u2013382. https:\/\/doi.org\/10.1038\/nri3210","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"7514_CR73","doi-asserted-by":"publisher","first-page":"4933","DOI":"10.1128\/IAI.72.9.4933-4939.2004","volume":"72","author":"HM Martin","year":"2004","unstructured":"Martin HM, Hancock JT, Salisbury V, Harrison R (2004) Role of xanthine oxidoreductase as an antimicrobial agent. Infect Immun 72(9):4933\u20134939. https:\/\/doi.org\/10.1128\/IAI.72.9.4933-4939.2004","journal-title":"Infect Immun"},{"issue":"35","key":"7514_CR74","doi-asserted-by":"publisher","first-page":"17480","DOI":"10.1073\/pnas.1904637116","volume":"116","author":"SK Matta","year":"2019","unstructured":"Matta SK et al (2019) Toxoplasma gondii effector TgIST blocks type I interferon signaling to promote infection. Proc Natl Acad Sci U S A 116(35):17480\u201317491. https:\/\/doi.org\/10.1073\/pnas.1904637116","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7514_CR75","doi-asserted-by":"publisher","unstructured":"Matta SK, Patten K, Wang Q, Kim BH, MacMicking JD, Sibley LD (2018) NADPH oxidase and guanylate binding protein 5 restrict survival of avirulent type III strains of Toxoplasma gondii in naive macrophages. mBio 9(4) https:\/\/doi.org\/10.1128\/mBio.01393-18","DOI":"10.1128\/mBio.01393-18"},{"issue":"2","key":"7514_CR76","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/cmi.12546","volume":"18","author":"E Meunier","year":"2016","unstructured":"Meunier E, Broz P (2016) Interferon-inducible GTPases in cell autonomous and innate immunity. Cell Microbiol 18(2):168\u2013180. https:\/\/doi.org\/10.1111\/cmi.12546","journal-title":"Cell Microbiol"},{"issue":"5","key":"7514_CR77","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1128\/IAI.72.5.2872-2878.2004","volume":"72","author":"BH Miller","year":"2004","unstructured":"Miller BH et al (2004) Mycobacteria inhibit nitric oxide synthase recruitment to phagosomes during macrophage infection. Infect Immun 72(5):2872\u20132878","journal-title":"Infect Immun"},{"issue":"9","key":"7514_CR78","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.4049\/jimmunol.159.9.4452","volume":"159","author":"DG Mordue","year":"1997","unstructured":"Mordue DG, Sibley LD (1997) Intracellular fate of vacuoles containing Toxoplasma gondii is determined at the time of formation and depends on the mechanism of entry. J Immunol 159(9):4452\u20134459","journal-title":"J Immunol"},{"issue":"6","key":"7514_CR79","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1189\/jlb.0403164","volume":"74","author":"DG Mordue","year":"2003","unstructured":"Mordue DG, Sibley LD (2003) A novel population of Gr-1+-activated macrophages induced during acute toxoplasmosis. J Leukoc Biol 74(6):1015\u20131025. https:\/\/doi.org\/10.1189\/jlb.0403164","journal-title":"J Leukoc Biol"},{"issue":"12","key":"7514_CR80","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1084\/jem.190.12.1783","volume":"190","author":"DG Mordue","year":"1999","unstructured":"Mordue DG, Desai N, Dustin M, Sibley LD (1999) Invasion by Toxoplasma gondii establishes a moving junction that selectively excludes host cell plasma membrane proteins on the basis of their membrane anchoring. J Exp Med 190(12):1783\u20131792","journal-title":"J Exp Med"},{"issue":"2","key":"7514_CR81","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1006\/expr.1999.4412","volume":"92","author":"DG Mordue","year":"1999","unstructured":"Mordue DG, Hakansson S, Niesman I, Sibley LD (1999) Toxoplasma gondii resides in a vacuole that avoids fusion with host cell endocytic and exocytic vesicular trafficking pathways. Exp Parasitol 92(2):87\u201399","journal-title":"Exp Parasitol"},{"issue":"Pt 6","key":"7514_CR82","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1242\/jcs.108.6.2457","volume":"108","author":"JH Morisaki","year":"1995","unstructured":"Morisaki JH, Heuser JE, Sibley LD (1995) Invasion of Toxoplasma gondii occurs by active penetration of the host cell. J Cell Sci 108(Pt 6):2457\u20132464","journal-title":"J Cell Sci"},{"issue":"3","key":"7514_CR83","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.cell.2015.12.032","volume":"164","author":"S Mostafavi","year":"2016","unstructured":"Mostafavi S et al (2016) Parsing the interferon transcriptional network and its disease associations. Cell 164(3):564\u2013578. https:\/\/doi.org\/10.1016\/j.cell.2015.12.032","journal-title":"Cell"},{"issue":"4","key":"7514_CR84","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1084\/jem.189.4.741","volume":"189","author":"HW Murray","year":"1999","unstructured":"Murray HW, Nathan CF (1999) Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani. J Exp Med 189(4):741\u2013746. https:\/\/doi.org\/10.1084\/jem.189.4.741","journal-title":"J Exp Med"},{"issue":"3","key":"7514_CR85","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.4049\/jimmunol.134.3.1982","volume":"134","author":"HW Murray","year":"1985","unstructured":"Murray HW, Rubin BY, Carriero SM, Harris AM, Jaffee EA (1985) Human mononuclear phagocyte antiprotozoal mechanisms: oxygen-dependent vs oxygen-independent activity against intracellular Toxoplasma gondii. J Immunol 134(3):1982\u20131988","journal-title":"J Immunol"},{"issue":"5","key":"7514_CR86","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.biochi.2010.02.009","volume":"92","author":"I Najjar","year":"2010","unstructured":"Najjar I, Fagard R (2010) STAT1 and pathogens, not a friendly relationship. Biochimie 92(5):425\u2013444. https:\/\/doi.org\/10.1016\/j.biochi.2010.02.009","journal-title":"Biochimie"},{"issue":"6","key":"7514_CR87","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.cell.2010.03.008","volume":"140","author":"C Nathan","year":"2010","unstructured":"Nathan C, Ding A (2010) SnapShot: reactive oxygen intermediates (ROI). Cell 140(6):951-951 e2. https:\/\/doi.org\/10.1016\/j.cell.2010.03.008","journal-title":"Cell"},{"issue":"16","key":"7514_CR88","doi-asserted-by":"publisher","first-page":"8841","DOI":"10.1073\/pnas.97.16.8841","volume":"97","author":"C Nathan","year":"2000","unstructured":"Nathan C, Shiloh MU (2000) Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc Natl Acad Sci USA 97(16):8841\u20138848","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"7514_CR89","doi-asserted-by":"publisher","first-page":"e1002784","DOI":"10.1371\/journal.ppat.1002784","volume":"8","author":"W Niedelman","year":"2012","unstructured":"Niedelman W et al (2012) The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response. PLoS Pathog 8(6):e1002784. https:\/\/doi.org\/10.1371\/journal.ppat.1002784","journal-title":"PLoS Pathog"},{"issue":"12","key":"7514_CR90","doi-asserted-by":"publisher","first-page":"4341","DOI":"10.1128\/IAI.00416-13","volume":"81","author":"W Niedelman","year":"2013","unstructured":"Niedelman W, Sprokholt JK, Clough B, Frickel EM, Saeij JP (2013) Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replication. Infect Immun 81(12):4341\u20134349. https:\/\/doi.org\/10.1128\/IAI.00416-13","journal-title":"Infect Immun"},{"issue":"12","key":"7514_CR91","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.pt.2015.08.001","volume":"31","author":"R Olekhnovitch","year":"2015","unstructured":"Olekhnovitch R, Bousso P (2015) Induction, propagation, and activity of host nitric oxide: lessons from Leishmania infection. Trends Parasitol 31(12):653\u2013664. https:\/\/doi.org\/10.1016\/j.pt.2015.08.001","journal-title":"Trends Parasitol"},{"issue":"4","key":"7514_CR92","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1172\/JCI72058","volume":"124","author":"R Olekhnovitch","year":"2014","unstructured":"Olekhnovitch R, Ryffel B, Muller AJ, Bousso P (2014) Collective nitric oxide production provides tissue-wide immunity during Leishmania infection. J Clin Invest 124(4):1711\u20131722. https:\/\/doi.org\/10.1172\/JCI72058","journal-title":"J Clin Invest"},{"issue":"1","key":"7514_CR93","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.chom.2016.06.006","volume":"20","author":"P Olias","year":"2016","unstructured":"Olias P, Etheridge RD, Zhang Y, Holtzman MJ, Sibley LD (2016) Toxoplasma effector recruits the Mi-2\/NuRD complex to repress STAT1 transcription and block IFN-gamma-dependent gene expression. Cell Host Microbe 20(1):72\u201382. https:\/\/doi.org\/10.1016\/j.chom.2016.06.006","journal-title":"Cell Host Microbe"},{"issue":"7","key":"7514_CR94","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1172\/JCI58525","volume":"122","author":"CN Paiva","year":"2012","unstructured":"Paiva CN et al (2012) Oxidative stress fuels Trypanosoma cruzi infection in mice. J Clin Invest 122(7):2531\u20132542. https:\/\/doi.org\/10.1172\/JCI58525","journal-title":"J Clin Invest"},{"issue":"4","key":"7514_CR95","doi-asserted-by":"publisher","first-page":"e1006928","DOI":"10.1371\/journal.ppat.1006928","volume":"14","author":"CN Paiva","year":"2018","unstructured":"Paiva CN, Medei E, Bozza MT (2018) ROS and Trypanosoma cruzi: fuel to infection, poison to the heart. PLoS Pathog 14(4):e1006928. https:\/\/doi.org\/10.1371\/journal.ppat.1006928","journal-title":"PLoS Pathog"},{"issue":"1","key":"7514_CR96","doi-asserted-by":"publisher","first-page":"a016246","DOI":"10.1101\/cshperspect.a016246","volume":"7","author":"S Pandey","year":"2014","unstructured":"Pandey S, Kawai T, Akira S (2014) Microbial sensing by Toll-like receptors and intracellular nucleic acid sensors. Cold Spring Harb Perspect Biol 7(1):a016246. https:\/\/doi.org\/10.1101\/cshperspect.a016246","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"2","key":"7514_CR97","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1093\/infdis\/171.2.516","volume":"171","author":"PK Peterson","year":"1995","unstructured":"Peterson PK, Gekker G, Hu S, Chao CC (1995) Human astrocytes inhibit intracellular multiplication of Toxoplasma gondii by a nitric oxide-mediated mechanism. J Infect Dis 171(2):516\u2013518","journal-title":"J Infect Dis"},{"issue":"6133","key":"7514_CR98","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1126\/science.1233028","volume":"340","author":"F Randow","year":"2013","unstructured":"Randow F, MacMicking JD, James LC (2013) Cellular self-defense: how cell-autonomous immunity protects against pathogens. Science 340(6133):701\u2013706. https:\/\/doi.org\/10.1126\/science.1233028","journal-title":"Science"},{"issue":"3","key":"7514_CR99","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1086\/315330","volume":"181","author":"M Ray","year":"2000","unstructured":"Ray M, Gam AA, Boykins RA, Kenney RT (2000) Inhibition of interferon-gamma signaling by Leishmania donovani. J Infect Dis 181(3):1121\u20131128. https:\/\/doi.org\/10.1086\/315330","journal-title":"J Infect Dis"},{"issue":"1","key":"7514_CR100","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.chom.2011.06.004","volume":"10","author":"AR Richardson","year":"2011","unstructured":"Richardson AR et al (2011) Multiple targets of nitric oxide in the tricarboxylic acid cycle of Salmonella enterica serovar typhimurium. Cell Host Microbe 10(1):33\u201343. https:\/\/doi.org\/10.1016\/j.chom.2011.06.004","journal-title":"Cell Host Microbe"},{"key":"7514_CR101","doi-asserted-by":"publisher","unstructured":"Rinkenberger N, Abrams ME, Matta SK, Schoggins JW, Alto NM, Sibley LD (2021) Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection. Elife 10https:\/\/doi.org\/10.7554\/eLife.73137","DOI":"10.7554\/eLife.73137"},{"issue":"D1","key":"7514_CR102","doi-asserted-by":"publisher","first-page":"D1040","DOI":"10.1093\/nar\/gks1215","volume":"41","author":"I Rusinova","year":"2013","unstructured":"Rusinova I et al (2013) INTERFEROME v2.0: an updated database of annotated interferon-regulated genes. Nucleic acids res 41(D1):D1040-6","journal-title":"Nucleic acids res"},{"issue":"5806","key":"7514_CR103","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1126\/science.1133690","volume":"314","author":"JP Saeij","year":"2006","unstructured":"Saeij JP et al (2006) Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science 314(5806):1780\u20131783. https:\/\/doi.org\/10.1126\/science.1133690","journal-title":"Science"},{"issue":"1","key":"7514_CR104","doi-asserted-by":"publisher","first-page":"3276","DOI":"10.1038\/s41467-020-16889-z","volume":"11","author":"JC Santos","year":"2020","unstructured":"Santos JC et al (2020) Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria. Nat Commun 11(1):3276. https:\/\/doi.org\/10.1038\/s41467-020-16889-z","journal-title":"Nat Commun"},{"issue":"6","key":"7514_CR105","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s12275-018-7545-1","volume":"56","author":"D Sarr","year":"2018","unstructured":"Sarr D, Toth E, Gingerich A, Rada B (2018) Antimicrobial actions of dual oxidases and lactoperoxidase. J Microbiol 56(6):373\u2013386. https:\/\/doi.org\/10.1007\/s12275-018-7545-1","journal-title":"J Microbiol"},{"key":"7514_CR106","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","volume":"32","author":"WM Schneider","year":"2014","unstructured":"Schneider WM, Chevillotte MD, Rice CM (2014) Interferon-stimulated genes: a complex web of host defenses. Annu Rev Immunol 32:513\u2013545. https:\/\/doi.org\/10.1146\/annurev-immunol-032713-120231","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"7514_CR107","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1146\/annurev-virology-092818-015756","volume":"6","author":"JW Schoggins","year":"2019","unstructured":"Schoggins JW (2019) Interferon-stimulated genes: what do they all do? Annu Rev Virol 6(1):567\u2013584. https:\/\/doi.org\/10.1146\/annurev-virology-092818-015756","journal-title":"Annu Rev Virol"},{"issue":"4","key":"7514_CR108","doi-asserted-by":"publisher","first-page":"e1003320","DOI":"10.1371\/journal.ppat.1003320","volume":"9","author":"EM Selleck","year":"2013","unstructured":"Selleck EM et al (2013) Guanylate-binding Protein 1 (Gbp1) Contributes to cell-autonomous Immunity against Toxoplasma gondii. PLoS Pathog 9(4):e1003320. https:\/\/doi.org\/10.1371\/journal.ppat.1003320","journal-title":"PLoS Pathog"},{"issue":"5","key":"7514_CR109","doi-asserted-by":"publisher","first-page":"e01157","DOI":"10.1128\/mBio.01157-15","volume":"6","author":"EM Selleck","year":"2015","unstructured":"Selleck EM et al (2015) A noncanonical autophagy pathway restricts Toxoplasma gondii growth in a strain-specific manner in IFN-gamma-activated human cells. mBio 6(5):e01157-15. https:\/\/doi.org\/10.1128\/mBio.01157-15","journal-title":"mBio"},{"issue":"5","key":"7514_CR110","doi-asserted-by":"publisher","first-page":"e1008470","DOI":"10.1371\/journal.ppat.1008470","volume":"16","author":"E Shekhova","year":"2020","unstructured":"Shekhova E (2020) Mitochondrial reactive oxygen species as major effectors of antimicrobial immunity. PLoS Pathog 16(5):e1008470. https:\/\/doi.org\/10.1371\/journal.ppat.1008470","journal-title":"PLoS Pathog"},{"issue":"7","key":"7514_CR111","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.4049\/jimmunol.147.7.2340","volume":"147","author":"LD Sibley","year":"1991","unstructured":"Sibley LD, Adams LB, Fukutomi Y, Krahenbuhl JL (1991) Tumor necrosis factor-alpha triggers antitoxoplasmal activity of IFN-gamma primed macrophages. J Immunol 147(7):2340\u20132345","journal-title":"J Immunol"},{"issue":"10","key":"7514_CR112","doi-asserted-by":"publisher","first-page":"e110512","DOI":"10.1371\/journal.pone.0110512","volume":"9","author":"P Stahl","year":"2014","unstructured":"Stahl P, Ruppert V, Schwarz RT, Meyer T (2014) Trypanosoma cruzi evades the protective role of interferon-gamma-signaling in parasite-infected cells. PLoS ONE 9(10):e110512. https:\/\/doi.org\/10.1371\/journal.pone.0110512","journal-title":"PLoS ONE"},{"issue":"12","key":"7514_CR113","doi-asserted-by":"publisher","first-page":"e1000576","DOI":"10.1371\/journal.pbio.1000576","volume":"8","author":"T Steinfeldt","year":"2010","unstructured":"Steinfeldt T et al (2010) Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii. PLoS Biol 8(12):e1000576. https:\/\/doi.org\/10.1371\/journal.pbio.1000576","journal-title":"PLoS Biol"},{"issue":"9","key":"7514_CR114","doi-asserted-by":"publisher","first-page":"e45440","DOI":"10.1371\/journal.pone.0045440","volume":"7","author":"AC Takacs","year":"2012","unstructured":"Takacs AC, Swierzy IJ, Luder CG (2012) Interferon-gamma restricts Toxoplasma gondii development in murine skeletal muscle cells via nitric oxide production and immunity-related GTPases. PLoS ONE 7(9):e45440. https:\/\/doi.org\/10.1371\/journal.pone.0045440","journal-title":"PLoS ONE"},{"issue":"7","key":"7514_CR115","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/s0092-8674(05)80061-3","volume":"71","author":"I Tardieux","year":"1992","unstructured":"Tardieux I et al (1992) Lysosome recruitment and fusion are early events required for trypanosome invasion of mammalian cells. Cell 71(7):1117\u20131130. https:\/\/doi.org\/10.1016\/s0092-8674(05)80061-3","journal-title":"Cell"},{"issue":"5806","key":"7514_CR116","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1126\/science.1133643","volume":"314","author":"S Taylor","year":"2006","unstructured":"Taylor S et al (2006) A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii. Science 314(5806):1776\u20131780. https:\/\/doi.org\/10.1126\/science.1133643","journal-title":"Science"},{"issue":"1","key":"7514_CR117","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1152\/physrev.00036.2017","volume":"99","author":"J Tejero","year":"2019","unstructured":"Tejero J, Shiva S, Gladwin MT (2019) Sources of vascular nitric oxide and reactive oxygen species and their regulation. Physiol Rev 99(1):311\u2013379. https:\/\/doi.org\/10.1152\/physrev.00036.2017","journal-title":"Physiol Rev"},{"key":"7514_CR118","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.imlet.2017.08.016","volume":"192","author":"DC Thomas","year":"2017","unstructured":"Thomas DC (2017) The phagocyte respiratory burst: historical perspectives and recent advances. Immunol Lett 192:88\u201396. https:\/\/doi.org\/10.1016\/j.imlet.2017.08.016","journal-title":"Immunol Lett"},{"issue":"20","key":"7514_CR119","doi-asserted-by":"publisher","first-page":"14457","DOI":"10.1016\/S0021-9258(17)36645-0","volume":"269","author":"SR Thomas","year":"1994","unstructured":"Thomas SR, Mohr D, Stocker R (1994) Nitric oxide inhibits indoleamine 2,3-dioxygenase activity in interferon-gamma primed mononuclear phagocytes. J Biol Chem 269(20):14457\u201314464","journal-title":"J Biol Chem"},{"issue":"33","key":"7514_CR120","doi-asserted-by":"publisher","first-page":"23778","DOI":"10.1074\/jbc.M700669200","volume":"282","author":"SR Thomas","year":"2007","unstructured":"Thomas SR et al (2007) Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide. J Biol Chem 282(33):23778\u201323787. https:\/\/doi.org\/10.1074\/jbc.M700669200","journal-title":"J Biol Chem"},{"issue":"10","key":"7514_CR121","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.4049\/jimmunol.146.10.3626","volume":"146","author":"F Torrico","year":"1991","unstructured":"Torrico F, Heremans H, Rivera MT, Van Marck E, Billiau A, Carlier Y (1991) Endogenous IFN-gamma is required for resistance to acute Trypanosoma cruzi infection in mice. J Immunol 146(10):3626\u20133632","journal-title":"J Immunol"},{"issue":"3","key":"7514_CR122","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1084\/jem.20182031","volume":"216","author":"K Tretina","year":"2019","unstructured":"Tretina K, Park ES, Maminska A, MacMicking JD (2019) Interferon-induced guanylate-binding proteins: guardians of host defense in health and disease. J Exp Med 216(3):482\u2013500. https:\/\/doi.org\/10.1084\/jem.20182031","journal-title":"J Exp Med"},{"issue":"8","key":"7514_CR123","doi-asserted-by":"publisher","first-page":"e9903","DOI":"10.15252\/emmm.201809903","volume":"11","author":"MC Ty","year":"2019","unstructured":"Ty MC et al (2019) Malaria inflammation by xanthine oxidase-produced reactive oxygen species. EMBO Mol Med 11(8):e9903. https:\/\/doi.org\/10.15252\/emmm.201809903","journal-title":"EMBO Mol Med"},{"key":"7514_CR124","doi-asserted-by":"publisher","unstructured":"Vainshtein A, Grumati P (2020) Selective autophagy by close encounters of the ubiquitin kind. Cells 9(11) https:\/\/doi.org\/10.3390\/cells9112349","DOI":"10.3390\/cells9112349"},{"issue":"6053","key":"7514_CR125","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1126\/science.1209791","volume":"334","author":"S Vaishnava","year":"2011","unstructured":"Vaishnava S et al (2011) The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science 334(6053):255\u2013258. https:\/\/doi.org\/10.1126\/science.1209791","journal-title":"Science"},{"issue":"2","key":"7514_CR126","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1084\/jem.151.2.328","volume":"151","author":"CB Wilson","year":"1980","unstructured":"Wilson CB, Tsai V, Remington JS (1980) Failure to trigger the oxidative metabolic burst by normal macrophages: possible mechanism for survival of intracellular pathogens. J Exp Med 151(2):328\u2013346","journal-title":"J Exp Med"},{"issue":"6","key":"7514_CR127","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1084\/jem.158.6.2016","volume":"158","author":"SD Wright","year":"1983","unstructured":"Wright SD, Silverstein SC (1983) Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes. J Exp Med 158(6):2016\u20132023. https:\/\/doi.org\/10.1084\/jem.158.6.2016","journal-title":"J Exp Med"},{"issue":"2","key":"7514_CR128","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.immuni.2012.06.009","volume":"37","author":"M Yamamoto","year":"2012","unstructured":"Yamamoto M et al (2012) A Cluster of interferon-gamma-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii. Immunity 37(2):302\u2013313. https:\/\/doi.org\/10.1016\/j.immuni.2012.06.009","journal-title":"Immunity"},{"issue":"5","key":"7514_CR129","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.chom.2008.10.003","volume":"4","author":"Z Zhao","year":"2008","unstructured":"Zhao Z et al (2008) Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe 4(5):458\u2013469. https:\/\/doi.org\/10.1016\/j.chom.2008.10.003","journal-title":"Cell Host Microbe"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-022-07514-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-022-07514-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-022-07514-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T09:36:49Z","timestamp":1675330609000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-022-07514-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,18]]},"references-count":129,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["7514"],"URL":"https:\/\/doi.org\/10.1007\/s00436-022-07514-7","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,18]]},"assertion":[{"value":"2 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}