{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T08:55:03Z","timestamp":1771145703355,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100007504","name":"Istanbul Teknik \u00dcniversitesi","doi-asserted-by":"publisher","award":["1239-39586"],"award-info":[{"award-number":["1239-39586"]}],"id":[{"id":"10.13039\/501100007504","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Genet Genomics"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s00438-022-01910-5","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T15:02:48Z","timestamp":1655305368000},"page":"1141-1150","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["MYO1H is a novel candidate gene for autosomal dominant pure hereditary spastic paraplegia"],"prefix":"10.1007","volume":"297","author":[{"given":"Ece","family":"Sel\u00e7uk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koray","family":"K\u0131r\u0131mtay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benan","family":"Temizci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eeyma","family":"Akarsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Everest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Bar\u0131\u015f","family":"Baslo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meltem","family":"Demirk\u0131ran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuhal","family":"Yap\u0131c\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5150-5349","authenticated-orcid":false,"given":"Arzu","family":"Karabay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"1910_CR1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/340565a0","volume":"340","author":"RJ Adams","year":"1989","unstructured":"Adams RJ, Pollard TD (1989) Binding of myosin I to membrane lipids. Nature 340:565\u2013568. https:\/\/doi.org\/10.1038\/340565a0","journal-title":"Nature"},{"key":"1910_CR2","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nmeth0410-248","volume":"7","author":"IA Adzhubei","year":"2010","unstructured":"Adzhubei IA, Schmidt S, Peshkin L et al (2010) A method and server for predicting damaging missense mutations. Nat Methods 7:248\u2013249","journal-title":"Nat Methods"},{"key":"1910_CR3","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.ajodo.2015.10.028","volume":"149","author":"RM Arun","year":"2016","unstructured":"Arun RM, Lakkakula BVKS, Chitharanjan AB (2016) Role of myosin 1H gene polymorphisms in mandibular retrognathism. Am J Orthod Dentofac Orthop 149:699\u2013704. https:\/\/doi.org\/10.1016\/j.ajodo.2015.10.028","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"1910_CR4","doi-asserted-by":"publisher","first-page":"D480","DOI":"10.1093\/nar\/gkaa1100","volume":"49","author":"A Bateman","year":"2021","unstructured":"Bateman A, Martin MJ, Orchard S et al (2021) UniProt: the universal protein knowledgebase in 2021. Nucleic Acids Res 49:D480\u2013D489. https:\/\/doi.org\/10.1093\/nar\/gkaa1100","journal-title":"Nucleic Acids Res"},{"key":"1910_CR5","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1091\/mbc.E09-07-0638","volume":"21","author":"AE Benesh","year":"2010","unstructured":"Benesh AE, Nambiar R, McConnell RE et al (2010) Differential localization and dynamics of class I myosins in the enterocyte microvillus. Mol Biol Cell 21:970\u2013978. https:\/\/doi.org\/10.1091\/mbc.E09-07-0638","journal-title":"Mol Biol Cell"},{"key":"1910_CR6","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1146\/annurev-neuro-062111-150400","volume":"35","author":"C Blackstone","year":"2012","unstructured":"Blackstone C (2012) Cellular pathways of hereditary spastic paraplegia. Annu Rev Neurosci 35:25\u201347","journal-title":"Annu Rev Neurosci"},{"key":"1910_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2018.04.025","author":"C Blackstone","year":"2018","unstructured":"Blackstone C (2018) Converging cellular themes for the hereditary spastic paraplegias. Curr Opin Neurobiol. https:\/\/doi.org\/10.1016\/j.conb.2018.04.025","journal-title":"Curr Opin Neurobiol"},{"key":"1910_CR8","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1091\/mbc.E19-08-0475","volume":"31","author":"H Brzeska","year":"2020","unstructured":"Brzeska H, Gonzalez J, Korn ED, Titus MA (2020) Basic-hydrophobic sites are localized in conserved positions inside and outside of PH domains and affect localization of Dictyostelium myosin 1s. Mol Biol Cell 31:101\u2013117. https:\/\/doi.org\/10.1091\/mbc.E19-08-0475","journal-title":"Mol Biol Cell"},{"key":"1910_CR9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0955-0674(92)90055-H","volume":"4","author":"RE Cheney","year":"1992","unstructured":"Cheney RE, Mooseker MS (1992) Unconventional myosins. Curr Opin Cell Biol 4:27\u201335. https:\/\/doi.org\/10.1016\/0955-0674(92)90055-H","journal-title":"Curr Opin Cell Biol"},{"key":"1910_CR10","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1093\/bioinformatics\/btv195","volume":"31","author":"Y Choi","year":"2015","unstructured":"Choi Y, Chan AP (2015) PROVEAN web server: a tool to predict the functional effect of amino acid substitutions and indels. Bioinformatics 31:2745\u20132747. https:\/\/doi.org\/10.1093\/bioinformatics\/btv195","journal-title":"Bioinformatics"},{"key":"1910_CR11","doi-asserted-by":"publisher","first-page":"230","DOI":"10.4161\/bioa.18406","volume":"1","author":"E Coudrier","year":"2011","unstructured":"Coudrier E, Almeida CG (2011) Myosin 1 controls membrane shape by coupling F-Actin to membrane. BioArchitecture 1:230\u2013235. https:\/\/doi.org\/10.4161\/bioa.18406","journal-title":"BioArchitecture"},{"key":"1910_CR12","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1177\/0022034515581643","volume":"94","author":"CSG da Fontoura","year":"2015","unstructured":"da Fontoura CSG, Miller SF, Wehby GL et al (2015) Candidate gene analyses of skeletal variation in malocclusion. J Dent Res 94:913\u2013920. https:\/\/doi.org\/10.1177\/0022034515581643","journal-title":"J Dent Res"},{"key":"1910_CR13","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1016\/S0006-3495(99)76968-7","volume":"77","author":"J Dai","year":"1999","unstructured":"Dai J, Ting-Beall HP, Hochmuth RM et al (1999) Myosin I contributes to the generation of resting cortical tension. Biophys J 77:1168\u20131176. https:\/\/doi.org\/10.1016\/S0006-3495(99)76968-7","journal-title":"Biophys J"},{"issue":"Suppl 1","key":"1910_CR14","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.expneurol.2003.08.005","volume":"184","author":"JK Fink","year":"2003","unstructured":"Fink JK (2003) Advances in the hereditary spastic paraplegias. Exp Neurol 184(Suppl 1):106\u2013110. https:\/\/doi.org\/10.1016\/j.expneurol.2003.08.005","journal-title":"Exp Neurol"},{"key":"1910_CR15","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.3389\/fnins.2019.01051","volume":"13","author":"PC Fowler","year":"2019","unstructured":"Fowler PC, Garcia-Pardo ME, Simpson JC, O\u2019Sullivan NC (2019) NeurodegenERation: the Central Role for ER Contacts in Neuronal Function and Axonopathy, lessons from hereditary spastic paraplegias and related diseases. Front Neurosci 13:1051","journal-title":"Front Neurosci"},{"key":"1910_CR16","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1136\/jnnp.44.10.871","volume":"44","author":"AE Harding","year":"1981","unstructured":"Harding AE (1981) Hereditary \u201cpure\u201d spastic paraplegia: a clinical and genetic study of 22 families. J Neurol Neurosurg Psychiatry 44:871\u2013883. https:\/\/doi.org\/10.1136\/jnnp.44.10.871","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1910_CR17","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/S0140-6736(83)92879-9","volume":"321","author":"AE Harding","year":"1983","unstructured":"Harding AE (1983) Classification of the hereditary ataxias and paraplegias. Lancet 321:1151\u20131155","journal-title":"Lancet"},{"key":"1910_CR18","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1242\/jcs.030205","volume":"122","author":"WA Hofmann","year":"2009","unstructured":"Hofmann WA, Richards TA, de Lanerolle P (2009) Ancient animal ancestry for nuclear myosin. J Cell Sci 122:636\u2013643. https:\/\/doi.org\/10.1242\/jcs.030205","journal-title":"J Cell Sci"},{"issue":"6","key":"1910_CR19","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1083\/jcb.201703205","volume":"217","author":"O Iuliano","year":"2018","unstructured":"Iuliano O, Yoshimura A, Prosp\u00e9ri M et al (2018) Myosin 1b promotes axon formation by regulating actin wave propagation and growth cone dynamics. J Cell Biol 217(6):2033\u20132046","journal-title":"J Cell Biol"},{"key":"1910_CR20","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/ana.25263","volume":"84","author":"X Jia","year":"2018","unstructured":"Jia X, Madireddy L, Caillier S et al (2018) Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis. Ann Neurol 84:51\u201363. https:\/\/doi.org\/10.1002\/ana.25263","journal-title":"Ann Neurol"},{"issue":"7","key":"1910_CR21","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1091\/mbc.e13-12-0712","volume":"25","author":"M Joensuu","year":"2014","unstructured":"Joensuu M, Belevich I, R\u00e4m\u00f6 O et al (2014) ER sheet persistence is coupled to myosin 1c\u2013regulated dynamic actin filament arrays. Mol Biol Cell 25(7):1111\u20131126","journal-title":"Mol Biol Cell"},{"key":"1910_CR22","doi-asserted-by":"publisher","first-page":"7809","DOI":"10.1038\/s41586-020-2308-7","volume":"581","author":"KJ Karczewski","year":"2020","unstructured":"Karczewski KJ, Francioli LC, Tiao G et al (2020) (2020) The mutational constraint spectrum quantified from variation in 141,456 humans. Nature 581:7809. https:\/\/doi.org\/10.1038\/s41586-020-2308-7 (581:434\u2013443)","journal-title":"Nature"},{"key":"1910_CR23","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.2026076118\/-\/dcsupplemental","author":"ME Kars","year":"2021","unstructured":"Kars ME, Ba\u015fak AN, Onat OE et al (2021) The genetic structure of the Turkish population reveals high levels of variation and admixture. Proc Natl Acad Sci USA. https:\/\/doi.org\/10.1073\/PNAS.2026076118\/-\/dcsupplemental","journal-title":"Proc Natl Acad Sci USA"},{"key":"1910_CR24","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1242\/jcs.181313","volume":"129","author":"N Kittelberger","year":"2016","unstructured":"Kittelberger N, Breunig M, Martin R et al (2016) The role of myosin 1c and myosin 1b in surfactant exocytosis. J Cell Sci 129:1685\u20131696. https:\/\/doi.org\/10.1242\/jcs.181313","journal-title":"J Cell Sci"},{"key":"1910_CR25","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/nprot.2009.86","volume":"4","author":"P Kumar","year":"2009","unstructured":"Kumar P, Henikoff S, Ng PC (2009) Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc 4:1073\u20131082. https:\/\/doi.org\/10.1038\/nprot.2009.86","journal-title":"Nat Protoc"},{"key":"1910_CR26","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.expneurol.2014.06.011","volume":"261","author":"T Lo Giudice","year":"2014","unstructured":"Lo Giudice T, Lombardi F, Santorelli FM et al (2014) Hereditary spastic paraplegia: clinical-genetic characteristics and evolving molecular mechanisms. Exp Neurol 261:518\u2013539","journal-title":"Exp Neurol"},{"key":"1910_CR27","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nsmb.2923","volume":"22","author":"Q Lu","year":"2015","unstructured":"Lu Q, Li J, Ye F, Zhang M (2015) Structure of myosin-1c tail bound to calmodulin provides insights into calcium-mediated conformational coupling. Nat Struct Mol Biol 22:81\u201387. https:\/\/doi.org\/10.1038\/nsmb.2923","journal-title":"Nat Struct Mol Biol"},{"key":"1910_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11030403","author":"A Mackay-Sim","year":"2021","unstructured":"Mackay-Sim A (2021) Hereditary spastic paraplegia: from genes, cells and networks to novel pathways for drug discovery. Brain Sci. https:\/\/doi.org\/10.3390\/brainsci11030403","journal-title":"Brain Sci"},{"key":"1910_CR29","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1086\/504927","volume":"79","author":"AU Mannan","year":"2006","unstructured":"Mannan AU, Krawen P, Sauter SM et al (2006) ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia. Am J Hum Genet 79:351\u2013357. https:\/\/doi.org\/10.1086\/504927","journal-title":"Am J Hum Genet"},{"key":"1910_CR30","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1073\/pnas.1108411109","volume":"109","author":"R Mazzolini","year":"2012","unstructured":"Mazzolini R, Dopeso H, Mateo-Lozano S et al (2012) Brush border Myosin Ia has tumor suppressor activity in the intestine. Proc Natl Acad Sci USA 109:1530\u20131535. https:\/\/doi.org\/10.1073\/pnas.1108411109","journal-title":"Proc Natl Acad Sci USA"},{"key":"1910_CR31","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.tcb.2010.04.004","volume":"20","author":"RE McConnell","year":"2010","unstructured":"McConnell RE, Tyska MJ (2010) Leveraging the membrane\u2014cytoskeleton interface with myosin-1. Trends Cell Biol 20:418\u2013426","journal-title":"Trends Cell Biol"},{"key":"1910_CR32","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.1242\/jcs.186403","volume":"129","author":"BB McIntosh","year":"2016","unstructured":"McIntosh BB, Ostap EM (2016) Myosin-I molecular motors at a glance. J Cell Sci 129:2689\u20132695. https:\/\/doi.org\/10.1242\/jcs.186403","journal-title":"J Cell Sci"},{"issue":"3","key":"1910_CR33","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.3390\/ijms23031697","volume":"23","author":"A Meyyazhagan","year":"2022","unstructured":"Meyyazhagan A, Orlacchio A (2022) Hereditary Spastic Paraplegia: An Update. Int J Mol Sci 23(3):1697","journal-title":"Int J Mol Sci"},{"issue":"3","key":"1910_CR34","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s10072-020-04981-7","volume":"42","author":"S Murala","year":"2021","unstructured":"Murala S, Nagarajan E, Bollu PC (2021) Hereditary spastic paraplegia. Neurol Sci 42(3):883\u2013894","journal-title":"Neurol Sci"},{"key":"1910_CR35","doi-asserted-by":"publisher","first-page":"11972","DOI":"10.1073\/pnas.0901641106","volume":"106","author":"R Nambiar","year":"2009","unstructured":"Nambiar R, McConnell RE, Tyska MJ (2009) Control of cell membrane tension by myosin-I. Proc Natl Acad Sci USA 106:11972\u201311977. https:\/\/doi.org\/10.1073\/pnas.0901641106","journal-title":"Proc Natl Acad Sci USA"},{"issue":"15","key":"1910_CR36","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1242\/jcs.084335","volume":"124","author":"A Rump","year":"2011","unstructured":"Rump A, Scholz T, Thiel C et al (2011) Myosin-1C associates with microtubules and stabilizes the mitotic spindle during cell division. J Cell Sci 124(15):2521\u20132528","journal-title":"J Cell Sci"},{"key":"1910_CR37","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/S1474-4422(08)70258-8","volume":"7","author":"S Salinas","year":"2008","unstructured":"Salinas S, Proukakis C, Crosby A, Warner TT (2008) Hereditary spastic paraplegia: clinical features and pathogenetic mechanisms. The Lancet Neurology 7:1127\u20131138. https:\/\/doi.org\/10.1016\/S1474-4422(08)70258-8","journal-title":"The Lancet Neurology"},{"key":"1910_CR38","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1212\/wnl.0b013e3181a6086c","volume":"72","author":"R Sch\u00fcle","year":"2009","unstructured":"Sch\u00fcle R, Bonin M, D\u00fcrr A et al (2009) Autosomal dominant spastic paraplegia with peripheral neuropathy maps to chr12q23-24. Neurology 72:1893\u20131898. https:\/\/doi.org\/10.1212\/wnl.0b013e3181a6086c","journal-title":"Neurology"},{"key":"1910_CR39","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nmeth0810-575","volume":"7","author":"JM Schwarz","year":"2010","unstructured":"Schwarz JM, R\u00f6delsperger C, Schuelke M, Seelow D (2010) MutationTaster evaluates disease-causing potential of sequence alterations. Nat Methods 7:575\u2013576","journal-title":"Nat Methods"},{"key":"1910_CR40","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1136\/jmedgenet-2017-104765","volume":"54","author":"M Spielmann","year":"2017","unstructured":"Spielmann M, Hernandez-Miranda LR, Ceccherini I et al (2017) Mutations in MYO1H cause a recessive form of central hypoventilation with autonomic dysfunction. J Med Genet 54:754\u2013761. https:\/\/doi.org\/10.1136\/jmedgenet-2017-104765","journal-title":"J Med Genet"},{"key":"1910_CR41","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1177\/0022034518784936","volume":"97","author":"R Sun","year":"2018","unstructured":"Sun R, Wang Y, Jin M et al (2018) Identification and functional studies of MYO1H for mandibular prognathism. J Dent Res 97:1501\u20131509. https:\/\/doi.org\/10.1177\/0022034518784936","journal-title":"J Dent Res"},{"key":"1910_CR42","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ajodo.2011.06.033","volume":"141","author":"M Tassopoulou-Fishell","year":"2012","unstructured":"Tassopoulou-Fishell M, Deeley K, Harvey EM et al (2012) Genetic variation in Myosin 1H contributes to mandibular prognathism. Am J Orthod Dentofac Orthop 141:51\u201359. https:\/\/doi.org\/10.1016\/j.ajodo.2011.06.033","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"1910_CR43","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1091\/mbc.e04-12-1116","volume":"16","author":"MJ Tyska","year":"2005","unstructured":"Tyska MJ, Mackey AT, Huang JD et al (2005) Myosin-1a is critical for normal brush border structure and composition. Mol Biol Cell 16:2443\u20132457. https:\/\/doi.org\/10.1091\/mbc.e04-12-1116","journal-title":"Mol Biol Cell"},{"key":"1910_CR44","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi1110s43","author":"GA van der Auwera","year":"2013","unstructured":"van der Auwera GA, Carneiro MO, Hartl C et al (2013) From fastQ data to high-confidence variant calls: the genome analysis toolkit best practices pipeline. Curr Protoc Bioinformatics. https:\/\/doi.org\/10.1002\/0471250953.bi1110s43","journal-title":"Curr Protoc Bioinformatics"},{"key":"1910_CR45","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq603","author":"K Wang","year":"2010","unstructured":"Wang K, Li M, Hakonarson H (2010) ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. https:\/\/doi.org\/10.1093\/nar\/gkq603","journal-title":"Nucleic Acids Res"},{"key":"1910_CR46","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1093\/bioinformatics\/btr350","volume":"27","author":"Y Yang","year":"2011","unstructured":"Yang Y, Faraggi E, Zhao H, Zhou Y (2011) Improving protein fold recognition and template-based modeling by employing probabilistic-based matching between predicted one-dimensional structural properties of query and corresponding native properties of templates. Bioinformatics 27:2076. https:\/\/doi.org\/10.1093\/bioinformatics\/btr350","journal-title":"Bioinformatics"}],"container-title":["Molecular Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-022-01910-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00438-022-01910-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-022-01910-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T04:10:28Z","timestamp":1656735028000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00438-022-01910-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,15]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["1910"],"URL":"https:\/\/doi.org\/10.1007\/s00438-022-01910-5","relation":{},"ISSN":["1617-4615","1617-4623"],"issn-type":[{"value":"1617-4615","type":"print"},{"value":"1617-4623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,15]]},"assertion":[{"value":"20 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Authors do not have any conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval was obtained by the Ethics Committee of Istanbul Technical University and Biruni University Hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}