{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T02:55:13Z","timestamp":1762484113484,"version":"build-2065373602"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["IN215323"],"award-info":[{"award-number":["IN215323"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Helminthic parasites cause chronic infections due to their ability to generate immune regulatory networks in their hosts; however, an additional component in this interplay is the microbiota. In this regard, new insights have emerged from intestinal helminthic infections, but whether extraintestinal worms are able to alter intestinal microbiota is unknown. Here, we explored microbiota changes occurring during experimental infection with the peritoneal, non-migrating cestode\n                    <jats:italic>Taenia crassiceps<\/jats:italic>\n                    . Our sequencing approach allowed for the identification of 56 families and 119 genera in the fecal samples. We compared the microbiota composition between wild-type (WT) and NLRP3-deficient mice (NLRP3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ), since we recently reported that the lack of NLRP3 dramatically enhanced mouse resistance against\n                    <jats:italic>T. crassiceps<\/jats:italic>\n                    . Prior to\n                    <jats:italic>T. crassiceps<\/jats:italic>\n                    infection, NLRP3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice harbored distinct microbial communities when compared to WT animals. The lack of NLRP3 resulted in enrichment of\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    and\n                    <jats:italic>Lachnospira<\/jats:italic>\n                    , while reducing\n                    <jats:italic>Clostridium<\/jats:italic>\n                    ,\n                    <jats:italic>Dubosiella<\/jats:italic>\n                    , and\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    . Strikingly,\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    presented a comparable abundance in uninfected WT and NLRP3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Upon infection, a progressive increase in\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    and a transitory expansion of\n                    <jats:italic>Lachnospiraceae<\/jats:italic>\n                    were observed in WT mice but not in NLRP3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. A remarkable finding was that\n                    <jats:italic>T. crassiceps<\/jats:italic>\n                    infection inhibited\n                    <jats:italic>Dubosiella,<\/jats:italic>\n                    whereas the groups with enhanced resistance to\n                    <jats:italic>T. crassiceps<\/jats:italic>\n                    (NLRP3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice and WT individuals co-housed with NLRP3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice) presented a greater abundance of\n                    <jats:italic>Dubosiella,<\/jats:italic>\n                    indicating that resistance against\n                    <jats:italic>T. crassiceps<\/jats:italic>\n                    might be coordinated by this bacterium. Our study reveals that intestinal microbiota can also be modulated through a peritoneal-gut axis, in which the players (antigens and immune cells) remain to be identified. In addition to resistance, microbiota changes could be involved in the\n                    <jats:italic>T. crassiceps<\/jats:italic>\n                    -evoked anti-inflammatory and anti-oncogenic effects.\n                  <\/jats:p>","DOI":"10.1007\/s00436-025-08574-1","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:17:05Z","timestamp":1761110225000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The peritoneal cestode Taenia crassiceps restructures gut bacterial communities in the mouse host: identification of potential resistance-associated bacteria"],"prefix":"10.1007","volume":"124","author":[{"given":"Diego","family":"Mateos-Arenas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Ruiz-de","family":"la Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor","family":"Mart\u00ednez-Gregorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisol I.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Vaca-Paniagua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara E.","family":"D\u00edaz-Vel\u00e1squez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertus","family":"Eksteen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Vannan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis I.","family":"Terrazas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 L.","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"issue":"1","key":"8574_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09361-0","volume":"10","author":"J Doonan","year":"2019","unstructured":"Doonan J, Tarafdar A, Pineda MA, Lumb FE, Crowe J, Khan AM, Hoskisson PA, Harnett MM, Harnett W (2019) The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis. 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