{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:02:41Z","timestamp":1789704161941,"version":"4.0.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s00436-022-07532-5","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T04:05:36Z","timestamp":1652155536000},"page":"2093-2109","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["In silico screening, molecular dynamic simulations, and in vitro activity of selected natural compounds as an inhibitor of Leishmania donovani 3-mercaptopyruvate sulfurtransferase"],"prefix":"10.1007","volume":"121","author":[{"given":"Vishnu","family":"Kant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan","family":"kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Ranjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debabrata","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5145-0384","authenticated-orcid":false,"given":"Saravanan","family":"Vijayakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"issue":"48","key":"7532_CR1","doi-asserted-by":"publisher","first-page":"48219","DOI":"10.1074\/jbc.M307187200","volume":"278","author":"MS Alphey","year":"2003","unstructured":"Alphey MS, Williams RA, Mottram JC, Coombs GH, Hunter WN (2003) The crystal structure of Leishmania major 3-mercaptopyruvate sulfurtransferase: a three-domain architecture with a serine protease-like triad at the active site. J Biol Chem 278(48):48219\u201348227","journal-title":"J Biol Chem"},{"issue":"11","key":"7532_CR2","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1128\/EC.05118-11","volume":"10","author":"A Ambit","year":"2011","unstructured":"Ambit A, Woods KL, Cull B, Coombs GH, Mottram JC (2011) Morphological events during the cell cycle of Leishmania major. Eukaryot Cell 10(11):1429\u20131438","journal-title":"Eukaryot Cell"},{"key":"7532_CR3","doi-asserted-by":"publisher","first-page":"106146","DOI":"10.1016\/j.actatropica.2021.106146","volume":"224","author":"CF Ara\u00fajo","year":"2021","unstructured":"Ara\u00fajo CF et al (2021) New World Leishmania spp. infection in people living with HIV: concerns about relapses and secondary prophylaxis. Acta Trop 224:106146. https:\/\/doi.org\/10.1016\/j.actatropica.2021.106146","journal-title":"Acta Trop"},{"key":"7532_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.12688\/f1000research.11120.1","volume":"6","author":"R Arenas","year":"2017","unstructured":"Arenas R, Torres-Guerrero E, Quintanilla-Cedillo MR, Ruiz-Esmenjaud J (2017) Leishmaniasis: a review. F1000Research 6:1\u201315. https:\/\/doi.org\/10.12688\/f1000research.11120.1","journal-title":"F1000Research"},{"key":"7532_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pntd.0009099","volume":"15","author":"M Azim","year":"2021","unstructured":"Azim M, Khan SA, Ullah S, Ullah S, Anjum SI (2021) Therapeutic advances in the topical treatment of cutaneous leishmaniasis: a review. PLoS Negl Trop Dis 15:1\u201315. https:\/\/doi.org\/10.1371\/journal.pntd.0009099","journal-title":"PLoS Negl Trop Dis"},{"issue":"8","key":"7532_CR6","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.3390\/molecules25081924","volume":"25","author":"T Battista","year":"2020","unstructured":"Battista T, Colotti G, Ilari A, Fiorillo A (2020) Targeting trypanothione reductase, a key enzyme in the redox trypanosomatid metabolism, to develop new drugs against leishmaniasis and trypanosomiases. Molecules 25(8):1924","journal-title":"Molecules"},{"key":"7532_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fchem.2021.622286","volume":"9","author":"J Brindha","year":"2021","unstructured":"Brindha J, Balamurali MM, Chanda K (2021) An overview on the therapeutics of neglected infectious diseases\u2014leishmaniasis and Chagas diseases. Front Chem 9:1\u201319. https:\/\/doi.org\/10.3389\/fchem.2021.622286","journal-title":"Front Chem"},{"key":"7532_CR8","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1080\/14656566.2019.1609940","volume":"20","author":"J Chakravarty","year":"2019","unstructured":"Chakravarty J, Sundar S (2019) Current and emerging medications for the treatment of leishmaniasis. Expert Opin Pharmacother 20:1251\u20131265. https:\/\/doi.org\/10.1080\/14656566.2019.1609940","journal-title":"Expert Opin Pharmacother"},{"issue":"9","key":"7532_CR9","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1002\/pro.5560020916","volume":"2","author":"C Colovos","year":"1993","unstructured":"Colovos C, Yeates TO (1993) Verification of protein structures: patterns of nonbonded atomic interactions. Protein Sci 2(9):1511\u20131519","journal-title":"Protein Sci"},{"key":"7532_CR10","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.exppara.2012.01.015","volume":"130","author":"ER Da Silva","year":"2012","unstructured":"Da Silva ER, Maquiaveli CdC, Magalh\u00e3es PP (2012) The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase. Exp Parasitol 130:183\u2013188. https:\/\/doi.org\/10.1016\/j.exppara.2012.01.015","journal-title":"Exp Parasitol"},{"key":"7532_CR11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1039\/FD9929300025","volume":"93","author":"D Eisenberg","year":"1992","unstructured":"Eisenberg D, Bowie JU, L\u00fcthy R, Choe S (1992) Three-dimensional profiles for analysing protein sequence\u2013structure relationships. Faraday Discuss 93:25\u201334","journal-title":"Faraday Discuss"},{"issue":"19","key":"7532_CR12","doi-asserted-by":"publisher","first-page":"8577","DOI":"10.1063\/1.470117","volume":"103","author":"U Essmann","year":"1995","unstructured":"Essmann U, Perera L, Berkowitz ML, Darden T, Lee H, Pedersen LG (1995) A smooth particle mesh Ewald method. J Chem Phys 103(19):8577\u20138593","journal-title":"J Chem Phys"},{"key":"7532_CR13","first-page":"1","volume":"1","author":"KS Fernandes","year":"1859","unstructured":"Fernandes KS, de Souza PEN, Dorta ML (1859) Alonso A (2017) The cytotoxic activity of miltefosine against Leishmania and macrophages is associated with dynamic changes in plasma membrane proteins. Biochimica et Biophysica Acta (BBA)-Biomembranes 1:1\u20139","journal-title":"Biochimica et Biophysica Acta (BBA)-Biomembranes"},{"key":"7532_CR14","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1007\/s00726-014-1786-z","volume":"47","author":"C Gotor","year":"2015","unstructured":"Gotor C et al (2015) Hydrogen sulfide in plants from dissipation of excess sulfur to signaling molecule. Amino Acids Springer 47:2155\u20132164. https:\/\/doi.org\/10.1007\/s00726-014-1786-z","journal-title":"Amino Acids Springer"},{"issue":"12","key":"7532_CR15","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","volume":"18","author":"B Hess","year":"1997","unstructured":"Hess B, Bekker H, Berendsen HJ, Fraaije JG (1997) LINCS: a linear constraint solver for molecular simulations. J Comput Chem 18(12):1463\u20131472","journal-title":"J Comput Chem"},{"issue":"2","key":"7532_CR16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/polb.21634","volume":"47","author":"L Hong","year":"2009","unstructured":"Hong L, Lei J (2009) Scaling law for the radius of gyration of proteins and its dependence on hydrophobicity. J Polym Sci Part B Polym Phys 47(2):207\u2013214","journal-title":"J Polym Sci Part B Polym Phys"},{"key":"7532_CR17","doi-asserted-by":"publisher","first-page":"653670","DOI":"10.3389\/fcimb.2021.653670","volume":"11","author":"ECA Horacio","year":"2021","unstructured":"Horacio ECA, Hickson J, Murta SMF, Ruiz JC, Nahum LA (2021) Perspectives from systems biology to improve knowledge of Leishmania drug resistance. Front Cell Infect Microbiol 11:653670. https:\/\/doi.org\/10.3389\/fcimb.2021.653670","journal-title":"Front Cell Infect Microbiol"},{"issue":"3","key":"7532_CR18","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1007\/s11130-013-0375-8","volume":"68","author":"P Kraujalis","year":"2013","unstructured":"Kraujalis P, Venskutonis PR, Kraujalien\u0117 V, Pukalskas A (2013) Antioxidant properties and preliminary evaluation of phytochemical composition of different anatomical parts of amaranth. Plant Foods Hum Nutr 68(3):322\u2013328","journal-title":"Plant Foods Hum Nutr"},{"issue":"2","key":"7532_CR19","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"RA Laskowski","year":"1993","unstructured":"Laskowski RA, MacArthur MW, Moss DS, Thornton JM (1993) PROCHECK: a program to check the stereochemical quality of protein structures. J Appl Crystallogr 26(2):283\u2013291","journal-title":"J Appl Crystallogr"},{"issue":"10","key":"7532_CR20","doi-asserted-by":"publisher","first-page":"2778","DOI":"10.1021\/ci200227u","volume":"51","author":"RA Laskowski","year":"2011","unstructured":"Laskowski RA, Swindells MB (2011) LigPlot+: multiple ligand\u2013protein interaction diagrams for drug discovery. ACS Publications 51(10):2778\u20132786. https:\/\/doi.org\/10.1021\/ci200227u","journal-title":"ACS Publications"},{"issue":"3","key":"7532_CR21","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/trstmh\/trab012","volume":"115","author":"EA Le Rutte","year":"2021","unstructured":"Le Rutte EA, Coffeng LE, Munoz J, de Vlas SJ (2021) Modelling the impact of COVID-19-related programme interruptions on visceral leishmaniasis in India. Trans R Soc Trop Med Hyg 115(3):229\u2013235. https:\/\/doi.org\/10.1093\/trstmh\/trab012","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"7532_CR22","doi-asserted-by":"publisher","first-page":"736386","DOI":"10.1155\/2013\/736386","volume":"2013","author":"Y-C Lin","year":"2013","unstructured":"Lin Y-C, Wang C-C, Chen I-S, Jheng J-L, Li J-H, Tung C-W (2013) TIPdb: a database of anticancer, antiplatelet, and antituberculosis phytochemicals from indigenous plants in Taiwan. Sci World J 2013:736386. https:\/\/doi.org\/10.1155\/2013\/736386","journal-title":"Sci World J"},{"issue":"2","key":"7532_CR23","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.molbiopara.2010.06.004","volume":"173","author":"D Marciano","year":"2010","unstructured":"Marciano D, Santana M, Mantilla BS, Silber AM, Marino-Buslje C, Nowicki C (2010) Biochemical characterization of serine acetyltransferase and cysteine desulfhydrase from Leishmania major. Mol Biochem Parasitol 173(2):170\u2013174. https:\/\/doi.org\/10.1016\/j.molbiopara.2010.06.004","journal-title":"Mol Biochem Parasitol"},{"issue":"7","key":"7532_CR24","doi-asserted-by":"publisher","first-page":"075503","DOI":"10.1103\/PhysRevLett.90.075503","volume":"90","author":"R Marto\u0148\u00e1k","year":"2003","unstructured":"Marto\u0148\u00e1k R, Laio A, Parrinello M (2003) Predicting crystal structures: the Parrinello-Rahman method revisited. Phys Rev Lett 90(7):075503","journal-title":"Phys Rev Lett"},{"key":"7532_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pntd.0003588","volume":"9","author":"LI McCall","year":"2015","unstructured":"McCall LI et al (2015) Targeting Ergosterol Biosynthesis in Leishmania donovani: essentiality of Sterol 14alpha-demethylase. PLoS Negl Trop Dis 9:1\u201317. https:\/\/doi.org\/10.1371\/journal.pntd.0003588","journal-title":"PLoS Negl Trop Dis"},{"issue":"Suppl 1","key":"7532_CR26","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1002\/prot.25049","volume":"84","author":"V Modi","year":"2016","unstructured":"Modi V, Xu Q, Adhikari S, Dunbrack RL Jr (2016) Assessment of template-based modeling of protein structure in CASP11. Proteins 84(Suppl 1):200\u2013220. https:\/\/doi.org\/10.1002\/prot.25049","journal-title":"Proteins"},{"issue":"36","key":"7532_CR27","doi-asserted-by":"publisher","first-page":"33588","DOI":"10.1074\/jbc.M104067200","volume":"276","author":"EG Mueller","year":"2001","unstructured":"Mueller EG, Palenchar PM, Buck CJ (2001) The role of the cysteine residues of ThiI in the generation of 4-thiouridine in tRNA. J Biol Chem 276(36):33588\u201333595","journal-title":"J Biol Chem"},{"issue":"17","key":"7532_CR28","doi-asserted-by":"publisher","first-page":"5621","DOI":"10.1046\/j.1432-1327.2000.01633.x","volume":"267","author":"T Nakamura","year":"2000","unstructured":"Nakamura T, Yamaguchi Y, Sano H (2000) Plant mercaptopyruvate sulfurtransferases: molecular cloning, subcellular localization and enzymatic activities. Eur J Biochem 267(17):5621\u20135630","journal-title":"Eur J Biochem"},{"issue":"12","key":"7532_CR29","doi-asserted-by":"publisher","first-page":"8283","DOI":"10.1074\/jbc.275.12.8283","volume":"275","author":"PM Palenchar","year":"2000","unstructured":"Palenchar PM, Buck CJ, Cheng H, Larson TJ, Mueller EG (2000) Evidence that ThiI, an enzyme shared between thiamin and 4-thiouridine biosynthesis, may be a sulfurtransferase that proceeds through a persulfide intermediate. J Biol Chem 275(12):8283\u20138286","journal-title":"J Biol Chem"},{"issue":"7","key":"7532_CR30","doi-asserted-by":"publisher","first-page":"eaaw1480","DOI":"10.1126\/sciadv.aaw1480","volume":"5","author":"A Pellerin","year":"2019","unstructured":"Pellerin A et al (2019) Large sulfur isotope fractionation by bacterial sulfide oxidation. Sci Adv 5(7):eaaw1480","journal-title":"Sci Adv"},{"issue":"12","key":"7532_CR31","doi-asserted-by":"publisher","first-page":"e0006052","DOI":"10.1371\/journal.pntd.0006052","volume":"11","author":"A Ponte-Sucre","year":"2017","unstructured":"Ponte-Sucre A et al (2017) Drug resistance and treatment failure in leishmaniasis: a 21st century challenge. PLoS Negl Trop Dis 11(12):e0006052","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"7532_CR32","doi-asserted-by":"publisher","first-page":"e0183583","DOI":"10.1371\/journal.pone.0183583","volume":"12","author":"BV Purse","year":"2017","unstructured":"Purse BV et al (2017) How will climate change pathways and mitigation options alter incidence of vector-borne diseases? A framework for leishmaniasis in South and Meso-America. PLoS ONE 12(10):e0183583","journal-title":"PLoS ONE"},{"issue":"11","key":"7532_CR33","doi-asserted-by":"publisher","first-page":"9159","DOI":"10.1007\/s11033-020-05936-z","volume":"47","author":"R Ranjan","year":"2020","unstructured":"Ranjan R, Das P, Vijayakumar S (2020) Differentially modulated proteins associated with Leishmaniasis\u2014a systematic review of in-vivo and in-vitro studies. Mol Biol Rep 47(11):9159\u20139178","journal-title":"Mol Biol Rep"},{"issue":"6","key":"7532_CR34","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1080\/17460441.2020.1743674","volume":"15","author":"JQ Reimao","year":"2020","unstructured":"Reimao JQ, Pita Pedro DP, Coelho AC (2020) The preclinical discovery and development of oral miltefosine for the treatment of visceral leishmaniasis: a case history. Expert Opin Drug Discov 15(6):647\u2013658","journal-title":"Expert Opin Drug Discov"},{"issue":"11","key":"7532_CR35","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1002\/jcc.1078","volume":"22","author":"LD Schuler","year":"2001","unstructured":"Schuler LD, Daura X, Van Gunsteren WF (2001) An improved GROMOS96 force field for aliphatic hydrocarbons in the condensed phase. J Comput Chem 22(11):1205\u20131218","journal-title":"J Comput Chem"},{"key":"7532_CR36","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.redox.2017.03.004","volume":"12","author":"K Singh","year":"2017","unstructured":"Singh K et al (2017) Deciphering the interplay between cysteine synthase and thiol cascade proteins in modulating Amphotericin B resistance and survival of Leishmania donovani under oxidative stress. Redox Biol 12:350\u2013366. https:\/\/doi.org\/10.1016\/j.redox.2017.03.004","journal-title":"Redox Biol"},{"key":"7532_CR37","doi-asserted-by":"publisher","first-page":"810","DOI":"10.5455\/2320-6012.ijrms20140808","volume":"2","author":"P Singh","year":"2014","unstructured":"Singh P, Kumar M (2014) Current treatment of visceral leishmaniasis (Kala-azar): an overview. Int J Res Med Sci 2:810. https:\/\/doi.org\/10.5455\/2320-6012.ijrms20140808","journal-title":"Int J Res Med Sci"},{"issue":"1","key":"7532_CR38","doi-asserted-by":"publisher","first-page":"BSR20203857","DOI":"10.1042\/BSR20203857","volume":"41","author":"S Tabrez","year":"2021","unstructured":"Tabrez S et al (2021) Cynaroside inhibits Leishmania donovani UDP-galactopyranose mutase and induces reactive oxygen species to exert antileishmanial response. Bioscience reports 41(1):BSR20203857","journal-title":"Bioscience reports"},{"issue":"18","key":"7532_CR39","doi-asserted-by":"publisher","first-page":"2000159","DOI":"10.2807\/1560-7917.ES.2021.26.18.2000159","volume":"26","author":"M Tzani","year":"2021","unstructured":"Tzani M, Barrasa A, Vakali A, Georgakopoulou T, Mellou K, Pervanidou D (2021) Surveillance data for human leishmaniasis indicate the need for a sustainable action plan for its management and control, Greece, 2004 to 2018. Eurosurveillance 26(18):2000159","journal-title":"Eurosurveillance"},{"issue":"3","key":"7532_CR40","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/BF00355047","volume":"10","author":"DM Van Aalten","year":"1996","unstructured":"Van Aalten DM, Bywater R, Findlay JB, Hendlich M, Hooft RW, Vriend G (1996) PRODRG, a program for generating molecular topologies and unique molecular descriptors from coordinates of small molecules. J Comput Aided Mol Des 10(3):255\u2013262","journal-title":"J Comput Aided Mol Des"},{"issue":"9","key":"7532_CR41","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1093\/bioinformatics\/bty816","volume":"35","author":"A Vangone","year":"2019","unstructured":"Vangone A et al (2019) Large-scale prediction of binding affinity in protein\u2013small ligand complexes: The PRODIGY-LIG web server. Bioinformatics 35(9):1585\u20131587","journal-title":"Bioinformatics"},{"issue":"4","key":"7532_CR42","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/prot.10465","volume":"52","author":"ML Verdonk","year":"2003","unstructured":"Verdonk ML, Cole JC, Hartshorn MJ, Murray CW, Taylor RD (2003) Improved protein\u2013ligand docking using GOLD. Proteins Struct Funct Bioinf 52(4):609\u2013623","journal-title":"Proteins Struct Funct Bioinf"},{"issue":"1","key":"7532_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exppara.2006.10.007","volume":"116","author":"NK Verma","year":"2007","unstructured":"Verma NK, Singh G, Dey CS (2007) Miltefosine induces apoptosis in arsenite-resistant Leishmania donovani promastigotes through mitochondrial dysfunction. Exp Parasitol 116(1):1\u201313","journal-title":"Exp Parasitol"},{"issue":"9","key":"7532_CR44","doi-asserted-by":"publisher","first-page":"3855","DOI":"10.1128\/AAC.00548-09","volume":"53","author":"M Vermeersch","year":"2009","unstructured":"Vermeersch M, da Luz RI, Tot\u00e9 K, Timmermans J-P, Cos P, Maes L (2009) In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differences. Antimicrob Agents Chemother 53(9):3855\u20133859","journal-title":"Antimicrob Agents Chemother"},{"key":"7532_CR45","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.actatropica.2018.02.010","volume":"181","author":"S Vijayakumar","year":"2018","unstructured":"Vijayakumar S, Das P (2018) Recent progress in drug targets and inhibitors towards combating leishmaniasis. Acta Trop 181:95\u2013104. https:\/\/doi.org\/10.1016\/j.actatropica.2018.02.010","journal-title":"Acta Trop"},{"key":"7532_CR46","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.actatropica.2018.12.022","volume":"190","author":"S Vijayakumar","year":"2019","unstructured":"Vijayakumar S, Kant V, Das P (2019) LeishInDB: a web-accessible resource for small molecule inhibitors against Leishmania sp. Acta Trop 190:375\u2013379","journal-title":"Acta Trop"},{"issue":"1","key":"7532_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cpbi.3","volume":"54","author":"B Webb","year":"2016","unstructured":"Webb B, Sali A (2016) Comparative protein structure modeling using MODELLER. Curr Protoc Bioinforma 54(1):1\u20135","journal-title":"Curr Protoc Bioinforma"},{"issue":"3","key":"7532_CR48","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1074\/jbc.M209395200","volume":"278","author":"RA Williams","year":"2003","unstructured":"Williams RA, Kelly SM, Mottram JC, Coombs GH (2003) 3-Mercaptopyruvate sulfurtransferase of Leishmania contains an unusual C-terminal extension and is involved in thioredoxin and antioxidant metabolism. J Biol Chem 278(3):1480\u20131486","journal-title":"J Biol Chem"},{"issue":"3","key":"7532_CR49","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1042\/BJ20082441","volume":"420","author":"RA Williams","year":"2009","unstructured":"Williams RA, Westrop GD, Coombs GH (2009) Two pathways for cysteine biosynthesis in Leishmania major. Biochemical Journal 420(3):451\u2013462","journal-title":"Biochemical Journal"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-022-07532-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-022-07532-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-022-07532-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T23:41:20Z","timestamp":1744155680000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-022-07532-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,10]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["7532"],"URL":"https:\/\/doi.org\/10.1007\/s00436-022-07532-5","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,10]]},"assertion":[{"value":"15 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}