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The objective of the study was to compare the prevalence and intensity of schistosomiasis and soil-transmitted helminth (STH) infections between preschool-aged children (PSAC) and school-age children (SAC) in the province of KwaZulu-Natal, South Africa. The study was conducted in the province of KZN. The target population was PSAC and SAC, with a sample size of 2000 children (1176 primary school-aged children and 824 pre-school-aged children). Ethical clearance was obtained from the Biomedical Research Ethics Committee of the University of KwaZulu-Natal; informed consent from parents\/legal guardians and verbal assent from SAC were solicited. Data collection involved collecting stool and urine samples from children. The prevalence and intensity of infections were compared between PSAC and SAC, using statistical methods to assess differences. The results showed that 49 (4.2%) SAC were positive for <jats:italic>Schistosoma haematobium<\/jats:italic>, while only 3 (0.41%) PSAC were infected. The total number of STH infections among participants was 281 (22%), with 91 in PSAC and 190 in SAC. The chi-square test showed that SAC were infected with schistosomiasis more than PSAC counterparts in the same location. However, the difference in STH prevalence between PSAC and SAC was not statistically significant, suggesting that there was not much of a difference in the prevalence of STH among SAC and PSAC. Among the STH infections, Taenia was the most prevalent, affecting approximately 20.5% of SAC and 23.4% of PSAC. This species accounted for a substantial proportion of the overall STH burden in both age groups. The study concluded that while SAC has a higher overall prevalence, a real burden exists among PSAC indicating the need to include them in MDA programs targeting <jats:italic>S. haematobium<\/jats:italic> in the province.<\/jats:p>","DOI":"10.1007\/s00436-025-08504-1","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T07:07:38Z","timestamp":1748848058000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A comparative analysis of the prevalence and intensity of schistosomiasis and soil-transmitted helminth infections between preschool-aged children and school-going children in KwaZulu-Natal Province"],"prefix":"10.1007","volume":"124","author":[{"given":"Tafadzwa","family":"Mindu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Chanhanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Mogaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Chimbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"8504_CR1","doi-asserted-by":"publisher","unstructured":"Bowie C, Purcell B, Shaba B,\u00a0Makaula P, Perez M et al (2004) A national survey of the prevalence of schistosomiasis and soil transmitted helminths in Mala\u0175i. 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