{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:58:34Z","timestamp":1781614714318,"version":"3.54.5"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010653","name":"Masaryk University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010653","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasitol Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study summarizes the findings of a comprehensive field investigation into the presence of\n                    <jats:italic>Angiostrongylus cantonensis<\/jats:italic>\n                    , a zoonotic nematode responsible for meningitis, in selected regions of the eastern Mediterranean. Samples were collected from intermediate hosts (gastropods), definitive hosts (rats), and potential paratenic hosts (reptiles) across Cyprus and the northern part of Egypt. Reptile and gastropod samples were analysed using a species-specific and highly sensitive LAMP assay, while rats were dissected and examined for adult nematodes in their pulmonary arteries. All samples from the surveyed localities tested negative for the parasite and its DNA. These findings led the authors to conclude that\n                    <jats:italic>A. cantonensis<\/jats:italic>\n                    is either absent or occurs at a very low prevalence in the areas studied in the eastern Mediterranean.\n                  <\/jats:p>","DOI":"10.1007\/s00436-025-08580-3","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T07:05:17Z","timestamp":1762758317000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In the eastern Mediterranean, the rat lungworm Angiostrongylus cantonensis is absent or extremely rare according to recent surveys"],"prefix":"10.1007","volume":"124","author":[{"given":"Lucia","family":"Anettov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"\u0160ipkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Cibulka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivienne","family":"Veli\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reham Fathey","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Modr\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"8580_CR1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268824000931","volume":"152","author":"L Anettov\u00e1","year":"2024","unstructured":"Anettov\u00e1 L, Bal\u00e1\u017e V, Coufal R, Hors\u00e1k M, Izquierdo-Rodriguez E, \u0160ipkov\u00e1 A, Foronda P, Modr\u00fd D (2024) Lizards as sentinels for the distribution of Angiostrongylus cantonensis. Epidemiol Infect 152:e168. https:\/\/doi.org\/10.1017\/S0950268824000931","journal-title":"Epidemiol Infect"},{"key":"8580_CR2","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1017\/S0031182025000034","volume":"152","author":"L Anettov\u00e1","year":"2025","unstructured":"Anettov\u00e1 L, \u0160ipkov\u00e1 A, Veli\u010d V, Ka\u010dma\u0159\u00edkov\u00e1 J, Javorsk\u00e1 K, Novotn\u00fd L, Cibulka P, Kv\u011bto\u0148 M, Modr\u00fd D (2025) Passage of Angiostrongylus cantonensis through the trophic web: an experimental study on reptiles. Parasitology 152:115\u2013122. https:\/\/doi.org\/10.1017\/S0031182025000034","journal-title":"Parasitology"},{"key":"8580_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011038","volume":"17","author":"V Bal\u00e1\u017e","year":"2023","unstructured":"Bal\u00e1\u017e V, Rivory P, Hayward D, Jaensch S, Malik R, Lee R, Modr\u00fd D, \u0160lapeta J (2023) Angie-LAMP for diagnosis of human eosinophilic meningitis using dog as proxy: a LAMP assay for Angiostrongylus cantonensis DNA in cerebrospinal fluid. PLoS Negl Trop Dis 17:e0011038. https:\/\/doi.org\/10.1371\/journal.pntd.0011038","journal-title":"PLoS Negl Trop Dis"},{"issue":"6 Suppl 2","key":"8580_CR4","first-page":"6","volume":"72","author":"RH Cowie","year":"2013","unstructured":"Cowie RH (2013a) Biology, systematics, life cycle, and distribution of Angiostrongylus cantonensis, the cause of rat lungworm disease. Hawaii J Med Public Health 72(6 Suppl 2):6\u20139","journal-title":"Hawaii J Med Public Health"},{"issue":"6 Suppl 2","key":"8580_CR5","first-page":"70","volume":"72","author":"RH Cowie","year":"2013","unstructured":"Cowie RH (2013b) Pathways for transmission of angiostrongyliasis and the risk of disease associated with them. Hawaii J Med Public Health 72(6 Suppl 2):70\u201374","journal-title":"Hawaii J Med Public Health"},{"key":"8580_CR6","doi-asserted-by":"publisher","first-page":"3153","DOI":"10.1016\/j.jas.2011.05.007","volume":"38","author":"M Finn\u00e9","year":"2011","unstructured":"Finn\u00e9 M, Holmgren K, Sundqvist H, Weiberg E, Lindblom M (2011) Climate in the Eastern Mediterranean, and adjacent regions, during the past 6000 years \u2013 a review. J Archaeol Sci 38:3153\u20133173. https:\/\/doi.org\/10.1016\/j.jas.2011.05.007","journal-title":"J Archaeol Sci"},{"key":"8580_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12040567","volume":"12","author":"MT Gal\u00e1n-Puchades","year":"2023","unstructured":"Gal\u00e1n-Puchades MT, G\u00f3mez-Sambl\u00e1s M, Osuna A, S\u00e1ez-Dur\u00e1n S, Bueno-Mar\u00ed R, Fuentes MV (2023) Update on the first finding of the rat lungworm, Angiostrongylus cantonensis, in Rattus spp. in continental Europe, Valencia, Spain, 2022. Pathogens 12:567. https:\/\/doi.org\/10.3390\/pathogens12040567","journal-title":"Pathogens"},{"key":"8580_CR8","doi-asserted-by":"publisher","unstructured":"Harding A, Palutikof J (2009) The climate system. In: Woodward J (ed) The physical geography of the mediterranean. Oxford Academic, Oxford, pp 69\u201398. https:\/\/doi.org\/10.1093\/oso\/9780199268030.003.0013","DOI":"10.1093\/oso\/9780199268030.003.0013"},{"key":"8580_CR9","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1051\/parasite\/2007141061","volume":"14","author":"MM Ibrahim","year":"2007","unstructured":"Ibrahim MM (2007) Prevalence and intensity of Angiostrongylus cantonensis in freshwater snails in relation to some ecological and biological factors. Parasite 14:61\u201370. https:\/\/doi.org\/10.1051\/parasite\/2007141061","journal-title":"Parasite"},{"key":"8580_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.onehlt.2023.100610","volume":"17","author":"S Jaume-Ramis","year":"2023","unstructured":"Jaume-Ramis S, Mart\u00ednez-Ort\u00ed A, Delgado-Serra S, Bargues MD, Mas-Coma S, Foronda P, Paredes-Esquivel C (2023) Potential intermediate hosts of Angiostrongylus cantonensis in the European mediterranean region (Mallorca, Spain). One Health 17:100610. https:\/\/doi.org\/10.1016\/j.onehlt.2023.100610","journal-title":"One Health"},{"key":"8580_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1571-9197(06)80003-0","volume":"4","author":"P Lionello","year":"2006","unstructured":"Lionello P, Malanotte-Rizzoli P, Boscolo R, Alpert P, Artale V, Li L, Luterbacher J, May W, Trigo R, Tsimplis M, Ulbrich U (2006) The mediterranean climate: an overview of the main characteristics and issues. Dev Earth Environ Sci 4:1\u201326. https:\/\/doi.org\/10.1016\/S1571-9197(06)80003-0","journal-title":"Dev Earth Environ Sci"},{"key":"8580_CR12","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1017\/S0031182020001857","volume":"148","author":"D Modr\u00fd","year":"2021","unstructured":"Modr\u00fd D, Feckov\u00e1 B, Putnov\u00e1 B, Manalo SM, Otranto D (2021) Alternative pathways in Angiostrongylus cantonensis (Metastrongyloidea: Angiostrongylidae) transmission. Parasitology 148:167\u2013173. https:\/\/doi.org\/10.1017\/S0031182020001857","journal-title":"Parasitology"},{"key":"8580_CR13","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.3201\/eid3109.250648","volume":"31","author":"D Pandian","year":"2025","unstructured":"Pandian D, \u0160ipkov\u00e1 A, Scarcelli S, Sgroi G, Ka\u010dma\u0159\u00edkov\u00e1 J, Buono F, Castaldo E, D\u2019Alessio N, \u010cerven\u00e1 B, Veneziano V, Modr\u00fd D (2025) Detection of rat lungworm (Angiostrongylus cantonensis) in rats and gatropods, Italy. Emerg Infect Dis 31:1833\u20131837. https:\/\/doi.org\/10.3201\/eid3109.250648","journal-title":"Emerg Infect Dis"},{"issue":"4","key":"8580_CR14","doi-asserted-by":"publisher","first-page":"857","DOI":"10.4269\/ajtmh.22-0782","volume":"108","author":"C Paredes-Esquivel","year":"2023","unstructured":"Paredes-Esquivel C, Foronda P, Dunavan CP, Cowie RH (2023) Neuroangiostrongyliasis: rat lungworm invades Europe. Am J Trop Med Hyg 108:857. https:\/\/doi.org\/10.4269\/ajtmh.22-0782","journal-title":"Am J Trop Med Hyg"},{"key":"8580_CR15","first-page":"498","volume":"25","author":"P Radomyos","year":"1994","unstructured":"Radomyos P, Tungtrongchitr A, Praewanich R, Khewwatchan P, Kantangkul T, Junlananto P, Ayudhya SI (1994) Occurrence of the infective stage of Angiostrongylus cantonensis in the yellow tree monitor (Varanus bengalensis) in five provinces of Thailand. Southeast Asian J Trop Med Public Health 25:498\u2013500","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"8580_CR16","doi-asserted-by":"publisher","first-page":"e150","DOI":"10.1093\/infdis\/jiaf173","volume":"232","author":"P Rivory","year":"2025","unstructured":"Rivory P, Lee R, Ward MP, \u0160lapeta J (2025) Rainfall- and temperature-driven emergence of neural angiostrongyliasis in eastern Australia, 2020\u20132024. J Infect Dis 232:e150\u2013e158. https:\/\/doi.org\/10.1093\/infdis\/jiaf173","journal-title":"J Infect Dis"},{"key":"8580_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.onehlt.2023.100658","volume":"17","author":"RL Rollins","year":"2023","unstructured":"Rollins RL, Medeiros MCI, Cowie RH (2023) Stressed snails release Angiostrongylus cantonensis (rat lungworm) larvae in their slime. One Health 17:100658. https:\/\/doi.org\/10.1016\/j.onehlt.2023.100658","journal-title":"One Health"},{"key":"8580_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00436-024-07376-1","volume":"123","author":"A \u0160ipkov\u00e1","year":"2024","unstructured":"\u0160ipkov\u00e1 A, Anettov\u00e1 L, Izquierdo-Rodriguez E, Veli\u010d V, Modr\u00fd D (2024) Release of Angiostrongylus cantonensis larvae from live intermediate hosts under stress. Parasitol Res 123:1\u20137. https:\/\/doi.org\/10.1007\/s00436-024-07376-1","journal-title":"Parasitol Res"},{"key":"8580_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103831","volume":"9","author":"EM York","year":"2014","unstructured":"York EM, Butler CJ, Lord WD (2014) Global decline in suitable habitat for Angiostrongylus (=\u2009Parastrongylus) cantonensis: the role of climate change. PLoS ONE 9:103831. https:\/\/doi.org\/10.1371\/journal.pone.0103831","journal-title":"PLoS ONE"},{"key":"8580_CR20","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/BF00930585","volume":"56","author":"F Yousif","year":"1978","unstructured":"Yousif F, Ibrahim A (1978) The first record of Angiostrongylus cantonensis from Egypt. Z Parasitenkd 56:73\u201380. https:\/\/doi.org\/10.1007\/BF00930585","journal-title":"Z Parasitenkd"}],"container-title":["Parasitology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-025-08580-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00436-025-08580-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00436-025-08580-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:27:13Z","timestamp":1781612833000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00436-025-08580-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["8580"],"URL":"https:\/\/doi.org\/10.1007\/s00436-025-08580-3","relation":{},"ISSN":["0932-0113","1432-1955"],"issn-type":[{"value":"0932-0113","type":"print"},{"value":"1432-1955","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"25 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was supported by the Czech Science Foundation grant no. 22\u201326136\u00a0S; the work of Anna \u0160ipkov\u00e1 and Lucia Anettov\u00e1 was supported by Specific research \u2013 support of student projects, no. MUNI\/A\/1762\/2024 and by the Masaryk University Mobility Scholarship for PhD students.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Financial support"}},{"value":"The authors consent to participate in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors consent to publish the manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"127"}}