{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:49:22Z","timestamp":1788266962988,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010032","name":"Health and Family Planning Commission of Sichuan Province","doi-asserted-by":"publisher","award":["WJ2019M011"],"award-info":[{"award-number":["WJ2019M011"]}],"id":[{"id":"10.13039\/501100010032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Genet Genomics"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>Hereditary factors are the main cause of pediatric nephrolithiasis (NL)\/nephrocalcinosis (NC). We summarized the\u00a0genotype\u2013phenotype correlation of hereditary NL\/NC in our center, to evaluate the role of genetic testing in early diagnosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The clinical data of 32 NL\/NC cases, which were suspected to have an inherited basis, were retrospectively analyzed from May 2017 to August 2020. The trio-whole exome sequencing was used as the main approach for genetic testing, variants were confirmed by Sanger sequencing, and pathogenicity\u00a0analysis according to protein function was predicted with custom-developed software.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Causative monogenic mutations were detected in 24 of 32 NL\/NC patients, and copy number variation was detected in one patient. A summary of manifestations in patients with inherited diseases revealed a significant degree of growth retardation, increased urinary excretion of the low-molecular weight protein, hypercalciuria, electrolyte imbalances, and young age of onset to be common in heredity disease. In addition, some patients had abnormal renal function (3\u00a0ppm 25). The most frequent pathology identified was distal renal tubular acidosis (with inclusion of <jats:italic>SLC4A1<\/jats:italic>, <jats:italic>ATP6V1B1<\/jats:italic>, and <jats:italic>ATP6VOA4<\/jats:italic> genes), followed by Dent disease (<jats:italic>CLCN5<\/jats:italic> and <jats:italic>OCRL1<\/jats:italic> genes), primary hyperoxaluria (PH) (<jats:italic>AGXT<\/jats:italic> and <jats:italic>HOGA1<\/jats:italic> genes) and Kabuki syndrome (<jats:italic>KMT2D<\/jats:italic> gene), which was more likely to present as NC or recurrent stone and having a higher correlation with a specific biochemical phenotype and extrarenal phenotype.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The etiology of NL\/NC is heterogeneous. This study explored in depth the relationship between phenotype and genotype in 32 patients, and confirmed that genetic testing and clinical phenotype evaluation enable the precision medicine approach to treating patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00438-022-01897-z","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T08:03:38Z","timestamp":1653465818000},"page":"1049-1061","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Genetic testing enables a precision medicine approach for nephrolithiasis and nephrocalcinosis in pediatrics: a single-center cohort"],"prefix":"10.1007","volume":"297","author":[{"given":"Lin","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaohong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"1897_CR1","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1007\/s00467-018-3965-8","volume":"33","author":"M Alonso-Varela","year":"2018","unstructured":"Alonso-Varela M, Gil-Pena H, Coto E, Gomez J, Rodriguez J, Rodriguez-Rubio E, Santos F, RenalTube G (2018) Distal renal tubular acidosis. Clinical manifestations in patients with different underlying gene mutations. Pediatr Nephrol 33:1523\u20131529. https:\/\/doi.org\/10.1007\/s00467-018-3965-8","journal-title":"Pediatr Nephrol"},{"key":"1897_CR2","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s00439-019-01978-x","volume":"138","author":"A Amar","year":"2019","unstructured":"Amar A et al (2019) Gene panel sequencing identifies a likely monogenic cause in 7% of 235 Pakistani families with nephrolithiasis. Hum Genet 138:211\u2013219. https:\/\/doi.org\/10.1007\/s00439-019-01978-x","journal-title":"Hum Genet"},{"key":"1897_CR3","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.arcped.2015.03.020","volume":"22","author":"M Arnaud","year":"2015","unstructured":"Arnaud M, Barat-Houari M, Gatinois V, Sanchez E, Lyonnet S, Touitou I, Genevieve D (2015) Kabuki syndrome: Update and review. Arch Pediatr 22:653\u2013660. https:\/\/doi.org\/10.1016\/j.arcped.2015.03.020","journal-title":"Arch Pediatr"},{"key":"1897_CR4","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.kint.2016.04.022","volume":"90","author":"A Blanchard","year":"2016","unstructured":"Blanchard A et al (2016) Observations of a large dent disease cohort. Kidney Int 90:430\u2013439. https:\/\/doi.org\/10.1016\/j.kint.2016.04.022","journal-title":"Kidney Int"},{"key":"1897_CR5","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s11934-017-0691-x","volume":"18","author":"JR Bonzo","year":"2017","unstructured":"Bonzo JR, Tasian GE (2017) The emergence of kidney stone disease during childhood-impact on adults. Curr Urol Rep 18:44. https:\/\/doi.org\/10.1007\/s11934-017-0691-x","journal-title":"Curr Urol Rep"},{"key":"1897_CR6","doi-asserted-by":"publisher","first-page":"664","DOI":"10.2215\/CJN.07540715","volume":"11","author":"DA Braun","year":"2016","unstructured":"Braun DA et al (2016) Prevalence of monogenic causes in pediatric patients with nephrolithiasis or nephrocalcinosis. Clin J Am Soc Nephrol 11:664\u2013672. https:\/\/doi.org\/10.2215\/CJN.07540715","journal-title":"Clin J Am Soc Nephrol"},{"key":"1897_CR7","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1056\/NEJMra1301564","volume":"369","author":"P Cochat","year":"2013","unstructured":"Cochat P, Rumsby G (2013) Primary hyperoxaluria. N Engl J Med 369:649\u2013658. https:\/\/doi.org\/10.1056\/NEJMra1301564","journal-title":"N Engl J Med"},{"key":"1897_CR8","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.kint.2017.06.025","volume":"93","author":"A Daga","year":"2018","unstructured":"Daga A et al (2018) Whole exome sequencing frequently detects a monogenic cause in early onset nephrolithiasis and nephrocalcinosis. Kidney Int 93:204\u2013213. https:\/\/doi.org\/10.1016\/j.kint.2017.06.025","journal-title":"Kidney Int"},{"key":"1897_CR9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1750-1172-5-28","volume":"5","author":"O Devuyst","year":"2010","unstructured":"Devuyst O, Thakker RV (2010) Dent\u2019s disease. Orphanet J Rare Dis 5:28. https:\/\/doi.org\/10.1186\/1750-1172-5-28","journal-title":"Orphanet J Rare Dis"},{"key":"1897_CR10","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1681\/ASN.2015040367","volume":"27","author":"NA Dhayat","year":"2016","unstructured":"Dhayat NA, Schaller A, Albano G, Poindexter J, Griffith C, Pasch A, Gallati S, Vogt B, Moe OW, Fuster DG (2016) The vacuolar H+-ATPase B1 subunit polymorphism p. E161K associates with impaired urinary acidification in recurrent stone formers. J Am Soc Nephrol 27:1544\u20131554. https:\/\/doi.org\/10.1681\/ASN.2015040367","journal-title":"J Am Soc Nephrol"},{"key":"1897_CR11","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/nrneph.2017.167","volume":"14","author":"EE Groopman","year":"2018","unstructured":"Groopman EE, Rasouly HM, Gharavi AG (2018) Genomic medicine for kidney disease. Nat Rev Nephrol 14:83\u2013104. https:\/\/doi.org\/10.1038\/nrneph.2017.167","journal-title":"Nat Rev Nephrol"},{"key":"1897_CR12","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s00467-011-1803-3","volume":"26","author":"MK G\u00fcrg\u00f6ze","year":"2011","unstructured":"G\u00fcrg\u00f6ze MK, Sar\u0131 MY (2011) Results of medical treatment and metabolic risk factors in children with urolithiasis. Pediatr Nephrol (berlin, Germany) 26:933\u2013937. https:\/\/doi.org\/10.1007\/s00467-011-1803-3","journal-title":"Pediatr Nephrol (berlin, Germany)"},{"key":"1897_CR13","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1681\/ASN.2014040388","volume":"26","author":"J Halbritter","year":"2015","unstructured":"Halbritter J et al (2015) Fourteen monogenic genes account for 15% of nephrolithiasis\/nephrocalcinosis. J Am Soc Nephrol 26:543\u2013551. https:\/\/doi.org\/10.1681\/ASN.2014040388","journal-title":"J Am Soc Nephrol"},{"key":"1897_CR14","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1001\/jamapediatrics.2015.1419","volume":"169","author":"JD Hernandez","year":"2015","unstructured":"Hernandez JD, Ellison JS, Lendvay TS (2015) Current trends, evaluation, and management of pediatric nephrolithiasis. JAMA Pediatr 169:964\u2013970. https:\/\/doi.org\/10.1001\/jamapediatrics.2015.1419","journal-title":"JAMA Pediatr"},{"key":"1897_CR15","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1086\/427887","volume":"76","author":"RR Hoopes Jr","year":"2005","unstructured":"Hoopes RR Jr et al (2005) Dent disease with mutations in OCRL1. Am J Hum Genet 76:260\u2013267. https:\/\/doi.org\/10.1086\/427887","journal-title":"Am J Hum Genet"},{"key":"1897_CR16","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/s41585-020-0332-x","volume":"17","author":"SA Howles","year":"2020","unstructured":"Howles SA, Thakker RV (2020) Genetics of kidney stone disease. Nat Rev Urol 17:407\u2013421. https:\/\/doi.org\/10.1038\/s41585-020-0332-x","journal-title":"Nat Rev Urol"},{"key":"1897_CR17","doi-asserted-by":"publisher","DOI":"10.1089\/end.2020.0108","author":"BA Johnson","year":"2020","unstructured":"Johnson BA et al (2020) Initial results from the M-STONE group: a multi-center collaboration to study treatment outcomes in nephrolithiasis evaluation. J Endourol. https:\/\/doi.org\/10.1089\/end.2020.0108","journal-title":"J Endourol"},{"key":"1897_CR18","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1038\/s41436-018-0259-2","volume":"21","author":"J Kennedy","year":"2019","unstructured":"Kennedy J et al (2019) KAT6A Syndrome: genotype-phenotype correlation in 76 patients with pathogenic KAT6A variants. Genet Med 21:850\u2013860. https:\/\/doi.org\/10.1038\/s41436-018-0259-2","journal-title":"Genet Med"},{"key":"1897_CR19","doi-asserted-by":"publisher","first-page":"16008","DOI":"10.1038\/nrdp.2016.8","volume":"2","author":"SR Khan","year":"2016","unstructured":"Khan SR, Pearle MS, Robertson WG, Gambaro G, Canales BK, Doizi S, Traxer O, Tiselius HG (2016) Kidney Stones. Nat Rev Dis Primers 2:16008. https:\/\/doi.org\/10.1038\/nrdp.2016.8","journal-title":"Nat Rev Dis Primers"},{"key":"1897_CR20","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1093\/ndt\/gfy409","volume":"34","author":"SC Lopez-Garcia","year":"2019","unstructured":"Lopez-Garcia SC et al (2019) Treatment and long-term outcome in primary distal renal tubular acidosis. Nephrol Dial Transplant 34:981\u2013991. https:\/\/doi.org\/10.1093\/ndt\/gfy409","journal-title":"Nephrol Dial Transplant"},{"key":"1897_CR21","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.kint.2016.12.017","volume":"91","author":"V Palazzo","year":"2017","unstructured":"Palazzo V et al (2017) The genetic and clinical spectrum of a large cohort of patients with distal renal tubular acidosis. Kidney Int 91:1243\u20131255. https:\/\/doi.org\/10.1016\/j.kint.2016.12.017","journal-title":"Kidney Int"},{"key":"1897_CR22","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1159\/000488698","volume":"43","author":"E Park","year":"2018","unstructured":"Park E, Cho MH, Hyun HS, Shin JI, Lee JH, Park YS, Choi HJ, Kang HG, Cheong HI (2018) Genotype\u2013phenotype analysis in pediatric patients with distal renal tubular acidosis. Kidney Blood Press Res 43:513\u2013521. https:\/\/doi.org\/10.1159\/000488698","journal-title":"Kidney Blood Press Res"},{"key":"1897_CR23","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/cge.13606","volume":"96","author":"J Rao","year":"2019","unstructured":"Rao J et al (2019) Genetic spectrum of renal disease for 1001 Chinese children based on a multicenter registration system. Clin Genet 96:402\u2013410. https:\/\/doi.org\/10.1111\/cge.13606","journal-title":"Clin Genet"},{"key":"1897_CR24","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.juro.2010.05.018","volume":"184","author":"JC Routh","year":"2010","unstructured":"Routh JC, Graham DA, Nelson CP (2010) Epidemiological trends in pediatric urolithiasis at United States freestanding pediatric hospitals. J Urol 184:1100\u20131104. https:\/\/doi.org\/10.1016\/j.juro.2010.05.018","journal-title":"J Urol"},{"key":"1897_CR25","doi-asserted-by":"publisher","first-page":"506e501","DOI":"10.1016\/j.jpurol.2017.03.015","volume":"13","author":"TR Saitz","year":"2017","unstructured":"Saitz TR, Mongoue-Tchokote S, Sharadin C, Giel DW, Corbett S, Kovacevic L, Bayne AP, Collaboration on Urolithiasis in Pediatrics Working G (2017) 24 Hour urine metabolic differences between solitary and multiple stone formers: results of the Collaboration on Urolithiasis in Pediatrics (CUP) working group. J Pediatr Urol 13:506e501-506e505. https:\/\/doi.org\/10.1016\/j.jpurol.2017.03.015","journal-title":"J Pediatr Urol"},{"key":"1897_CR26","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/ki.2010.473","volume":"79","author":"K Sakhaee","year":"2011","unstructured":"Sakhaee K, Maalouf NM, Kumar R, Pasch A, Moe OW (2011) Nephrolithiasis-associated bone disease: pathogenesis and treatment options. Kidney Int 79:393\u2013403. https:\/\/doi.org\/10.1038\/ki.2010.473","journal-title":"Kidney Int"},{"key":"1897_CR27","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1681\/ASN.2016050576","volume":"28","author":"JA Sayer","year":"2017","unstructured":"Sayer JA (2017) Progress in understanding the genetics of calcium-containing nephrolithiasis. J Am Soc Nephrol 28:748\u2013759. https:\/\/doi.org\/10.1681\/ASN.2016050576","journal-title":"J Am Soc Nephrol"},{"key":"1897_CR28","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/ki.2015.76","volume":"88","author":"L Shavit","year":"2015","unstructured":"Shavit L, Jaeger P, Unwin RJ (2015) What is nephrocalcinosis? Kidney Int 88:35\u201343. https:\/\/doi.org\/10.1038\/ki.2015.76","journal-title":"Kidney Int"},{"key":"1897_CR29","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1089\/end.2017.0467","volume":"31","author":"X Shu","year":"2017","unstructured":"Shu X, Cai H, Xiang YB, Li H, Lipworth L, Miller NL, Zheng W, Shu XO, Hsi RS (2017) Nephrolithiasis among middle aged and elderly urban Chinese: a report from prospective cohort studies in Shanghai. J Endourol 31:1327\u20131334. https:\/\/doi.org\/10.1089\/end.2017.0467","journal-title":"J Endourol"},{"key":"1897_CR30","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1007\/s00467-008-0769-2","volume":"23","author":"FR Spivacow","year":"2008","unstructured":"Spivacow FR, Negri AL, del Valle EE, Calvino I, Fradinger E, Zanchetta JR (2008) Metabolic risk factors in children with kidney stone disease. Pediatr Nephrol 23:1129\u20131133. https:\/\/doi.org\/10.1007\/s00467-008-0769-2","journal-title":"Pediatr Nephrol"},{"key":"1897_CR31","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/01.mnh.0000447017.28852.52","volume":"23","author":"X Tang","year":"2014","unstructured":"Tang X, Lieske JC (2014) Acute and chronic kidney injury in nephrolithiasis. Curr Opin Nephrol Hypertens 23:385\u2013390. https:\/\/doi.org\/10.1097\/01.mnh.0000447017.28852.52","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"1897_CR32","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/s41581-020-0320-7","volume":"16","author":"C Thongprayoon","year":"2020","unstructured":"Thongprayoon C, Krambeck AE, Rule AD (2020) Determining the true burden of kidney stone disease. Nat Rev Nephrol 16:736\u2013746. https:\/\/doi.org\/10.1038\/s41581-020-0320-7","journal-title":"Nat Rev Nephrol"},{"key":"1897_CR33","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.eururo.2015.07.040","volume":"69","author":"C Turk","year":"2016","unstructured":"Turk C, Petrik A, Sarica K, Seitz C, Skolarikos A, Straub M, Knoll T (2016) EAU guidelines on diagnosis and conservative management of urolithiasis. Eur Urol 69:468\u2013474. https:\/\/doi.org\/10.1016\/j.eururo.2015.07.040","journal-title":"Eur Urol"},{"key":"1897_CR34","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1681\/ASN.2005121305","volume":"17","author":"R Vargas-Poussou","year":"2006","unstructured":"Vargas-Poussou R et al (2006) Genetic investigation of autosomal recessive distal renal tubular acidosis: evidence for early sensorineural hearing loss associated with mutations in the ATP6V0A4 gene. J Am Soc Nephrol 17:1437\u20131443. https:\/\/doi.org\/10.1681\/ASN.2005121305","journal-title":"J Am Soc Nephrol"},{"key":"1897_CR35","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/s41588-018-0281-y","volume":"51","author":"M Verbitsky","year":"2019","unstructured":"Verbitsky M et al (2019) The copy number variation landscape of congenital anomalies of the kidney and urinary tract. Nat Genet 51:117\u2013127. https:\/\/doi.org\/10.1038\/s41588-018-0281-y","journal-title":"Nat Genet"},{"key":"1897_CR36","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nrneph.2015.205","volume":"12","author":"A Vivante","year":"2016","unstructured":"Vivante A, Hildebrandt F (2016) Exploring the genetic basis of early-onset chronic kidney disease. Nat Rev Nephrol 12:133\u2013146. https:\/\/doi.org\/10.1038\/nrneph.2015.205","journal-title":"Nat Rev Nephrol"},{"key":"1897_CR37","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1038\/ki.2015.254","volume":"88","author":"AL Zisman","year":"2015","unstructured":"Zisman AL, Evan AP, Coe FL, Worcester EM (2015) Do kidney stone formers have a kidney disease? Kidney Int 88:1240\u20131249. https:\/\/doi.org\/10.1038\/ki.2015.254","journal-title":"Kidney Int"}],"container-title":["Molecular Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-022-01897-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00438-022-01897-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-022-01897-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T04:09:50Z","timestamp":1656734990000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00438-022-01897-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,25]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["1897"],"URL":"https:\/\/doi.org\/10.1007\/s00438-022-01897-z","relation":{},"ISSN":["1617-4615","1617-4623"],"issn-type":[{"value":"1617-4615","type":"print"},{"value":"1617-4623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,25]]},"assertion":[{"value":"19 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}