{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:26:29Z","timestamp":1760300789213,"version":"3.37.3"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1007\/s00436-023-07784-9","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T08:03:44Z","timestamp":1675325024000},"page":"717-727","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Molecular surveillance of Kelch-13 gene in Plasmodium falciparum field isolates from Mayurbhanj District, Odisha, India, and in silico artemisinin-Kelch-13 protein interaction study"],"prefix":"10.1007","volume":"122","author":[{"given":"Laxman Kumar","family":"Murmu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhusmita","family":"Panda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biswa Ranjan","family":"Meher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasant","family":"Purohit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayantiprava","family":"Behera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3814-4061","authenticated-orcid":false,"given":"Tapan Kumar","family":"Barik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"issue":"11","key":"7784_CR1","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.ijpara.2016.05.009","volume":"46","author":"HR Ansari","year":"2016","unstructured":"Ansari HR, Templeton TJ, Subudhi AK, Ramaprasad A, Tang J, Lu F, Naeem R, Hashish Y, Oguike MC, Benavente ED, Clark TG, Sutherland CJ, Barnwell JW, Culleton R, Cao J, Pain A (2016) Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species. Int J Parasitol 46(11):685\u2013696. https:\/\/doi.org\/10.1016\/j.ijpara.2016.05.009","journal-title":"Int J Parasitol"},{"issue":"2","key":"7784_CR2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.actatropica.2012.10.008","volume":"125","author":"S Antinori","year":"2013","unstructured":"Antinori S, Galimberti L, Milazzo L, Corbellino M (2013) Plasmodium knowlesi: The emerging zoonotic malaria parasite. Acta Trop 125(2):191\u2013201. https:\/\/doi.org\/10.1016\/j.actatropica.2012.10.008","journal-title":"Acta Trop"},{"issue":"7481","key":"7784_CR3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/nature12876","volume":"505","author":"F Ariey","year":"2014","unstructured":"Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois AC, Khim N, Kim S, Duru V, Bouchier C, Ma L, Lim P, Leang R, Duong S, Sreng S, Suon S, Chuor CM, Bout DM, M\u00e9nard S, Rogers WO, Genton B, Fandeur T, Miotto O, Ringwald P, Le-Bras J, Berry A, Barale JC, Fairhurst RM, Benoit-Vical F, Mercereau-Puijalon O, M\u00e9nard D (2014) A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature 505(7481):50\u201355. https:\/\/doi.org\/10.1038\/nature12876","journal-title":"Nature"},{"key":"7784_CR4","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1314981","author":"EA Ashley","year":"2014","unstructured":"Ashley EA, Dhorda M, Fairhurst RM, Amaratunga C, Lim P, Suon S, Sreng S, Anderson JM, Mao S, Sam B, Sopha C, Chuor CM, Nguon C, Sovannaroth S, Pukrittayakamee S, Jittamala P, Chotivanich K, Chutasmit K, Suchatsoonthorn C, White NJ (2014) Spread of Artemisinin Resistance in Plasmodium falciparum Malaria. New England J Med. https:\/\/doi.org\/10.1056\/nejmoa1314981","journal-title":"New England J Med"},{"issue":"4","key":"7784_CR5","doi-asserted-by":"publisher","first-page":"225","DOI":"10.2174\/1570163812666150907100019","volume":"12","author":"TK Barik","year":"2015","unstructured":"Barik TK (2015) Antimalarial Drug: From its Development to Deface. Curr Drug Discov Technol 12(4):225\u2013228. https:\/\/doi.org\/10.2174\/1570163812666150907100019","journal-title":"Curr Drug Discov Technol"},{"key":"7784_CR6","doi-asserted-by":"publisher","first-page":"10269","DOI":"10.1021\/j100142a004","volume":"97","author":"CL Bayly","year":"1993","unstructured":"Bayly CL, Cieplak P, Cornell WD, Kollman PA (1993) A well-behaved electrostatic potential based method using charge restraints for determining atom-centered charges: the RESP model. J Phys Chem 97:10269","journal-title":"J Phys Chem"},{"key":"7784_CR7","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.1063\/1.448118","volume":"81","author":"HJC Berendsen","year":"1984","unstructured":"Berendsen HJC, Postma JPM, Van Gunsteren WF, Dinola A, Haak JR (1984) Molecular dynamics with coupling to an external bath. J Chem Phys 81:3684","journal-title":"J Chem Phys"},{"issue":"3\u20134","key":"7784_CR8","first-page":"92","volume":"40","author":"S Biswas","year":"2003","unstructured":"Biswas S, Valecha N, Tyagi PK, Phookan S, Dev V, Sharma SK, Subbarao SK (2003) Assessment of therapeutic efficacy of chloroquine and sulphadoxine-pyrimethamine in uncomplicated falciparum malaria. J Vector Borne Dis 40(3\u20134):92\u201399","journal-title":"J Vector Borne Dis"},{"issue":"1","key":"7784_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-018-06221-1","volume":"9","author":"JL Bridgford","year":"2018","unstructured":"Bridgford JL, Xie SC, Cobbold SA, Pasaje CFA, Herrmann S, Yang T, Gillett DL, Dick LR, Ralph SA, Dogovski C, Spillman NJ, Tilley L (2018) Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome. Nat Commun 9(1):1\u20139. https:\/\/doi.org\/10.1038\/s41467-018-06221-1","journal-title":"Nat Commun"},{"key":"7784_CR10","volume-title":"AMBER 18","author":"DA Case","year":"2018","unstructured":"Case DA, Ben-Shalom IY, Brozell SR, Cerutti DS, Cheatham TE, Cruzeiro VWD, Darden TA, Duke RE, Ghoreishi D, Gilson MK, Gohlke H, Goetz AW, Greene D, Harris R, Homeyer N, Huang Y, Izadi S, Kovalenko A, Kurtzman T, Lee TS, LeGrand S, Li P, Lin C, Liu J, Luchko T, Luo R, Mermelstein DJ, Merz KM, Miao Y, Monard G, Nguyen C, Nguyen H, Omelyan I, Onufriev A, Pan F, Qi R, Roe DR, Roitberg A, Sagui C, Schott-Verdugo S, Shen J, Simmerling CL, Smith J, Ferrer SR, Swails J, Walker RC, Wang J, Wei H, Wolf RM, Wu X, Xiao L, York DM, Kollman PA (2018) AMBER 18. University of California, San Francis co, CA, USA"},{"key":"7784_CR11","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1186\/s12936-021-03907-8","volume":"20","author":"M Chang","year":"2021","unstructured":"Chang M, Johnston S, Seilie AM, Hergott D, Murphy SC (2021) Application of dried blood spot sample pooling strategies for Plasmodium 18S rRNA biomarker testing to facilitate identification of infected persons in large-scale epidemiological studies. Malar J 20:391. https:\/\/doi.org\/10.1186\/s12936-021-03907-8","journal-title":"Malar J"},{"issue":"5","key":"7784_CR12","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1093\/trstmh\/trv015","volume":"109","author":"N Chaturvedi","year":"2015","unstructured":"Chaturvedi N, Bhandari S, Bharti PK, Basak SK, Singh MP, Singh N (2015) Sympatric distribution of Plasmodium ovale curtisi and P. ovale wallikeri in India: implication for the diagnosis of malaria and its control. Trans R Soc Trop Med Hyg 109(5):352\u2013354. https:\/\/doi.org\/10.1093\/trstmh\/trv015","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"7784_CR13","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ijpddr.2019.10.001","volume":"11","author":"J Chhibber-Goel","year":"2019","unstructured":"Chhibber-Goel J, Sharma A (2019) Profiles of Kelch mutations in Plasmodium falciparum across South Asia and their implications for tracking drug resistance. Int J Parasitol Drugs Drug Resist 11:49\u201358","journal-title":"Int J Parasitol Drugs Drug Resist"},{"issue":"1","key":"7784_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-47034-6","volume":"9","author":"R Copp\u00e9e","year":"2019","unstructured":"Copp\u00e9e R, Jeffares DC, Miteva MA, Sabbagh A, Clain J (2019) Comparative structural and evolutionary analyses predict functional sites in the artemisinin resistance malaria protein K13. Sci Rep 9(1):1\u201317","journal-title":"Sci Rep"},{"issue":"3","key":"7784_CR15","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.ijpddr.2017.06.002","volume":"7","author":"S Das","year":"2017","unstructured":"Das S, Tripathy S, Chattopadhayay S, Das B, KarMahapatra S, Hati AK, Roy S (2017) Progressive increase in point mutations associates chloroquine resistance: Even after withdrawal of chloroquine use in India. Int J Parasitol: Drugs Drug Resist 7(3):251\u2013261. https:\/\/doi.org\/10.1016\/j.ijpddr.2017.06.002","journal-title":"Int J Parasitol: Drugs Drug Resist"},{"key":"7784_CR16","doi-asserted-by":"publisher","unstructured":"Das S, Saha B, Hati AK, Roy S (2018) Evidence of Artemisinin-Resistant Plasmodium falciparum Malaria in Eastern India. N Engl J Med 379(20):1962\u20131964. https:\/\/doi.org\/10.1056\/NEJMc1713777","DOI":"10.1056\/NEJMc1713777"},{"issue":"7","key":"7784_CR17","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1093\/cid\/ciy1038","volume":"69","author":"S Das","year":"2019","unstructured":"Das S, Manna S, Saha B, Hati AK, Roy S (2019) Novel pfkelch13 Gene Polymorphism Associates with Artemisinin Resistance in Eastern India. Clin Infect Dis 69(7):1144\u20131152. https:\/\/doi.org\/10.1093\/cid\/ciy1038","journal-title":"Clin Infect Dis"},{"key":"7784_CR18","doi-asserted-by":"publisher","first-page":"3902","DOI":"10.1021\/ja00299a024","volume":"107","author":"MJS Dewar","year":"1985","unstructured":"Dewar MJS, Zoebisch EG, Healy EF, Stewart JP (1985) Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model. J Am Chem Soc 107:3902","journal-title":"J Am Chem Soc"},{"issue":"5","key":"7784_CR19","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1056\/NEJMoa0808859","volume":"361","author":"AM Dondorp","year":"2012","unstructured":"Dondorp AM, Nosten F, Yi P, Das D, Hanpithakpong W, Lee SJ, Ringwald P, Imwong M, Chotivanich K, Lim P (2012) Artemisinin Resistance in Plasmodium falciparum Malaria. New Engl J Med 361(5):455\u2013467. https:\/\/doi.org\/10.1056\/NEJMoa0808859","journal-title":"New Engl J Med"},{"key":"7784_CR20","doi-asserted-by":"publisher","first-page":"8577","DOI":"10.1063\/1.470117","volume":"103","author":"U Essmann","year":"1995","unstructured":"Essmann U, Perera L, Berkowitz ML, Darden T, Lee H, Pedersen LG (1995) A smooth particle mesh ewald method. J Chem Phys 103:8577","journal-title":"J Chem Phys"},{"key":"7784_CR21","doi-asserted-by":"publisher","first-page":"783","DOI":"10.2307\/2408678","volume":"39","author":"J Felsenstein","year":"1985","unstructured":"Felsenstein J (1985) Confidence limits on phylogenies: An approach using the bootstrap. Evol 39:783\u2013791","journal-title":"Evol"},{"key":"7784_CR22","unstructured":"Hall TA (1999) BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT.\u00a0Nucleic Acids Symp\u00a0Ser\u00a041:95\u201398"},{"issue":"6","key":"7784_CR23","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.4269\/ajtmh.19-0379","volume":"101","author":"MR Hassett","year":"2019","unstructured":"Hassett MR, Roepe PD (2019) Origin and spread of evolving artemisinin-resistant Plasmodium falciparum malarial parasites in Southeast Asia. Am J Trop Med Hyg 101(6):1204\u20131211. https:\/\/doi.org\/10.4269\/ajtmh.19-0379","journal-title":"Am J Trop Med Hyg"},{"key":"7784_CR24","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1063\/1.445869","volume":"79","author":"WL Jorgensen","year":"1983","unstructured":"Jorgensen WL, Chandrasekhar J, Madura JD (1983) Comparison of simple potential functions for simulating liquid water. J Chem Phys 79:926","journal-title":"J Chem Phys"},{"issue":"1","key":"7784_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-18026-1","volume":"8","author":"V Joste","year":"2018","unstructured":"Joste V, Kamaliddin C, Kendjo E, Hubert V, Argy N, Houz\u00e9 S (2018) Distinction of Plasmodium ovale wallikeri and Plasmodium ovale curtisi using quantitative Polymerase Chain Reaction with High Resolution Melting revelation. Sci Rep 8(1):1\u20138. https:\/\/doi.org\/10.1038\/s41598-017-18026-1","journal-title":"Sci Rep"},{"issue":"6","key":"7784_CR26","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/nprot.2015.053","volume":"10","author":"LA Kelley","year":"2015","unstructured":"Kelley LA, Mezulis S, Yates CM, Wass MN, Sternberg MJ (2015) The Phyre2 web portal for protein modeling, prediction and analysis. Nat Protoc 10(6):845\u2013858","journal-title":"Nat Protoc"},{"key":"7784_CR27","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/BF01731581","volume":"16","author":"M Kimura","year":"1980","unstructured":"Kimura M (1980) A simple method for estimating evolutionary rate of base substitutions through comparative studies of nucleotide sequences. J Mol Evol 16:111\u2013120","journal-title":"J Mol Evol"},{"key":"7784_CR28","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1093\/molbev\/msy096","volume":"35","author":"S Kumar","year":"2018","unstructured":"Kumar S, Stecher G, Li M, Knyaz C, Tamura K (2018) MEGA X: Molecular Evolutionary Genetics Analysis across computing platforms. Mol Biol Evol 35:1547\u20131549","journal-title":"Mol Biol Evol"},{"key":"7784_CR29","doi-asserted-by":"publisher","first-page":"2778","DOI":"10.1021\/ci200227u","volume":"51","author":"RA Laskowski","year":"2011","unstructured":"Laskowski RA, Swindells MB (2011) LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. J Chem Inf Mod 51:2778\u20132786","journal-title":"J Chem Inf Mod"},{"key":"7784_CR30","doi-asserted-by":"publisher","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","volume":"11","author":"JA Maier","year":"2015","unstructured":"Maier JA, Martinez Kasavajhala K, Wickstrom L, Hauser KE, Simmerling C (2015) ff14SB: Improving the accuracy of protein side chain and backbone parameters from ff99SB. J Chem Theory Comput 11:3696\u20133713","journal-title":"J Chem Theory Comput"},{"key":"7784_CR31","unstructured":"Mayurbhanj District Population Census 2011\u20132021, https:\/\/www.census2011.co.in\/census\/district\/400-mayurbhanj.html. Accessed 10\/22\/2021"},{"issue":"25","key":"7784_CR32","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1056\/NEJMoa1513137","volume":"374","author":"D M\u00e9nard","year":"2016","unstructured":"M\u00e9nard D, Khim N, Beghain J, Adegnika AA, Shafiul-Alam M, Amodu O, Rahim-Awab G, Barnadas C, Berry A, Boum Y, Bustos MD, Cao J, Chen JH, Collet L, Cui L, Thakur GD, Dieye A, Djall\u00e9 D, Dorkenoo MA, Eboumbou-Moukoko CE, Espino FECJ, Fandeur T, Ferreira-da-Cruz MF, Fola AA, Fuehrer HP, Hassan AM, Herrera S, Hongvanthong B, Houz\u00e9 S, Ibrahim ML, Jahirul-Karim M, Jiang L, Kano S, Ali-Khan W, Khanthavong M, Kremsner PG, Lacerda M, Leang R, Leelawong M, Li M, Lin K, Mazarati JB, M\u00e9nard S, Morlais I, Muhindo-Mavoko H, Musset L, Na-Bangchang K, Nambozi M, Niar\u00e9 K, Noedl H, Ou\u00e9draogo JB, Pillai DR, Pradines B, Quang-Phuc B, Ramharter M, Randrianarivelojosia M, Sattabongkot J, Sheikh-Omar A, Silu\u00e9 KD, Sirima SB, Sutherland C, Syafruddin D, Tahar R, Tang LH, Tour\u00e9 OA, Tshibangu-wa-Tshibangu P, Vigan-Womas I, Warsame M, Wini L, Zakeri S, Kim S, Eam R, Berne L, Khean C, Chy S, Ken M, Loch K, Canier L, Duru V, Legrand E, Barale JC, Stokes B, Straimer J, Witkowski B, Fidock DA, Rogier C, Ringwald P, Ariey F, Mercereau-Puijalon O (2016) A worldwide map of Plasmodium falciparum K13-propeller polymorphisms. N Engl J Med 374(25):2453\u20132464. https:\/\/doi.org\/10.1056\/NEJMoa1513137","journal-title":"N Engl J Med"},{"key":"7784_CR33","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.1021\/ct300418h","volume":"8","author":"BR Miller III","year":"2012","unstructured":"Miller BR III, McGee TD Jr, Swails JM, Homeyer N, Gohlke H, Roitberg AE (2012) MMPBSA.py: An efficient program for end-state free energy calculations. J Chem Theory Comput 8:3314\u20133321","journal-title":"J Chem Theory Comput"},{"issue":"5","key":"7784_CR34","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.1128\/AAC.04632-14","volume":"59","author":"N Mishra","year":"2015","unstructured":"Mishra N, Prajapati SK, Kaitholia K, Bharti RS, Srivastava B, Phookan S, Anvikar AR, Dev V, Sonal GS, Dhariwal AC, White NJ, Valecha N (2015) Surveillance of artemisinin resistance in Plasmodium falciparum in India using the kelch13 molecular marker. Antimicrob Agents Chemother 59(5):2548\u20132553. https:\/\/doi.org\/10.1128\/AAC.04632-14","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"7784_CR35","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12936-016-1636-4","volume":"15","author":"N Mishra","year":"2016","unstructured":"Mishra N, Bharti RS, Mallick P, Singh OP, Srivastava B, Rana R, Phookan S, Gupta HP, Ringwald P, Valecha N (2016) Emerging polymorphisms in falciparum Kelch 13 gene in Northeastern region of India. Malar J 15(1):4\u20139. https:\/\/doi.org\/10.1186\/s12936-016-1636-4","journal-title":"Malar J"},{"key":"7784_CR36","doi-asserted-by":"publisher","unstructured":"Mishra N, Kaitholia K, Srivastava B, Shah NK, Narayan JP, De V, Phookan S, Anvikar AR, Rana R, Bharti RS, Sonal GS,Dhariwal AC, Valecha N (2014) Declining efficacy of artesunate plus sulphadoxine-pyrimethamine in northeastern India. Malar J 13(284). https:\/\/doi.org\/10.1186\/1475-2875-13-284","DOI":"10.1186\/1475-2875-13-284"},{"issue":"5","key":"7784_CR37","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1111\/j.1365-3156.2005.01401.x","volume":"10","author":"PK Mohapatra","year":"2005","unstructured":"Mohapatra PK, Prakash A, Taison K, Negmu K, Gohain AC, Namchoom NS, Wange D, Bhattacharyya DR, Goswami BK, Borgohain BK, Mahanta J (2005) Evaluation of chloroquine (CQ) and sulphadoxine\/pyrimethamine (SP) therapy in uncomplicated falciparum malaria in Indo-Myanmar border areas. Trop Med Int Health 10(5):478\u2013483. https:\/\/doi.org\/10.1111\/j.1365-3156.2005.01401.x","journal-title":"Trop Med Int Health"},{"key":"7784_CR38","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"16","author":"GM Morris","year":"2009","unstructured":"Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, Olson AJ (2009) Autodock4 and AutoDockTools4: automated docking with selective receptor flexibility. J Comput Chem 16:2785\u20132791","journal-title":"J Comput Chem"},{"key":"7784_CR39","doi-asserted-by":"publisher","unstructured":"Nagasundaram N, George Priya Doss C, Chiranjib Chakraborty, Karthick V, Thirumal Kumar D, Balaji V, Siva R, Aiping Lu, Zhang Ge, Hailong Zhu (2016) Mechanism of artemisinin resistance for malaria PfATP6 L263 mutations and discovering potential antimalarials: An integrated computational approach. Scientific Reports 6(1):30106.\u00a0https:\/\/doi.org\/10.1038\/srep30106","DOI":"10.1038\/srep30106"},{"issue":"24","key":"7784_CR40","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1056\/nejmc0805011","volume":"359","author":"H Noedl","year":"2008","unstructured":"Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM (2008) Evidence of Artemisinin-Resistant Malaria in Western Cambodia. N Engl J Med 359(24):2619\u20132620. https:\/\/doi.org\/10.1056\/nejmc0805011","journal-title":"N Engl J Med"},{"key":"7784_CR41","doi-asserted-by":"publisher","unstructured":"Nzoumbou-Boko R, Pant\u00e9-Wockama CBG, Ngoagoni C, Petiot N, Legrand E, Vickos U, Gody JC, Manirakiza A, Ndoua C, Lombart JP, M\u00e9nard D (2020) Molecular assessment of kelch13 non-synonymous mutations in Plasmodium falciparum isolates from Central African Republic (2017\u20132019). Malar J 19(191). https:\/\/doi.org\/10.1186\/s12936-020-03264-y","DOI":"10.1186\/s12936-020-03264-y"},{"issue":"6","key":"7784_CR42","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.ijpara.2011.01.004","volume":"41","author":"MC Oguike","year":"2011","unstructured":"Oguike MC, Betson M, Burke M, Nolder D, Stothard JR, Kleinschmidt I, Proietti C, Bousema T, Ndounga M, Tanabe K, Ntege E, Culleton R, Sutherland CJ (2011) Plasmodium ovale curtisi and Plasmodium ovale wallikeri circulate simultaneously in African communities. Int J Parasitol 41(6):677\u2013683. https:\/\/doi.org\/10.1016\/j.ijpara.2011.01.004","journal-title":"Int J Parasitol"},{"key":"7784_CR43","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/0021-9991(77)90098-5","volume":"23","author":"JP Ryckaert","year":"1977","unstructured":"Ryckaert JP, Ciccotti G, Berendsen HJC (1977) Numerical integration of the Cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes. J Comput Phys 23:327\u2013341","journal-title":"J Comput Phys"},{"issue":"4","key":"7784_CR44","first-page":"175","volume":"5","author":"PN Sehgal","year":"1973","unstructured":"Sehgal PN, Sharma MID, Sharma SL, Gogai S (1973) Resistance to chloroquine in falciparum malaria in Assam State. India J Commun Dis 5(4):175\u2013180","journal-title":"India J Commun Dis"},{"issue":"2\u20133","key":"7784_CR45","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s10969-016-9205-1","volume":"17","author":"GP Singh","year":"2016","unstructured":"Singh GP, Goel P, Sharma A (2016) Structural mapping of Kelch13 mutations associated with artemisinin resistance in malaria. J Struct Funct Genomics 17(2\u20133):51\u201356","journal-title":"J Struct Funct Genomics"},{"issue":"1","key":"7784_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12859-014-0399-6","volume":"15","author":"L Skj\u00e6rven","year":"2014","unstructured":"Skj\u00e6rven L, Yao XQ, Scarabelli G, Grant BJ (2014) Integrating protein structural dynamics and evolutionary analysis with Bio3D. BMC Bioinform 15(1):1\u201311","journal-title":"BMC Bioinform"},{"issue":"6220","key":"7784_CR47","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1126\/science.1260867","volume":"347","author":"J Straimer","year":"2015","unstructured":"Straimer J, Gnadig NF, Witkowski B, Amaratunga C, Duru V, Ramadani AP, Dacheux M, Khim N, Zhang L, Lam S, Gregory PD, Urnov FD, Mercereau-Puijalon O, Benoit-Vical F, Fairhurst RM, M\u00e9nard D, Fidock DA (2015) K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates. Sci 347(6220):428\u2013431. https:\/\/doi.org\/10.1126\/science.1260867","journal-title":"Sci"},{"key":"7784_CR48","doi-asserted-by":"crossref","unstructured":"Trott O, Olson AJ (2010) AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem 31(2):455\u2013461","DOI":"10.1002\/jcc.21334"},{"issue":"10","key":"7784_CR49","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1038\/s41591-020-1005-2","volume":"26","author":"A Uwimana","year":"2020","unstructured":"Uwimana A, Legrand E, Stokes BH, Ndikumana JLM, Warsame M, Umulisa N, Ngamije D, Munyaneza T, Mazarati JB, Munguti K, Campagne P, Criscuolo A, Ariey F, Murindahabi M, Ringwald P, Fidock DA, Mbituyumuremyi A, Menard D (2020) Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda. Nat Med 26(10):1602\u20131608. https:\/\/doi.org\/10.1038\/s41591-020-1005-2","journal-title":"Nat Med"},{"key":"7784_CR50","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1002\/jcc.20035","volume":"25","author":"J Wang","year":"2004","unstructured":"Wang J, Wolf RM, Caldwell JW, Kollman PA, Case DA (2004) Development and testing of a general amber force field. J Comput Chem 25:1157\u20131174","journal-title":"J Comput Chem"},{"key":"7784_CR51","unstructured":"WHO (2018) Global Malaria Programme. Artemisinin resistance and artemisinin-based combination therapy efficacy. Status report. https:\/\/www.who.int\/malaria\/publications\/atoz\/artemisinin-resistance-august2018\/en\/. Accessed 12 Oct\u00a02020"},{"key":"7784_CR52","unstructured":"WHO (2020) World malaria report 2020. 20 Years of Global Progress and Challenges.  https:\/\/www.who.int\/teams\/global-malaria-programme\/reports\/world-malaria-report-2020. Accessed 21\/10\/2021."}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-023-07784-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-023-07784-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-023-07784-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T09:11:25Z","timestamp":1678093885000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-023-07784-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,2]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["7784"],"URL":"https:\/\/doi.org\/10.1007\/s00436-023-07784-9","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"type":"print","value":"0932-0113"},{"type":"electronic","value":"1432-1955"}],"subject":[],"published":{"date-parts":[[2023,2,2]]},"assertion":[{"value":"8 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}