{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:45:33Z","timestamp":1788547533013,"version":"build-2803163510"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Genet Genomics"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s00438-024-02133-6","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T09:47:16Z","timestamp":1709804836000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predicting genetic risk factors for AA amyloidosis in Algerian patients with familial Mediterranean fever"],"prefix":"10.1007","volume":"299","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5834-4442","authenticated-orcid":false,"given":"Djouher","family":"Ait-Idir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahia","family":"Djerdjouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Latreche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawda","family":"Sari-Hamidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghalia","family":"Khellaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"2133_CR2","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1093\/rheumatology\/ker328","volume":"50","author":"D Ait-Idir","year":"2011","unstructured":"Ait-Idir D, Khilan A, Djerdjouri B, El-Shanti H (2011) Spectrum of mutations and carrier frequency of familial Mediterranean fever gene in the Algerian population. Rheumatology 50:2306\u20132310","journal-title":"Rheumatology"},{"key":"2133_CR1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.ejmg.2016.12.003","volume":"60","author":"D Ait-Idir","year":"2017","unstructured":"Ait-Idir D, Djerdjouri B, Bouldjennet F, Taha RZ, El-Shanti H, Sari-Hamidou R, Khellaf G, Benmansour M, Benabadji M, Haddoum F (2017) The M694I\/M694I genotype: a genetic risk factor of AA-amyloidosis in a group of Algerian patients with familial Mediterranean fever. Eur J Med Genet 60:149\u2013153","journal-title":"Eur J Med Genet"},{"key":"2133_CR3","first-page":"318","volume":"19","author":"N Akar","year":"2006","unstructured":"Akar N, Hasipek M, Ozt\u00fcrk A, Akar E, Tekin M (2006) Serum amyloid A1 -13 T\/C alleles in Turkish familial Mediterranean fever patients with and without amyloidosis. J Nephrol 19:318\u2013321","journal-title":"J Nephrol"},{"key":"2133_CR4","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.gene.2011.10.012","volume":"492","author":"T Akpolat","year":"2012","unstructured":"Akpolat T, \u00d6zkaya O, \u00d6zen S (2012) Homozygous M694V as a risk factor for amyloidosis in Turkish FMF patients. Gene 492:285\u2013289","journal-title":"Gene"},{"key":"2133_CR5","first-page":"72","volume":"34","author":"S Atoyan","year":"2016","unstructured":"Atoyan S, Hayrapetyan H, Sarkisian T, Ben-Chetrit E (2016) MEFV and SAA1 genotype associations with clinical features of familial Mediterranean fever and amyloidosis in Armenia. Clin Exp Rheumatol 34:72\u201376","journal-title":"Clin Exp Rheumatol"},{"key":"2133_CR6","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1084\/jem.180.1.203","volume":"180","author":"R Badolato","year":"1994","unstructured":"Badolato R, Wang JM, Murphy WJ, Lloyd AR, Michiel DF, Bausserman LL, Kelvin DJ, Oppenheim JJ (1994) Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes. J Exp Med 180:203\u2013209","journal-title":"J Exp Med"},{"key":"2133_CR7","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.crvi.2005.11.005","volume":"329","author":"L Belmahi","year":"2006","unstructured":"Belmahi L, Sefiani A, Fouveau C, Feingold J, Delpech M, Grateau G, Dod\u00e9 C (2006) Prevalence and distribution of MEFV mutations among arabs from the Maghreb patients suffering from familial Mediterranean fever. C R Biol 329:71\u201374","journal-title":"C R Biol"},{"key":"2133_CR8","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/S0140-6736(97)09408-7","volume":"351","author":"E Ben-Chetrit","year":"1998","unstructured":"Ben-Chetrit E, Levy M (1998) Familial Mediterranean fever. Lancet 351:659\u2013664","journal-title":"Lancet"},{"key":"2133_CR9","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1002\/art.24458","volume":"61","author":"E Ben-Chetrit","year":"2009","unstructured":"Ben-Chetrit E, Touitou I (2009) Familial mediterranean fever in the world. Arthritis Rheum 61:1447\u20131453","journal-title":"Arthritis Rheum"},{"key":"2133_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/13506129.2014.980942","volume":"22","author":"N Blank","year":"2015","unstructured":"Blank N, Hegenbart U, Lohse P, Beimler J, R\u00f6cken C, Ho AD, Lorenz HM, Sch\u00f6nland SO (2015) Risk factors for AA amyloidosis in Germany. Amyloid 22:1\u20137","journal-title":"Amyloid"},{"key":"2133_CR11","first-page":"1136","volume":"67","author":"C Cazeneuve","year":"2000","unstructured":"Cazeneuve C, Ajrapetyan H, Papin S, Roudot-Thoraval F, Genevi\u00e8ve D, Mndjoyan E, Papazian M, Sarkisian A, Babloyan A, Boissier B, Duquesnoy P, Kouyoumdjian JC, Girodon-Boulandet E, Grateau G, Sarkisian T, Amselem S (2000) Identification of MEFV-independent modifying genetic factors for familial Mediterranean fever. Am J Hum Genet 67:1136\u20131143","journal-title":"Am J Hum Genet"},{"key":"2133_CR12","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/j.1365-2141.2009.07733.x","volume":"146","author":"JJ Chae","year":"2009","unstructured":"Chae JJ, Aksentijevich I, Kastner DL (2009) Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy. Br J Haematol 146:467\u2013478","journal-title":"Br J Haematol"},{"key":"2133_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1146\/annurev-biochem-061516-045115","volume":"86","author":"F Chiti","year":"2017","unstructured":"Chiti F, Dobson CM (2017) Protein misfolding, amyloid formation, and Human Disease: a Summary of Progress over the last decade. Annu Rev Biochem 86:27\u201368","journal-title":"Annu Rev Biochem"},{"key":"2133_CR14","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.cytogfr.2015.12.010","volume":"30","author":"M De Buck","year":"2016","unstructured":"De Buck M, Gouwy M, Wang JM, Van Snick J, Proost P, Struyf S, Van Damme J (2016) The cytokine-serum amyloid A-chemokine network. Cytokine Growth Factor Rev 30:55\u201369","journal-title":"Cytokine Growth Factor Rev"},{"key":"2133_CR15","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1159\/000087824","volume":"25","author":"A Deliba\u015f","year":"2005","unstructured":"Deliba\u015f A, Oner A, Balci B, Demircin G, Bulbul M, Bek K, Erdo\u011fan O, Baysun S, Yilmaz E (2005) Genetic risk factors of amyloidogenesis in familial Mediterranean fever. Am J Nephrol 25:434\u2013440","journal-title":"Am J Nephrol"},{"key":"2133_CR17","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1089\/gtmb.2009.0180","volume":"14","author":"DA El Gezery","year":"2010","unstructured":"El Gezery DA, Abou-Zeid AA, Hashad DI, El-Sayegh HK (2010) MEFV gene mutations in Egyptian patients with familial Mediterranean fever. Genet Test Mol Biomarkers 14:263\u2013268","journal-title":"Genet Test Mol Biomarkers"},{"key":"2133_CR16","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/S0140-6736(06)68430-4","volume":"367","author":"H El-Shanti","year":"2006","unstructured":"El-Shanti H, Majeed HA, El-Khateeb M (2006) Familial mediterranean fever in arabs. Lancet 367:1016\u20131024","journal-title":"Lancet"},{"key":"2133_CR18","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1006\/bbrc.2000.2143","volume":"268","author":"CJ Furlaneto","year":"2000","unstructured":"Furlaneto CJ, Campa A (2000) A novel function of serum amyloid A: a potent stimulus for the release of tumor necrosis factor-alpha, interleukin-1beta, and interleukin-8 by human blood neutrophil. Biochem Biophys Res Commun 268:405\u2013408","journal-title":"Biochem Biophys Res Commun"},{"key":"2133_CR19","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1136\/annrheumdis-2019-215048","volume":"78","author":"M Gattorno","year":"2019","unstructured":"Gattorno M, Hofer M, Federici S, Vanoni F, Bovis F, Aksentijevich I, Anton J, Arostegui JI, Barron K, Ben-Cherit E, Brogan PA, Cantarini L, Ceccherini I, De Benedetti F, Dedeoglu F, Demirkaya E, Frenkel J, Goldbach-Mansky R, Gul A, Hentgen V, Hoffman H, Kallinich T, Kone-Paut I, Kuemmerle-Deschner J, Lachmann HJ, Laxer RM, Livneh A, Obici L, Ozen S, Rowczenio D, Russo R, Shinar Y, Simon A, Toplak N, Touitou I, Uziel Y, van Gijn M, Foell D, Garassino C, Kastner D, Martini A, Sormani MP, Ruperto N (2019) Classification criteria for autoinflammatory recurrent fevers. Ann Rheum Dis 78:1025\u20131032","journal-title":"Ann Rheum Dis"},{"key":"2133_CR20","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1002\/art.10944","volume":"48","author":"R Gershoni-Baruch","year":"2003","unstructured":"Gershoni-Baruch R, Brik R, Zacks N, Shinawi M, Lidar M, Livneh A (2003) The contribution of genotypes at the MEFV and SAA1 loci to amyloidosis and disease severity in patients with familial Mediterranean fever. Arthritis Rheum 48:1149\u20131155","journal-title":"Arthritis Rheum"},{"key":"2133_CR21","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1182\/blood-2002-05-1431","volume":"101","author":"R He","year":"2003","unstructured":"He R, Sang H, Ye RD (2003) Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1\/LXA4R. Blood 101:1572\u20131581","journal-title":"Blood"},{"key":"2133_CR22","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/eji.201746947","volume":"48","author":"R Heilig","year":"2018","unstructured":"Heilig R, Broz P (2018) Function and mechanism of the pyrin inflammasome. Eur J Immunol 48:230\u2013238","journal-title":"Eur J Immunol"},{"key":"2133_CR23","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1042\/bj3340489","volume":"334","author":"LE Jensen","year":"1998","unstructured":"Jensen LE, Whitehead AS (1998) Regulation of serum amyloid A protein expression during the acute-phase response. Biochem J 334:489\u2013503","journal-title":"Biochem J"},{"key":"2133_CR25","doi-asserted-by":"publisher","first-page":"167","DOI":"10.5414\/CN110577","volume":"97","author":"G Khellaf","year":"2022","unstructured":"Khellaf G, Benziane A, Kaci L, Benabadji M (2022) AA renal amyloidosis: clinical observations over 20 years. Clin Nephrol 97:167\u2013172","journal-title":"Clin Nephrol"},{"key":"2133_CR24","doi-asserted-by":"publisher","first-page":"172","DOI":"10.5414\/CN110930","volume":"99","author":"G Khellaf","year":"2023","unstructured":"Khellaf G, Benziane A, Kaci L, Ait-Idir D, Missoum S, Benabadji M (2023) Renal involvement in familial Mediterranean fever in an Algerian population. Clin Nephrol 99:172\u2013179","journal-title":"Clin Nephrol"},{"key":"2133_CR26","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/0006-291X(86)90352-9","volume":"137","author":"B Kluve-Beckerman","year":"1986","unstructured":"Kluve-Beckerman B, Naylor SL, Marshall A, Gardner JC, Shows TB, Benson MD (1986) Localization of human SAA gene(s) to chromosome 11 and detection of DNA polymorphisms. Biochem Biophys Res Commun 137:1196\u20131204","journal-title":"Biochem Biophys Res Commun"},{"key":"2133_CR27","doi-asserted-by":"publisher","first-page":"18","DOI":"10.55563\/clinexprheumatol\/hvktbk","volume":"132","author":"G Kriegsh\u00e4user","year":"2021","unstructured":"Kriegsh\u00e4user G, Hayrapetyan H, Atoyan S, Oberkanins C, Sarkisian T (2021a) Association between serum amyloid A1 genotype and age of onset restricts to M694 homozygote familial Mediterranean fever patients in Armenia. Clin Exp Rheumatol 132:18\u201321","journal-title":"Clin Exp Rheumatol"},{"key":"2133_CR28","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1093\/rheumatology\/keaa452","volume":"60","author":"G Kriegsh\u00e4user","year":"2021","unstructured":"Kriegsh\u00e4user G, Hayrapetyan H, Atoyan S, Oberkanins C, Sarkisian T (2021b) Serum amyloid A1 genotype associates with adult-onset familial Mediterranean fever in patients homozygous for mutation M694V. Rheumatology 60:441\u2013444","journal-title":"Rheumatology"},{"key":"2133_CR29","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/nep.14166","volume":"28","author":"S La Bella","year":"2023","unstructured":"La Bella S, Di Ludovico A, Di Donato G, Scorrano G, Chiarelli F, Vivarelli M, Breda L (2023) Renal involvement in monogenic autoinflammatory diseases: a narrative review. Nephrology 28:363\u2013371","journal-title":"Nephrology"},{"key":"2133_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/13506129908993281","volume":"6","author":"A Livneh","year":"1999","unstructured":"Livneh A, Langevitz P, Shinar Y, Zaks N, Kastner DL, Pras M, Pras E (1999) MEFV mutation analysis in patients suffering from amyloidosis of familial Mediterranean fever. Amyloid 6:1\u20136","journal-title":"Amyloid"},{"key":"2133_CR31","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1186\/1471-2350-5-4","volume":"5","author":"M Medlej-Hashim","year":"2004","unstructured":"Medlej-Hashim M, Delague V, Chouery E, Salem N, Rawashdeh M, Lefranc G, Loiselet J, M\u00e9garban\u00e9 A (2004) Amyloidosis in familial Mediterranean fever patients: correlation with MEFV genotype and SAA1 and MICA polymorphisms effects. BMC Med Genet 5:1471\u20132350","journal-title":"BMC Med Genet"},{"key":"2133_CR32","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1371\/journal.pone.0055227","volume":"8","author":"K Migita","year":"2013","unstructured":"Migita K, Agematsu K, Masumoto J, Ida H, Honda S, Jiuchi Y, Izumi Y, Maeda Y, Uehara R, Nakamura Y, Koga T, Kawakami A, Nakashima M, Fujieda Y, Nonaka F, Eguchi K, Furukawa H, Nakamura T, Nakamura M, Yasunami M (2013) The contribution of SAA1 polymorphisms to familial Mediterranean fever susceptibility in the Japanese population. PLoS ONE 8:20","journal-title":"PLoS ONE"},{"key":"2133_CR33","doi-asserted-by":"crossref","unstructured":"Migita K, Izumi Y, Jiuchi Y, Kozuru H, Kawahara C, Nakamura M, Nakamura T, Agematsu K, Masumoto J, Yasunami M, Kawakami A, Eguchi K (2014) Serum amyloid a induces NLRP-3-mediated IL-1\u03b2 secretion in neutrophils. PLoS ONE 9","DOI":"10.1371\/journal.pone.0096703"},{"key":"2133_CR34","doi-asserted-by":"crossref","unstructured":"Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16","DOI":"10.1093\/nar\/16.3.1215"},{"key":"2133_CR36","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1007\/s004399900150","volume":"105","author":"M Moriguchi","year":"1999","unstructured":"Moriguchi M, Terai C, Koseki Y, Uesato M, Nakajima A, Inada S, Nishinarita M, Uchida S, Nakajima A, Kim SY, Chen CL, Kamatani N (1999) Influence of genotypes at SAA1 and SAA2 loci on the development and the length of latent period of secondary AA-amyloidosis in patients with rheumatoid arthritis. Hum Genet 105:360\u2013366","journal-title":"Hum Genet"},{"key":"2133_CR35","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1002\/1529-0131(200106)44:6<1266::AID-ART218>3.0.CO;2-3","volume":"44","author":"M Moriguchi","year":"2001","unstructured":"Moriguchi M, Terai C, Kaneko H, Koseki Y, Kajiyama H, Uesato M, Inada S, Kamatani N (2001) A novel single-nucleotide polymorphism at the 5\u2019-flanking region of SAA1 associated with risk of type AA amyloidosis secondary to rheumatoid arthritis. Arthritis Rheum 44:1266\u20131272","journal-title":"Arthritis Rheum"},{"key":"2133_CR37","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1007\/s00296-014-3205-x","volume":"35","author":"NA Mukhin","year":"2015","unstructured":"Mukhin NA, Kozlovskaya LV, Bogdanova MV, Rameev VV, Moiseev SV, Simonyan A (2015) Predictors of AA amyloidosis in familial Mediterranean fever. Rheumatol Int 35:1257\u20131261","journal-title":"Rheumatol Int"},{"key":"2133_CR38","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/rheumatology\/kei112","volume":"45","author":"T Nakamura","year":"2005","unstructured":"Nakamura T, Higashi S, Tomoda K, Tsukano M, Baba S, Shono M (2005) Significance of SAA1.3 allele genotype in Japanese patients with amyloidosis secondary to rheumatoid arthritis. Rheumatology 45:43\u201349","journal-title":"Rheumatology"},{"key":"2133_CR39","first-page":"319","volume":"226","author":"H Nakashima","year":"2003","unstructured":"Nakashima H, Akahoshi M, Tanaka Y (2003) Mutation detection using RT-PCR-RFLP. Methods Mol Biol 226:319\u2013322","journal-title":"Methods Mol Biol"},{"key":"2133_CR40","doi-asserted-by":"crossref","unstructured":"Nevone A, Merlini G, Nuvolone M (2020) Treating protein misfolding diseases: therapeutic successes against systemic amyloidoses. Front Pharmacol 11","DOI":"10.3389\/fphar.2020.01024"},{"key":"2133_CR41","doi-asserted-by":"publisher","first-page":"6119","DOI":"10.4049\/jimmunol.1002843","volume":"186","author":"K Niemi","year":"2011","unstructured":"Niemi K, Teiril\u00e4 L, Lappalainen J, Rajam\u00e4ki K, Baumann MH, \u00d6\u00f6rni K, Wolff H, Kovanen PT, Matikainen S, Eklund KK (2011) Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway. J Immunol 186:6119\u20136128","journal-title":"J Immunol"},{"key":"2133_CR42","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1002\/art.20301","volume":"50","author":"R O\u2019Hara","year":"2004","unstructured":"O\u2019Hara R, Murphy EP, Whitehead AS, FitzGerald O, Bresnihan B (2004) Local expression of the serum amyloid A and formyl peptide receptor-like 1 genes in synovial tissue is associated with matrix metalloproteinase production in patients with inflammatory arthritis. Arthritis Rheum 50:1788\u20131799","journal-title":"Arthritis Rheum"},{"key":"2133_CR43","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.autrev.2012.07.016","volume":"12","author":"L Obici","year":"2012","unstructured":"Obici L, Merlini G (2012) Amyloidosis in autoinflammatory syndromes. Autoimmun Rev 12:14\u201317","journal-title":"Autoimmun Rev"},{"key":"2133_CR44","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.1016\/j.lpm.2018.08.014","volume":"48","author":"H Ozdogan","year":"2019","unstructured":"Ozdogan H, Ugurlu S (2019) Familial Mediterranean Fever. Presse Med 48:e61\u2013e76","journal-title":"Presse Med"},{"key":"2133_CR45","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1136\/annrheumdis-2012-202708","volume":"73","author":"S Ozen","year":"2014","unstructured":"Ozen S, Demirkaya E, Amaryan G, Kon\u00e9-Paut I, Polat A, Woo P, Uziel Y, Modesto C, Finetti M, Quartier P, Papadopoulou-Alataki E, Al-Mayouf SM, Fabio G, Gallizzi R, Cantarini L, Frenkel J, Nielsen S, Hofer M, Insalaco A, Acikel C, Ozdogan H, Martini A, Ruperto N, Gattorno M (2014) Results from a multicentre international registry of familial Mediterranean fever: impact of environment on the expression of a monogenic disease in children. Ann Rheum Dis 73:662\u2013667","journal-title":"Ann Rheum Dis"},{"key":"2133_CR46","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1038\/ni.3457","volume":"17","author":"YH Park","year":"2016","unstructured":"Park YH, Wood G, Kastner DL, Chae JJ (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol 17:914\u2013921","journal-title":"Nat Immunol"},{"key":"2133_CR47","doi-asserted-by":"crossref","unstructured":"Schnappauf O, Chae JJ, Kastner DL, Aksentijevich I (2019) The pyrin inflammasome in Health and Disease. Front Immunol 10","DOI":"10.3389\/fimmu.2019.01745"},{"key":"2133_CR48","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.gene.2016.02.044","volume":"583","author":"L Sun","year":"2016","unstructured":"Sun L, Ye RD (2016) Serum amyloid A1: structure, function and gene polymorphism. Gene 583:48\u201357","journal-title":"Gene"},{"key":"2133_CR49","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1002\/art.22507","volume":"56","author":"I Touitou","year":"2007","unstructured":"Touitou I, Sarkisian T, Medlej-Hashim M, Tunca M, Livneh A, Cattan D, Yal\u00e7inkaya F, Ozen S, Majeed H, Ozdogan H, Kastner D, Booth D, Ben-Chetrit E, Pugn\u00e8re D, Michelon C, S\u00e9guret F, Gershoni-Baruch R (2007) Country as the primary risk factor for renal amyloidosis in familial Mediterranean fever. Arthritis Rheum 56:1706\u20131712","journal-title":"Arthritis Rheum"},{"key":"2133_CR50","first-page":"274","volume":"36","author":"JR Wright","year":"1977","unstructured":"Wright JR, Calkins E, Humphrey RL (1977) Potassium permanganate reaction in amyloidosis. A histologic method to assist in differentiating forms of this disease. Lab Invest 36:274\u2013281","journal-title":"Lab Invest"},{"key":"2133_CR51","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3109\/13506120308995250","volume":"10","author":"T Yamada","year":"2003","unstructured":"Yamada T, Okuda Y, Takasugi K, Wang L, Marks D, Benson MD, Kluve-Beckerman B (2003) An allele of serum amyloid A1 associated with amyloidosis in both Japanese and caucasians. Amyloid 10:7\u201311","journal-title":"Amyloid"},{"key":"2133_CR52","first-page":"198","volume":"45","author":"E Yilmaz","year":"2003","unstructured":"Yilmaz E, Balci B, Kutlay S, Ozen S, Ert\u00fcrk S, Oner A, Be\u015fba\u015f N, Bakkalo\u011flu A (2003) Analysis of the modifying effects of SAA1, SAA2 and TNF-alpha gene polymorphisms on development of amyloidosis in FMF patients. Turk J Pediatr 45:198\u2013202","journal-title":"Turk J Pediatr"}],"container-title":["Molecular Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-024-02133-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00438-024-02133-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-024-02133-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T10:02:00Z","timestamp":1709805720000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00438-024-02133-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["2133"],"URL":"https:\/\/doi.org\/10.1007\/s00438-024-02133-6","relation":{},"ISSN":["1617-4615","1617-4623"],"issn-type":[{"value":"1617-4615","type":"print"},{"value":"1617-4623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,7]]},"assertion":[{"value":"28 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All patients and their physicians at the university hospitals were informed of the needs of this study\u2019s purpose and provided consent. All data collected was treated confidentially. The ethics committee and deontology of USTHB University (University of Sciences and Technology Houari Boumediene, Algiers) which uses the standards and Recommendations of the Declaration of Helsinki approved the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All the participants consented to participate to this study (For deceased patients, we had consent from their physicians).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"25"}}