{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:28:36Z","timestamp":1785241716203,"version":"3.55.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s00436-024-08418-4","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T04:46:27Z","timestamp":1732941987000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Potential anti-schistosomal effect of Daflon, a repurposed drug targeting different stages of Schistosome maturity"],"prefix":"10.1007","volume":"123","author":[{"given":"Nahla","family":"El Skhawy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala E.","family":"Diab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Ahmed","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aceel Y.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"issue":"3","key":"8418_CR1","doi-asserted-by":"publisher","first-page":"511","DOI":"10.21608\/jesp.2015.96281","volume":"45","author":"R Abdel-Ghany","year":"2015","unstructured":"Abdel-Ghany R, Rabia I, El-Ahwany E, Saber S, Gamal R, Nagy F, Mahmoud O, Hamad RS, Barakat W (2015) Blockade of PGE2, PGD2 receptors confers protection against prepatent schistosomiasis mansoni in mice. J Egypt Soc Parasitol 45(3):511\u2013520. https:\/\/doi.org\/10.21608\/jesp.2015.96281","journal-title":"J Egypt Soc Parasitol"},{"issue":"1","key":"8418_CR2","doi-asserted-by":"publisher","first-page":"e13165","DOI":"10.1111\/and.13165","volume":"51","author":"MB Abdel-Naser","year":"2019","unstructured":"Abdel-Naser MB, Altenburg A, Zouboulis CC, Wollina U (2019) Schistosomiasis (bilharziasis) and male infertility. Andrologia 51(1):e13165. https:\/\/doi.org\/10.1111\/and.13165","journal-title":"Andrologia"},{"key":"8418_CR3","doi-asserted-by":"publisher","first-page":"105891","DOI":"10.1016\/j.actatropica.2021.105891","volume":"218","author":"IF Abou-El-Naga","year":"2021","unstructured":"Abou-El-Naga IF, El-Temsahy MM, Mogahed N, Sheta E, Makled S, Ibrahim EI (2021) Effect of celecoxib against different developmental stages of experimental Schistosoma mansoni infection. Acta Trop 218:105891. https:\/\/doi.org\/10.1016\/j.actatropica.2021.105891","journal-title":"Acta Trop"},{"issue":"4","key":"8418_CR4","doi-asserted-by":"publisher","first-page":"563","DOI":"10.4314\/ahs.v12i4.26","volume":"12","author":"J Adisa","year":"2012","unstructured":"Adisa J, Egbujo EM, Yahaya BA, Echejoh G (2012) Primary infertility associated with Schistosoma mansoni: a case report from the Jos plateau, North Central Nigeria. Afr Health Sci 12(4):563\u2013565. https:\/\/doi.org\/10.4314\/ahs.v12i4.26","journal-title":"Afr Health Sci"},{"issue":"2","key":"8418_CR5","doi-asserted-by":"publisher","first-page":"323","DOI":"10.21608\/jesp.2023.312164","volume":"53","author":"T Al-Attar","year":"2023","unstructured":"Al-Attar T, Matar A, Kora M, Faheem M (2023) Daflon as a new drug in treating murine experimental cryptosporidiosis. J Egypt Soc Parasitol 53(2):323\u2013335. https:\/\/doi.org\/10.21608\/jesp.2023.312164","journal-title":"J Egypt Soc Parasitol"},{"key":"8418_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biopha.2023.115095","volume":"165","author":"MJ Alqahtani","year":"2023","unstructured":"Alqahtani MJ, Negm WA, Saad HM, Salem EA, Hussein IA, Ibrahim HA (2023) Fenofibrate and Diosmetin in a rat model of testicular toxicity: new insight on their protective mechanism through PPAR-alpha\/NRF-2\/HO-1 signaling pathway. Biomed Pharmacother 165:1\u201316. https:\/\/doi.org\/10.1016\/j.biopha.2023.115095","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"8418_CR7","doi-asserted-by":"publisher","first-page":"67","DOI":"10.7705\/biomedica.5913","volume":"42","author":"EI Amer","year":"2022","unstructured":"Amer EI, Abou-El-Naga IF, Boulos LM, Ramadan HS, Younis SS (2022) Praziquantel-encapsulated niosomes against Schistosoma mansoni with reduced sensitivity to praziquantel. Biomedica 42(1):67\u201384. https:\/\/doi.org\/10.7705\/biomedica.5913","journal-title":"Biomedica"},{"issue":"5","key":"8418_CR8","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1016\/j.juro.2012.07.009","volume":"188","author":"A Armagan","year":"2012","unstructured":"Armagan A, Dogan F, Oksay T, Akman T, Darici H, Aylak F, Ergun O (2012) The effect of micronized purified flavonoid fraction on the prevention of testicular pathologies in adolescent rats with experimentally induced varicocele. J Urol 188(5):2007\u20132013. https:\/\/doi.org\/10.1016\/j.juro.2012.07.009","journal-title":"J Urol"},{"issue":"3","key":"8418_CR9","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1006\/expr.1997.4229","volume":"87","author":"JL Bennett","year":"1997","unstructured":"Bennett JL, Day T, Liang Fengtao LF, Ismail M, Farghaly A (1997) The development of resistance to anthelmintics: a perspective with an emphasis on the antischistosomal drug praziquantel. Exp Parasitol 87(3):260\u2013267. https:\/\/doi.org\/10.1006\/expr.1997.4229","journal-title":"Exp Parasitol"},{"issue":"10","key":"8418_CR10","doi-asserted-by":"publisher","first-page":"4276","DOI":"10.1128\/iai.05431-11","volume":"79","author":"R Bhardwaj","year":"2011","unstructured":"Bhardwaj R, Krautz-Peterson G, Da\u2019dara A, Tzipori S, Skelly PJ (2011) Tegumental phosphodiesterase SmNPP-5 is a virulence factor for schistosomes. Infect Immun 79(10):4276\u20134284. https:\/\/doi.org\/10.1128\/iai.05431-11","journal-title":"Infect Immun"},{"key":"8418_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exppara.2019.107793","volume":"208","author":"SS Botros","year":"2020","unstructured":"Botros SS, El-Lakkany NM, Seif El-Din SH, William S, Sabra AN, Hammam OA, De Koning HP (2020) The phosphodiesterase-4 inhibitor roflumilast impacts Schistosoma mansoni ovipositing in vitro but displays only modest antischistosomal activity in vivo. Exp Parasitol 208:1\u201334. https:\/\/doi.org\/10.1016\/j.exppara.2019.107793","journal-title":"Exp Parasitol"},{"issue":"1","key":"8418_CR12","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1186\/s13071-018-3132-x","volume":"11","author":"V Buchter","year":"2018","unstructured":"Buchter V, Hess J, Gasser G, Keiser J (2018) Assessment of tegumental damage to Schistosoma mansoni and S. haematobium after in vitro exposure to ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine using scanning electron microscopy. Parasit Vectors 11(1):580. https:\/\/doi.org\/10.1186\/s13071-018-3132-x","journal-title":"Parasit Vectors"},{"key":"8418_CR13","volume-title":"Histotechnology. A self-instructional text","author":"FL Carson","year":"1990","unstructured":"Carson FL (1990) Histotechnology. A self-instructional text. Lippincott Williams and Wilkins, Publisher"},{"issue":"2","key":"8418_CR14","first-page":"328","volume":"39","author":"AW Cheever","year":"1968","unstructured":"Cheever AW (1968) Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissues. Bull World Health Organ 39(2):328\u2013331","journal-title":"Bull World Health Organ"},{"issue":"1","key":"8418_CR15","first-page":"29","volume":"30","author":"D Cova","year":"1992","unstructured":"Cova D, De Angelis L, Giavarini F, Palladini G, Perego R (1992) Pharmacokinetics and metabolism of oral diosmin in healthy volunteers. Int J Clin Pharmacol Ther 30(1):29\u201333","journal-title":"Int J Clin Pharmacol Ther"},{"issue":"1","key":"8418_CR16","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4314\/ajcem.v4i1.7316","volume":"4","author":"JS Dafur","year":"2003","unstructured":"Dafur JS, Lar PM (2003) The effect of Schistosoma Mansoni cercaria infection and treatment with niridazole on testicular histology of the mice. Afr J Clin Exper Microbiol 4(1):2\u20135. https:\/\/doi.org\/10.4314\/ajcem.v4i1.7316","journal-title":"Afr J Clin Exper Microbiol"},{"key":"8418_CR17","first-page":"139","volume-title":"Carleton\u2019s histological technique","author":"RaB Drury","year":"1980","unstructured":"Drury RaB, Wallington EA (1980) Carleton\u2019s histological technique, 5th edn. Oxford University Press, New York, pp 139\u2013142","edition":"5"},{"key":"8418_CR18","doi-asserted-by":"publisher","unstructured":"Duarte Galhardo De Albuquerque RD, Mahomoodally MF, Lobine D, Suroowan S, Rengasamy KR (2020) Botanical products in the treatment and control of schistosomiasis: recent studies and distribution of active plant resources according to affected regions. Biology (Basel) 9(8):223. https:\/\/doi.org\/10.3390\/biology9080223","DOI":"10.3390\/biology9080223"},{"issue":"2","key":"8418_CR19","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/1756-3305-4-73","volume":"41","author":"MM Eissa","year":"2011","unstructured":"Eissa MM, El-Azzouni MZ, Amer EI, Baddour NM (2011) Miltefosine, a promising novel agent for schistosomiasis mansoni. Int J Parasitol 41(2):235\u2013242. https:\/\/doi.org\/10.1186\/1756-3305-4-73","journal-title":"Int J Parasitol"},{"key":"8418_CR20","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.actatropica.2016.11.006","volume":"166","author":"MM Eissa","year":"2017","unstructured":"Eissa MM, Mossallam SF, Amer EI, Younis LK, Rashed HA (2017) Repositioning of chlorambucil as a potential anti-schistosomal agent. Acta Trop 166:58\u201366. https:\/\/doi.org\/10.1016\/j.actatropica.2016.11.006","journal-title":"Acta Trop"},{"key":"8418_CR21","doi-asserted-by":"publisher","unstructured":"El-Kady AM, Ahmad AA, Hassan TM, El-Deek HE, Fouad SS, Althagfan SS (2019) Eugenol, a potential schistosomicidal agent with anti-inflammatory and antifibrotic effects against Schistosoma mansoni, induced liver pathology. Infect Drug Resist 12:709\u2013719. https:\/\/doi.org\/10.2147\/idr.s196544","DOI":"10.2147\/idr.s196544"},{"issue":"1","key":"8418_CR22","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12906-018-2406-3","volume":"19","author":"MF El-Khadragy","year":"2019","unstructured":"El-Khadragy MF, Al-Olayan EM, Elmallah MIY, Alharbi AM, Yehia HM, Abdel Moneim AE (2019) Probiotics and yogurt modulate oxidative stress and fibrosis in livers of Schistosoma mansoni-infected mice. BMC Complement Altern Med 19(1):3. https:\/\/doi.org\/10.1186\/s12906-018-2406-3","journal-title":"BMC Complement Altern Med"},{"issue":"6","key":"8418_CR23","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1007\/s11101-022-09836-x","volume":"22","author":"HR El-Seedi","year":"2022","unstructured":"El-Seedi HR, SaM K, Mohamed AH, Yosri N, Zhao C, El-Wakeil N, Attia NF, Xu B, Abdelhafez AR, Boskabady MH, Elseedy S, Efferth T, Verpoorte R (2022) Plant extracts and compounds for combating schistosomiasis. Phytochem Rev 22(6):1691\u20131806. https:\/\/doi.org\/10.1007\/s11101-022-09836-x","journal-title":"Phytochem Rev"},{"issue":"3","key":"8418_CR24","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S2221-1691(12)60049-5","volume":"2","author":"B Erko","year":"2012","unstructured":"Erko B, Degarege A, Tadesse K, Mathiwos A, Legesse M (2012) Efficacy and side effects of praziquantel in the treatment of schistosomiasis mansoni in schoolchildren in Shesha Kekele Elementary School, Wondo Genet, Southern Ethiopia. Asian Pac J Trop Biomed 2(3):235\u2013239. https:\/\/doi.org\/10.1016\/S2221-1691(12)60049-5","journal-title":"Asian Pac J Trop Biomed"},{"key":"8418_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exppara.2021.108124","volume":"226\u2013227","author":"A Fahmy","year":"2021","unstructured":"Fahmy A, Abuelenain GL, Rasheed N, Abdou A (2021) \u2018de Novo\u2019 repurposing of Daflon as anti-intestinal parasitic drug in experimental giardiasis. Exp Parasitol 226\u2013227:1\u20138. https:\/\/doi.org\/10.1016\/j.exppara.2021.108124","journal-title":"Exp Parasitol"},{"issue":"4","key":"8418_CR26","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/S1368-7646(98)80004-6","volume":"1","author":"PG Fallon","year":"1998","unstructured":"Fallon PG (1998) Schistosome resistance to praziquantel. Drug Resist Updat 1(4):236\u2013241","journal-title":"Drug Resist Updat"},{"issue":"2","key":"8418_CR27","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/bf00389899","volume":"52","author":"R G\u00f6nnert","year":"1977","unstructured":"G\u00f6nnert R, Andrews P (1977) Praziquantel, a new board-spectrum antischistosomal agent. Z Parasitenkd 52(2):129\u2013150. https:\/\/doi.org\/10.1007\/bf00389899","journal-title":"Z Parasitenkd"},{"issue":"3","key":"8418_CR28","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1139\/bcb-2016-0142","volume":"95","author":"HF Hasan","year":"2017","unstructured":"Hasan HF, Abdel-Rafei MK, Galal SM (2017) Diosmin attenuates radiation-induced hepatic fibrosis by boosting PPAR-\u03b3 expression and hampering miR-17-5p-activated canonical Wnt\u2013\u03b2-catenin signaling. Biochem Cell Biol 95(3):400\u2013414. https:\/\/doi.org\/10.1139\/bcb-2016-0142","journal-title":"Biochem Cell Biol"},{"issue":"6","key":"8418_CR29","doi-asserted-by":"publisher","first-page":"2124 e2121","DOI":"10.1016\/j.fertnstert.2010.12.050","volume":"95","author":"A Hassan","year":"2011","unstructured":"Hassan A, El-Mogy S, Zalata K, Mostafa T (2011) Testicular schistosomiasis: a case study. Fertil Steril 95(6):2124 e2121-2124. https:\/\/doi.org\/10.1016\/j.fertnstert.2010.12.050","journal-title":"Fertil Steril"},{"key":"8418_CR30","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1590\/0037-8682-0241-2016","volume":"49","author":"EA Hassan","year":"2016","unstructured":"Hassan EA, Abdel-Rahman MA, Ibrahim MM, Soliman MFM (2016) In vitro antischistosomal activity of venom from the Egyptian snake Cerastes cerastes. Rev Soc Bras Med Trop 49:752\u2013757. https:\/\/doi.org\/10.1590\/0037-8682-0241-2016","journal-title":"Rev Soc Bras Med Trop"},{"issue":"3","key":"8418_CR31","first-page":"173","volume":"18","author":"H He","year":"2000","unstructured":"He H, Ohta N, Kawaguchi H (2000) Effect of Schistosoma japonicum infection on serum testosterone levels in mice. CJPPD 18(3):173\u2013175","journal-title":"CJPPD"},{"key":"8418_CR32","doi-asserted-by":"publisher","unstructured":"Hosawi S (2023) Current update on role of hesperidin in inflammatory lung diseases: chemistry, pharmacology, and drug delivery approaches. Life (Basel) 13(4):937. https:\/\/doi.org\/10.3390\/life13040937","DOI":"10.3390\/life13040937"},{"issue":"5","key":"8418_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biomedicines10051076","volume":"10","author":"E Huwait","year":"2022","unstructured":"Huwait E, Mobashir M (2022) Potential and therapeutic roles of diosmin in human diseases. Biomedicines 10(5):1\u201325. https:\/\/doi.org\/10.3390\/biomedicines10051076","journal-title":"Biomedicines"},{"issue":"2","key":"8418_CR34","first-page":"143","volume":"4","author":"HB Jatsa","year":"2002","unstructured":"Jatsa HB, Kamtchouing P, Takougang I, Sokeng SD (2002) Testicular dysfunction in BALB C mice with Schistosoma intercalatum bilharziasis. Asian J Androl 4(2):143\u2013147","journal-title":"Asian J Androl"},{"key":"8418_CR35","doi-asserted-by":"publisher","unstructured":"Jatsa HB, Femoe UM, Dongmo CN, Kamwa RIN, Fesuh BN, Tchuente LaT, Kamtchouing P (2022) Reduction of testosterone levels in Schistosoma haematobium- or Schistosoma mansoni-infected men: a cross-sectional study in two schistosomiasis-endemic areas of the Adamawa region of Cameroon. BMC Infect Dis 22(1):230. https:\/\/doi.org\/10.1186\/s12879-022-07195-8","DOI":"10.1186\/s12879-022-07195-8"},{"issue":"10","key":"8418_CR36","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1016\/j.bcp.2004.06.030","volume":"68","author":"WC Ko","year":"2004","unstructured":"Ko WC, Shih CM, Lai YH, Chen JH, Huang HL (2004) Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships. Biochem Pharmacol 68(10):2087\u20132094. https:\/\/doi.org\/10.1016\/j.bcp.2004.06.030","journal-title":"Biochem Pharmacol"},{"issue":"6 Pt 2","key":"8418_CR37","first-page":"524","volume":"45","author":"C Labrid","year":"1994","unstructured":"Labrid C (1994) Pharmacologic properties of Daflon 500 mg. Angiology 45(6 Pt 2):524\u201330","journal-title":"Angiology"},{"issue":"11","key":"8418_CR38","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1038\/s41374-021-00645-y","volume":"101","author":"YL Liu","year":"2021","unstructured":"Liu YL, Huang FJ, Du PJ, Wang J, Guo F, Shao MW, Song Y, Liu YX, Qin GJ (2021) Long noncoding RNA MIR22HG promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-125a-5p that targets N-Myc downstream-regulated gene 2 in late-onset hypogonadism. Lab Invest 101(11):1484\u20131493. https:\/\/doi.org\/10.1038\/s41374-021-00645-y","journal-title":"Lab Invest"},{"issue":"1","key":"8418_CR39","doi-asserted-by":"publisher","first-page":"222","DOI":"10.4049\/jimmunol.112.1.222","volume":"112","author":"AA Mahmoud","year":"1974","unstructured":"Mahmoud AA, Warren KS (1974) Anti-inflammatory effects of Tartar emetic and niridazole: suppression of schistosome egg granuloma. J Immun 112(1):222\u2013228. https:\/\/doi.org\/10.4049\/jimmunol.112.1.222","journal-title":"J Immun"},{"issue":"2","key":"8418_CR40","first-page":"581","volume":"27","author":"ZM Marzouki","year":"1997","unstructured":"Marzouki ZM, Amin AM (1997) The effect of Schistosoma mansoni infection on testicular lipid in mice. J Egypt Soc Parasitol 27(2):581\u2013595","journal-title":"J Egypt Soc Parasitol"},{"issue":"4","key":"8418_CR41","first-page":"325","volume":"4","author":"A Mohamed","year":"2008","unstructured":"Mohamed A, Mahmoud S, Farrag ARA (2008) Influence of sativa seeds against liver fibrosis and consequence complications in murine schistosomiasis. IJBB 4(4):325\u2013347","journal-title":"IJBB"},{"key":"8418_CR42","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.actatropica.2014.12.005","volume":"143","author":"SF Mossallam","year":"2015","unstructured":"Mossallam SF, Amer EI, El-Faham MH (2015) Efficacy of Synriam\u2122, a new antimalarial combination of OZ277 and piperaquine, against different developmental stages of Schistosoma mansoni. Acta Trop 143:36\u201346. https:\/\/doi.org\/10.1016\/j.actatropica.2014.12.005","journal-title":"Acta Trop"},{"issue":"1","key":"8418_CR43","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.sjbs.2021.08.068","volume":"29","author":"O Mostafa","year":"2022","unstructured":"Mostafa O, Al-Shehri M, Moustafa M (2022) Promising antiparasitic agents from marine sponges. Saudi J Biol Sci 29(1):217\u2013227. https:\/\/doi.org\/10.1016\/j.sjbs.2021.08.068","journal-title":"Saudi J Biol Sci"},{"issue":"1","key":"8418_CR44","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1080\/26895293.2022.2080281","volume":"15","author":"FL Mtemeli","year":"2022","unstructured":"Mtemeli FL, Ndlovu J, Mugumbate G, Makwikwi T, Shoko R (2022) Advances in schistosomiasis drug discovery based on natural products. All Life 15(1):608\u2013623. https:\/\/doi.org\/10.1080\/26895293.2022.2080281","journal-title":"All Life"},{"key":"8418_CR45","doi-asserted-by":"publisher","first-page":"100122","DOI":"10.1016\/j.crphar.2022.100122","volume":"3","author":"S Mustafa","year":"2022","unstructured":"Mustafa S, Akbar M, Khan MA, Sunita K, Parveen S, Pawar JS, Massey S, Agarwal NR, Husain SA (2022) Plant metabolite diosmin as the therapeutic agent in human diseases. Curr Res Pharmacol Drug Discov 3:100122. https:\/\/doi.org\/10.1016\/j.crphar.2022.100122","journal-title":"Curr Res Pharmacol Drug Discov"},{"issue":"5","key":"8418_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7243\/2055-091X-1-5","volume":"1","author":"G Musumeci","year":"2014","unstructured":"Musumeci G (2014) Past, present and future: overview on histology and histopathology. J Histol Histopathol 1(5):1\u20133. https:\/\/doi.org\/10.7243\/2055-091X-1-5","journal-title":"J Histol Histopathol"},{"issue":"2","key":"8418_CR47","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351\u2013358. https:\/\/doi.org\/10.1016\/0003-2697(79)90738-3","journal-title":"Anal Biochem"},{"issue":"3","key":"8418_CR48","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s43188-021-00120-2","volume":"38","author":"AO Olatunji","year":"2022","unstructured":"Olatunji AO, Ayo JO, Suleiman MM, Ambali SF, Shittu M, Akorede GJ, Raji LO, Atata JA, Biobaku KT, Azeez MO (2022) Effect of Daflon-500\u00ae, a flavonoid compound on chlorpyriphos-induced oxidative changes in the hypophysis and testes in adult male rats. Toxicol Res 38(3):345\u2013353. https:\/\/doi.org\/10.1007\/s43188-021-00120-2","journal-title":"Toxicol Res"},{"issue":"2","key":"8418_CR49","doi-asserted-by":"publisher","first-page":"34","DOI":"10.62347\/ORPK5021","volume":"15","author":"MO Oyovwi","year":"2024","unstructured":"Oyovwi MO, Ben-Azu B, Tesi EP, Ojetola AA, Olowe TG, Joseph UG, Emojevwe V, Oghenetega OB, Rotu RA, Rotu RA, Falajiki FY (2024) Diosmin protects the testicles from doxorubicin-induced damage by increasing steroidogenesis and suppressing oxido-inflammation and apoptotic mediators. Int J Biochem Mol Biol 15(2):34\u201350. https:\/\/doi.org\/10.62347\/ORPK5021","journal-title":"Int J Biochem Mol Biol"},{"issue":"4","key":"8418_CR50","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.ijpara.2003.12.003","volume":"34","author":"L Pica-Mattoccia","year":"2004","unstructured":"Pica-Mattoccia L, Cioli D (2004) Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment. Int J Parasitol 34(4):527\u2013533. https:\/\/doi.org\/10.1016\/j.ijpara.2003.12.003","journal-title":"Int J Parasitol"},{"issue":"1_suppl","key":"8418_CR51","doi-asserted-by":"publisher","first-page":"S49","DOI":"10.1177\/0003319701052001S07","volume":"52","author":"AA Ramelet","year":"2001","unstructured":"Ramelet AA (2001) Clinical benefits of Daflon 500 mg in the most severe stages of chronic venous insufficiency. Angiology 52(1_suppl):S49\u2013S56. https:\/\/doi.org\/10.1177\/0003319701052001S07","journal-title":"Angiology"},{"key":"8418_CR52","unstructured":"Riad NH, Taha HA, Mahmoud YI (2009) Effects of garlic on albino mice experimentally infected with Schistosoma mansoni: a parasitological and ultrastructural study.Trop Biomed 26(1): 40\u201350"},{"issue":"1","key":"8418_CR53","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.molbiopara.2009.02.006","volume":"166","author":"HK Rofatto","year":"2009","unstructured":"Rofatto HK, Tararam CA, Borges WC, Wilson RA, Leite LC, Farias LP (2009) Characterization of phosphodiesterase-5 as a surface protein in the tegument of Schistosoma mansoni. Mol Biochem Parasitol 166(1):32\u201341. https:\/\/doi.org\/10.1016\/j.molbiopara.2009.02.006","journal-title":"Mol Biochem Parasitol"},{"issue":"4","key":"8418_CR54","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1017\/s0031182000086248","volume":"55","author":"SR Smithers","year":"1965","unstructured":"Smithers SR, Terry RJ (1965) The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms. Parasitology 55(4):695\u2013700. https:\/\/doi.org\/10.1017\/s0031182000086248","journal-title":"Parasitology"},{"issue":"2","key":"8418_CR55","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s11255-011-0038-3","volume":"44","author":"H Soylemez","year":"2012","unstructured":"Soylemez H, Kilic S, Atar M, Penbegul N, Sancaktutar AA, Bozkurt Y (2012) Effects of micronised purified flavonoid fraction on pain, semen analysis and scrotal color Doppler parameters in patients with painful varicocele; results of a randomized placebo-controlled study. Int Urol Nephrol 44(2):401\u2013408. https:\/\/doi.org\/10.1007\/s11255-011-0038-3","journal-title":"Int Urol Nephrol"},{"issue":"2","key":"8418_CR56","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1179\/his.2006.29.2.99","volume":"29","author":"M Titford","year":"2006","unstructured":"Titford M (2006) A short history of histopathology technique. J Histotechnol 29(2):99\u2013110. https:\/\/doi.org\/10.1179\/his.2006.29.2.99","journal-title":"J Histotechnol"},{"key":"8418_CR57","doi-asserted-by":"publisher","first-page":"664","DOI":"10.3390\/antibiotics9100664","volume":"9","author":"M Tonk","year":"2020","unstructured":"Tonk M, Vilcinskas A, Grevelding C, Haeberlein S (2020) Anthelminthic activity of Assassin bug venom against the blood fluke Schistosoma mansoni. Antibiotics 9:664. https:\/\/doi.org\/10.3390\/antibiotics9100664","journal-title":"Antibiotics"},{"issue":"5","key":"8418_CR58","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.phrs.2003.11.006","volume":"49","author":"S Tsakiris","year":"2004","unstructured":"Tsakiris S, Schulpis KH, Marinou K, Behrakis PK (2004) Protective effect of L-cysteine and glutathione on the modulated suckling rat brain Na+, K+, -ATPase and Mg2+ -ATPase activities induced by the in vitro galactosaemia. Pharmacol Res 49(5):475\u2013479. https:\/\/doi.org\/10.1016\/j.phrs.2003.11.006","journal-title":"Pharmacol Res"},{"issue":"1","key":"8418_CR59","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S1043-6618(03)00011-2","volume":"48","author":"A \u00dcnl\u00fc","year":"2003","unstructured":"\u00dcnl\u00fc A, Sucu N, Tamer L, Coskun B, Y\u00fccebilgi\u00e7 G, Ercan B, G\u00fcl A, Dikmengil M, Atik U (2003) Effects of Daflon on oxidative stress induced by hindlimb ischemia\/reperfusion. Pharmacol Res 48(1):11\u201315. https:\/\/doi.org\/10.1016\/S1043-6618(03)00011-2","journal-title":"Pharmacol Res"},{"key":"8418_CR60","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2147\/RRTM.S204345","volume":"10","author":"MA Verjee","year":"2019","unstructured":"Verjee MA (2019) Schistosomiasis: Still a cause of significant morbidity and mortality. Res Rep Trop Med 10:153\u2013163. https:\/\/doi.org\/10.2147\/RRTM.S204345","journal-title":"Res Rep Trop Med"},{"issue":"5","key":"8418_CR61","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1007\/s00436-012-3151-z","volume":"111","author":"W Wang","year":"2012","unstructured":"Wang W, Wang L, Liang YS (2012) Susceptibility or resistance of praziquantel in human schistosomiasis: a review. Parasitol Res 111(5):1871\u20131877. https:\/\/doi.org\/10.1007\/s00436-012-3151-z","journal-title":"Parasitol Res"},{"key":"8418_CR62","unstructured":"WHO (2023) World Health Organization, Schistosomiasis. Fact Sheet [online]. World Health Organization, Geneva; Switzerland Available at: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/schistosomiasis.\u00a0Accessed November 2024"},{"key":"8418_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/20587392211067292","volume":"19","author":"X Yu","year":"2021","unstructured":"Yu X, Liu Y (2021) Diosmetin attenuate experimental ulcerative colitis in rats via suppression of NF-\u03baB, TNF-\u03b1 and IL-6 signalling pathways correlated with down-regulation of apoptotic events. Eur J Inflamm 19:1\u201313. https:\/\/doi.org\/10.1177\/20587392211067292","journal-title":"Eur J Inflamm"},{"issue":"3","key":"8418_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/iai.00309-20","volume":"89","author":"J Zhao","year":"2021","unstructured":"Zhao J, Liu X, Chen Y, Zhang L-S, Zhang Y-R, Ji D-R, Liu S-M, Jia M-Z, Zhu Y-H, Qi Y-F (2021) STAT3 promotes schistosome-induced liver injury by inflammation, oxidative stress, proliferation, and apoptosis signal pathway. Infect Immun 89(3):1\u201316. https:\/\/doi.org\/10.1128\/iai.00309-20","journal-title":"Infect Immun"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-024-08418-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-024-08418-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-024-08418-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T08:11:53Z","timestamp":1736237513000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-024-08418-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,30]]},"references-count":64,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["8418"],"URL":"https:\/\/doi.org\/10.1007\/s00436-024-08418-4","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,30]]},"assertion":[{"value":"31 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed. All procedures and animal treatments complied with the ARRIVE guidelines for the care and use of laboratory animals and were approved by the Institutional Animal Care and Use Committee in the Faculty of Medicine, Alexandria University (IACUC, 0306276).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"402"}}