{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T06:46:24Z","timestamp":1763621184203,"version":"3.37.3"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009827","name":"Alexandria University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009827","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>MicroRNAs (miRNAs) play regulatory roles in several diseases. In schistosomiasis, the main pathological changes are caused by the granulomatous reaction induced by egg deposition. We aimed to study the changes in host miRNA-223 and miRNA-146b expression in relation to egg deposition and development of hepatic pathology in murine schistosomiasis mansoni. Blood and liver tissue samples were collected from non-infected mice (group I), <jats:italic>S. mansoni<\/jats:italic>\u2013infected mice at the 4th, 8th, and 12th weeks post-infection (p.i.) (groups II\u2013IV), and 4 weeks after praziquantel treatment (group V). The collected samples were processed for RNA extraction, reverse transcription, and real-time PCR analysis of miRNA-223 and miRNA-146b. miRNAs\u2019 relative expression was estimated by the \u0394\u0394C<jats:sub>t<\/jats:sub> method. Liver tissue samples were examined for egg count estimation and histopathological evaluation. Results revealed that miRNA-223 was significantly downregulated in liver tissues 8 and 12 weeks p.i., whereas miRNA-146b expression increased gradually with the progression of infection with a significantly higher level at week 12 p.i. compared to week 4 p.i. Serum expression levels nearly followed the same pattern as the tissue levels. The dysregulated expression of miRNAs correlated with liver egg counts and was more obvious with the demonstration of chronic granulomas, fibrous transformation, and distorted hepatic architecture 12 weeks p.i. Restoration of normal expression levels was observed 4 weeks after treatment. Collectively, these findings provide new insights for in-depth understanding of host-parasite interaction in schistosomiasis and pave a new way for monitoring the progress of hepatic pathology before and after treatment.<\/jats:p>","DOI":"10.1007\/s00436-022-07542-3","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T07:12:45Z","timestamp":1652685165000},"page":"1963-1972","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Expression of microRNA-223 and microRNA-146b in serum and liver tissue of mice infected with Schistosoma mansoni"],"prefix":"10.1007","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5152-2704","authenticated-orcid":false,"given":"Hend A","family":"El-Taweel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmine A","family":"Issa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha F","family":"Mady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada A","family":"Shehata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman A","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona M","family":"Tolba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"7542_CR1","doi-asserted-by":"publisher","first-page":"e68479","DOI":"10.1371\/journal.pone.0068479","volume":"8","author":"BJ Anthony","year":"2013","unstructured":"Anthony BJ, James KR, Gobert GN, Ramm GA, McManus DP (2013) Schistosoma japonicum eggs induce a proinflammatory, anti-fibrogenic phenotype in hepatic stellate cells. PLoS One 8:e68479","journal-title":"PLoS One"},{"key":"7542_CR2","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.exppara.2009.12.009","volume":"124","author":"BJ Anthony","year":"2010","unstructured":"Anthony BJ, Mathieson W, de Castro-Borges W, Allen JT (2010) Schistosoma mansoni: egg-induced downregulation of hepatic stellate cell activation and fibrogenesis. Exp Parasitol 124:409\u2013420","journal-title":"Exp Parasitol"},{"key":"7542_CR3","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1586\/14737159.5.2.209","volume":"5","author":"M Arya","year":"2005","unstructured":"Arya M, Shergill IS, Williamson M, Gommersall L, Arya N, Patel HRH (2005) Basic principles of real-time quantitative PCR. Expert Rev Mol Diagn 5:209\u2013219","journal-title":"Expert Rev Mol Diagn"},{"key":"7542_CR4","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s11658-018-0111-3","volume":"23","author":"R Bartoszewski","year":"2018","unstructured":"Bartoszewski R, Sikorski AF (2018) Editorial focus: entering into the non-coding RNA era. Cell Mol Biol Lett 23:45","journal-title":"Cell Mol Biol Lett"},{"key":"7542_CR5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1042\/CS20050086","volume":"09","author":"SA Bustin","year":"2005","unstructured":"Bustin SA, Mueller R (2005) Real-time reverse transcription PCR (qRT-PCR) and its potential use in clinical diagnosis. Clin Sci1 09:365\u2013379","journal-title":"Clin Sci1"},{"key":"7542_CR6","doi-asserted-by":"publisher","first-page":"e0003965","DOI":"10.1371\/journal.pntd.0003965","volume":"9","author":"P Cai","year":"2015","unstructured":"Cai P, Gobert GN, You H, Duke M, McManus DP (2015) Circulating miRNAs: potential novel biomarkers for hepatopathology progression and diagnosis of schistosomiasis japonica in two murine models. PLoS Negl Trop Dis 9:e0003965","journal-title":"PLoS Negl Trop Dis"},{"key":"7542_CR7","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.ebiom.2018.10.048","volume":"37","author":"P Cai","year":"2018","unstructured":"Cai P, Mu Y, Olveda RM, Ross AG, Olveda DU, McManus DP (2018) Circulating miRNAs as footprints for liver fibrosis grading in schistosomiasis. EBioMedicine 37:334\u2013343","journal-title":"EBioMedicine"},{"key":"7542_CR8","doi-asserted-by":"publisher","first-page":"e67037","DOI":"10.1371\/journal.pone.0067037","volume":"8","author":"P Cai","year":"2013","unstructured":"Cai P, Piao X, Liu S, Hou N, Wang H, Chen Q (2013) MicroRNA-gene expression network in murine liver during Schistosoma japonicum infection. PLoS One 8:e67037","journal-title":"PLoS One"},{"key":"7542_CR9","first-page":"328","volume":"39","author":"AW Cheever","year":"1968","unstructured":"Cheever AW (1968) Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissues. Bull World Health Organ 39:328\u2013331","journal-title":"Bull World Health Organ"},{"key":"7542_CR10","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/cr.2008.282","volume":"18","author":"X Chen","year":"2008","unstructured":"Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K et al (2008) Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18:997\u20131006","journal-title":"Cell Res"},{"key":"7542_CR11","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","volume":"383","author":"DG Colley","year":"2014","unstructured":"Colley DG, Bustinduy AL, Secor WE, King CH (2014) Human schistosomiasis. Lancet 383:2253\u20132264","journal-title":"Lancet"},{"key":"7542_CR12","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3390\/cells9020276","volume":"9","author":"CE Condrat","year":"2020","unstructured":"Condrat CE, Thompson DC, Barbu MG, Bugnar OL, Boboc A, Cretoiu D, Suciu N, Cretoiu SM, Voinea SC (2020) miRNAs as biomarkers in disease: latest findings regarding their Rrle in diagnosis and prognosis. Cells 9:276","journal-title":"Cells"},{"key":"7542_CR13","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3389\/fimmu.2017.00118","volume":"8","author":"CN Correia","year":"2017","unstructured":"Correia CN, Nalpas NC, McLoughlin KE, Browne JA, Gordon SV, MacHugh DE, Shaughnessy RG (2017) Circulating microRNAs as potential biomarkers of infectious disease. Front Immunol 8:118","journal-title":"Front Immunol"},{"key":"7542_CR14","doi-asserted-by":"publisher","first-page":"11499","DOI":"10.1073\/pnas.1219852110","volume":"110","author":"G Curtale","year":"2013","unstructured":"Curtale G, Mirolo M, Renzi TA, Rossato M, Bazzoni F, Locati M (2013) Negative regulation of Toll-like receptor 4 signaling by IL-10\u2013dependent microRNA-146b. Proc Natl Acad Sci U S A 110:11499\u201311504","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7542_CR15","volume-title":"Manson\u2019s tropical diseases","author":"A Davis","year":"2009","unstructured":"Davis A (2009) Schistosomiasis. In: Cook GC, Zumla AL (eds) Manson\u2019s tropical diseases, 22nd edn. Elsevier, London","edition":"22"},{"key":"7542_CR16","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/nbt.3947","volume":"35","author":"D de Rie","year":"2017","unstructured":"de Rie D, Abugessaisa I, Alam T, Arner E, Arner P, Ashoor H et al (2017) An integrated expression atlas of miRNAs and their promoters in human and mouse. Nat Biotechnol 35:872\u2013878","journal-title":"Nat Biotechnol"},{"key":"7542_CR17","doi-asserted-by":"publisher","first-page":"8788","DOI":"10.1002\/jcp.27537","volume":"234","author":"N Ding","year":"2019","unstructured":"Ding N, Wang Y, Dou C, Liu F, Guan G, Wei K et al (2019) Physalin D regulates macrophage M1\/M2 polarization via the STAT1\/6 pathway. J Cell Physiol 234:8788\u20138796","journal-title":"J Cell Physiol"},{"key":"7542_CR18","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1756-3305-5-9","volume":"5","author":"NM El-Lakkany","year":"2012","unstructured":"El-Lakkany NM, Hammam OA, El-Maadawy WH, Badawy AA, Ain-Shoka AA, Ebeid FA (2012) Anti-inflammatory\/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis. Parasit Vectors 5:9","journal-title":"Parasit Vectors"},{"key":"7542_CR19","doi-asserted-by":"publisher","unstructured":"Fischer AH, Jacobson KA, Rose J, Zeller R (2008) Hematoxylin and eosin staining of tissue and cell sections. CSH Protoc 2008, pdb.prot4986. https:\/\/doi.org\/10.1101\/pdb.prot4986","DOI":"10.1101\/pdb.prot4986"},{"key":"7542_CR20","first-page":"918","volume":"15","author":"S Ge","year":"2016","unstructured":"Ge S, Zhang L, Xie J, Liu F, He J, He J, Wang X, Xiang T (2016) MicroRNA-146b regulates hepatic stellate cell activation via targeting of KLF4. Ann Hepatol 15:918\u2013928","journal-title":"Ann Hepatol"},{"key":"7542_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molbiopara.2013.02.001","volume":"188","author":"H Han","year":"2013","unstructured":"Han H, Peng J, Hong Y, Zhang M, Han Y, Liu D, Fu Z, Shi Y, Xu J, Tao J, Lin J (2013) MicroRNA expression profile in different tissues of BALB\/c mice in the early phase of Schistosoma japonicum infection. Mol Biochem Parasitol 188:1\u20139","journal-title":"Mol Biochem Parasitol"},{"key":"7542_CR22","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/joim.12099","volume":"274","author":"M Haneklaus","year":"2013","unstructured":"Haneklaus M, Gerlic M, O'Neill LA, Masters SL (2013) miR-223: infection, inflammation and cancer. J Intern Med 274:215\u2013226","journal-title":"J Intern Med"},{"key":"7542_CR23","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1186\/1756-3305-6-272","volume":"6","author":"X He","year":"2013","unstructured":"He X, Sai X, Chen C, Zhang Y, Xu X, Zhang D, Pan W (2013) Host serum miR-223 is a potential new biomarker for Schistosoma japonicum infection and the response to chemotherapy. Parasit Vectors 6:272","journal-title":"Parasit Vectors"},{"key":"7542_CR24","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.ebiom.2016.10.024","volume":"13","author":"X He","year":"2016","unstructured":"He X, Tang R, Sun Y, Wang YG, Zhen KY, Zhang DM, Pan WQ (2016) MicroR-146 blocks the activation of M1 macrophage by targeting signal transducer and activator of transcription 1 in hepatic schistosomiasis. EBioMedicine 13:339\u2013347","journal-title":"EBioMedicine"},{"key":"7542_CR25","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1002\/hep.27671","volume":"61","author":"X He","year":"2015","unstructured":"He X, Xie J, Zhang D, Su Q, Sai X, Bai R, Chen C, Luo X, Gao G, Pan W (2015) Recombinant adeno-associated virus-mediated inhibition of microRNA-21 protects mice against the lethal schistosome infection by repressing both IL-13 and transforming growth factor beta 1 pathways. Hepatology 61:2008\u20132017","journal-title":"Hepatology"},{"key":"7542_CR26","doi-asserted-by":"publisher","first-page":"e2701","DOI":"10.1371\/journal.pntd.0002701","volume":"8","author":"AM Hoy","year":"2014","unstructured":"Hoy AM, Lundie RJ, Ivens A, Quintana JF, Nausch N, Forster T et al (2014) Parasite-derived microRNAs in host serum as novel biomarkers of helminth infection. PLoS Negl Trop Dis 8:e2701","journal-title":"PLoS Negl Trop Dis"},{"key":"7542_CR27","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrg2936","volume":"12","author":"E Huntzinger","year":"2011","unstructured":"Huntzinger E, Izaurralde E (2011) Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet 12:99\u2013110","journal-title":"Nat Rev Genet"},{"key":"7542_CR28","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.3389\/fimmu.2018.02781","volume":"9","author":"SD Kamdem","year":"2018","unstructured":"Kamdem SD, Moyou-Somo R, Brombacher F, Nono JK (2018) Host regulators of liver fibrosis during human schistosomiasis. Front Immunol 9:2781","journal-title":"Front Immunol"},{"key":"7542_CR29","unstructured":"Kiernan JA (1999) Histological and histochemical methods: theory and practice, 3rd edn. Butterworth-Heinemann, Oxford"},{"key":"7542_CR30","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/jcm5030038","volume":"5","author":"M Kitano","year":"2016","unstructured":"Kitano M, Bloomston PM (2016) Hepatic stellate cells and microRNAs in pathogenesis of liver fibrosis. J Clin Med 5:38","journal-title":"J Clin Med"},{"key":"7542_CR31","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","volume":"75","author":"RC Lee","year":"1993","unstructured":"Lee RC, Feinbaum RL, Ambros V (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843\u2013854","journal-title":"Cell"},{"key":"7542_CR32","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.gpb.2012.07.005","volume":"10","author":"Y Li","year":"2012","unstructured":"Li Y, Kowdley KV (2012) MicroRNAs in common human diseases. Genomics Proteomics Bioinformatics 10:246\u2013253","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"7542_CR33","first-page":"34","volume":"1","author":"YS Liang","year":"1987","unstructured":"Liang YS, Bruce JI, Boyd DA (1987) Laboratory cultivation of schistosome vector snails and maintenance of schistosome life cycles. Proceeding of the 1st Sino-American Symposium 1:34\u201348","journal-title":"Proceeding of the 1st Sino-American Symposium"},{"key":"7542_CR34","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1590\/0037-8682-0087-2017","volume":"50","author":"CWR Lima","year":"2017","unstructured":"Lima CWR, Oliveira NMC, de Silva SVD, da Duarte MEL, Barbosa APF (2017) Ectopic forms of schistosomiasis mansoni in the second macroregion of Alagoas: case series report and review of the literature. Rev Soc Bras Med Trop 50:812\u2013818","journal-title":"Rev Soc Bras Med Trop"},{"key":"7542_CR35","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"7542_CR36","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s40249-018-0431-6","volume":"7","author":"RK M'Bra","year":"2018","unstructured":"M'Bra RK, Kone B, Yapi YG, Silu\u00e9 KD, Sy I, Vienneau D, Soro N, Ciss\u00e9 G, Utzinger J (2018) Risk factors for schistosomiasis in an urban area in northern C\u00f4te d'Ivoire. Infect Dis Pov erty 7:47","journal-title":"Infect Dis Pov erty"},{"key":"7542_CR37","doi-asserted-by":"publisher","first-page":"3554","DOI":"10.3390\/ijms22073554","volume":"22","author":"A Morishita","year":"2021","unstructured":"Morishita A, Oura K, Tadokoro T, Fujita K, Tani J, Masaki T (2021) MicroRNA interference in hepatic host-pathogen interactions. Int J Mol Sci 22:3554","journal-title":"Int J Mol Sci"},{"key":"7542_CR38","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3389\/fendo.2018.00402","volume":"9","author":"J O'Brien","year":"2018","unstructured":"O'Brien J, Hayder H, Zayed Y, Peng C (2018) Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne) 9:402","journal-title":"Front Endocrinol (Lausanne)"},{"key":"7542_CR39","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nrd.2016.246","volume":"16","author":"R Rupaimoole","year":"2017","unstructured":"Rupaimoole R, Slack F (2017) MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov 16:203\u2013222","journal-title":"Nat Rev Drug Discov"},{"key":"7542_CR40","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1093\/nar\/gks1030","volume":"41","author":"LN Schulte","year":"2013","unstructured":"Schulte LN, Westermann AJ, Vogel J (2013) Differential activation and functional specialization of miR-146 and miR-155 in innate immune sensing. Nucleic Acids Res 41:542\u2013553","journal-title":"Nucleic Acids Res"},{"key":"7542_CR41","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1017\/S0031182000086248","volume":"55","author":"SR Smithers","year":"1965","unstructured":"Smithers SR, Terry RJ (1965) The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms. Parasitology 55:695\u2013700","journal-title":"Parasitology"},{"key":"7542_CR42","doi-asserted-by":"publisher","first-page":"12481","DOI":"10.1073\/pnas.0605298103","volume":"103","author":"KD Taganov","year":"2006","unstructured":"Taganov KD, Boldin MP, Chang KJ, Baltimore D (2006) NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A 103:12481\u201312486","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7542_CR43","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1002\/jcb.26475","volume":"119","author":"R Tao","year":"2018","unstructured":"Tao R, Fan XX, Yu HJ, Ai G, Zhang HY, Kong HY, Song QQ, Huang Y, Huang JQ, Ning Q (2018) MicroRNA-29b-3p prevents Schistosoma japonicum-induced liver fibrosis by targeting COL1A1 and COL3A1. J Cell Biochem 119:3199\u20133209","journal-title":"J Cell Biochem"},{"key":"7542_CR44","first-page":"149","volume":"72","author":"F Von Lichtenberg","year":"1973","unstructured":"Von Lichtenberg F, Erickson DG, Sadun EH (1973) Comparative histopathology of schistosome granulomas in the hamster. Am J Pathol 72:149\u2013178","journal-title":"Am J Pathol"},{"key":"7542_CR45","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1053\/j.gastro.2012.04.007","volume":"142","author":"XW Wang","year":"2012","unstructured":"Wang XW, Heegaard NH, Orum H (2012) MicroRNAs in liver disease. Gastroenterology 142:1431\u20131443","journal-title":"Gastroenterology"},{"key":"7542_CR46","unstructured":"World Health Organization (2020) Ending the neglect to attain the Sustainable Development Goals \u2013 a road map for neglected tropical diseases 2021\u20132030. Geneva: World Health Organization. https:\/\/www.who.int\/neglected_diseases\/Revised-Draft-NTD-Roadmap-23Apr2020.pdf?ua=1 [Accessed 13-11-2021)"},{"key":"7542_CR47","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.cca.2021.01.008","volume":"516","author":"Y Wu","year":"2021","unstructured":"Wu Y, Li Q, Zhang R, Dai X, Chen W, Xing D (2021) Circulating microRNAs: biomarkers of disease. Clin Chim Acta 516:46\u201354","journal-title":"Clin Chim Acta"},{"key":"7542_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0153-7","volume":"50","author":"D Ye","year":"2018","unstructured":"Ye D, Zhang T, Lou G, Liu Y (2018) Role of miR-223 in the pathophysiology of liver diseases. Exp Mol Med 50:1\u201312","journal-title":"Exp Mol Med"},{"key":"7542_CR49","doi-asserted-by":"publisher","first-page":"10543","DOI":"10.1111\/jcmm.16985","volume":"25","author":"Q Ye","year":"2021","unstructured":"Ye Q, Liu Q, Ma X, Bai S, Chen P, Zhao Y, Bai C, Liu Y, Liu K, Xin M, Zeng C, Zhao C, Yao Y, Ma Y, Wang J (2021) MicroRNA-146b-5p promotes atrial fibrosis in atrial fibrillation by repressing TIMP4. J Cell Mol Med 25:10543\u201310553","journal-title":"J Cell Mol Med"},{"issue":"10","key":"7542_CR50","doi-asserted-by":"publisher","first-page":"e109431. pmid:2","DOI":"10.1371\/journal.pone.0109431","volume":"9","author":"E Yepes","year":"2014","unstructured":"Yepes E, Varela-M RE, L\u00f3pez-Ab\u00e1n J, Dakir ELH, Mollinedo F, Muro A (2014) In vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog Edelfosine. PLoS One 9(10):e109431. pmid:25302497","journal-title":"PLoS One"},{"key":"7542_CR51","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1002\/JLB.3MR0218-079R","volume":"104","author":"X Yuan","year":"2018","unstructured":"Yuan X, Berg N, Lee JW, Le TT, Neudecker V, Jing N, Eltzschig H (2018) MicroRNA miR-223 as regulator of innate immunity. J Leukoc Biol 104:515\u2013524","journal-title":"J Leukoc Biol"},{"key":"7542_CR52","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.intimp.2019.01.007","volume":"69","author":"Y Zhao","year":"2019","unstructured":"Zhao Y, Dang Z, Chong S (2019) Mmu-miR-92a-2-5p targets TLR2 to relieve Schistosoma japonicum-induced liver fibrosis. Int Immunopharmacol 69:126\u2013135","journal-title":"Int Immunopharmacol"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-022-07542-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-022-07542-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-022-07542-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T04:07:37Z","timestamp":1655179657000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-022-07542-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,16]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["7542"],"URL":"https:\/\/doi.org\/10.1007\/s00436-022-07542-3","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"type":"print","value":"0932-0113"},{"type":"electronic","value":"1432-1955"}],"subject":[],"published":{"date-parts":[[2022,5,16]]},"assertion":[{"value":"1 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}