{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:37:12Z","timestamp":1784687832673,"version":"3.55.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Postgraduate Study Support Grant of Faculty of Medicine, Khon Kaen University"},{"name":"The Fundamental Fund of Khon Kaen University and the National Science, Research and Innovation Fund","award":["NSRF-FF2565"],"award-info":[{"award-number":["NSRF-FF2565"]}]},{"name":"The Fundamental Fund of Khon Kaen University and the National Science, Research and Innovation Fund","award":["NSRF-FF2565"],"award-info":[{"award-number":["NSRF-FF2565"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1007\/s00436-024-08154-9","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T05:02:12Z","timestamp":1708059732000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["T helper cell responses to Opisthorchis viverrini infection associate with host susceptibility"],"prefix":"10.1007","volume":"123","author":[{"given":"Pattaraporn","family":"Srisai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujittra","family":"Chaiyadet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amonrat","family":"Jumnainsong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sutas","family":"Suttiprapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanvit","family":"Leelayuwat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasert","family":"Saichua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"issue":"7","key":"8154_CR1","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1002\/1521-4141(200007)30:7<2083::AID-IMMU2083>3.0.CO;2-3","volume":"30","author":"AJ Bancroft","year":"2000","unstructured":"Bancroft AJ, Artis D, Donaldson DD, Sypek JP, Grencis RK (2000) Gastrointestinal nematode expulsion in IL-4 knockout mice is IL-13 dependent. Eur J Immunol 30(7):2083\u20132091. https:\/\/doi.org\/10.1002\/1521-4141(200007)30:7%3c2083::AID-IMMU2083%3e3.0.CO;2-3","journal-title":"Eur J Immunol"},{"issue":"3","key":"8154_CR2","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/s00436-008-1268-x","volume":"104","author":"T Boonmars","year":"2009","unstructured":"Boonmars T, Boonjaraspinyo S, Kaewsamut B (2009) Animal models for Opisthorchis viverrini infection. Parasitol Res 104(3):701\u2013703. https:\/\/doi.org\/10.1007\/s00436-008-1268-x","journal-title":"Parasitol Res"},{"issue":"1","key":"8154_CR3","doi-asserted-by":"publisher","first-page":"3197","DOI":"10.1038\/s41598-022-07149-9","volume":"12","author":"Y Corripio-Miyar","year":"2022","unstructured":"Corripio-Miyar Y, Hayward A, Lemon H, Sweeny AR, Bal X, Kenyon F, Pilkington JG, Pemberton JM, Nussey DH, McNeilly TN (2022) Functionally distinct T-helper cell phenotypes predict resistance to different types of parasites in a wild mammal. Sci Rep 12(1):3197. https:\/\/doi.org\/10.1038\/s41598-022-07149-9","journal-title":"Sci Rep"},{"issue":"4","key":"8154_CR4","doi-asserted-by":"publisher","first-page":"e00009","DOI":"10.1128\/IAI.00009-17","volume":"85","author":"R Dangtakot","year":"2017","unstructured":"Dangtakot R, Pinlaor S, Itthitaetrakool U, Chaidee A, Chomvarin C, Sangka A, Wilailuckana C, Pinlaor P (2017) Coinfection with Helicobacter pylori and Opisthorchis viverrini enhances the severity of hepatobiliary abnormalities in hamsters. Infect Immun 85(4):e00009-17. https:\/\/doi.org\/10.1128\/IAI.00009-17","journal-title":"Infect Immun"},{"issue":"6","key":"8154_CR5","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1093\/intimm\/3.6.599","volume":"3","author":"FD Finkelman","year":"1991","unstructured":"Finkelman FD, Urban JF Jr, Beckmann MP, Schooley KA, Holmes JM, Katona IM (1991) Regulation of murine in vivo IgG and IgE responses by a monoclonal anti-IL-4 receptor antibody. Int Immunol 3(6):599\u2013607. https:\/\/doi.org\/10.1093\/intimm\/3.6.599","journal-title":"Int Immunol"},{"issue":"19","key":"8154_CR6","doi-asserted-by":"publisher","first-page":"9929","DOI":"10.1128\/JVI.05356-11","volume":"85","author":"CD Hammerbeck","year":"2011","unstructured":"Hammerbeck CD, Hooper JW (2011) T cells are not required for pathogenesis in the syrian hamster model of hantavirus pulmonary syndrome. J Virol 85(19):9929\u20139944. https:\/\/doi.org\/10.1128\/JVI.05356-11","journal-title":"J Virol"},{"issue":"1","key":"8154_CR7","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1371\/journal.ppat.0030001","volume":"3","author":"WG Horsnell","year":"2007","unstructured":"Horsnell WG, Cutler AJ, Hoving JC, Mearns H, Myburgh E, Arendse B, Finkelman FD, Owens GK, Erle D, Brombacher F (2007) Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4R\u03b1\u2013deficient mice. PLoS Pathog 3(1):e1. https:\/\/doi.org\/10.1371\/journal.ppat.0030001","journal-title":"PLoS Pathog"},{"issue":"3","key":"8154_CR8","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/j.1365-3024.2006.00929.x","volume":"29","author":"J Jittimanee","year":"2007","unstructured":"Jittimanee J, Sermswan RW, Puapairoj A, Maleewong W, Wongratanacheewin S (2007) Cytokine expression in hamsters experimentally infected with Opisthorchis viverrini. Parasite Immunol 29(3):159\u2013167. https:\/\/doi.org\/10.1111\/j.1365-3024.2006.00929.x","journal-title":"Parasite Immunol"},{"issue":"2","key":"8154_CR9","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.actatropica.2012.01.010","volume":"122","author":"J Jittimanee","year":"2012","unstructured":"Jittimanee J, Sermswan RW, Kaewraemruaen C, Barta JR, Macinnes JI, Maleewong W, Wongratanacheewin S (2012) Protective immunization of hamsters against Opisthorchis viverrini infection is associated with the reduction of TGF-\u03b2 expression. Acta Trop 122(2):189\u2013195. https:\/\/doi.org\/10.1016\/j.actatropica.2012.01.010","journal-title":"Acta Trop"},{"key":"8154_CR10","doi-asserted-by":"publisher","first-page":"D1171","DOI":"10.2741\/A353","volume":"3","author":"DE Jones","year":"1998","unstructured":"Jones DE, Elloso MM, Scott P (1998) Host susceptibility factors to cutaneous leishmaniasis. Front Biosci 3:D1171\u2013D1180. https:\/\/doi.org\/10.2741\/A353","journal-title":"Front Biosci"},{"issue":"11","key":"8154_CR11","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1111\/pim.12358","volume":"38","author":"C Kaewraemruaen","year":"2016","unstructured":"Kaewraemruaen C, Sermswan RW, Wongratanacheewin S (2016) Induction of regulatory T cells by Opisthorchis viverrini. Parasite Immunol 38(11):688\u2013697. https:\/\/doi.org\/10.1111\/pim.12358","journal-title":"Parasite Immunol"},{"issue":"9","key":"8154_CR12","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/nri1183","volume":"3","author":"RM Maizels","year":"2003","unstructured":"Maizels RM, Yazdanbakhsh M (2003) Immune regulation by helminth parasites: cellular and molecular mechanisms. Nat Rev Immunol 3(9):733\u2013744. https:\/\/doi.org\/10.1038\/nri1183","journal-title":"Nat Rev Immunol"},{"key":"8154_CR13","unstructured":"Mangiafico SS (2023) rcompanion: functions to support extension education program evaluation. Rutgers Cooperative Extension, New Brunswick, New Jersey. version 2.4.34.\u00a0https:\/\/CRAN.R-project.org\/package=rcompanion\/"},{"key":"8154_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1471-2172-9-11","volume":"9","author":"RG Marillier","year":"2008","unstructured":"Marillier RG, Michels C, Smith EM, Fick LC, Leeto M, Dewals B, Horsnell WG, Brombacher F (2008) IL-4\/IL-13 independent goblet cell hyperplasia in experimental helminth infections. BMC Immunol 9:11. https:\/\/doi.org\/10.1186\/1471-2172-9-11","journal-title":"BMC Immunol"},{"issue":"4","key":"8154_CR15","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.parint.2010.09.008","volume":"59","author":"K Ninlawan","year":"2010","unstructured":"Ninlawan K, O\u2019Hara SP, Splinter PL, Yongvanit P, Kaewkes S, Surapaitoon A, LaRusso NF, Sripa B (2010) Opisthorchis viverrini excretory\/secretory products induce toll-like receptor 4 upregulation and production of interleukin 6 and 8 in cholangiocyte. Parasitol Int 59(4):616\u2013621. https:\/\/doi.org\/10.1016\/j.parint.2010.09.008","journal-title":"Parasitol Int"},{"issue":"1","key":"8154_CR16","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1017\/S0022149X07212106","volume":"81","author":"C Nithikathkul","year":"2007","unstructured":"Nithikathkul C, Tesana S, Sithithaworn P, Balakanich S (2007) Early stage biliary and intrahepatic migration of Opisthorchis viverrini in the golden hamster. J Helminthol 81(1):39\u201341. https:\/\/doi.org\/10.1017\/S0022149X07212106","journal-title":"J Helminthol"},{"key":"8154_CR17","unstructured":"R Core Team (2022) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https:\/\/www.R-project.org\/"},{"issue":"1","key":"8154_CR18","first-page":"95","volume":"20","author":"M Riganti","year":"1989","unstructured":"Riganti M, Pungpak S, Punpoowong B, Bunnag D, Harinasuta T (1989) Human pathology of Opisthorchis viverrini infection: a comparison of adults and children. Southeast Asian J Trop Med Public Health 20(1):95\u2013100","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"5","key":"8154_CR19","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.4049\/jimmunol.168.5.2383","volume":"168","author":"LR Schopf","year":"2002","unstructured":"Schopf LR, Hoffmann KF, Cheever AW, Urban JF Jr, Wynn TA (2002) IL-10 Is critical for host resistance and survival during gastrointestinal helminth infection. J Immunol 168(5):2383\u20132392. https:\/\/doi.org\/10.4049\/jimmunol.168.5.2383","journal-title":"J Immunol"},{"issue":"1","key":"8154_CR20","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1186\/s13071-017-2538-1","volume":"10","author":"W Shi","year":"2017","unstructured":"Shi W, Wei ZY, Elsheikha HM, Zhang FK, Sheng ZA, Lu KJ, Wang DY, Huang WY, Zhu XQ (2017) Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes. Parasit Vectors 10(1):602. https:\/\/doi.org\/10.1186\/s13071-017-2538-1","journal-title":"Parasit Vectors"},{"issue":"6","key":"8154_CR21","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/s0020-7519(00)00054-0","volume":"30","author":"B Sripa","year":"2000","unstructured":"Sripa B, Kaewkes S (2000a) Localisation of parasite antigens and in\u00afammatory responses in experimental opisthorchiasis. Int J Parasitol 30(6):735\u2013740. https:\/\/doi.org\/10.1016\/s0020-7519(00)00054-0","journal-title":"Int J Parasitol"},{"issue":"3","key":"8154_CR22","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1046\/j.1365-3024.2000.00286.x","volume":"22","author":"B Sripa","year":"2000","unstructured":"Sripa B, Kaewkes S (2000b) Relationship between parasite-specific antibody responses and intensity of Opisthorchis viverrini infection in hamsters. Parasite Immunol 22(3):139\u2013145. https:\/\/doi.org\/10.1046\/j.1365-3024.2000.00286.x","journal-title":"Parasite Immunol"},{"key":"8154_CR23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/bs.apar.2018.05.002","volume":"101","author":"A Suwannatrai","year":"2018","unstructured":"Suwannatrai A, Saichua P, Haswell M (2018) Epidemiology of Opisthorchis viverrini infection. Adv Parasitol 101:41\u201367. https:\/\/doi.org\/10.1016\/bs.apar.2018.05.002","journal-title":"Adv Parasitol"},{"issue":"9","key":"8154_CR24","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.3390\/pathogens10091089","volume":"10","author":"W Suyapoh","year":"2021","unstructured":"Suyapoh W, Tirnitz-Parker JEE, Tangkawattana S, Suttiprapa S, Sripa B (2021) Biliary migration, colonization, and pathogenesis of O. viverrini co-infected with CagA+ Helicobacter pylori. Pathogens 10(9):1089. https:\/\/doi.org\/10.3390\/pathogens10091089","journal-title":"Pathogens"},{"key":"8154_CR25","doi-asserted-by":"publisher","unstructured":"Thongrin T, Suyapoh W, Wendo W, Tangkawattana P, Sukon P, Salao K, Suttiprapa S, Saichua P, Tangkawatana S (2023) Inflammatory cell responses in biliary mucosa during Opisthorchis viverrini infection: insights into susceptibility differences among hosts. Open Vet J 13(9):1150\u20131166. https:\/\/doi.org\/10.5455\/OVJ.2023.v13.i9.11","DOI":"10.5455\/OVJ.2023.v13.i9.11"},{"issue":"5\u20136","key":"8154_CR26","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/pim.12028","volume":"35","author":"JD Turner","year":"2013","unstructured":"Turner JD, Meurs L, Dool P, Bourke CD, Mbow M, Di\u00e8ye TN, Mboup S, Polman K, Mountford AP (2013) Schistosome infection is associated with enhanced whole-blood IL-10 secretion in response to cercarial excretory\/secretory products. Parasite Immunol 35(5\u20136):147\u2013156. https:\/\/doi.org\/10.1111\/pim.12028","journal-title":"Parasite Immunol"},{"issue":"9","key":"8154_CR27","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.22034\/APJCP.2018.19.9.2437","volume":"19","author":"S Upontain","year":"2018","unstructured":"Upontain S, Sereerak P, Laha T, Sripa B, Tangkawatana P, Brindley PJ, Tangkawatana S (2018) Granulin expression in hamsters during Opisthorchis viverrini infection-induced cholangiocarcinogenesis. Asian Pac J Cancer Prev 19(9):2437\u20132445. https:\/\/doi.org\/10.22034\/APJCP.2018.19.9.2437","journal-title":"Asian Pac J Cancer Prev"},{"issue":"13","key":"8154_CR28","doi-asserted-by":"publisher","first-page":"5513","DOI":"10.1073\/pnas.88.13.5513","volume":"88","author":"JF Urban Jr","year":"1991","unstructured":"Urban JF Jr, Katona IM, Paul WE, Finkelman FD (1991) Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc Natl Acad Sci U S A 88(13):5513\u20135517. https:\/\/doi.org\/10.1073\/pnas.88.13.5513","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"8154_CR29","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1017\/S0031182023000112","volume":"150","author":"K Watakulsin","year":"2023","unstructured":"Watakulsin K, Surapaitoon A, Ulag LH, Kaing S, Suyapoh W, Saichua P, Salao K, Tangkawatana S, Suttiprapa S (2023) Distinct antibody response in susceptible and non-susceptible hosts of the carcinogenic liver fluke Opisthorchis viverrini infection. Parasitology 150(8):653\u2013660. https:\/\/doi.org\/10.1017\/S0031182023000112","journal-title":"Parasitology"},{"issue":"6","key":"8154_CR30","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1038\/s41385-022-00513-y","volume":"15","author":"HC Webster","year":"2022","unstructured":"Webster HC, Gamino V, Andrusaite AT, Ridgewell OJ, McCowan J, Shergold AL, Heieis GA, Milling SWF, Maizels RM, Perona-Wright G (2022) Tissue-based IL-10 signalling in helminth infection limits IFN\u03b3 expression and promotes the intestinal Th2 response. Mucosal Immunol 15(6):1257\u20131269. https:\/\/doi.org\/10.1038\/s41385-022-00513-y","journal-title":"Mucosal Immunol"},{"key":"8154_CR31","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4","volume-title":"ggplot2: elegant graphics for data analysis","author":"H Wickham","year":"2016","unstructured":"Wickham H (2016) ggplot2: elegant graphics for data analysis. Springer-Verlag, New York"},{"key":"8154_CR32","unstructured":"Wickham H and Seidel D (2022) scales: scale functions for visualization. R package version version 1.2.1. https:\/\/CRAN.R-project.org\/package=scales"},{"issue":"2","key":"8154_CR33","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1017\/S0022149X00009913","volume":"61","author":"S Wongratanacheewin","year":"1987","unstructured":"Wongratanacheewin S, Rattanasiriwilai W, Priwan R, Sirisinha S (1987) Immunodepression in hamsters experimentally infected with Opisthorchis viverrini. J Helminthol 61(2):151\u2013156. https:\/\/doi.org\/10.1017\/S0022149X00009913","journal-title":"J Helminthol"},{"issue":"11","key":"8154_CR34","doi-asserted-by":"publisher","first-page":"e0143217","DOI":"10.1371\/journal.pone.0143217","volume":"10","author":"C Yan","year":"2015","unstructured":"Yan C, Zhang BB, Hua H, Li B, Zhang B, Yu Q, Li XY, Liu Y, Pan W, Liu XY, Tang RX, Zheng KY (2015) The dynamics of Treg\/Th17 and the imbalance of Treg\/Th17 in Clonorchis sinensis-infected mice. PLoS One 10(11):e0143217. https:\/\/doi.org\/10.1371\/journal.pone.0143217","journal-title":"PLoS One"},{"issue":"9","key":"8154_CR35","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/pim.12090","volume":"36","author":"C Zaph","year":"2014","unstructured":"Zaph C, Cooper PJ, Harris NL (2014) Mucosal immune responses following intestinal nematode infection. Parasite Immunol 36(9):439\u2013452. https:\/\/doi.org\/10.1111\/pim.12090","journal-title":"Parasite Immunol"},{"issue":"2","key":"8154_CR36","doi-asserted-by":"publisher","first-page":"e0171005","DOI":"10.1371\/journal.pone.0171005","volume":"12","author":"BB Zhang","year":"2017","unstructured":"Zhang BB, Yan C, Fang F, Du Y, Ma R, Li XY, Yu Q, Meng D, Tang RX, Zheng KY (2017) Increased hepatic Th2 and Treg subsets are associated with biliary fibrosis in different strains of mice caused by Clonorchis sinensis. PLoS One 12(2):e0171005. https:\/\/doi.org\/10.1371\/journal.pone.0171005","journal-title":"PLoS One"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-024-08154-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-024-08154-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-024-08154-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T21:50:55Z","timestamp":1709934655000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-024-08154-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["8154"],"URL":"https:\/\/doi.org\/10.1007\/s00436-024-08154-9","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"26 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Protocols for experimental practices of hamsters and mice in this study were approved by animal ethics committees of Northeast Laboratory Animal Center, Khon Kaen. The approval code is IACUC-KKU-70\/64.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"135"}}