{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T13:35:03Z","timestamp":1751376903817,"version":"3.37.3"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI111604"],"award-info":[{"award-number":["AI111604"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s00436-022-07567-8","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T02:03:36Z","timestamp":1654740216000},"page":"2453-2455","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["In vitro activity of amixicile against T. vaginalis from clinical isolates"],"prefix":"10.1007","volume":"121","author":[{"given":"Eisha","family":"Jain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edna I.","family":"Zaenker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4417-0445","authenticated-orcid":false,"given":"Cirle A.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"7567_CR1","unstructured":"Agency, Aars | Wells, Dallas Integrated Creative Communications (2015) Management of persistent and recurrent trichomonas. SASGOG Pearls of Exxcellence | The Society for Academic Specialists in General Obstetrics & Gynecology. September 1, 2015.\u00a0https:\/\/exxcellence.org:443\/list-of-pearls\/management-of-persistent-and-recurrent-trichomoniasis\/.\u00a0Accessed 13 Nov 2021"},{"key":"7567_CR2","unstructured":"Centers for Disease Control and Prevention (2021) Trichomoniasis - STI treatment guidelines. Centers for Disease Control and Prevention. August 18, 2021.\u00a0https:\/\/www.cdc.gov\/std\/treatment-guidelines\/trichomoniasis.htm.\u00a0Accessed 13 Nov 2021"},{"issue":"13","key":"7567_CR3","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1017\/S0031182020001237","volume":"147","author":"KJ Graves","year":"2020","unstructured":"Graves KJ, Jan Novak W, Secor E, Kissinger PJ, Schwebke JR, Muzny CA (2020) A systematic review of the literature on mechanisms of 5-nitroimidazole resistance in Trichomonas vaginalis. Parasitology 147(13):1383\u20131391. https:\/\/doi.org\/10.1017\/S0031182020001237","journal-title":"Parasitology"},{"issue":"November","key":"7567_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2021.752929","volume":"2","author":"Q Gui","year":"2021","unstructured":"Gui Q, Lyons DJ, Deeb JG, Ross Belvin B, Hoffman PS, Lewis JP (2021) Non-human primate Macaca Mulatta as an animal model for testing efficacy of amixicile as a targeted anti-periodontitis therapy. Frontiers in Oral Health 2(November):752929. https:\/\/doi.org\/10.3389\/froh.2021.752929","journal-title":"Frontiers in Oral Health"},{"issue":"5","key":"7567_CR5","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3390\/antibiotics9050213","volume":"9","author":"PS Hoffman","year":"2020","unstructured":"Hoffman PS (2020) Antibacterial discovery: 21st century challenges. Antibiotics 9(5):213. https:\/\/doi.org\/10.3390\/antibiotics9050213","journal-title":"Antibiotics"},{"issue":"8","key":"7567_CR6","doi-asserted-by":"publisher","first-page":"4703","DOI":"10.1128\/AAC.03112-14","volume":"58","author":"PS Hoffman","year":"2014","unstructured":"Hoffman PS, Bruce AM, Olekhnovich I, Warren CA, Burgess SL, Hontecillas R, Viladomiu M, Bassaganya-Riera J, Guerrant RL, Macdonald TL (2014) Preclinical studies of amixicile, a systemic therapeutic developed for treatment of clostridium difficile infections that also shows efficacy against Helicobacter pylori. Antimicrob Agents Chemother 58(8):4703\u20134712. https:\/\/doi.org\/10.1128\/AAC.03112-14","journal-title":"Antimicrob Agents Chemother"},{"key":"7567_CR7","volume-title":"Sexually transmitted diseases","year":"2008","unstructured":"Holmes KK (ed) (2008) Sexually transmitted diseases, 4th edn. McGraw-Hill Medical, New York","edition":"4"},{"issue":"7","key":"7567_CR8","doi-asserted-by":"publisher","first-page":"3980","DOI":"10.1128\/AAC.00670-16","volume":"60","author":"AJ Kennedy","year":"2016","unstructured":"Kennedy AJ, Bruce AM, Catherine Gineste T, Ballard E, Olekhnovich IN, Macdonald TL, Hoffman PS (2016) Synthesis and antimicrobial evaluation of amixicile-based inhibitors of the pyruvate-ferredoxin oxidoreductases of anaerobic bacteria and epsilonproteobacteria. Antimicrob Agents Chemother 60(7):3980\u20133987. https:\/\/doi.org\/10.1128\/AAC.00670-16","journal-title":"Antimicrob Agents Chemother"},{"issue":"7","key":"7567_CR9","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1517\/14656566.2015.1035255","volume":"16","author":"R Sobel","year":"2015","unstructured":"Sobel R, Sobel JD (2015) Metronidazole for the Treatment of vaginal infections. Expert Opin Pharmacother 16(7):1109\u20131115. https:\/\/doi.org\/10.1517\/14656566.2015.1035255","journal-title":"Expert Opin Pharmacother"},{"issue":"8","key":"7567_CR10","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.1128\/AAC.00360-12","volume":"56","author":"CA Warren","year":"2012","unstructured":"Warren CA, Edward van Opstal T, Ballard E, Kennedy A, Wang X, Riggins M, Olekhnovich I et al (2012) Amixicile, a novel inhibitor of pyruvate:ferredoxin oxidoreductase, shows efficacy against clostridium difficile in a mouse infection model. Antimicrob Agents Chemother 56(8):4103\u20134111. https:\/\/doi.org\/10.1128\/AAC.00360-12","journal-title":"Antimicrob Agents Chemother"},{"key":"7567_CR11","unstructured":"Weir CB, Le JK (2021) Metronidazole. In StatPearls. StatPearls Publishing, Treasure Island. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539728\/.\u00a0Accessed 13 Nov 2021"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-022-07567-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-022-07567-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-022-07567-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T07:12:02Z","timestamp":1657696322000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-022-07567-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,9]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["7567"],"URL":"https:\/\/doi.org\/10.1007\/s00436-022-07567-8","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"type":"print","value":"0932-0113"},{"type":"electronic","value":"1432-1955"}],"subject":[],"published":{"date-parts":[[2022,6,9]]},"assertion":[{"value":"25 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}