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Purification of the D-isomer of praziquantel allows a comparative evaluation of both palatability and efficacy of the isomers. We showed that rainbow trout (\n                    <jats:italic>Oncorhynchus mykiss<\/jats:italic>\n                    ) preferred feed containing D-PZQ feed (60% acceptance) compared to M-PZQ feed (20% acceptance) (inclusion of 400\u00a0g PZQ\/kg feed). Subsequent efficacy studies using eyefluke\n                    <jats:italic>Diplostomum pseudospathaceum<\/jats:italic>\n                    cercariae (\n                    <jats:italic>in vitro<\/jats:italic>\n                    ) and experimentally infected rainbow trout carrying metacercariae (\n                    <jats:italic>in vivo<\/jats:italic>\n                    ) demonstrated a strong antiparasitic effect of both PZQ-forms.\n                    <jats:italic>In vitro<\/jats:italic>\n                    assays documented that both M-PZQ and D-PZQ induced rapid and concentration-dependent mortality in cercaria (100% within 4\u00a0h in 0.125\u00a0mg PZQ\/L), but with a significantly higher killing rate of of D-PZQ.\n                    <jats:italic>In viv<\/jats:italic>\n                    o assays (17 days feeding medicated feed) showed significant efficacy of both D-PZQ and M-PZQ. A slightly (non-significant) faster effect of D-PZQ may partly be ascribed to a combination of higher consumption of this isomer (due to its higher palatability) and higher efficacy. Cataract formation occurred in control fish but was prevented by both drug types indicating that metabolic and\/or mechanical activities of live parasites are associated with cataract induction. This rainbow trout\/eyefluke infection may serve as a model for non-piscine host-parasite systems as well.\n                  <\/jats:p>","DOI":"10.1007\/s00436-026-08733-y","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:54:06Z","timestamp":1785113646000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative palatability and efficacy of two praziquantel isomers in rainbow trout infected by eyefluke"],"prefix":"10.1007","volume":"125","author":[{"given":"Shilu","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaan","family":"Kumas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2747-237X","authenticated-orcid":false,"given":"Kurt","family":"Buchmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"8733_CR1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/med.2610030204","volume":"3","author":"P Andrews","year":"1983","unstructured":"Andrews P, Thomas H, Pohlke R, Seubert J (1983) Praziquantel. 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All ethical standards at the University of Copenhagen were met during fish keeping and experimentation. All authors (SH, KK, KB) have expressed their consent to participate.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors (SH, KB, KK) have expressed their consent to this submission.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"127"}}