{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T21:10:36Z","timestamp":1753737036185},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,4,18]],"date-time":"2015-04-18T00:00:00Z","timestamp":1429315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"German Federal Ministry of Education and Research","award":["ID0EDFAE207"],"award-info":[{"award-number":["ID0EDFAE207"]}]},{"name":"German Federal Ministry of Education and Research","award":["ID0EHGAE208"],"award-info":[{"award-number":["ID0EHGAE208"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Genet Genomics"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1007\/s00438-015-1045-3","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T09:24:17Z","timestamp":1429262657000},"page":"1911-1917","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Genetic variants associated with celiac disease and the risk for coronary artery disease"],"prefix":"10.1007","volume":"290","author":[{"given":"Henning","family":"Jansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Willenborg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Schlesinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola G.","family":"Ferrario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inke R.","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette","family":"Erdmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilesh J.","family":"Samani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Lieb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heribert","family":"Schunkert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,4,18]]},"reference":[{"key":"1045_CR1","doi-asserted-by":"publisher","first-page":"316","DOI":"10.4239\/wjd.v5.i3.316","volume":"5","author":"G Auburger","year":"2014","unstructured":"Auburger G, Gispert S, Lahut S, Om\u00fcr O, Damrath E, Heck M, Basak N (2014) 12q24 locus association with type 1 diabetes: SH2B3 or ATXN2? World J Diabetes 5:316\u2013327","journal-title":"World J Diabetes"},{"key":"1045_CR2","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.gtc.2007.01.006","volume":"36","author":"SH Barton","year":"2007","unstructured":"Barton SH, Kelly DG, Murray JA (2007) Nutritional deficiencies in celiac disease. Gastroenterol Clin North Am 36:93\u2013108","journal-title":"Gastroenterol Clin North Am"},{"key":"1045_CR3","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/ng.543","volume":"42","author":"PCA Dubois","year":"2010","unstructured":"Dubois PCA, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GAR, Ad\u00e1ny R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RSN, Fern\u00e1ndez-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJM, Gwilliam R, Houwen RHJ, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, M\u00e4ki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, N\u00fa\u00f1ez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek WHM, Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA (2010) Multiple common variants for celiac disease influencing immune gene expression. Nat Genet 42:295\u2013302","journal-title":"Nat Genet"},{"key":"1045_CR4","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1111\/apt.12271","volume":"9","author":"L Emilsson","year":"2013","unstructured":"Emilsson L, Carlsson R, Holmqvist M, James S, Ludvigsson JF (2013a) The characterisation and risk factors of ischaemic heart disease in patients with coeliac disease. Aliment Pharmacol Ther 9:905\u2013914","journal-title":"Aliment Pharmacol Ther"},{"key":"1045_CR5","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1177\/2047487313502446","volume":"22","author":"L Emilsson","year":"2013","unstructured":"Emilsson L, Carlsson R, James S, Hambraeus K, Ludvigsson JF (2013b) Follow-up of ischaemic heart disease in patients with coeliac disease. Eur J Prev Cardiol 22:83\u201390","journal-title":"Eur J Prev Cardiol"},{"key":"1045_CR6","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1111\/eci.12242","volume":"44","author":"L Emilsson","year":"2014","unstructured":"Emilsson L, James S, Ludvigsson JF (2014) Ischaemic heart disease in first-degree relatives to coeliac patients. Eur J Clin Invest 44:359\u2013364","journal-title":"Eur J Clin Invest"},{"key":"1045_CR7","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1089\/jmf.2014.0025","volume":"17","author":"S Farnetti","year":"2014","unstructured":"Farnetti S, Zocco MA, Garcovich M, Gasbarrini A, Capristo E (2014) Functional and metabolic disorders in celiac disease: new implications for nutritional treatment. J Med Food 17:1159\u20131164","journal-title":"J Med Food"},{"key":"1045_CR8","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3390\/nu4040243","volume":"4","author":"G Ferretti","year":"2012","unstructured":"Ferretti G, Bacchetti T, Masciangelo S, Saturni L (2012) Celiac disease, inflammation and oxidative damage: a nutrigenetic approach. Nutrients 4:243\u2013257","journal-title":"Nutrients"},{"key":"1045_CR9","first-page":"S0735","volume":"63","author":"RD Gajulapall","year":"2014","unstructured":"Gajulapalli RD, Pattanshetty D (2014) Coronary artery disease prevalence is higher among celiac disease patients. J Am Coll Cardiol 63:S0735\u2013S1097","journal-title":"J Am Coll Cardiol"},{"key":"1045_CR10","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/ng.102","volume":"40","author":"KA Hunt","year":"2008","unstructured":"Hunt KA, Zhernakova A, Turner G, Heap GAR, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GKT, Howdle PD, Walters JRF, Sanders DS, Playford RJ, Trynka G, Mulder CJJ, Mearin ML, Verbeek WHM, Trimble V, Stevens FM, O\u2019Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA et al (2008) Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet 40:395\u2013402","journal-title":"Nat Genet"},{"key":"1045_CR11","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1093\/bioinformatics\/btn564","volume":"24","author":"AD Johnson","year":"2008","unstructured":"Johnson AD, Handsaker RE, Pulit SL, Nizzari MM, O\u00b4Donnell CJ, de Bakker PI (2008) SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinforma Oxf Engl 24:2938\u20132939","journal-title":"Bioinforma Oxf Engl"},{"key":"1045_CR12","doi-asserted-by":"publisher","first-page":"e422","DOI":"10.1161\/CIRCULATIONAHA.111.028027","volume":"124","author":"J Lagro","year":"2011","unstructured":"Lagro J, Duijts L, Jaddoe VWVW (2011) Letter by Lagro et al. regarding article, \u2018Nationwide cohort study of risk of ischemic heart disease in patients with celiac disease\u2019. Circulation 124:e422","journal-title":"Circulation"},{"key":"1045_CR13","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1161\/CIRCULATIONAHA.110.965624","volume":"123","author":"JF Ludvigsson","year":"2011","unstructured":"Ludvigsson JF, James S, Askling J, Stenestrand U, Ingelsson E (2011) Nationwide cohort study of risk of ischemic heart disease in patients with celiac disease. Circulation 123:483\u2013490","journal-title":"Circulation"},{"key":"1045_CR14","doi-asserted-by":"publisher","first-page":"5658","DOI":"10.3748\/wjg.v19.i34.5658","volume":"19","author":"L Norsa","year":"2013","unstructured":"Norsa L, Shamir R, Zevit N, Verduci E, Hartman C, Ghisleni D, Riva E, Giovannini M (2013) Cardiovascular disease risk factor profiles in children with celiac disease on gluten-free diets. World J Gastroenterol 19:5658\u20135664","journal-title":"World J Gastroenterol"},{"key":"1045_CR15","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1080\/00365520903132013","volume":"44","author":"O Ol\u00e9n","year":"2009","unstructured":"Ol\u00e9n O, Montgomery SM, Marcus C, Ekbom A, Ludvigsson JF (2009) Coeliac disease and body mass index: a study of two Swedish general population-based registers. Scand J Gastroenterol 44:1198\u20131206","journal-title":"Scand J Gastroenterol"},{"key":"1045_CR16","doi-asserted-by":"publisher","first-page":"e70174","DOI":"10.1371\/journal.pone.0070174","volume":"8","author":"M \u00d6stensson","year":"2013","unstructured":"\u00d6stensson M, Mont\u00e9n C, Bacelis J, Gudjonsdottir AH, Adamovic S, Ek J, Ascher H, Pollak E, Arnell H, Browaldh L, Agardh D, Wahlstr\u00f6m J, Nilsson S, Torinsson-Naluai \u00c5 (2013) A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. PLoS One 8:e70174","journal-title":"PLoS One"},{"key":"1045_CR17","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1179\/2046905513Y.0000000078","volume":"34","author":"B Poddar","year":"2014","unstructured":"Poddar B, Shava U, Srivastava A, Kapoor A (2014) Severe heart failure, dilated cardiomyopathy and pulmonary haemosiderosis in coeliac disease: report of two cases. Paediatr Int Child Health 34:142\u2013144","journal-title":"Paediatr Int Child Health"},{"key":"1045_CR18","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1161\/CIRCGENETICS.109.899443","volume":"3","author":"M Preuss","year":"2010","unstructured":"Preuss M, K\u00f6nig IR, Thompson JR, Erdmann J, Absher D, Assimes TL, Blankenberg S, Boerwinkle E, Chen L, Cupples LA, Hall AS, Halperin E, Hengstenberg C, Holm H, Laaksonen R, Li M, M\u00e4rz W, McPherson R, Musunuru K, Nelson CP, Burnett, Epstein SE, O\u2019Donnell CJ, Quertermous T, Rader DJ, Roberts R, Schillert A, Stefansson K, Stewart AFR, Thorleifsson G, Voight BF, Wells GA, Ziegler A, Kathiresan S, Reilly MP, Samani NJ, Schunkert H, CARDIoGRAM Consortium (2010) Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: a genome-wide association meta-analysis involving more than 22,000 cases and 60,000 controls. Circ Cardiovasc Genet 3:475\u2013483","journal-title":"Circ Cardiovasc Genet"},{"key":"1045_CR19","volume-title":"Case-control studies: design, conduct, analysis (monographs in epidemiology and biostatistics)","author":"JJ Schlesselman","year":"1982","unstructured":"Schlesselman JJ, Stolley PD (1982) Case-control studies: design, conduct, analysis (monographs in epidemiology and biostatistics). Oxford Univ Pr, Oxford"},{"key":"1045_CR20","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/ng.784","volume":"43","author":"H Schunkert","year":"2011","unstructured":"Schunkert H, K\u00f6nig IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AFR, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, Andersen K, Anderson JL, Ardissino D, Ball SG, Balmforth AJ, Barnes TA, Becker DM, Becker LC, Berger K, Bis JC, Boekholdt SM, Boerwinkle E, Braund PS, Brown MJ, Burnett, Buysschaert MS, Cardiogenics I, Carlquist JF, Chen L, Cichon S, Codd V, Davies RW, Dedoussis G, Dehghan A, Demissie S, Devaney JM, Diemert P, Do R, Doering A, Eifert S, Mokhtari NEE, Ellis SG, Elosua R, Engert JC, Epstein SE, de Faire U, Fischer M, Folsom AR, Freyer J, Gigante B, Girelli D, Gretarsdottir S, Gudnason V, Gulcher JR, Halperin E, Hammond N, Hazen SL, Hofman A, Horne BD, Illig T, Jones GT, Jukema JW, Kaiser MA, Kaplan LM, Kastelein JJP, Khaw K-T, Knowles JW, Kolovou G, Kong A, Laaksonen R, Lambrechts D, Leander K, Lettre G, Li M, Lieb W, Loley C, Lotery AJ, Mannucci PM, Maouche S, Martinelli N, McKeown PP, Meisinger C, Meitinger T, Melander O, Merlini PA, Mooser V, Morgan T, M\u00fchleisen TW, Muhlestein JB, M\u00fcnzel T, Musunuru K, Nahrstaedt J, Nelson CP, N\u00f6then MM, Olivieri O, Patel RS, Patterson CC, Peters A, Peyvandi F, Qu L, Quyyumi AA, Rader DJ, Rallidis LS, Rice C, Rosendaal FR, Rubin D, Salomaa V, Sampietro ML, Sandhu MS, Schadt E, Sch\u00e4fer A, Schillert A, Schreiber S, Schrezenmeir J, Schwartz SM, Siscovick DS, Sivananthan M, Sivapalaratnam S, Smith A, Smith TB, Snoep JD, Soranzo N, Spertus JA, Stark K, Stirrups K, Stirrups K, Stoll M, Tang WHW, Tennstedt S, Thorgeirsson G, Thorleifsson G, Tomaszewski M, Uitterlinden AG, Uitterlinden AG, van Rij AM, Voight BF, Wareham NJ, Wells GA, Wichmann H-E, Wild PS, Willenborg C, Witteman JCM, Wright BJ, Ye S, Zeller T, Ziegler A, Cambien F, Goodall AH, Cupples LA, Quertermous T, M\u00e4rz W, Hengstenberg C, Blankenberg S, Ouwehand WH, Hall AS, Deloukas P, Deloukas P, Thompson JR, Stefansson K, Roberts R, Thorsteinsdottir U, O\u2019Donnell CJ, McPherson R, Erdmann J, CARDIoGRAM Consortium, Samani NJ (2011) Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 43:333\u2013338","journal-title":"Nat Genet"},{"key":"1045_CR21","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1038\/ng.998","volume":"43","author":"G Trynka","year":"2011","unstructured":"Trynka G, Hunt KA, Bockett NA, Romanos J, Mistry V, Szperl A, Bakker SF, Bardella MT, Castillejo G, de Concha la EG, de Almeida RC, Dias K-RM, van Diemen CC, Dubois PCA, Duerr RH, Edkins S, Franke L, Fransen K, Gutierrez J, Heap GAR, Hrdlickova B, Hunt S, Plaza Izurieta L, Izzo V, Joosten LAB, Langford C, Mazzilli MC, Mein CA, Midah V, Mitrovic M, Mora B, Morelli M, Nutland S, N\u00fa\u00f1ez C, Onengut-Gumuscu S, Pearce K, Platteel M, Polanco I, Potter S, Ribes-Koninckx C, Rica\u00f1o-Ponce I, Rich SS, Rybak A, Santiago JL, Senapati S, Sood A, Szajewska H, Varad\u00e9 J, Wallace C, Wolters VM, Zhernakova A, Thelma BK, Cukrowska B, Urcelay E, Bilbao JR, Mearin ML, Barisani D, Barrett JC, Plagnol V, Deloukas P, Wijmenga C, van Heel DA, Spanish Consortium on the Genetics of Coeliac Disease (CEGEC), PreventCD Study Group, Wellcome Trust Case Control Consortium (WTCCC) (2011) Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet 43:1193\u20131201","journal-title":"Nat Genet"},{"key":"1045_CR22","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/ng2058","volume":"39","author":"DA Heel Van","year":"2007","unstructured":"Van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MCNM, Bethel G, Holmes GKT, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JRF, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR, Deloukas P, Wijmenga C (2007) A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet 39:827\u2013829","journal-title":"Nat Genet"},{"key":"1045_CR23","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.dld.2006.03.002","volume":"38","author":"M Viljamaa","year":"2006","unstructured":"Viljamaa M, Kaukinen K, Pukkala E, Hervonen K, Reunala T, Collin P (2006) Malignancies and mortality in patients with coeliac disease and dermatitis herpetiformis: 30-year population-based study. Dig Liver Dis 38:374\u2013380","journal-title":"Dig Liver Dis"},{"key":"1045_CR24","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1111\/j.1365-2036.2007.03594.x","volume":"27","author":"L Wei","year":"2008","unstructured":"Wei L, Spiers E, Reynolds N, Walsh S, Fahey T, MacDonald TM (2008) The association between coeliac disease and cardiovascular disease. Aliment Pharmacol Ther 27:514\u2013519","journal-title":"Aliment Pharmacol Ther"},{"key":"1045_CR25","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1365-2036.2004.02008.x","volume":"20","author":"J West","year":"2004","unstructured":"West J, Logan RFA, Card TR, Smith C, Hubbard R (2004) Risk of vascular disease in adults with diagnosed coeliac disease: a population-based study. Aliment Pharmacol 20:73\u201379","journal-title":"Aliment Pharmacol"},{"key":"1045_CR26","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0140-6736(76)92843-9","volume":"2","author":"PJ Whorwell","year":"1976","unstructured":"Whorwell PJ, Alderson MR, Foster KJ, Wright R (1976) Death from ischaemic heart-disease and malignancy in adult patients with coeliac disease. Lancet 2:113\u2013114","journal-title":"Lancet"}],"container-title":["Molecular Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-015-1045-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00438-015-1045-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-015-1045-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-015-1045-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T06:53:43Z","timestamp":1577948023000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00438-015-1045-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,18]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["1045"],"URL":"https:\/\/doi.org\/10.1007\/s00438-015-1045-3","relation":{},"ISSN":["1617-4615","1617-4623"],"issn-type":[{"value":"1617-4615","type":"print"},{"value":"1617-4623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,18]]},"assertion":[{"value":"6 January 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}