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This enzymatic mechanism is coupled with the pumping of H\u2009+\u2009and\/or Na\u2009+\u2009across membranes, which can be either K\u2009+\u2009-dependent or K\u2009+\u2009-independent. Inorganic proton\u2013translocating pyrophosphatases (H\u2009+\u2009-PPases) can transport protons across cell membranes and are reported in various organisms such as plants, bacteria, and protozoan parasites. The evolutionary implications of these enzymes are of great interest for proposing approaches related to the treatment of parasitic of phytopathogenic diseases. This work presents a literature review on pyrophosphate, pyrophosphatases, their inhibitors and emphasizes H\u2009+\u2009-PPases found in various medically significant protozoan parasites such as <jats:italic>Toxoplasma gondii<\/jats:italic>, the causative agent of toxoplasmosis, and <jats:italic>Plasmodium falciparum<\/jats:italic>, the causative agent of malaria, as well as protozoan species that primarily affect animals, such as <jats:italic>Eimeria maxima<\/jats:italic> and <jats:italic>Besnoitia besnoiti<\/jats:italic>.<\/jats:p>","DOI":"10.1007\/s00436-024-08362-3","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T04:02:32Z","timestamp":1729224152000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["H+-translocating pyrophosphatases in protozoan parasites"],"prefix":"10.1007","volume":"123","author":[{"given":"Karina","family":"Araujo-Ruiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Mondrag\u00f3n-Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"issue":"5","key":"8362_CR1","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1099\/mic.0.28581-0","volume":"152","author":"MK Au","year":"2006","unstructured":"Au MK, Barabote DR, Hu YK, Milton SH (2006) Evolutionary appearance of H +-translocating pyrophosphatases. 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