{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:53:50Z","timestamp":1778176430410,"version":"3.51.4"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Support Foundation for Scientific and Technological Research of the Federal Rural University of Rio de Janeiro"},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1007\/s00436-023-08037-5","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T09:02:15Z","timestamp":1702544535000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Do combinations of fipronil, eugenol and carvacrol have synergistic effects against Rhipicephalus sanguineus?"],"prefix":"10.1007","volume":"123","author":[{"given":"Fernando Rocha","family":"Miranda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara Rauta","family":"Avelar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid Lins Raquel","family":"de Jesus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brena Gava","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle Vilela","family":"Bonfim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melina Cardilo Campos","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thais Paes","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thais Ribeiro Correa","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yara Peluso","family":"Cid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio Barbour","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"8037_CR1","unstructured":"Abbott WS (1987) A method of computing the effectiveness of an insecticide. 1925. J Am Mosq Control Assoc 3(2):302\u2013303"},{"key":"8037_CR2","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00436-016-5267-z","volume":"116","author":"FM Alves","year":"2017","unstructured":"Alves FM, Bernardo CC, Paix\u00e3o FR, Barreto LP, Luz C, Humber RA, Fernandes \u00c9K (2017) Heat-stressed Metarhizium anisopliae: Viability (in vitro) and virulence (in vivo) assessments against the tick Rhipicephalus sanguineus. Parasitol Res 116:111\u2013121. https:\/\/doi.org\/10.1007\/s00436-016-5267-z","journal-title":"Parasitol Res"},{"issue":"1","key":"8037_CR3","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1038\/s41598-022-06302-8","volume":"12","author":"K Adhikari","year":"2022","unstructured":"Adhikari K, Khanikor B, Sarma R (2022) Persistent susceptibility of Aedes aegypti to eugenol. Sci Rep 12(1):2277","journal-title":"Sci Rep"},{"issue":"4","key":"8037_CR4","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/mve.12181","volume":"30","author":"LX Ara\u00fajo","year":"2016","unstructured":"Ara\u00fajo LX, Novato TPL, Zeringota V, Maturano R, Melo D, Da Silva BC, Daemon E, De Carvalho MG, Monteiro CMO (2016) Synergism of thymol, carvacrol and eugenol in larvae of the cattle tick, Rhipicephalus microplus, and brown dog tick, Rhipicephalus sanguineus. Med Vet Entomol 30(4):377\u2013382. https:\/\/doi.org\/10.1111\/mve.12181","journal-title":"Med Vet Entomol"},{"issue":"4","key":"8037_CR5","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.vetpar.2011.03.045","volume":"179","author":"D Baggott","year":"2011","unstructured":"Baggott D, Ollagnier C, Yoon SS, Collidor N, Mallouk Y, Cramer LG (2011) Efficacy of a novel combination of fipronil, amitraz and (S)-methoprene for treatment and control of tick species infesting dogs in Europe. Vet Parasitol 179(4):330\u2013334. https:\/\/doi.org\/10.1016\/j.vetpar.2011.03.045","journal-title":"Vet Parasitol"},{"issue":"2","key":"8037_CR6","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.fct.2007.09.106","volume":"46","author":"F Bakkali","year":"2008","unstructured":"Bakkali F, Averbeck S, Averbeck D, Idaomar M (2008) Biological effects of essential oils\u2013a review. Food Chem Toxicol 46(2):446\u2013475","journal-title":"Food Chem Toxicol"},{"key":"8037_CR7","unstructured":"Barros-Battesti DM, Arzua M, Bechara GH (2006) Carrapatos de import\u00e2ncia m\u00e9dico-veterin\u00e1ria da regi\u00e3o neotropical: um guia ilustrado para identifica\u00e7\u00e3o de esp\u00e9cies. In Carrapatos de import\u00e2ncia m\u00e9dico-veterin\u00e1ria da regi\u00e3o neotropical: um guia ilustrado para identifica\u00e7\u00e3o de esp\u00e9cies. S\u00e3o Paulo, VoxlICTTD-3\/Butantan, p 223"},{"issue":"5","key":"8037_CR8","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.ttbdis.2019.05.015","volume":"10","author":"S Becker","year":"2019","unstructured":"Becker S, Webster A, Doyle RL, Martins JR, Reck J, Klafke GM (2019) Resistance to deltamethrin, fipronil and ivermectin in the brown dog tick, Rhipicephalus sanguineus sensu stricto, Latreille (Acari: Ixodidae). Ticks Tick-Borne Dis 10(5):1046\u20131050. https:\/\/doi.org\/10.1016\/j.ttbdis.2019.05.015","journal-title":"Ticks Tick-Borne Dis"},{"key":"8037_CR9","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.indcrop.2018.02.072","volume":"117","author":"G Benelli","year":"2018","unstructured":"Benelli G, Pavela R (2018) Beyond mosquitoes\u2014Essential oil toxicity and repellency against bloodsucking insects. Ind Crops Prod 117:382\u2013392. https:\/\/doi.org\/10.1016\/j.indcrop.2018.02.072","journal-title":"Ind Crops Prod"},{"issue":"6","key":"8037_CR10","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.cvsm.2009.07.001","volume":"39","author":"BL Blagburn","year":"2009","unstructured":"Blagburn BL, Dryden MW (2009) Biology Treatment and Control of Flea and Tick Infestations. Vet Clin N Am Small Anim Pract 39(6):1173\u20131200. https:\/\/doi.org\/10.1016\/j.cvsm.2009.07.001","journal-title":"Vet Clin N Am Small Anim Pract"},{"issue":"3","key":"8037_CR11","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1124\/pr.58.3.10","volume":"58","author":"TC Chou","year":"2006","unstructured":"Chou TC (2006) Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 58(3):621\u2013681. https:\/\/doi.org\/10.1124\/pr.58.3.10","journal-title":"Pharmacol Rev"},{"key":"8037_CR12","doi-asserted-by":"publisher","first-page":"108989","DOI":"10.1016\/j.vetpar.2019.108989","volume":"277","author":"L Coelho","year":"2020","unstructured":"Coelho L, de Paula LGF, Alves SDGA, Sampaio ALN, Bezerra GP, Vilela FMP, Matos RS, Zering\u00f3ta V, Borges LMF, Monteiro C (2020) Combination of thymol and eugenol for the control of Rhipicephalus sanguineus sensu lato: Evaluation of synergism on immature stages and formulation development. Vet Parasitol 277:108989. https:\/\/doi.org\/10.1016\/j.vetpar.2019.108989","journal-title":"Vet Parasitol"},{"issue":"3\u20134","key":"8037_CR13","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.vetpar.2007.12.030","volume":"152","author":"F Dantas-Torres","year":"2008","unstructured":"Dantas-Torres F (2008) The brown dog tick, Rhipicephalus sanguineus (Latreille, 1806)(Acari: Ixodidae): From taxonomy to control. Vet Parasitol 152(3\u20134):173\u2013185. https:\/\/doi.org\/10.1016\/j.vetpar.2007.12.030","journal-title":"Vet Parasitol"},{"key":"8037_CR14","doi-asserted-by":"publisher","unstructured":"Dawood MA, El Basuini MF, Zaineldin AI, Yilmaz S, Hasan MT, Ahmadifar, E El Asely AM, Abdel-Latif HMR Alagawany M, Abu-Elala NM, Doan HV, Sewilam H (2021) Antiparasitic and antibacterial functionality of essential oils: An alternative approach for sustainable aquaculture. Pathogens 10(2):185.https:\/\/doi.org\/10.3390\/pathogens10020185","DOI":"10.3390\/pathogens10020185"},{"issue":"3","key":"8037_CR15","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1093\/jme\/tjv005","volume":"52","author":"AL Eiden","year":"2015","unstructured":"Eiden AL, Kaufman PE, Oi FM, Allan SA, Miller RJ (2015) Detection of permethrin resistance and fipronil tolerance in Rhipicephalus sanguineus (Acari: Ixodidae) in the United States. J Med Entomol 52(3):429\u2013436. https:\/\/doi.org\/10.1093\/jme\/tjv005","journal-title":"J Med Entomol"},{"issue":"3","key":"8037_CR16","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/mve.12033","volume":"28","author":"L Ellse","year":"2014","unstructured":"Ellse L, Wall R (2014) The use of essential oils in veterinary ectoparasite control: a review. Abstract Medical and Veterinary Entomology 28(3):233\u2013243. https:\/\/doi.org\/10.1111\/mve.12033","journal-title":"Abstract Medical and Veterinary Entomology"},{"key":"8037_CR17","unstructured":"FAO (2004) Resistance. Management and integrated parasite control in ruminants\u2014Guidelines, Module 1. Ticks: Acaricide resistance: Diagnosis, management and prevention. Food and Agriculture Organization. Animal Production and Health Division, Rome"},{"issue":"3\u20134","key":"8037_CR18","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.vetpar.2013.07.026","volume":"197","author":"JJ Fourie","year":"2013","unstructured":"Fourie JJ, Stanneck D, Luus HG, Beugnet F, Wijnveld M, Jongejan F (2013) Transmission of Ehrlichia canis by Rhipicephalus sanguineus ticks feeding on dogs and on artificial membranes. Vet Parasitol 197(3\u20134):595\u2013603. https:\/\/doi.org\/10.1016\/j.vetpar.2013.07.026","journal-title":"Vet Parasitol"},{"key":"8037_CR19","doi-asserted-by":"publisher","unstructured":"Gaire S, Scharf ME, Gondhalekar AD (2020) Synergistic toxicity interactions between plant essential oil components against the common bed bug (Cimex lectularius L.). Insects 11(2):133. https:\/\/doi.org\/10.3390\/insects11020133","DOI":"10.3390\/insects11020133"},{"issue":"4","key":"8037_CR20","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/j.1476-4431.2012.00780.x","volume":"22","author":"AG Genovese","year":"2012","unstructured":"Genovese AG, McLean MK, Khan SA (2012) Adverse reactions from essential oil-containing natural flea products exempted from Environmental Protection Agency regulations in dogs and cats. J Vet Emerg Crit Care 22(4):470\u2013475. https:\/\/doi.org\/10.1111\/j.1476-4431.2012.00780.x","journal-title":"J Vet Emerg Crit Care"},{"key":"8037_CR21","doi-asserted-by":"publisher","unstructured":"Gonzaga BCF, de Moraes NR, Gomes GW, Coutinho AL, Vale FL, e Sousa LJMP, Marreto L, Rodrigues DC, Prata MCA, Marchesini P, Lopes WDZ, Monteiro C (2022) Combination of synthetic acaricides with (E)-cinnamaldehyde to control Rhipicephalus microplus. Exp Appl Acarol 88(2):191\u2013207. https:\/\/doi.org\/10.1007\/s10493-022-00743-6","DOI":"10.1007\/s10493-022-00743-6"},{"key":"8037_CR22","doi-asserted-by":"publisher","unstructured":"Gupta RC, Anad\u00f3n A (2018). Fipronil. In: Veterinary toxicology (pp. 533\u2013538). Academic Press. https:\/\/doi.org\/10.1016\/B978-0-12-811410-0.00042-8","DOI":"10.1016\/B978-0-12-811410-0.00042-8"},{"issue":"2","key":"8037_CR23","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/S0195-5616(01)00013-4","volume":"32","author":"LR Hovda","year":"2002","unstructured":"Hovda LR, Hooser SB (2002) Toxicology of newer pesticides for use in dogs and cats. Vet Clin N Am Small Anim Pract 32(2):455\u2013467. https:\/\/doi.org\/10.1016\/S0195-5616(01)00013-4","journal-title":"Vet Clin N Am Small Anim Pract"},{"issue":"08","key":"8037_CR24","doi-asserted-by":"publisher","first-page":"174","DOI":"10.4236\/pp.2020.118016","volume":"11","author":"F Ibarra-Velarde","year":"2020","unstructured":"Ibarra-Velarde F, Vera-Montenegro Y, Acala-Canto Y, Cruz-Mendoza I (2020) Additive efficiency of fipronil + methoprene compared to fipronil alone against rhipicephalus sanguineus ticks in naturally infested dogs. Pharmacology & Pharmacy 11(08):174\u2013187. https:\/\/doi.org\/10.4236\/pp.2020.118016","journal-title":"Pharmacology & Pharmacy"},{"issue":"5","key":"8037_CR25","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.eng.2019.07.027","volume":"6","author":"AS Li","year":"2020","unstructured":"Li AS, Iijima A, Huang J, Li QX, Chen Y (2020) Putative mode of action of the monoterpenoids linalool, methyl eugenol, estragole, and citronellal on ligand-gated ion channels. Engineering 6(5):541\u2013545. https:\/\/doi.org\/10.1016\/j.eng.2019.07.027","journal-title":"Engineering"},{"issue":"1","key":"8037_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-015-1207-5","volume":"8","author":"F Jongejan","year":"2015","unstructured":"Jongejan F, De Vos C, Fourie JJ, Beugnet F (2015) A novel combination of fipronil and permethrin (Frontline Tri-Act\u00ae\/Frontect\u00ae) reduces risk of transmission of Babesia canis by Dermacentor reticulatus and of Ehrlichia canis by Rhipicephalus sanguineus ticks to dogs. Parasit Vectors 8(1):1\u201310. https:\/\/doi.org\/10.1186\/s13071-015-1207-5","journal-title":"Parasit Vectors"},{"key":"8037_CR27","doi-asserted-by":"publisher","first-page":"109126","DOI":"10.1016\/j.vetpar.2020.109126","volume":"282","author":"MM Lambert","year":"2020","unstructured":"Lambert MM, Campos DR, Borges DA, de Avelar BR, Ferreira TP, Cid YP, Boylan F, Scott FB, Chaves DSDA, Coumendouros K (2020) Activity of Syzygium aromaticum essential oil and its main constituent eugenol in the inhibition of the development of ctenocephalides felis felis and the control of adults. Vet Parasitol 282:109126. https:\/\/doi.org\/10.1016\/j.vetpar.2020.109126","journal-title":"Vet Parasitol"},{"key":"8037_CR28","doi-asserted-by":"publisher","unstructured":"Lambert MM, de Almeida Chaves DS, de Avelar BR, Campos DR, Borges DA, Moreira LO, Pereira GA, Cid YP, Scott FB, Coumendouros K (2021) In vitro evaluation of the acaricidal activity of Syzygium aromaticum (L.) essential oil and eugenol against non-fed larvae of Rhipicephalus sanguineus. Braz J Vet Med 43:e002620. https:\/\/doi.org\/10.29374\/2527-2179.bjvm002620","DOI":"10.29374\/2527-2179.bjvm002620"},{"issue":"1","key":"8037_CR29","doi-asserted-by":"publisher","first-page":"e0117316","DOI":"10.1371\/journal.pone.0117316","volume":"10","author":"SH Lee","year":"2015","unstructured":"Lee SH, Moon JY, Jung SJ, Kang JG, Choi SP, Jang JH (2015) Eugenol inhibits the GABAA current in trigeminal ganglion neurons. PLoS One 10(1):e0117316. https:\/\/doi.org\/10.1371\/journal.pone.0117316","journal-title":"PLoS One"},{"key":"8037_CR30","doi-asserted-by":"publisher","unstructured":"Louly CCB, Soares SF, da N\u00f3brega Silveira D, Guimar\u00e3es MS, Borges LMF (2010) Differences in the behavior of Rhipicephalus sanguineus tested against resistant and susceptible dogs. Exp Appl Acarol 51:353\u2013362. https:\/\/doi.org\/10.1007\/s10493-009-9334-3","DOI":"10.1007\/s10493-009-9334-3"},{"key":"8037_CR31","unstructured":"Miranda FR (2022) In vitro evaluation of synergistic activity between fipronil, eugenol and carvacrol front larvae, nymphs and unfed adults of Rhipicephalus sanguineus sensu lato (Latreille, 1806) (Dissertation (Master\u2019s in veterinary science, Veterinary Parasitology)). Veterinary Institute, Department of Animal Parasitology, Federal Rural University of Rio de Janeiro, Serop\u00e9dica, RJ, p. 65"},{"key":"8037_CR32","doi-asserted-by":"publisher","first-page":"107774","DOI":"10.1016\/j.exppara.2019.107774","volume":"207","author":"TLP Novato","year":"2019","unstructured":"Novato TLP, Marchesini P, Muniz N, de AzevedoPrata MC, Furlong J, Vilela FMP, Daemon E, Maturano R, Monteiro C (2019) Evaluation of synergism and development of a formulation with thymol, carvacrol and eugenol for Rhipicephalus microplus control. Exp Parasitol 207:107774. https:\/\/doi.org\/10.1016\/j.exppara.2019.107774","journal-title":"Exp Parasitol"},{"issue":"3\u20134","key":"8037_CR33","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.vetpar.2015.08.021","volume":"212","author":"TPL Novato","year":"2015","unstructured":"Novato TPL, Ara\u00fajo LX, de Monteiro CMO, Maturano R, Senra TDOS, da Silva Matos R, Gomes GA, de Carvalho MG, Daemon E (2015) Evaluation of the combined effect of thymol, carvacrol and (E)-cinnamaldehyde on Amblyomma sculptum (Acari: Ixodidae) and Dermacentor nitens (Acari: Ixodidae) larvae. Vet Parasitol 212(3\u20134):331\u2013335. https:\/\/doi.org\/10.1016\/j.vetpar.2015.08.021","journal-title":"Vet Parasitol"},{"key":"8037_CR34","doi-asserted-by":"crossref","unstructured":"Nicholson, WL, Sonenshine, DE, Noden, BH, Brown, RN (2019) Ticks (Ixodida). In Medical and veterinary entomology Jan 1: 603\u2013672","DOI":"10.1016\/B978-0-12-814043-7.00027-3"},{"key":"8037_CR35","doi-asserted-by":"publisher","unstructured":"Oliveira LM, de Almeida Chaves DS, de Jesus ILR, Miranda FR, Ferreira TP, e Silva CN, Alves NS, Alves MCC, Avelar BR, Scott FB, Campos DR, Cid YP (2022) Ocimum gratissimum essential oil and eugenol against Ctenocephalides felis felis and Rhipicephalus sanguineus: In vitro activity and residual efficacy of a eugenol-based spray formulation. Veterinary Parasitology 309109771. https:\/\/doi.org\/10.1016\/j.vetpar.2022.109771","DOI":"10.1016\/j.vetpar.2022.109771"},{"issue":"1\u20132","key":"8037_CR36","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.vetpar.2009.08.015","volume":"166","author":"CPM Pereira","year":"2009","unstructured":"Pereira CPM, Oliveira PR, Furquim KCS, Bechara GH, Camargo-Mathias MI (2009) Effects of fipronil (active ingredient of Frontline\u00ae) on salivary gland cells of Rhipicephalus sanguineus females (Latreille, 1806)(Acari: Ixodidae). Vet Parasitol 166(1\u20132):124\u2013130. https:\/\/doi.org\/10.1016\/j.vetpar.2009.08.015","journal-title":"Vet Parasitol"},{"issue":"2","key":"8037_CR37","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s10493-011-9424-x","volume":"54","author":"JB Prullage","year":"2011","unstructured":"Prullage JB, Cawthorne WG, Hir Le, de Fallois LP, Timmons PR (2011) Synergy between fipronil and amitraz in a Rhipicephalus sanguineus tick residual contact test. Exp Appl Acarol 54(2):173\u2013176. https:\/\/doi.org\/10.1007\/s10493-011-9424-x","journal-title":"Exp Appl Acarol"},{"issue":"1","key":"8037_CR38","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/mve.12207","volume":"31","author":"RI Rodriguez-Vivas","year":"2017","unstructured":"Rodriguez-Vivas RI, Ojeda-Chi MM, Trinidad-Martinez I, Bolio-Gonz\u00e1lez ME (2017) First report of amitraz and cypermethrin resistance in Rhipicephalus sanguineus sensu lato infesting dogs in Mexico. Med Vet Entomol 31(1):72\u201377. https:\/\/doi.org\/10.1111\/mve.12207","journal-title":"Med Vet Entomol"},{"key":"8037_CR39","doi-asserted-by":"publisher","unstructured":"Senra TOS, Calmon F, Zering\u00f3ta V (2013) Investigation of activity of monoterpenes and phenylpropanoids against immature stages of Amblyomma cajennense and Rhipicephalus sanguineus (Acari: Ixodidae). Parasitol Res 112:3471\u20133476.https:\/\/doi.org\/10.1007\/s00436-013-3527-8","DOI":"10.1007\/s00436-013-3527-8"},{"key":"8037_CR40","doi-asserted-by":"publisher","unstructured":"Silva IS, Vale L, Coutinho AL, e Sousa LJMP, Marchesini P, da Silva Matos R, Anholeto LA, Mathias MIC, Ferreira LL, Arruda W, Monteiro C (2023) Thymol and eugenol against Rhipicephalus sanguineus sensu lato engorged females: Biological, histopathological and bioinformatic analysis. Vet Parasitol 319:109938. https:\/\/doi.org\/10.1016\/j.vetpar.2023.109938","DOI":"10.1016\/j.vetpar.2023.109938"},{"key":"8037_CR41","unstructured":"Sonenshine DE, Roe RM (2014) External and internal anatomy of ticks. Biol 74\u201398"},{"key":"8037_CR42","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1017\/S000748530004832X","volume":"53","author":"BF Stone","year":"1962","unstructured":"Stone BF, Haydock KP (1962) A method for measuring the acaricide susceptibility of the cattle B. microplus (Can.). Bull Entomol Res 53:563\u2013578","journal-title":"Bull Entomol Res"},{"issue":"11","key":"8037_CR43","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1023\/A:1006347200373","volume":"23","author":"MP Szab\u00f3","year":"1999","unstructured":"Szab\u00f3 MP, Bechara GH (1999) Sequential histopathology at the Rhipicephalus sanguineus tick feeding site on dogs and guinea pigs. Exp Appl Acarol 23(11):915\u2013928. https:\/\/doi.org\/10.1023\/A:1006347200373","journal-title":"Exp Appl Acarol"},{"key":"8037_CR44","doi-asserted-by":"publisher","unstructured":"Tabari MA, Youssefi, MR, Maggi F, Benelli G (2017) Toxic and repellent activity of selected monoterpenoids (thymol, carvacrol and linalool) against the castor bean tick, Ixodes ricinus (Acari: Ixodidae). Vet Parasitol 245:86\u201391. https:\/\/doi.org\/10.1016\/j.vetpar.2017.08.012","DOI":"10.1016\/j.vetpar.2017.08.012"},{"issue":"1","key":"8037_CR45","doi-asserted-by":"publisher","first-page":"101874","DOI":"10.1016\/j.ttbdis.2021.101874","volume":"13","author":"CP Tavares","year":"2022","unstructured":"Tavares CP, Sousa IC, Gomes MN, Mir\u00f3 V, Virkel G, Lifschitz A, Costa-Junior LM (2022) Combination of cypermethrin and thymol for control of Rhipicephalus microplus: Efficacy evaluation and description of an action mechanism. Ticks Tick-Borne Dis 13(1):101874","journal-title":"Ticks Tick-Borne Dis"},{"issue":"3","key":"8037_CR46","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1053\/tvjl.2000.0549","volume":"161","author":"MA Taylor","year":"2001","unstructured":"Taylor MA (2001) Recent developments in ectoparasiticides. Vet J 161(3):253\u2013268. https:\/\/doi.org\/10.1053\/tvjl.2000.0549","journal-title":"Vet J"},{"issue":"2","key":"8037_CR47","doi-asserted-by":"publisher","first-page":"279","DOI":"10.56808\/2985-1130.2478","volume":"43","author":"S Tiawsirisup","year":"2013","unstructured":"Tiawsirisup S, Thiansirikhun K, Thanadumkerng K, Pastarapatee N, Trirattananuwong N, Rattanatayarom W (2013) Antiparasitic efficacy of 10% w\/v fipronil spot-on (Fiproline Spot-on) against experimental tick (Rhipicephalus sanguineus) infestations on dogs. Thai J Vet Med 43(2):279\u2013284","journal-title":"Thai J Vet Med"},{"issue":"3","key":"8037_CR48","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.pestbp.2010.07.003","volume":"98","author":"F Tong","year":"2010","unstructured":"Tong F, Coats JR (2010) Effects of monoterpenoid insecticides on [3H]-TBOB binding in house fly GABA receptor and 36Cl\u2212 uptake in American cockroach ventral nerve cord. Pestic Biochem Physiol 98(3):317\u2013324. https:\/\/doi.org\/10.1016\/j.pestbp.2010.07.003","journal-title":"Pestic Biochem Physiol"},{"key":"8037_CR49","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1007\/s00436-015-4508-x","volume":"114","author":"SM Trailovi\u0107","year":"2015","unstructured":"Trailovi\u0107 SM, Marjanovi\u0107 DS, Nedeljkovi\u0107Trailovi\u0107 J, Robertson AP, Martin RJ (2015) Interaction of carvacrol with the Ascaris suum nicotinic acetylcholine receptors and gamma-aminobutyric acid receptors, potential mechanism of antinematodal action. Parasitol Res 114:3059\u20133068","journal-title":"Parasitol Res"},{"issue":"6","key":"8037_CR50","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/j.ttbdis.2021.101816","volume":"12","author":"L Vale","year":"2021","unstructured":"Vale L, de Paula LGF, Vieira MS, Alves SDGA, de Moraes Junior NR, Gomes MDF, Teixeira WFP, Rizzo PV, Freitas FMC, Ferreira LL, Lopes WDZ, Monteiro C (2021) Binary combinations of thymol, carvacrol and eugenol for Amblyomma sculptum control: Evaluation of in vitro synergism and effectiveness under semi-field conditions. Ticks Tick-Borne Dis 12(6):1018. https:\/\/doi.org\/10.1016\/j.ttbdis.2021.101816","journal-title":"Ticks Tick-Borne Dis"},{"issue":"1","key":"8037_CR51","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.fitote.2010.11.016","volume":"82","author":"H Wagner","year":"2011","unstructured":"Wagner H (2011) Synergy research: Approaching a new generation of phytopharmaceuticals. Fitoterapia 82(1):34\u201337","journal-title":"Fitoterapia"},{"issue":"1","key":"8037_CR52","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1124\/jpet.104.065516","volume":"310","author":"X Zhao","year":"2004","unstructured":"Zhao X, Yeh JZ, Salgado VL, Narahashi T (2004) Fipronil is a potent open channel blocker of glutamate-activated chloride channels in cockroach neurons. J Pharmacol Exp Ther 310(1):192\u2013201. https:\/\/doi.org\/10.1124\/jpet.104.065516","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-023-08037-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-023-08037-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-023-08037-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T08:16:18Z","timestamp":1706861778000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-023-08037-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,14]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["8037"],"URL":"https:\/\/doi.org\/10.1007\/s00436-023-08037-5","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,14]]},"assertion":[{"value":"26 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable here.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"I confirm that I understand that the journal Parasitology Research is a transformative journal. When research is accepted for publication, there is a choice to publish using either immediate gold open access or the traditional publishing route.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate and to publish"}},{"value":"The authors declare that there are no competing interests as defined by Springer or other interests that might be perceived to influence the results and\/or discussion reported in this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"48"}}