{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T08:04:24Z","timestamp":1758960264289},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s00436-023-07915-2","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T03:24:47Z","timestamp":1688441087000},"page":"1961-1971","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The nucleolus of Giardia and its ribosomal biogenesis"],"prefix":"10.1007","volume":"122","author":[{"given":"Francisco Alejandro","family":"Lagunas-Rangel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"7915_CR1","doi-asserted-by":"crossref","unstructured":"Arg\u00fcello-Garc\u00eda R, Leitsch D, Skinner-Adams T, Ortega-Pierres MG (2020) Drug resistance in Giardia: Mechanisms and alternative treatments for Giardiasis. In: Advances in Parasitology. pp 201\u2013282","DOI":"10.1016\/bs.apar.2019.11.003"},{"key":"7915_CR2","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/nrd1468","volume":"3","author":"TT Ashburn","year":"2004","unstructured":"Ashburn TT, Thor KB (2004) Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov 3:673\u2013683. https:\/\/doi.org\/10.1038\/nrd1468","journal-title":"Nat Rev Drug Discov"},{"key":"7915_CR3","doi-asserted-by":"publisher","first-page":"e00343","DOI":"10.1128\/mSphere.00343-16","volume":"2","author":"NR Barash","year":"2017","unstructured":"Barash NR, Nosala C, Pham JK et al (2017) Giardia colonizes and encysts in high-density foci in the murine small intestine. mSphere 2:e00343-16. https:\/\/doi.org\/10.1128\/mSphere.00343-16","journal-title":"mSphere"},{"key":"7915_CR4","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1091\/mbc.e06-06-0512","volume":"18","author":"KA Bernstein","year":"2007","unstructured":"Bernstein KA, Bleichert F, Bean JM et al (2007) Ribosome biogenesis is sensed at the start cell cycle checkpoint. Mol Biol Cell 18:953\u2013964. https:\/\/doi.org\/10.1091\/mbc.e06-06-0512","journal-title":"Mol Biol Cell"},{"key":"7915_CR5","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/nrm2184","volume":"8","author":"F-M Boisvert","year":"2007","unstructured":"Boisvert F-M, van Koningsbruggen S, Navascu\u00e9s J, Lamond AI (2007) The multifunctional nucleolus. Nat Rev Mol Cell Biol 8:574\u2013585. https:\/\/doi.org\/10.1038\/nrm2184","journal-title":"Nat Rev Mol Cell Biol"},{"key":"7915_CR6","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.tree.2019.08.008","volume":"35","author":"F Burki","year":"2020","unstructured":"Burki F, Roger AJ, Brown MW, Simpson AGB (2020) The new tree of eukaryotes. Trends Ecol Evol 35:43\u201355. https:\/\/doi.org\/10.1016\/j.tree.2019.08.008","journal-title":"Trends Ecol Evol"},{"key":"7915_CR7","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/j.1365-3024.2011.01304.x","volume":"34","author":"C Cantacessi","year":"2012","unstructured":"Cantacessi C, Campbell BE, Jex AR et al (2012) Bioinformatics meets parasitology. Parasite Immunol 34:265\u2013275. https:\/\/doi.org\/10.1111\/j.1365-3024.2011.01304.x","journal-title":"Parasite Immunol"},{"key":"7915_CR8","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.3390\/cells8091090","volume":"8","author":"P Carotenuto","year":"2019","unstructured":"Carotenuto P, Pecoraro A, Palma G et al (2019) Therapeutic approaches targeting nucleolus in cancer. Cells 8:1090. https:\/\/doi.org\/10.3390\/cells8091090","journal-title":"Cells"},{"key":"7915_CR9","doi-asserted-by":"publisher","first-page":"e1007250","DOI":"10.1371\/journal.ppat.1007250","volume":"14","author":"L Cernikova","year":"2018","unstructured":"Cernikova L, Faso C, Hehl AB (2018) Five facts about Giardia lamblia. Plos Pathog 14:e1007250. https:\/\/doi.org\/10.1371\/journal.ppat.1007250","journal-title":"Plos Pathog"},{"key":"7915_CR10","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.tibs.2022.09.006","volume":"48","author":"A Corman","year":"2023","unstructured":"Corman A, Sirozh O, Lafarga V, Fernandez-Capetillo O (2023) Targeting the nucleolus as a therapeutic strategy in human disease. Trends Biochem Sci 48:274\u2013287. https:\/\/doi.org\/10.1016\/j.tibs.2022.09.006","journal-title":"Trends Biochem Sci"},{"key":"7915_CR11","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1146\/annurev-biochem-060614-033917","volume":"84","author":"J de la Cruz","year":"2015","unstructured":"de la Cruz J, Karbstein K, Woolford JL (2015) Functions of ribosomal proteins in assembly of eukaryotic ribosomes in vivo. Annu Rev Biochem 84:93\u2013129. https:\/\/doi.org\/10.1146\/annurev-biochem-060614-033917","journal-title":"Annu Rev Biochem"},{"key":"7915_CR12","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.2217\/fon.14.65","volume":"10","author":"Z Dorosti","year":"2014","unstructured":"Dorosti Z, Yousefi M, Sharafi SM, Darani HY (2014) Mutual action of anticancer and antiparasitic drugs: are there any shared targets? Futur Oncol 10:2529\u20132539. https:\/\/doi.org\/10.2217\/fon.14.65","journal-title":"Futur Oncol"},{"key":"7915_CR13","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/978-3-319-38882-3_2","volume-title":"The functional nucleus","author":"M-L Dubois","year":"2016","unstructured":"Dubois M-L, Boisvert F-M (2016) The nucleolus: structure and function. The functional nucleus. Springer International Publishing, Cham, pp 29\u201349"},{"key":"7915_CR14","doi-asserted-by":"publisher","first-page":"7889","DOI":"10.1093\/nar\/15.19.7889","volume":"15","author":"TD Edlind","year":"1987","unstructured":"Edlind TD, Chakraborty PR (1987) Unusual ribosomal RNA of the intestinal parasite Giardia lamblia. Nucleic Acids Res 15:7889\u20137901. https:\/\/doi.org\/10.1093\/nar\/15.19.7889","journal-title":"Nucleic Acids Res"},{"key":"7915_CR15","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/0378-1119(90)90266-T","volume":"96","author":"TD Edlind","year":"1990","unstructured":"Edlind TD, Sharetzky C, Cha ME (1990) Ribosomal RNA of the primitive eukaryote Giardia lamblia: large subunit domain I and potential processing signals. Gene 96:289\u2013293. https:\/\/doi.org\/10.1016\/0378-1119(90)90266-T","journal-title":"Gene"},{"key":"7915_CR16","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.mib.2016.07.019","volume":"34","author":"E Einarsson","year":"2016","unstructured":"Einarsson E, Ma\u2019ayeh S, Sv\u00e4rd SG (2016) An up-date on Giardia and giardiasis. Curr Opin Microbiol 34:47\u201352. https:\/\/doi.org\/10.1016\/j.mib.2016.07.019","journal-title":"Curr Opin Microbiol"},{"key":"7915_CR17","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1186\/s12864-020-6679-9","volume":"21","author":"J-M Feng","year":"2020","unstructured":"Feng J-M, Yang C-L, Tian H-F et al (2020) Identification and evolutionary analysis of the nucleolar proteome of Giardia lamblia. BMC Genomics 21:269. https:\/\/doi.org\/10.1186\/s12864-020-6679-9","journal-title":"BMC Genomics"},{"key":"7915_CR18","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/nature12636","volume":"502","author":"C Fern\u00e1ndez-Tornero","year":"2013","unstructured":"Fern\u00e1ndez-Tornero C, Moreno-Morcillo M, Rashid UJ et al (2013) Crystal structure of the 14-subunit RNA polymerase I. Nature 502:644\u2013649. https:\/\/doi.org\/10.1038\/nature12636","journal-title":"Nature"},{"key":"7915_CR19","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3390\/cells9020266","volume":"9","author":"R Ferreira","year":"2020","unstructured":"Ferreira R, Schneekloth JS, Panov KI et al (2020) Targeting the RNA polymerase I transcription for cancer therapy comes of age. Cells 9:266. https:\/\/doi.org\/10.3390\/cells9020266","journal-title":"Cells"},{"key":"7915_CR20","doi-asserted-by":"publisher","first-page":"29551","DOI":"10.1074\/jbc.M501595200","volume":"280","author":"JK Friedrich","year":"2005","unstructured":"Friedrich JK, Panov KI, Cabart P et al (2005) TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter. J Biol Chem 280:29551\u201329558. https:\/\/doi.org\/10.1074\/jbc.M501595200","journal-title":"J Biol Chem"},{"key":"7915_CR21","doi-asserted-by":"publisher","first-page":"216","DOI":"10.2174\/1570163814666170425155154","volume":"14","author":"Z Gong","year":"2017","unstructured":"Gong Z, Hu G, Li Q et al (2017) Compound libraries: recent advances and their applications in drug discovery. Curr Drug Discov Technol 14:216\u2013228. https:\/\/doi.org\/10.2174\/1570163814666170425155154","journal-title":"Curr Drug Discov Technol"},{"key":"7915_CR22","doi-asserted-by":"crossref","unstructured":"Goodfellow SJ, Zomerdijk JCBM (2013) Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes. pp 211\u2013236","DOI":"10.1007\/978-94-007-4525-4_10"},{"key":"7915_CR23","doi-asserted-by":"publisher","first-page":"4626","DOI":"10.1111\/j.1742-4658.2010.07892.x","volume":"277","author":"I Grummt","year":"2010","unstructured":"Grummt I (2010) Wisely chosen paths - regulation of rRNA synthesis. FEBS J 277:4626\u20134639. https:\/\/doi.org\/10.1111\/j.1742-4658.2010.07892.x","journal-title":"FEBS J"},{"key":"7915_CR24","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00412-013-0430-0","volume":"122","author":"I Grummt","year":"2013","unstructured":"Grummt I (2013) The nucleolus\u2014guardian of cellular homeostasis and genome integrity. Chromosoma 122:487\u2013497. https:\/\/doi.org\/10.1007\/s00412-013-0430-0","journal-title":"Chromosoma"},{"key":"7915_CR25","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1080\/10520290500050981","volume":"80","author":"J Guo","year":"2005","unstructured":"Guo J, Chen Y, Zhou K, Li J (2005) Distribution of rDNA in the nucleus of Giardia lamblia\u202f: detection by Ag-I silver stain. Biotech Histochem 80:31\u201334. https:\/\/doi.org\/10.1080\/10520290500050981","journal-title":"Biotech Histochem"},{"key":"7915_CR26","doi-asserted-by":"publisher","first-page":"4006","DOI":"10.1093\/nar\/18.13.4006","volume":"18","author":"A Healey","year":"1990","unstructured":"Healey A, Mitchell R, Upcroft JA et al (1990) Complete nucleotide sequence of the ribosomal RNA tandem repeat unit from Giardia intestinalis. Nucleic Acids Res 18:4006","journal-title":"Nucleic Acids Res"},{"key":"7915_CR27","doi-asserted-by":"publisher","first-page":"189","DOI":"10.4161\/nucl.2.3.16246","volume":"2","author":"D Hernandez-Verdun","year":"2011","unstructured":"Hernandez-Verdun D (2011) Assembly and disassembly of the nucleolus during the cell cycle. Nucleus 2:189\u2013194. https:\/\/doi.org\/10.4161\/nucl.2.3.16246","journal-title":"Nucleus"},{"key":"7915_CR28","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1093\/nar\/gkac046","volume":"50","author":"D-G Hiregange","year":"2022","unstructured":"Hiregange D-G, Rivalta A, Bose T et al (2022) Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia. Nucleic Acids Res 50:1770\u20131782. https:\/\/doi.org\/10.1093\/nar\/gkac046","journal-title":"Nucleic Acids Res"},{"key":"7915_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcimb.2022.882995","volume":"12","author":"R-S Hu","year":"2022","unstructured":"Hu R-S, Hesham AE-L, Zou Q (2022) Machine learning and its applications for protozoal pathogens and protozoal infectious diseases. Front Cell Infect Microbiol 12:1\u201317. https:\/\/doi.org\/10.3389\/fcimb.2022.882995","journal-title":"Front Cell Infect Microbiol"},{"key":"7915_CR30","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.2147\/DDDT.S308973","volume":"15","author":"H Huang","year":"2021","unstructured":"Huang H, He Q, Guo B et al (2021) Progress in redirecting antiparasitic drugs for cancer treatment. Drug Des Devel Ther 15:2747\u20132767. https:\/\/doi.org\/10.2147\/DDDT.S308973","journal-title":"Drug Des Devel Ther"},{"key":"7915_CR31","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s12038-020-00129-z","volume":"46","author":"PF Islas-Morales","year":"2021","unstructured":"Islas-Morales PF, Jim\u00e9nez-Garc\u00eda LF, Mosqueira-Santill\u00e1n M, Voolstra CR (2021) Evolutionary cell biology (ECB): lessons, challenges, and opportunities for the integrative study of cell evolution. J Biosci 46:9. https:\/\/doi.org\/10.1007\/s12038-020-00129-z","journal-title":"J Biosci"},{"key":"7915_CR32","doi-asserted-by":"publisher","first-page":"251686571984909","DOI":"10.1177\/2516865719849090","volume":"12","author":"A Iyer-Bierhoff","year":"2019","unstructured":"Iyer-Bierhoff A, Grummt I (2019) Stop-and-go: dynamics of nucleolar transcription during the cell cycle. Epigenetics Insights 12:251686571984909. https:\/\/doi.org\/10.1177\/2516865719849090","journal-title":"Epigenetics Insights"},{"key":"7915_CR33","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.molbiopara.2009.04.011","volume":"167","author":"GD Jhingan","year":"2009","unstructured":"Jhingan GD, Panigrahi SK, Bhattacharya A, Bhattacharya S (2009) The nucleolus in Entamoeba histolytica and Entamoeba invadens is located at the nuclear periphery. Mol Biochem Parasitol 167:72\u201380. https:\/\/doi.org\/10.1016\/j.molbiopara.2009.04.011","journal-title":"Mol Biochem Parasitol"},{"key":"7915_CR34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.15406\/mojap.2017.03.00083","volume":"3","author":"LF Jim\u00e9nez-Garc\u00eda","year":"2017","unstructured":"Jim\u00e9nez-Garc\u00eda LF (2017) The nucleolus of Giardia lamblia. MOJ Anat Physiol 3:41\u201343. https:\/\/doi.org\/10.15406\/mojap.2017.03.00083","journal-title":"MOJ Anat Physiol"},{"key":"7915_CR35","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.ijpara.2008.04.012","volume":"38","author":"LF Jim\u00e9nez-Garc\u00eda","year":"2008","unstructured":"Jim\u00e9nez-Garc\u00eda LF, Zavala G, Ch\u00e1vez-Mungu\u00eda B et al (2008) Identification of nucleoli in the early branching protist Giardia duodenalis. Int J Parasitol 38:1297\u20131304. https:\/\/doi.org\/10.1016\/j.ijpara.2008.04.012","journal-title":"Int J Parasitol"},{"key":"7915_CR36","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0168-9525(90)90141-R","volume":"6","author":"KS Kabnick","year":"1990","unstructured":"Kabnick KS, Peattie DA (1990) In situ analyses reveal that the two nuclei of Giardia lamblia are equivalent. Trends Genet 6:143. https:\/\/doi.org\/10.1016\/0168-9525(90)90141-R","journal-title":"Trends Genet"},{"key":"7915_CR37","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0378-1119(94)00677-K","volume":"152","author":"SK Katiyar","year":"1995","unstructured":"Katiyar SK, Visvesvara GS, Edlind TD (1995) Comparisons of ribosomal RNA sequences from amitochondrial protozoa: implications for processing, mRNA binding and paromomycin susceptibility. Gene 152:27\u201333. https:\/\/doi.org\/10.1016\/0378-1119(94)00677-K","journal-title":"Gene"},{"key":"7915_CR38","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1016\/j.cell.2007.10.051","volume":"131","author":"C-D Kuhn","year":"2007","unstructured":"Kuhn C-D, Geiger SR, Baumli S et al (2007) Functional architecture of RNA polymerase I. Cell 131:1260\u20131272. https:\/\/doi.org\/10.1016\/j.cell.2007.10.051","journal-title":"Cell"},{"key":"7915_CR39","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nsmb.2939","volume":"22","author":"DLJ Lafontaine","year":"2015","unstructured":"Lafontaine DLJ (2015) Noncoding RNAs in eukaryotic ribosome biogenesis and function. Nat Struct Mol Biol 22:11\u201319. https:\/\/doi.org\/10.1038\/nsmb.2939","journal-title":"Nat Struct Mol Biol"},{"key":"7915_CR40","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/s41580-020-0272-6","volume":"22","author":"DLJ Lafontaine","year":"2021","unstructured":"Lafontaine DLJ, Riback JA, Bascetin R, Brangwynne CP (2021) The nucleolus as a multiphase liquid condensate. Nat Rev Mol Cell Biol 22:165\u2013182. https:\/\/doi.org\/10.1038\/s41580-020-0272-6","journal-title":"Nat Rev Mol Cell Biol"},{"key":"7915_CR41","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1007\/s11686-022-00612-7","volume":"67","author":"FA Lagunas-Rangel","year":"2022","unstructured":"Lagunas-Rangel FA (2022a) Ribosomal RNA transcription machineries in intestinal protozoan parasites: a bioinformatic analysis. Acta Parasitol 67:1788\u20131799. https:\/\/doi.org\/10.1007\/s11686-022-00612-7","journal-title":"Acta Parasitol"},{"key":"7915_CR42","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1007\/s11686-022-00521-9","volume":"67","author":"FA Lagunas-Rangel","year":"2022","unstructured":"Lagunas-Rangel FA (2022b) Sequence analysis and comparison of TCTP proteins from human protozoan parasites. Acta Parasitol 67:1024\u20131031. https:\/\/doi.org\/10.1007\/s11686-022-00521-9","journal-title":"Acta Parasitol"},{"key":"7915_CR43","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.biochi.2018.10.008","volume":"156","author":"FA Lagunas-Rangel","year":"2019","unstructured":"Lagunas-Rangel FA, Berm\u00fadez-Cruz RM (2019) Epigenetics in the early divergent eukaryotic Giardia duodenalis: an update. Biochimie 156:123\u2013128. https:\/\/doi.org\/10.1016\/j.biochi.2018.10.008","journal-title":"Biochimie"},{"key":"7915_CR44","doi-asserted-by":"publisher","first-page":"107822","DOI":"10.1016\/j.exppara.2019.107822","volume":"209","author":"FA Lagunas-Rangel","year":"2020","unstructured":"Lagunas-Rangel FA, Baz\u00e1n-Tejeda ML, Garc\u00eda-Villa E, Berm\u00fadez-Cruz RM (2020) Nicotinamide induces G2 cell cycle arrest in Giardia duodenalis trophozoites and promotes changes in sirtuins transcriptional expression. Exp Parasitol 209:107822. https:\/\/doi.org\/10.1016\/j.exppara.2019.107822","journal-title":"Exp Parasitol"},{"key":"7915_CR45","doi-asserted-by":"publisher","first-page":"105872","DOI":"10.1016\/j.actatropica.2021.105872","volume":"217","author":"FA Lagunas-Rangel","year":"2021","unstructured":"Lagunas-Rangel FA, Baz\u00e1n-Tejeda ML, Berm\u00fadez-Cruz RM (2021a) Ribosomal DNA in the protozoan parasite Giardia duodenalis has a differential chromatin distribution and epigenetic markings across the subunits. Acta Trop 217:105872. https:\/\/doi.org\/10.1016\/j.actatropica.2021.105872","journal-title":"Acta Trop"},{"key":"7915_CR46","doi-asserted-by":"publisher","first-page":"126807","DOI":"10.1016\/j.micres.2021.126807","volume":"250","author":"FA Lagunas-Rangel","year":"2021","unstructured":"Lagunas-Rangel FA, Yee J, Berm\u00fadez-Cruz RM (2021b) An update on cell division of Giardia duodenalis trophozoites. Microbiol Res 250:126807. https:\/\/doi.org\/10.1016\/j.micres.2021.126807","journal-title":"Microbiol Res"},{"key":"7915_CR47","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1111\/mmi.14710","volume":"115","author":"FA Lagunas-Rangel","year":"2021","unstructured":"Lagunas-Rangel FA, Yee J, Baz\u00e1n-Tejeda ML et al (2021c) Sirtuin GdSir2.4 participates in the regulation of rRNA transcription in the Giardia duodenalis parasite. Mol Microbiol 115:1039\u20131053. https:\/\/doi.org\/10.1111\/mmi.14710","journal-title":"Mol Microbiol"},{"key":"7915_CR48","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1002\/ar.23323","volume":"299","author":"R Lara-Mart\u00ednez","year":"2016","unstructured":"Lara-Mart\u00ednez R, De Lourdes S-V, La Mora-De De, La Mora I et al (2016) Morphological studies of nucleologenesis in Giardia lamblia. Anat Rec 299:549\u2013556. https:\/\/doi.org\/10.1002\/ar.23323","journal-title":"Anat Rec"},{"key":"7915_CR49","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/S0966-842X(02)02306-5","volume":"10","author":"D Lloyd","year":"2002","unstructured":"Lloyd D, Harris JC (2002) Giardia: highly evolved parasite or early branching eukaryote? Trends Microbiol 10:122\u2013127. https:\/\/doi.org\/10.1016\/S0966-842X(02)02306-5","journal-title":"Trends Microbiol"},{"key":"7915_CR50","doi-asserted-by":"publisher","unstructured":"Majumdar S, Emmerich A, Krakovka S, et al (2023) Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis. Nucleic Acids Res 1\u201316. https:\/\/doi.org\/10.1093\/nar\/gkad176","DOI":"10.1093\/nar\/gkad176"},{"key":"7915_CR51","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3390\/cells8050421","volume":"8","author":"S Mart\u00ednez-Calvillo","year":"2019","unstructured":"Mart\u00ednez-Calvillo S, Florencio-Mart\u00ednez LE, Nepomuceno-Mej\u00eda T (2019) Nucleolar structure and function in trypanosomatid protozoa. Cells 8:421. https:\/\/doi.org\/10.3390\/cells8050421","journal-title":"Cells"},{"key":"7915_CR52","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1080\/15476286.2022.2079890","volume":"19","author":"V Mitterer","year":"2022","unstructured":"Mitterer V, Pertschy B (2022) RNA folding and functions of RNA helicases in ribosome biogenesis. RNA Biol 19:781\u2013810. https:\/\/doi.org\/10.1080\/15476286.2022.2079890","journal-title":"RNA Biol"},{"issue":"317","key":"7915_CR53","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1126\/science.1143837","volume":"80-","author":"HG Morrison","year":"2007","unstructured":"Morrison HG, McArthur AG, Gillin FD et al (2007) Genomic minimalism in the early diverging intestinal parasite Giardia lamblia. Science 80-(317):1921\u20131926. https:\/\/doi.org\/10.1126\/science.1143837","journal-title":"Science"},{"key":"7915_CR54","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.tig.2019.07.006","volume":"35","author":"JO Nelson","year":"2019","unstructured":"Nelson JO, Watase GJ, Warsinger-Pepe N, Yamashita YM (2019) Mechanisms of rDNA copy number maintenance. Trends Genet 35:734\u2013742. https:\/\/doi.org\/10.1016\/j.tig.2019.07.006","journal-title":"Trends Genet"},{"key":"7915_CR55","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1093\/nar\/28.6.1283","volume":"28","author":"MR Paule","year":"2000","unstructured":"Paule MR, White RJ (2000) Survey and summary: transcription by RNA polymerases I and III. Nucleic Acids Res 28:1283\u20131298. https:\/\/doi.org\/10.1093\/nar\/28.6.1283","journal-title":"Nucleic Acids Res"},{"key":"7915_CR56","doi-asserted-by":"publisher","first-page":"a000638","DOI":"10.1101\/cshperspect.a000638","volume":"3","author":"T Pederson","year":"2011","unstructured":"Pederson T (2011) The nucleolus. Cold Spring Harb Perspect Biol 3:a000638\u2013a000638. https:\/\/doi.org\/10.1101\/cshperspect.a000638","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"7915_CR57","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nrd.2018.168","volume":"18","author":"S Pushpakom","year":"2019","unstructured":"Pushpakom S, Iorio F, Eyers PA et al (2019) Drug repurposing: progress, challenges and recommendations. Nat Rev Drug Discov 18:41\u201358. https:\/\/doi.org\/10.1038\/nrd.2018.168","journal-title":"Nat Rev Drug Discov"},{"key":"7915_CR58","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1042\/bss0730203","volume":"73","author":"J Russell","year":"2006","unstructured":"Russell J, Zomerdijk JCBM (2006) The RNA polymerase I transcription machinery. Biochem Soc Symp 73:203\u2013216. https:\/\/doi.org\/10.1042\/bss0730203","journal-title":"Biochem Soc Symp"},{"key":"7915_CR59","doi-asserted-by":"publisher","first-page":"4889","DOI":"10.1242\/jcs.03276","volume":"119","author":"MS Sagolla","year":"2006","unstructured":"Sagolla MS, Dawson SC, Mancuso JJ, Cande WZ (2006) Three-dimensional analysis of mitosis and cytokinesis in the binucleate parasite Giardia intestinalis. J Cell Sci 119:4889\u20134900. https:\/\/doi.org\/10.1242\/jcs.03276","journal-title":"J Cell Sci"},{"key":"7915_CR60","doi-asserted-by":"publisher","first-page":"27804","DOI":"10.1074\/jbc.M303316200","volume":"278","author":"V Seshadri","year":"2003","unstructured":"Seshadri V, McArthur AG, Sogin ML, Adam RD (2003) Giardia lamblia RNA Polymerase II. J Biol Chem 278:27804\u201327810. https:\/\/doi.org\/10.1074\/jbc.M303316200","journal-title":"J Biol Chem"},{"key":"7915_CR61","doi-asserted-by":"publisher","first-page":"R611","DOI":"10.1016\/j.cub.2022.04.083","volume":"32","author":"D Shore","year":"2022","unstructured":"Shore D, Albert B (2022) Ribosome biogenesis and the cellular energy economy. Curr Biol 32:R611\u2013R617. https:\/\/doi.org\/10.1016\/j.cub.2022.04.083","journal-title":"Curr Biol"},{"key":"7915_CR62","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1128\/MMBR.00005-16","volume":"80","author":"R Srivastava","year":"2016","unstructured":"Srivastava R, Srivastava R, Ahn SH (2016) The epigenetic pathways to ribosomal DNA silencing. Microbiol Mol Biol Rev 80:545\u2013563. https:\/\/doi.org\/10.1128\/MMBR.00005-16","journal-title":"Microbiol Mol Biol Rev"},{"key":"7915_CR63","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s00436-009-1715-3","volume":"106","author":"XF Tian","year":"2010","unstructured":"Tian XF, Yang ZH, Shen H et al (2010) Identification of the nucleoli of Giardia lamblia with TEM and CFM. Parasitol Res 106:789\u2013793. https:\/\/doi.org\/10.1007\/s00436-009-1715-3","journal-title":"Parasitol Res"},{"key":"7915_CR64","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.tcb.2018.03.007","volume":"28","author":"V Tiku","year":"2018","unstructured":"Tiku V, Antebi A (2018) Nucleolar function in lifespan regulation. Trends Cell Biol 28:662\u2013672. https:\/\/doi.org\/10.1016\/j.tcb.2018.03.007","journal-title":"Trends Cell Biol"},{"key":"7915_CR65","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1002\/mbo3.351","volume":"5","author":"P T\u016fmov\u00e1","year":"2016","unstructured":"T\u016fmov\u00e1 P, Uzl\u00edkov\u00e1 M, Jurczyk T, Noh\u00fdnkov\u00e1 E (2016) Constitutive aneuploidy and genomic instability in the single-celled eukaryote Giardia intestinalis. Microbiologyopen 5:560\u2013574. https:\/\/doi.org\/10.1002\/mbo3.351","journal-title":"Microbiologyopen"},{"key":"7915_CR66","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1101\/gr.7.1.37","volume":"7","author":"P Upcroft","year":"1997","unstructured":"Upcroft P, Chen N, Upcroft JA (1997) Telomeric organization of a variable and inducible toxin gene family in the ancient eukaryote Giardia duodenalis. Genome Res 7:37\u201346. https:\/\/doi.org\/10.1101\/gr.7.1.37","journal-title":"Genome Res"},{"key":"7915_CR67","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.pt.2010.07.002","volume":"26","author":"JA Upcroft","year":"2010","unstructured":"Upcroft JA, Krauer KG, Upcroft P (2010) Chromosome sequence maps of the Giardia lamblia assemblage A isolate WB. Trends Parasitol 26:484\u2013491. https:\/\/doi.org\/10.1016\/j.pt.2010.07.002","journal-title":"Trends Parasitol"},{"key":"7915_CR68","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s10158-007-0055-1","volume":"7","author":"DJ Woods","year":"2007","unstructured":"Woods DJ, Williams TM (2007) The challenges of developing novel antiparasitic drugs. Invertebr Neurosci 7:245\u2013250. https:\/\/doi.org\/10.1007\/s10158-007-0055-1","journal-title":"Invertebr Neurosci"},{"key":"7915_CR69","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41597-020-0377-y","volume":"7","author":"F Xu","year":"2020","unstructured":"Xu F, Jex A, Sv\u00e4rd SG (2020) A chromosome-scale reference genome for Giardia intestinalis WB. Sci Data 7:38. https:\/\/doi.org\/10.1038\/s41597-020-0377-y","journal-title":"Sci Data"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-023-07915-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-023-07915-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-023-07915-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T10:08:59Z","timestamp":1692180539000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-023-07915-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,4]]},"references-count":69,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["7915"],"URL":"https:\/\/doi.org\/10.1007\/s00436-023-07915-2","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,4]]},"assertion":[{"value":"3 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The author declares no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}