{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T19:23:38Z","timestamp":1780773818714,"version":"3.54.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Genet Genomics"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s00438-024-02116-7","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T20:05:59Z","timestamp":1710360359000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mesenchymal stem cells-derived exosomes carrying microRNA-30b confer protection against pulmonary fibrosis by downregulating Runx1 via Spred2"],"prefix":"10.1007","volume":"299","author":[{"given":"Liang","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-7519","authenticated-orcid":false,"given":"Huaxiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"2116_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.600711","volume":"9","author":"SC Abreu","year":"2021","unstructured":"Abreu SC, Lopes-Pacheco M, Weiss DJ, Rocco PRM (2021) Mesenchymal stromal cell-derived extracellular vesicles in lung diseases: current status and perspectives. Front Cell Dev Biol 9:600711","journal-title":"Front Cell Dev Biol"},{"key":"2116_CR2","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1136\/jcp.41.4.467","volume":"41","author":"T Ashcroft","year":"1988","unstructured":"Ashcroft T, Simpson JM, Timbrell V (1988) Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol 41:467\u2013470","journal-title":"J Clin Pathol"},{"key":"2116_CR3","first-page":"219","volume":"90","author":"OS Chioma","year":"2017","unstructured":"Chioma OS, Drake WP (2017) Role of microbial agents in pulmonary fibrosis. Yale J Biol Med 90:219\u2013227","journal-title":"Yale J Biol Med"},{"key":"2116_CR4","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1002\/jcp.30684","volume":"237","author":"S Dubey","year":"2022","unstructured":"Dubey S, Dubey PK, Umeshappa CS, Ghebre YT, Krishnamurthy P (2022) Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts. J Cell Physiol 237:2169\u20132182","journal-title":"J Cell Physiol"},{"key":"2116_CR5","doi-asserted-by":"publisher","first-page":"580","DOI":"10.3904\/kjim.2015.30.5.580","volume":"30","author":"YW Eom","year":"2015","unstructured":"Eom YW, Shim KY, Baik SK (2015) Mesenchymal stem cell therapy for liver fibrosis. Korean J Intern Med 30:580\u2013589","journal-title":"Korean J Intern Med"},{"key":"2116_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.653296","volume":"9","author":"S Ghafouri-Fard","year":"2021","unstructured":"Ghafouri-Fard S, Niazi V, Hussen BM, Omrani MD, Taheri M, Basiri A (2021) The emerging role of exosomes in the treatment of human disorders with a special focus on mesenchymal stem cells-derived exosomes. Front Cell Dev Biol 9:653296","journal-title":"Front Cell Dev Biol"},{"key":"2116_CR7","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s00408-017-9993-5","volume":"195","author":"J Guiot","year":"2017","unstructured":"Guiot J, Moermans C, Henket M, Corhay JL, Louis R (2017) Blood biomarkers in idiopathic pulmonary fibrosis. Lung 195:273\u2013280","journal-title":"Lung"},{"key":"2116_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007798","volume":"33","author":"Q Ji","year":"2021","unstructured":"Ji Q, Hou J, Yong X, Gong G, Muddassir M, Tang T, Xie J, Fan W, Chen X (2021) Targeted dual small interfering ribonucleic acid delivery via non-viral polymeric vectors for pulmonary fibrosis therapy. Adv Mater 33:e2007798","journal-title":"Adv Mater"},{"key":"2116_CR9","doi-asserted-by":"publisher","first-page":"16490","DOI":"10.1038\/s41598-020-73752-3","volume":"10","author":"A Kawara","year":"2020","unstructured":"Kawara A, Mizuta R, Fujisawa M, Ito T, Li C, Nakamura K, Sun C, Kuwabara M, Kitabatake M, Yoshimura T, Matsukawa A (2020) Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin. Sci Rep 10:16490","journal-title":"Sci Rep"},{"key":"2116_CR10","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s12943-017-0706-8","volume":"16","author":"W Li","year":"2017","unstructured":"Li W, Li C, Zhou T, Liu X, Liu X, Li X, Chen D (2017) Role of exosomal proteins in cancer diagnosis. Mol Cancer 16:145","journal-title":"Mol Cancer"},{"key":"2116_CR11","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ejphar.2019.01.022","volume":"852","author":"JW Li","year":"2019","unstructured":"Li JW, Wei L, Han Z, Chen Z (2019) Mesenchymal stromal cells-derived exosomes alleviate ischemia\/reperfusion injury in mouse lung by transporting anti-apoptotic miR-21-5p. Eur J Pharmacol 852:68\u201376","journal-title":"Eur J Pharmacol"},{"key":"2116_CR12","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/s41419-020-02889-w","volume":"11","author":"S Lin","year":"2020","unstructured":"Lin S, Zhang R, Xu L, Ma R, Xu L, Zhu L, Hu J, An X (2020) LncRNA Hoxaas3 promotes lung fibroblast activation and fibrosis by targeting miR-450b-5p to regulate Runx1. Cell Death Dis 11:706","journal-title":"Cell Death Dis"},{"key":"2116_CR13","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/rheumatology\/kep375","volume":"49","author":"R Nakashima","year":"2010","unstructured":"Nakashima R, Imura Y, Kobayashi S, Yukawa N, Yoshifuji H, Nojima T, Kawabata D, Ohmura K, Usui T, Fujii T, Okawa K, Mimori T (2010) The RIG-I-like receptor IFIH1\/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody. Rheumatology (oxford) 49:433\u2013440","journal-title":"Rheumatology (oxford)"},{"key":"2116_CR14","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1183\/09059180.00002512","volume":"21","author":"L Nalysnyk","year":"2012","unstructured":"Nalysnyk L, Cid-Ruzafa J, Rotella P, Esser D (2012) Incidence and prevalence of idiopathic pulmonary fibrosis: review of the literature. Eur Respir Rev 21:355\u2013361","journal-title":"Eur Respir Rev"},{"key":"2116_CR15","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/j.ajpath.2021.04.006","volume":"191","author":"M O'Hare","year":"2021","unstructured":"O\u2019Hare M, Amarnani D, Whitmore HAB, An M, Marino C, Ramos L, Delgado-Tirado S, Hu X, Chmielewska N, Chandrahas A, Fitzek A, Heinrich F, Steurer S, Ondruschka B, Glatzel M, Krasemann S, Sepulveda-Falla D, Lagares D, Pedron J, Bushweller JH, Liu P, Arboleda-Velasquez JF, Kim LA (2021) Targeting runt-related transcription factor 1 prevents pulmonary fibrosis and reduces expression of severe acute respiratory syndrome coronavirus 2 host mediators. Am J Pathol 191:1193\u20131208","journal-title":"Am J Pathol"},{"key":"2116_CR16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3389\/fimmu.2019.00017","volume":"10","author":"T Ohkura","year":"2019","unstructured":"Ohkura T, Yoshimura T, Fujisawa M, Ohara T, Marutani R, Usami K, Matsukawa A (2019) Spred2 regulates high fat diet-induced adipose tissue inflammation, and metabolic abnormalities in mice. Front Immunol 10:17","journal-title":"Front Immunol"},{"key":"2116_CR17","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1164\/rccm.201505-1010OC","volume":"192","author":"JM Oldham","year":"2015","unstructured":"Oldham JM, Ma SF, Martinez FJ, Anstrom KJ, Raghu G, Schwartz DA, Valenzi E, Witt L, Lee C, Vij R, Huang Y, Strek ME, Noth I, Investigators IP (2015) TOLLIP, MUC5B, and the response to N-acetylcysteine among individuals with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 192:1475\u20131482","journal-title":"Am J Respir Crit Care Med"},{"key":"2116_CR18","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1186\/s12864-021-08073-4","volume":"22","author":"UE Perera","year":"2021","unstructured":"Perera UE, Derseh HB, Dewage SNV, Stent A, Wijayarathna R, Snibson KJ (2021) Evaluation of microRNA expression in a sheep model for lung fibrosis. BMC Genomics 22:827","journal-title":"BMC Genomics"},{"key":"2116_CR19","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12931-018-0730-2","volume":"19","author":"G Sgalla","year":"2018","unstructured":"Sgalla G, Iovene B, Calvello M, Ori M, Varone F, Richeldi L (2018) Idiopathic pulmonary fibrosis: pathogenesis and management. Respir Res 19:32","journal-title":"Respir Res"},{"key":"2116_CR20","first-page":"S176","volume":"23","author":"R Sharif","year":"2017","unstructured":"Sharif R (2017) Overview of idiopathic pulmonary fibrosis (IPF) and evidence-based guidelines. Am J Manag Care 23:S176\u2013S182","journal-title":"Am J Manag Care"},{"key":"2116_CR21","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.5966\/sctm.2015-0121","volume":"4","author":"N Srour","year":"2015","unstructured":"Srour N, Thebaud B (2015) Mesenchymal stromal cells in animal bleomycin pulmonary fibrosis models: a systematic review. Stem Cells Transl Med 4:1500\u20131510","journal-title":"Stem Cells Transl Med"},{"key":"2116_CR22","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1165\/rcmb.2016-0319OC","volume":"57","author":"X Tang","year":"2017","unstructured":"Tang X, Sun L, Jin X, Chen Y, Zhu H, Liang Y, Wu Q, Han X, Liang J, Liu X, Liang Z, Wang G, Luo F (2017) Runt-related transcription factor 1 regulates LPS-induced acute lung injury via NF-kappaB signaling. Am J Respir Cell Mol Biol 57:174\u2013183","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2116_CR23","first-page":"172","volume":"19","author":"X Tang","year":"2018","unstructured":"Tang X, Sun L, Wang G, Chen B, Luo F (2018) RUNX1: a regulator of NF-kB signaling in pulmonary diseases. Curr Protein Pept Sci 19:172\u2013178","journal-title":"Curr Protein Pept Sci"},{"key":"2116_CR24","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","volume":"164","author":"M Tkach","year":"2016","unstructured":"Tkach M, Thery C (2016) Communication by extracellular vesicles: where we are and where we need to go. Cell 164:1226\u20131232","journal-title":"Cell"},{"key":"2116_CR25","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1164\/rccm.201705-0925OC","volume":"197","author":"GR Willis","year":"2018","unstructured":"Willis GR, Fernandez-Gonzalez A, Anastas J, Vitali SH, Liu X, Ericsson M, Kwong A, Mitsialis SA, Kourembanas S (2018) Mesenchymal stromal cell exosomes ameliorate experimental bronchopulmonary dysplasia and restore lung function through macrophage immunomodulation. Am J Respir Crit Care Med 197:104\u2013116","journal-title":"Am J Respir Crit Care Med"},{"key":"2116_CR26","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/S2213-2600(18)30007-9","volume":"6","author":"PJ Wolters","year":"2018","unstructured":"Wolters PJ, Blackwell TS, Eickelberg O, Loyd JE, Kaminski N, Jenkins G, Maher TM, Molina-Molina M, Noble PW, Raghu G, Richeldi L, Schwarz MI, Selman M, Wuyts WA, Schwartz DA (2018) Time for a change: is idiopathic pulmonary fibrosis still idiopathic and only fibrotic? Lancet Respir Med 6:154\u2013160","journal-title":"Lancet Respir Med"},{"key":"2116_CR27","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/s41419-020-03034-3","volume":"11","author":"K Xiao","year":"2020","unstructured":"Xiao K, He W, Guan W, Hou F, Yan P, Xu J, Zhou T, Liu Y, Xie L (2020) Mesenchymal stem cells reverse EMT process through blocking the activation of NF-kappaB and Hedgehog pathways in LPS-induced acute lung injury. Cell Death Dis 11:863","journal-title":"Cell Death Dis"},{"key":"2116_CR28","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1016\/j.celrep.2018.03.010","volume":"22","author":"T Xie","year":"2018","unstructured":"Xie T, Wang Y, Deng N, Huang G, Taghavifar F, Geng Y, Liu N, Kulur V, Yao C, Chen P, Liu Z, Stripp B, Tang J, Liang J, Noble PW, Jiang D (2018) Single-cell deconvolution of fibroblast heterogeneity in mouse pulmonary fibrosis. Cell Rep 22:3625\u20133640","journal-title":"Cell Rep"},{"key":"2116_CR29","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1186\/s13287-020-02023-9","volume":"11","author":"C Xu","year":"2020","unstructured":"Xu C, Zhao J, Li Q, Hou L, Wang Y, Li S, Jiang F, Zhu Z, Tian L (2020) Exosomes derived from three-dimensional cultured human umbilical cord mesenchymal stem cells ameliorate pulmonary fibrosis in a mouse silicosis model. Stem Cell Res Ther 11:503","journal-title":"Stem Cell Res Ther"},{"key":"2116_CR30","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.2169\/internalmedicine.0297-17","volume":"57","author":"M Yagishita","year":"2018","unstructured":"Yagishita M, Kondo Y, Terasaki T, Terasaki M, Shimizu M, Honda F, Oyama A, Takahashi H, Yokosawa M, Asashima H, Hagiwara S, Tsuboi H, Matsumoto I, Sumida T (2018) Clinically amyopathic dermatomyositis with interstitial pneumonia that was successfully treated with plasma exchange. Intern Med 57:1935\u20131938","journal-title":"Intern Med"},{"key":"2116_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.05.035","volume":"383","author":"X Yi","year":"2019","unstructured":"Yi X, Wei X, Lv H, An Y, Li L, Lu P, Yang Y, Zhang Q, Yi H, Chen G (2019) Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3. Exp Cell Res 383:111454","journal-title":"Exp Cell Res"},{"key":"2116_CR32","doi-asserted-by":"publisher","first-page":"4142","DOI":"10.3390\/ijms15034142","volume":"15","author":"B Yu","year":"2014","unstructured":"Yu B, Zhang X, Li X (2014) Exosomes derived from mesenchymal stem cells. Int J Mol Sci 15:4142\u20134157","journal-title":"Int J Mol Sci"},{"key":"2116_CR33","doi-asserted-by":"publisher","first-page":"13938","DOI":"10.1111\/jcmm.16002","volume":"24","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, Ge L, Zhang S, Wang J, Jiang W, Xin Q, Luan Y (2020) The protective effects of MSC-EXO against pulmonary hypertension through regulating Wnt5a\/BMP signalling pathway. J Cell Mol Med 24:13938\u201313948","journal-title":"J Cell Mol Med"},{"key":"2116_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154916","volume":"125","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Cai Y, Zhang H, Zhang J, Zeng Y, Fan C, Zou S, Wu C, Fang S, Li P, Lin X, Wang L, Guan M (2021) Brown adipose tissue transplantation ameliorates diabetic nephropathy through the miR-30b pathway by targeting Runx1. Metabolism 125:154916","journal-title":"Metabolism"},{"key":"2116_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109476","volume":"114","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, Ban J, Chang S, Qu H, Chen J, Liu F (2023) The aggravate role of exosomal circRNA11:120406118|12040782 on macrophage pyroptosis through miR-30b-5p\/NLRP3 axis in silica-induced lung fibrosis. Int Immunopharmacol 114:109476","journal-title":"Int Immunopharmacol"},{"key":"2116_CR36","first-page":"1269","volume":"38","author":"L Zhu","year":"2023","unstructured":"Zhu L, Chen M, Wang W, Zhu J, Wu H (2023) microRNA-141-3p mediates epithelial cell proliferation, apoptosis, and epithelial-mesenchymal transition and alleviates pulmonary fibrosis in mice via Spred2. Histol Histopathol 38:1269\u20131282","journal-title":"Histol Histopathol"}],"container-title":["Molecular Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-024-02116-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00438-024-02116-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-024-02116-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T17:04:02Z","timestamp":1710608642000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00438-024-02116-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,13]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["2116"],"URL":"https:\/\/doi.org\/10.1007\/s00438-024-02116-7","relation":{},"ISSN":["1617-4615","1617-4623"],"issn-type":[{"value":"1617-4615","type":"print"},{"value":"1617-4623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,13]]},"assertion":[{"value":"5 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare there is no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Ethics Committee of the Second Affiliated Hospital, Zhejiang University School of Medicine and fully complied with the declaration of Helsinki. All participants were signed informed consent forms.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"33"}}