{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:49:33Z","timestamp":1789213773750,"version":"build-2803163510"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1007\/s00436-024-08231-z","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T01:01:50Z","timestamp":1716339710000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Essential oil of oregano (Origanum vulgare L.) reduces infection and proliferation of Toxoplasma gondii in BeWo cells with induction of autophagy and death of tachyzoites through a mechanism similar to necrosis"],"prefix":"10.1007","volume":"123","author":[{"given":"Ang\u00e9lica Paulina","family":"Nunes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin Munhoz","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Arruda","family":"da Silva Sanfelice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virg\u00ednia Marcia","family":"Concato-Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylon Felipe","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Tomiotto-Pellissier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Lazarin-Bidoia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayanne Regina Beltrame","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Daniel","family":"de Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Luis","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivete","family":"Conchon-Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wander Rog\u00e9rio","family":"Pavanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Katsuko Takayama","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bellisa","family":"de Freitas Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloisa Am\u00e1lia Vieira","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idessania Nazareth","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"8231_CR1","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.2147\/IJN.S122178","volume":"12","author":"OS Adeyemi","year":"2017","unstructured":"Adeyemi OS, Murata Y, Sugi T, Kato K (2017) Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential. Int J Nanomedicine 12:1647\u20131661. https:\/\/doi.org\/10.2147\/IJN.S122178","journal-title":"Int J Nanomedicine"},{"key":"8231_CR2","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/S10393-019-01405-7","volume":"16","author":"AA Aguirre","year":"2019","unstructured":"Aguirre AA, Longcore T, Barbieri M et al (2019) The one health approach to toxoplasmosis: epidemiology, control, and prevention strategies. EcoHealth 16:378\u2013390. https:\/\/doi.org\/10.1007\/S10393-019-01405-7","journal-title":"EcoHealth"},{"key":"8231_CR3","doi-asserted-by":"publisher","unstructured":"Akkaoui S, Johansson A, Yagoubi M et al (2020) Chemical composition, antimicrobial activity, in vitro cytotoxicity and leukotoxin neutralization of essential oil from Origanum vulgare against Aggregatibacter actinomycetemcomitans. Pathogens 9. https:\/\/doi.org\/10.3390\/PATHOGENS9030192","DOI":"10.3390\/PATHOGENS9030192"},{"key":"8231_CR4","doi-asserted-by":"publisher","unstructured":"Alonso L, de Paula JC, Bar\u00e9a P et al (2021) Membrane dynamics in Leishmania amazonensis and antileishmanial activities of \u03b2-carboline derivatives. Biochim Biophys Acta Biomembr 1863. https:\/\/doi.org\/10.1016\/J.BBAMEM.2020.183473","DOI":"10.1016\/J.BBAMEM.2020.183473"},{"key":"8231_CR5","doi-asserted-by":"publisher","first-page":"660","DOI":"10.3390\/PATHOGENS12050660","volume":"12","author":"AB Alves","year":"2023","unstructured":"Alves AB, da Silva Bortoleti BT, Tomiotto-Pellissier F et al (2023) Synergistic antileishmanial effect of oregano essential oil and silver nanoparticles: mechanisms of action on Leishmania amazonensis. Pathogens 12:660. https:\/\/doi.org\/10.3390\/PATHOGENS12050660","journal-title":"Pathogens"},{"key":"8231_CR6","doi-asserted-by":"publisher","unstructured":"Angiolella L, Rojas F, Mussin J, Giusiano G (2023) Modulatory effect of Origanum vulgare essential oil and carvacrol on Malassezia spp. virulence factors. Med Mycol 61. https:\/\/doi.org\/10.1093\/MMY\/MYAD026","DOI":"10.1093\/MMY\/MYAD026"},{"key":"8231_CR7","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/J.CHOM.2017.04.007","volume":"21","author":"N Arora","year":"2017","unstructured":"Arora N, Sadovsky Y, Dermody TS, Coyne CB (2017) Microbial vertical transmission during human pregnancy. Cell Host Microbe 21:561\u2013567. https:\/\/doi.org\/10.1016\/J.CHOM.2017.04.007","journal-title":"Cell Host Microbe"},{"key":"8231_CR8","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1111\/J.1365-2249.2007.03583.X","volume":"151","author":"BF Barbosa","year":"2008","unstructured":"Barbosa BF, Silva DAO, Costa IN et al (2008) BeWo trophoblast cell susceptibility to Toxoplasma gondii is increased by interferon-\u03b3, interleukin-10 and transforming growth factor-\u03b21. Clin Exp Immunol 151:536. https:\/\/doi.org\/10.1111\/J.1365-2249.2007.03583.X","journal-title":"Clin Exp Immunol"},{"key":"8231_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5216\/RPT.V44I1.34798","volume":"44","author":"MA Barbosa","year":"2015","unstructured":"Barbosa MA, Angelin LG, Saikawa GIA et al (2015) Potenciais alternativas terap\u00eauticas em estudo para a toxoplasmose cong\u00eanita: Uma revis\u00e3o bibliogr\u00e1fica. Rev Patol Trop \/ J Trop Pathol 44:1\u201311. https:\/\/doi.org\/10.5216\/RPT.V44I1.34798","journal-title":"Rev Patol Trop \/ J Trop Pathol"},{"key":"8231_CR10","doi-asserted-by":"publisher","first-page":"3989","DOI":"10.3390\/MOLECULES17043989","volume":"17","author":"IHN Bassol\u00e9","year":"2012","unstructured":"Bassol\u00e9 IHN, Juliani HR (2012) Essential oils in combination and their antimicrobial properties. Molecules 17:3989\u20134006. https:\/\/doi.org\/10.3390\/MOLECULES17043989","journal-title":"Molecules"},{"key":"8231_CR11","doi-asserted-by":"publisher","unstructured":"B\u011blono\u017en\u00edkov\u00e1 K, Sladkovsk\u00e1 E, Kavan D et al (2023) Effect of Agrimonia eupatoria L. and Origanum vulgare L. Leaf, Flower, Stem, and Root Extracts on the Survival of Pseudomonas aeruginosa. Molecules 28. https:\/\/doi.org\/10.3390\/MOLECULES28031019","DOI":"10.3390\/MOLECULES28031019"},{"key":"8231_CR12","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/J.MIB.2017.10.008","volume":"40","author":"S Besteiro","year":"2017","unstructured":"Besteiro S (2017) Autophagy in apicomplexan parasites. Curr Opin Microbiol 40:14\u201320. https:\/\/doi.org\/10.1016\/J.MIB.2017.10.008","journal-title":"Curr Opin Microbiol"},{"key":"8231_CR13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/J.PHYMED.2018.06.010","volume":"46","author":"BTDS Bortoleti","year":"2018","unstructured":"Bortoleti BTDS, Gon\u00e7alves MD, Tomiotto-Pellissier F et al (2018) Grandiflorenic acid promotes death of promastigotes via apoptosis-like mechanism and affects amastigotes by increasing total iron bound capacity. Phytomedicine 46:11\u201320. https:\/\/doi.org\/10.1016\/J.PHYMED.2018.06.010","journal-title":"Phytomedicine"},{"key":"8231_CR14","unstructured":"Centers for disease control and prevention - CDC (2019) Toxoplasmosis - epidemiology & risk factors. Retrieved January 9, 2024, from https:\/\/www.cdc.gov\/parasites\/toxoplasmosis\/epi.html"},{"key":"8231_CR15","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/S11686-020-00300-4","volume":"66","author":"K Cheraghipour","year":"2021","unstructured":"Cheraghipour K, Masoori L, Ezzatpour B et al (2021) The experimental role of medicinal plants in treatment of Toxoplasma gondii Infection: a systematic review. Acta Parasitol 66:303\u2013328. https:\/\/doi.org\/10.1007\/S11686-020-00300-4","journal-title":"Acta Parasitol"},{"key":"8231_CR16","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3390\/MEDICINES4030058","volume":"4","author":"S Chouhan","year":"2017","unstructured":"Chouhan S, Sharma K, Guleria S (2017) Antimicrobial activity of some essential oils-present status and future perspectives. Medicines (basel) 4:58. https:\/\/doi.org\/10.3390\/MEDICINES4030058","journal-title":"Medicines (basel)"},{"key":"8231_CR17","doi-asserted-by":"publisher","first-page":"6410","DOI":"10.1080\/14786419.2022.2034809","volume":"36","author":"ECA da Silva","year":"2022","unstructured":"da Silva ECA, Leuthier LL, Almeida J\u00fanior A et al (2022) Physicochemical characteristics and antimicrobial activity of Origanum vulgare L. essential oil and carvacrol on cariogenic bacteria: an in vitro and in silico study. Nat Prod Res 36:6410\u20136413. https:\/\/doi.org\/10.1080\/14786419.2022.2034809","journal-title":"Nat Prod Res"},{"key":"8231_CR18","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1111\/J.1469-0691.2008.02091.X","volume":"14","author":"F Derouin","year":"2008","unstructured":"Derouin F, Pelloux H (2008) Prevention of toxoplasmosis in transplant patients. Clin Microbiol Infect 14:1089\u20131101. https:\/\/doi.org\/10.1111\/J.1469-0691.2008.02091.X","journal-title":"Clin Microbiol Infect"},{"key":"8231_CR19","doi-asserted-by":"publisher","unstructured":"Dunay IR, Gajurel K, Dhakal R et al (2018) Treatment of toxoplasmosis: historical perspective, animal models, and current clinical practice. Clin Microbiol Rev 31. https:\/\/doi.org\/10.1128\/CMR.00057-17","DOI":"10.1128\/CMR.00057-17"},{"key":"8231_CR20","doi-asserted-by":"publisher","unstructured":"Ebani VV, Nardoni S, Bertelloni F et al (2018) Antimicrobial activity of five essential oils against bacteria and fungi responsible for urinary tract infections. Molecules 23. https:\/\/doi.org\/10.3390\/MOLECULES23071668","DOI":"10.3390\/MOLECULES23071668"},{"key":"8231_CR21","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/J.PUHE.2007.08.009","volume":"122","author":"HM Elsheikha","year":"2008","unstructured":"Elsheikha HM (2008) Congenital toxoplasmosis: priorities for further health promotion action. Public Health 122:335\u2013353. https:\/\/doi.org\/10.1016\/J.PUHE.2007.08.009","journal-title":"Public Health"},{"key":"8231_CR22","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1128\/IAI.70.5.2690-2693.2002","volume":"70","author":"G Entrican","year":"2002","unstructured":"Entrican G, Wattegedera S, Chui M et al (2002) Gamma interferon fails to induce expression of indoleamine 2,3-dioxygenase and does not control the growth of Chlamydophila abortus in BeWo trophoblast cells. Infect Immun 70:2690\u20132693. https:\/\/doi.org\/10.1128\/IAI.70.5.2690-2693.2002","journal-title":"Infect Immun"},{"key":"8231_CR23","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/CDD.2014.150","volume":"22","author":"G Filomeni","year":"2015","unstructured":"Filomeni G, De Zio D, Cecconi F (2015) Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ 22:377\u2013388. https:\/\/doi.org\/10.1038\/CDD.2014.150","journal-title":"Cell Death Differ"},{"key":"8231_CR24","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1002\/PTR.5869","volume":"31","author":"M Garc\u00eda","year":"2017","unstructured":"Garc\u00eda M, Scull R, Satyal P et al (2017) Chemical characterization, antileishmanial activity, and cytotoxicity effects of the essential oil from leaves of Pluchea carolinensis (Jacq.) G. Don. (Asteraceae). Phytother Res 31:1419\u20131426. https:\/\/doi.org\/10.1002\/PTR.5869","journal-title":"Phytother Res"},{"key":"8231_CR25","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/J.PARINT.2017.11.001","volume":"67","author":"S Gaur","year":"2018","unstructured":"Gaur S, Kuhlenschmidt TB, Kuhlenschmidt MS, Andrade JE (2018) Effect of oregano essential oil and carvacrol on Cryptosporidium parvum infectivity in HCT-8 cells. Parasitol Int 67:170\u2013175. https:\/\/doi.org\/10.1016\/J.PARINT.2017.11.001","journal-title":"Parasitol Int"},{"key":"8231_CR26","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1111\/J.1462-5822.2011.01745.X","volume":"14","author":"D Ghosh","year":"2012","unstructured":"Ghosh D, Walton JL, Roepe PD, Sinai AP (2012) Autophagy is a cell death mechanism in Toxoplasma gondii. Cell Microbiol 14:589. https:\/\/doi.org\/10.1111\/J.1462-5822.2011.01745.X","journal-title":"Cell Microbiol"},{"key":"8231_CR27","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/J.MICPATH.2016.03.003","volume":"95","author":"H Hajlaoui","year":"2016","unstructured":"Hajlaoui H, Mighri H, Aouni M et al (2016) Chemical composition and in vitro evaluation of antioxidant, antimicrobial, cytotoxicity and anti-acetylcholinesterase properties of Tunisian Origanum majorana L. essential oil. Microb Pathog 95:86\u201394. https:\/\/doi.org\/10.1016\/J.MICPATH.2016.03.003","journal-title":"Microb Pathog"},{"key":"8231_CR28","doi-asserted-by":"publisher","unstructured":"Hou H, Zhang X, Zhao T, Zhou L (2020) Effects of Origanum vulgare essential oil and its two main components, carvacrol and thymol, on the plant pathogen Botrytis cinerea. PeerJ 8. https:\/\/doi.org\/10.7717\/PEERJ.9626","DOI":"10.7717\/PEERJ.9626"},{"key":"8231_CR29","volume-title":"Farmacologia B\u00e1sica & Cl\u00ednica","author":"BC Katzung","year":"2006","unstructured":"Katzung BC (2006) Farmacologia B\u00e1sica & Cl\u00ednica, 6th edn. Guanabara Koogan, Rio de Janeiro","edition":"6"},{"key":"8231_CR30","doi-asserted-by":"publisher","first-page":"9653","DOI":"10.3390\/IJMS21249653","volume":"21","author":"A Lombrea","year":"2020","unstructured":"Lombrea A, Antal D, Ardelean F et al (2020) A recent insight regarding the phytochemistry and bioactivity of Origanum vulgare L. essential oil. Int J Mol Sci 21:9653. https:\/\/doi.org\/10.3390\/IJMS21249653","journal-title":"Int J Mol Sci"},{"key":"8231_CR31","doi-asserted-by":"publisher","unstructured":"Machado LF, Sanfelice RA, Bosqui LR et al (2020) Biogenic silver nanoparticles reduce adherence, infection, and proliferation of toxoplasma gondii RH strain in HeLa cells without inflammatory mediators induction. Exp Parasitol 211. https:\/\/doi.org\/10.1016\/J.EXPPARA.2020.107853","DOI":"10.1016\/J.EXPPARA.2020.107853"},{"key":"8231_CR32","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1023\/A:1013311632207","volume":"228","author":"V Manohar","year":"2001","unstructured":"Manohar V, Ingram C, Gray J et al (2001) Antifungal activities of origanum oil against Candida albicans. Mol Cell Biochem 228:111\u2013117. https:\/\/doi.org\/10.1023\/A:1013311632207","journal-title":"Mol Cell Biochem"},{"key":"8231_CR33","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/S41579-021-00610-Y","volume":"20","author":"CJ Megli","year":"2022","unstructured":"Megli CJ, Coyne CB (2022) Infections at the maternal-fetal interface: an overview of pathogenesis and defence. Nat Rev Microbiol 20:67\u201382. https:\/\/doi.org\/10.1038\/S41579-021-00610-Y","journal-title":"Nat Rev Microbiol"},{"key":"8231_CR34","first-page":"97","volume":"2","author":"D Miladinovi\u0107","year":"2000","unstructured":"Miladinovi\u0107 D, Miladinovi\u0107 L (2000) Antimicrobial activity of essential oil of sage from Serbia. Chem Technol 2:97\u2013100","journal-title":"Chem Technol"},{"key":"8231_CR35","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/J.EJPHAR.2019.03.049","volume":"853","author":"MM Miranda-Sapla","year":"2019","unstructured":"Miranda-Sapla MM, Tomiotto-Pellissier F, Assolini JP et al (2019) Trans-chalcone modulates Leishmania amazonensis infection in vitro by Nrf2 overexpression affecting iron availability. Eur J Pharmacol 853:275\u2013288. https:\/\/doi.org\/10.1016\/J.EJPHAR.2019.03.049","journal-title":"Eur J Pharmacol"},{"key":"8231_CR36","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.2174\/1381612825666190702095612","volume":"25","author":"A Moghrovyan","year":"2019","unstructured":"Moghrovyan A, Sahakyan N, Babayan A et al (2019) Essential oil and ethanol extract of oregano (Origanum vulgare L.) from Armenian flora as a natural source of terpenes, flavonoids and other phytochemicals with antiradical, antioxidant, metal chelating, tyrosinase inhibitory and antibacterial activity. Curr Pharm Des 25:1809\u20131816. https:\/\/doi.org\/10.2174\/1381612825666190702095612","journal-title":"Curr Pharm Des"},{"key":"8231_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12906-020-02888-6\/TABLES\/4","volume":"20","author":"S Moumni","year":"2020","unstructured":"Moumni S, Elaissi A, Trabelsi A et al (2020) Correlation between chemical composition and antibacterial activity of some Lamiaceae species essential oils from Tunisia. BMC Complement Med Ther 20:1\u201315. https:\/\/doi.org\/10.1186\/S12906-020-02888-6\/TABLES\/4","journal-title":"BMC Complement Med Ther"},{"key":"8231_CR38","unstructured":"National Center for Biotechnology Information (2023a). PubChem Compound Summary for CID 10364, Carvacrol. Retrieved January 9, 2023, from https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Carvacrol"},{"key":"8231_CR39","unstructured":"National Center for Biotechnology Information (2023b). PubChem Compound Summary for CID 5281515, Caryophyllene. Retrieved January 9, 2023, from https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Caryophyllene"},{"key":"8231_CR40","unstructured":"National Center for Biotechnology Information (2023c). PubChem compound summary for CID 7461, gamma-terpinene. Retrieved January 9, 2023, from https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/gamma-Terpinene"},{"key":"8231_CR41","unstructured":"National Center for Biotechnology Information (2023d). PubChem compound summary for CID 7463, p-CYMENE. Retrieved January 9, 2023, from https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/p-CYMENE"},{"key":"8231_CR42","unstructured":"National Center for Biotechnology Information (2023e). PubChem compound summary for CID 6989, thymol. Retrieved January 9, 2023, from https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Thymol"},{"key":"8231_CR43","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1017\/S0031182021001086","volume":"148","author":"L Nishi","year":"2021","unstructured":"Nishi L, da Silva Sanfelice RA, da Silva Bortoleti BT et al (2021) Moringa oleifera extract promotes apoptosis-like death in Toxoplasma gondii tachyzoites in vitro. Parasitology 148:1447\u20131457. https:\/\/doi.org\/10.1017\/S0031182021001086","journal-title":"Parasitology"},{"key":"8231_CR44","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/J.PLACENTA.2005.06.006","volume":"27","author":"JG Oliveira","year":"2006","unstructured":"Oliveira JG, Silva NM, Santos AAD et al (2006) BeWo trophoblasts are unable to control replication of Toxoplasma gondii, even in the presence of exogenous IFN-gamma. Placenta 27:691\u2013698. https:\/\/doi.org\/10.1016\/J.PLACENTA.2005.06.006","journal-title":"Placenta"},{"key":"8231_CR45","first-page":"1231","volume":"28","author":"RA Pattillo","year":"1968","unstructured":"Pattillo RA, Gey GO (1968) The establishment of a cell line of human hormone-synthesizing trophoblastic cells in vitro. Cancer Res 28:1231\u20131236","journal-title":"Cancer Res"},{"key":"8231_CR46","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/J.SINY.2007.01.011","volume":"12","author":"E Petersen","year":"2007","unstructured":"Petersen E (2007) Toxoplasmosis. Semin Fetal Neonatal Med 12:214\u2013223. https:\/\/doi.org\/10.1016\/J.SINY.2007.01.011","journal-title":"Semin Fetal Neonatal Med"},{"key":"8231_CR47","doi-asserted-by":"publisher","unstructured":"Peyron F, Mc Leod R, Ajzenberg D et al (2017) Congenital toxoplasmosis in France and the United States: one parasite, two diverging approaches. PLoS Negl Trop Dis 11. https:\/\/doi.org\/10.1371\/JOURNAL.PNTD.0005222","DOI":"10.1371\/JOURNAL.PNTD.0005222"},{"key":"8231_CR48","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1016\/J.IJPARA.2005.08.003","volume":"35","author":"AW Pfaff","year":"2005","unstructured":"Pfaff AW, Villard O, Klein JP et al (2005) Regulation of Toxoplasma gondii multiplication in BeWo trophoblast cells: cross-regulation of nitric oxide production and polyamine biosynthesis. Int J Parasitol 35:1569\u20131576. https:\/\/doi.org\/10.1016\/J.IJPARA.2005.08.003","journal-title":"Int J Parasitol"},{"key":"8231_CR49","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/J.ACTATROPICA.2016.12.006","volume":"167","author":"RA Sanfelice","year":"2017","unstructured":"Sanfelice RA, da Silva SS, Bosqui LR et al (2017) Pravastatin and simvastatin inhibit the adhesion, replication and proliferation of Toxoplasma gondii (RH strain) in HeLa cells. Acta Trop 167:208\u2013215. https:\/\/doi.org\/10.1016\/J.ACTATROPICA.2016.12.006","journal-title":"Acta Trop"},{"key":"8231_CR50","doi-asserted-by":"publisher","unstructured":"Sanfelice RADS, Bortoleti BTDS, Tomiotto-Pellissier F et al (2021) Biogenic silver nanoparticles (AgNp-Bio) reduce Toxoplasma gondii infection and proliferation in HeLa cells, and induce autophagy and death of tachyzoites by apoptosis-like mechanism. Acta Trop 222. https:\/\/doi.org\/10.1016\/J.ACTATROPICA.2021.106070","DOI":"10.1016\/J.ACTATROPICA.2021.106070"},{"key":"8231_CR51","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/S00436-006-0326-5","volume":"100","author":"GF Santoro","year":"2007","unstructured":"Santoro GF, Das Gra\u00e7as Cardoso M, Guimar\u00e3es LGL et al (2007) Effect of oregano (Origanum vulgare L.) and thyme (Thymus vulgaris L.) essential oils on Trypanosoma cruzi (Protozoa: Kinetoplastida) growth and ultrastructure. Parasitol Res 100:783\u2013790. https:\/\/doi.org\/10.1007\/S00436-006-0326-5","journal-title":"Parasitol Res"},{"key":"8231_CR52","doi-asserted-by":"publisher","first-page":"181296","DOI":"10.3389\/FMICB.2016.00760\/BIBTEX","volume":"7","author":"S Scandorieiro","year":"2016","unstructured":"Scandorieiro S, de Camargo LC, Lancheros CAC et al (2016) Synergistic and additive effect of oregano essential oil and biological silver nanoparticles against multidrug-resistant bacterial strains. Front Microbiol 7:181296. https:\/\/doi.org\/10.3389\/FMICB.2016.00760\/BIBTEX","journal-title":"Front Microbiol"},{"key":"8231_CR53","volume-title":"Farmacologia","author":"P Silva","year":"1988","unstructured":"Silva P (1988) Farmacologia, 5th edn. Guanabara Koogan, Rio de Janeiro","edition":"5"},{"key":"8231_CR54","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/J.IJPARA.2020.11.001","volume":"51","author":"NC Smith","year":"2021","unstructured":"Smith NC, Goulart C, Hayward JA et al (2021) Control of human toxoplasmosis. Int J Parasitol 51:95\u2013121. https:\/\/doi.org\/10.1016\/J.IJPARA.2020.11.001","journal-title":"Int J Parasitol"},{"key":"8231_CR55","doi-asserted-by":"publisher","unstructured":"Stringaro A, Colone M, Cecchetti S et al (2023) \u201cIn vivo\u201d and \u201cin vitro\u201d antimicrobial activity of Origanum vulgare essential oil and its two phenolic compounds on clinical isolates of Candida spp. Arch Microbiol 205. https:\/\/doi.org\/10.1007\/S00203-022-03355-1","DOI":"10.1007\/S00203-022-03355-1"},{"key":"8231_CR56","doi-asserted-by":"publisher","unstructured":"Syn G, Anderson D, Blackwell JM, Jamieson SE (2017) Toxoplasma gondii infection is associated with mitochondrial dysfunction in-vitro. Front Cell Infect Microbiol 7. https:\/\/doi.org\/10.3389\/FCIMB.2017.00512","DOI":"10.3389\/FCIMB.2017.00512"},{"key":"8231_CR57","doi-asserted-by":"publisher","unstructured":"Szewczyk-Golec K, Paw\u0142owska M, Weso\u0142owski R et al (2021) Oxidative stress as a possible target in the treatment of toxoplasmosis: perspectives and ambiguities. Int J Mol Sci 22. https:\/\/doi.org\/10.3390\/IJMS22115705","DOI":"10.3390\/IJMS22115705"},{"key":"8231_CR58","doi-asserted-by":"publisher","first-page":"158","DOI":"10.17058\/RECI.V5I3.5178","volume":"5","author":"PM Tabile","year":"2015","unstructured":"Tabile PM, Teixeira RM, Crespo Pires M et al (2015) Toxoplasmose gestacional: uma revis\u00e3o da literatura. Rev Epidemiol Control Infec\u00e7\u00e3o 5:158\u2013162. https:\/\/doi.org\/10.17058\/RECI.V5I3.5178","journal-title":"Rev Epidemiol Control Infec\u00e7\u00e3o"},{"key":"8231_CR59","doi-asserted-by":"publisher","unstructured":"Tasdemir D, Kaiser M, Demirci B et al (2019) Antiprotozoal activity of Turkish Origanum onites Essential Oil and Its Components. Molecules 24. https:\/\/doi.org\/10.3390\/MOLECULES24234421","DOI":"10.3390\/MOLECULES24234421"},{"key":"8231_CR60","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/J.BIOPHA.2017.12.083","volume":"98","author":"F Tomiotto-Pellissier","year":"2018","unstructured":"Tomiotto-Pellissier F, Alves DR, Miranda-Sapla MM et al (2018) Caryocar coriaceum extracts exert leishmanicidal effect acting in promastigote forms by apoptosis-like mechanism and intracellular amastigotes by Nrf2\/HO-1\/ferritin dependent response and iron depletion: Leishmanicidal effect of Caryocar coriaceum leaf extracts. Biomed Pharmacother 98:662\u2013672. https:\/\/doi.org\/10.1016\/J.BIOPHA.2017.12.083","journal-title":"Biomed Pharmacother"},{"key":"8231_CR61","doi-asserted-by":"publisher","unstructured":"Tomiotto-Pellissier F, Bortoleti BT da S, Concato VM et al (2022) The cytotoxic and anti-leishmanial activity of Oregano (Origanum vulgare) essential oil: an in vitro, in vivo, and in silico study. Ind Crops Prod 187. https:\/\/doi.org\/10.1016\/J.INDCROP.2022.115367","DOI":"10.1016\/J.INDCROP.2022.115367"},{"key":"8231_CR62","unstructured":"Toulah FH, EHA, KS (2012) The efficacy of Origanum vulgare on Eimeria tenella. J Egypt Soc Parasitol 42:245\u2013250"},{"key":"8231_CR63","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1290\/0404033.1","volume":"40","author":"KH Tsui","year":"2004","unstructured":"Tsui KH, Chen LY, Shieh ML et al (2004) Interleukin-8 can stimulate progesterone secretion from a human trophoblast cell line, BeWo. In Vitro Cell Dev Biol Anim 40:331\u2013336. https:\/\/doi.org\/10.1290\/0404033.1","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"8231_CR64","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/JP.2014.161","volume":"35","author":"P Valentini","year":"2015","unstructured":"Valentini P, Buonsenso D, Barone G et al (2015) Spiramycin\/cotrimoxazole versus pyrimethamine\/sulfonamide and spiramycin alone for the treatment of toxoplasmosis in pregnancy. J Perinatol 35:90\u201394. https:\/\/doi.org\/10.1038\/JP.2014.161","journal-title":"J Perinatol"},{"key":"8231_CR65","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/J.IMLET.2007.09.014","volume":"115","author":"U von Rango","year":"2008","unstructured":"von Rango U (2008) Fetal tolerance in human pregnancy\u2013a crucial balance between acceptance and limitation of trophoblast invasion. Immunol Lett 115:21\u201332. https:\/\/doi.org\/10.1016\/J.IMLET.2007.09.014","journal-title":"Immunol Lett"},{"key":"8231_CR66","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1385\/1-59259-983-4:227","volume":"121","author":"MW Wolfe","year":"2006","unstructured":"Wolfe MW (2006) Culture and transfection of human choriocarcinoma cells. Methods Mol Med 121:229\u2013239. https:\/\/doi.org\/10.1385\/1-59259-983-4:227","journal-title":"Methods Mol Med"},{"key":"8231_CR67","doi-asserted-by":"publisher","first-page":"793089","DOI":"10.3389\/FCIMB.2021.793089\/BIBTEX","volume":"11","author":"N Yao","year":"2021","unstructured":"Yao N, Xu Q, He JK et al (2021) Evaluation of Origanum vulgare essential oil and its active ingredients as potential drugs for the treatment of toxoplasmosis. Front Cell Infect Microbiol 11:793089. https:\/\/doi.org\/10.3389\/FCIMB.2021.793089\/BIBTEX","journal-title":"Front Cell Infect Microbiol"},{"key":"8231_CR68","doi-asserted-by":"publisher","unstructured":"Youssefi MR, Moghaddas E, Tabari MA et al (2019) In Vitro and in vivo effectiveness of carvacrol, thymol and linalool against Leishmania infantum. Molecules 24. https:\/\/doi.org\/10.3390\/MOLECULES24112072","DOI":"10.3390\/MOLECULES24112072"}],"updated-by":[{"DOI":"10.1007\/s00436-024-08261-7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000}}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-024-08231-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-024-08231-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-024-08231-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T05:02:28Z","timestamp":1718254948000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-024-08231-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":68,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["8231"],"URL":"https:\/\/doi.org\/10.1007\/s00436-024-08231-z","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00436-024-08261-7","asserted-by":"object"}]},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"19 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00436-024-08261-7","URL":"https:\/\/doi.org\/10.1007\/s00436-024-08261-7","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"217"}}