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Despite the availability of treatments for this parasitic infection, therapeutic failures are alarmingly frequent. Thus, there is a clear need to identify new therapeutic targets. <jats:italic>Giardia<\/jats:italic> telomeres were previously identified, but our understanding of these structures and the critical role played by <jats:italic>Giardia<\/jats:italic> telomerase in maintaining genomic stability and its influence on cellular processes remains limited. In this regard, it is known that all <jats:italic>Giardia<\/jats:italic> chromosomes are capped by small telomeres, organized and protected by specific proteins that regulate their functions. To counteract natural telomere shortening and maintain high proliferation, <jats:italic>Giardia<\/jats:italic> exhibits constant telomerase activity and employs additional mechanisms, such as the formation of G-quadruplex structures and the involvement of transposable elements linked to telomeric repeats. Thus, this study aims to address the existing knowledge gap by compiling the available information (until 2023) about <jats:italic>Giardia<\/jats:italic> telomeres and telomerase, focusing on highlighting the distinctive features within this parasite. Furthermore, the potential feasibility of targeting <jats:italic>Giardia<\/jats:italic> telomeres and\/or telomerase as an innovative therapeutic strategy is discussed.<\/jats:p>","DOI":"10.1007\/s00436-024-08200-6","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T03:10:07Z","timestamp":1712545807000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Giardia telomeres and telomerase"],"prefix":"10.1007","volume":"123","author":[{"given":"Francisco Alejandro","family":"Lagunas-Rangel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"8200_CR1","doi-asserted-by":"publisher","first-page":"3326","DOI":"10.1128\/MCB.11.6.3326","volume":"11","author":"RD Adam","year":"1991","unstructured":"Adam RD, Nash TE, Wellems TE (1991) Telomeric location of Giardia rDNA genes. 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