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It has been proposed that antibodies opsonize <jats:italic>Naegleria fowleri<\/jats:italic> trophozoites; subsequently, the polymorphonuclear cells (PMNs) surround the trophozoites to avoid the infection. Fc\u03b3Rs activate signaling pathways of adapter proteins such as Syk and Hck on PMNs to promote different effector cell functions which are induced by the Fc portion of the antibody-antigen complexes. In this work, we analyzed the activation of PMNs, epithelial cells, and nasal passage cells via the expression of Syk and Hck genes. Our results showed an increment of the Fc\u03b3RIII and IgG subclasses in the nasal cavity from immunized mice as well as Syk and Hck expression was increased, whereas in the in vitro assay, we observed that when the trophozoites of <jats:italic>N. fowleri<\/jats:italic> were opsonized with IgG anti-<jats:italic>N. fowleri<\/jats:italic> and interacted with PMN, the expression of Syk and Hck was also increased. We suggest that PMNs are activated via their Fc\u03b3RIII, which leads to the elimination of the trophozoites in vitro, while in the nasal cavity, the adhesion and consequently infection are avoided.<\/jats:p>","DOI":"10.1007\/s00436-023-07810-w","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T05:02:55Z","timestamp":1678683775000},"page":"1087-1105","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Role of Fc\u03b3RIII in the nasal cavity of BALB\/c mice in the primary amebic meningoencephalitis protection model"],"prefix":"10.1007","volume":"122","author":[{"given":"Diego Alexander","family":"Rojas-Ortega","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sa\u00fal","family":"Rojas-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Elena","family":"S\u00e1nchez-Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Modesto","family":"G\u00f3mez-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer Viridiana","family":"S\u00e1nchez-Camacho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Rosales-Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Maricela Carrasco","family":"Y\u00e9pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"7810_CR1","doi-asserted-by":"publisher","first-page":"2908034","DOI":"10.1155\/2016\/2908034","volume":"2016","author":"OR Alem\u00e1n","year":"2016","unstructured":"Alem\u00e1n OR, Mora N, Cortes-Vieyra R, Uribe-Querol E, Rosales C (2016) Differential use of human neutrophil Fc\u03b3 receptors for inducing neutrophil extracellular trap formation. 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