{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T19:55:46Z","timestamp":1784577346694,"version":"3.55.0"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Genet Genomics"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00438-024-02215-5","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T03:17:05Z","timestamp":1735269425000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of shared pathogenic signatures of multiple sclerosis and chronic obstructive pulmonary disease: an integrated transcriptomic analysis of blood specimens"],"prefix":"10.1007","volume":"300","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6373-7999","authenticated-orcid":false,"given":"Arman","family":"Mokaram Doust Delkhah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"issue":"13","key":"2215_CR13","doi-asserted-by":"publisher","first-page":"7372","DOI":"10.3390\/ijms25137372","volume":"25","author":"B Arneth","year":"2024","unstructured":"Arneth B (2024) Current Knowledge about Nonclassical Monocytes in Patients with Multiple Sclerosis, a Systematic Review. Int J Mol Sci 25(13):7372","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2215_CR44","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/s41598-019-57108-0","volume":"10","author":"W Bertrams","year":"2020","unstructured":"Bertrams W, Griss K, Han M, Seidel K, Klemmer A, Sittka-Stark A et al (2020) Transcriptional analysis identifies potential biomarkers and molecular regulators in pneumonia and COPD exacerbation. Sci Rep 10(1):241","journal-title":"Sci Rep"},{"key":"2215_CR21","doi-asserted-by":"crossref","unstructured":"Brightling C, Greening N (2019) Airway inflammation in COPD: progress to precision medicine. Eur Respir J.;54(2)","DOI":"10.1183\/13993003.00651-2019"},{"key":"2215_CR62","doi-asserted-by":"publisher","first-page":"608666","DOI":"10.3389\/fimmu.2020.608666","volume":"11","author":"JA Ca\u00f1as","year":"2021","unstructured":"Ca\u00f1as JA, Rodrigo-Mu\u00f1oz JM, Sastre B, Gil-Martinez M, Redondo N (2021) Del Pozo V. MicroRNAs as potential regulators of immune response networks in asthma and chronic obstructive pulmonary disease. Front Immunol 11:608666","journal-title":"Front Immunol"},{"issue":"19","key":"2215_CR27","doi-asserted-by":"publisher","first-page":"6419","DOI":"10.3390\/jcm12196419","volume":"12","author":"CAM Cavalli","year":"2023","unstructured":"Cavalli CAM, Gabbiadini R, Dal Buono A, Quadarella A, De Marco A, Repici A et al (2023) Lung Involvement in Inflammatory Bowel Diseases: Shared Pathways and Unwanted Connections. J Clin Med 12(19):6419","journal-title":"J Clin Med"},{"issue":"2\u20133","key":"2215_CR34","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ygeno.2016.01.004","volume":"107","author":"Y Chang","year":"2016","unstructured":"Chang Y, Glass K, Liu YY, Silverman EK, Crapo JD, Tal-Singer R et al (2016) COPD subtypes identified by network-based clustering of blood gene expression. Genomics 107(2\u20133):51\u201358","journal-title":"Genomics"},{"issue":"D1","key":"2215_CR40","doi-asserted-by":"publisher","first-page":"D127","DOI":"10.1093\/nar\/gkz757","volume":"48","author":"Y Chen","year":"2020","unstructured":"Chen Y, Wang X (2020) miRDB: an online database for prediction of functional microRNA targets. Nucleic Acids Res 48(D1):D127\u2013D31","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"2215_CR61","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.3390\/ijms25042255","volume":"25","author":"GL Cipriano","year":"2024","unstructured":"Cipriano GL, Schepici G, Mazzon E, Anchesi I (2024) Multiple sclerosis: roles of miRNA, lcnRNA, and circRNA and their implications in cellular pathways. Int J Mol Sci 25(4):2255","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2215_CR73","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1164\/rccm.201506-1182OC","volume":"195","author":"G Conickx","year":"2017","unstructured":"Conickx G, Mestdagh P, Avila Cobos F, Verhamme FM, Maes T, Vanaudenaerde BM et al (2017) MicroRNA Profiling Reveals a Role for MicroRNA-218-5p in the Pathogenesis of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 195(1):43\u201356","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"2215_CR60","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1074\/mcp.M113.033340","volume":"13","author":"LF Dagley","year":"2014","unstructured":"Dagley LF, Croft NP, Isserlin R, Olsen JB, Fong V, Emili A et al (2014) Discovery of novel disease-specific and membrane-associated candidate markers in a mouse model of multiple sclerosis. Mol Cell Proteom 13(3):679\u2013700","journal-title":"Mol Cell Proteom"},{"issue":"12","key":"2215_CR12","doi-asserted-by":"publisher","first-page":"4558","DOI":"10.3390\/ijms21124558","volume":"21","author":"M De Bondt","year":"2020","unstructured":"De Bondt M, Hellings N, Opdenakker G, Struyf S (2020) Neutrophils: underestimated players in the pathogenesis of multiple sclerosis (MS). Int J Mol Sci 21(12):4558","journal-title":"Int J Mol Sci"},{"key":"2215_CR24","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1183\/16000617.0137-2023","volume":"33","author":"L-L Dong","year":"2024","unstructured":"Dong L-L, Liu Z-Y, Chen K-J, Li Z-Y, Zhou J-S, Shen H-H et al (2024) The persistent inflammation in COPD: is autoimmunity the core mechanism? Eur Respiratory Rev 33:171","journal-title":"Eur Respiratory Rev"},{"issue":"4","key":"2215_CR47","doi-asserted-by":"publisher","first-page":"12","DOI":"10.59204\/2314-6788.1063","volume":"36","author":"ES Essa","year":"2024","unstructured":"Essa ES, Meshaal SS, Mounir AN, Abouelatta ZAM (2024) Study of TP53 Gene Expression in Multiple Sclerosis Patients. Menoufia Med J 36(4):12","journal-title":"Menoufia Med J"},{"key":"2215_CR57","doi-asserted-by":"crossref","unstructured":"Feng X, Dong H, Li B, Yu L, Zhu J, Lou C et al (2023) Integrative analysis of the expression profiles of whole coding and non-coding RNA transcriptomes and construction of the competing endogenous RNA networks for chronic obstructive pulmonary disease. Front Genet.;14","DOI":"10.3389\/fgene.2023.1050783"},{"key":"2215_CR4","doi-asserted-by":"publisher","first-page":"105546","DOI":"10.1016\/j.msard.2024.105546","volume":"85","author":"H Ghoshouni","year":"2024","unstructured":"Ghoshouni H, Rafiei N, Yazdan Panah M, Dehghani Firouzabadi D, Mahmoudi F, Asghariahmadabad M et al (2024) Asthma and chronic obstructive pulmonary disease (COPD) in people with multiple sclerosis: A systematic review and meta-analysis. Mult Scler Relat Disord 85:105546","journal-title":"Mult Scler Relat Disord"},{"issue":"1","key":"2215_CR63","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12974-023-02811-z","volume":"20","author":"A Gonzalez-Martinez","year":"2023","unstructured":"Gonzalez-Martinez A, Patel R, Healy BC, Lokhande H, Paul A, Saxena S et al (2023) miRNA 548a-3p as biomarker of NEDA-3 at 2 years in multiple sclerosis patients treated with fingolimod. J Neuroinflammation 20(1):131","journal-title":"J Neuroinflammation"},{"key":"2215_CR78","doi-asserted-by":"crossref","unstructured":"Guo-Parke H, Linden D, Weldon S, Kidney JC, Taggart CC (2020) Mechanisms of Virus-Induced Airway Immunity Dysfunction in the Pathogenesis of COPD Disease, Progression, and Exacerbation. Front Immunol.;11","DOI":"10.3389\/fimmu.2020.01205"},{"key":"2215_CR17","doi-asserted-by":"crossref","unstructured":"Hou J, Sun Y (2020) Role of Regulatory T Cells in Disturbed Immune Homeostasis in Patients With Chronic Obstructive Pulmonary Disease. Front Immunol.;11","DOI":"10.3389\/fimmu.2020.00723"},{"issue":"1\u20132","key":"2215_CR52","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jneuroim.2004.01.017","volume":"150","author":"AH Iglesias","year":"2004","unstructured":"Iglesias AH, Camelo S, Hwang D, Villanueva R, Stephanopoulos G, Dangond F (2004) Microarray detection of E2F pathway activation and other targets in multiple sclerosis peripheral blood mononuclear cells. J Neuroimmunol 150(1\u20132):163\u2013177","journal-title":"J Neuroimmunol"},{"issue":"1","key":"2215_CR14","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12974-022-02408-y","volume":"19","author":"E Kamma","year":"2022","unstructured":"Kamma E, Lasisi W, Libner C, Ng HS, Plemel JR (2022) Central nervous system macrophages in progressive multiple sclerosis: relationship to neurodegeneration and therapeutics. J Neuroinflamm 19(1):45","journal-title":"J Neuroinflamm"},{"issue":"7","key":"2215_CR48","doi-asserted-by":"publisher","first-page":"3614","DOI":"10.4049\/jimmunol.1300509","volume":"191","author":"H Kawashima","year":"2013","unstructured":"Kawashima H, Takatori H, Suzuki K, Iwata A, Yokota M, Suto A et al (2013) Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells. J Immunol 191(7):3614\u20133623","journal-title":"J Immunol"},{"issue":"1","key":"2215_CR31","doi-asserted-by":"publisher","first-page":"e000053","DOI":"10.1136\/bmjopen-2011-000053","volume":"1","author":"AK Kemppinen","year":"2011","unstructured":"Kemppinen AK, Kaprio J, Palotie A, Saarela J (2011) Systematic review of genome-wide expression studies in multiple sclerosis. BMJ Open 1(1):e000053","journal-title":"BMJ Open"},{"issue":"3","key":"2215_CR70","doi-asserted-by":"publisher","first-page":"357","DOI":"10.3390\/ph16030357","volume":"16","author":"A Khalifa","year":"2023","unstructured":"Khalifa A, Ibrahim HIM, Sheikh A, Khalil HE (2023) Probiotic-Fermented Camel Milk Attenuates Neurodegenerative Symptoms via SOX5\/miR-218 Axis Orchestration in Mouse Models. Pharmaceuticals 16(3):357","journal-title":"Pharmaceuticals"},{"issue":"2","key":"2215_CR15","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1152\/physrev.00036.2021","volume":"103","author":"F Kheradmand","year":"2023","unstructured":"Kheradmand F, Zhang Y, Corry DB (2023) Contribution of adaptive immunity to human COPD and experimental models of emphysema. Physiol Rev 103(2):1059\u20131093","journal-title":"Physiol Rev"},{"key":"2215_CR6","first-page":"100787","volume-title":"The lung-brain axis in multiple sclerosis: Mechanistic insights and future directions","author":"L Kular","year":"2024","unstructured":"Kular L (2024) The lung-brain axis in multiple sclerosis: Mechanistic insights and future directions. Brain, Behavior, & Immunity-Health, p 100787"},{"issue":"9","key":"2215_CR29","doi-asserted-by":"publisher","first-page":"e161","DOI":"10.1371\/journal.pgen.0030161","volume":"3","author":"JT Leek","year":"2007","unstructured":"Leek JT, Storey JD (2007) Capturing heterogeneity in gene expression studies by surrogate variable analysis. PLoS Genet 3(9):e161","journal-title":"PLoS Genet"},{"key":"2215_CR80","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3389\/fnmol.2016.00084","volume":"9","author":"SM Leibowitz","year":"2016","unstructured":"Leibowitz SM, Yan J (2016) NF-\u03baB pathways in the pathogenesis of multiple sclerosis and the therapeutic implications. Front Mol Neurosci 9:84","journal-title":"Front Mol Neurosci"},{"issue":"11","key":"2215_CR65","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1166\/nnl.2020.3246","volume":"12","author":"C-T Li","year":"2020","unstructured":"Li C-T, Zhang J-Q, Dai L-M, Zhang J-Q, Fang L-Z, Feng J-G (2020) Study on the expression spectrum of miRNAs in peripheral blood from patients and the value of miR-548\u00a0h-5p in the diagnosis of chronic obstructive pulmonary disease. Nanosci Nanatechnol Lett 12(11):1323\u20131328","journal-title":"Nanosci Nanatechnol Lett"},{"key":"2215_CR30","doi-asserted-by":"crossref","unstructured":"Ligges U, M\u00e4chler M (2002) Scatterplot3d-an r package for visualizing multivariate data. Technical report","DOI":"10.18637\/jss.v008.i11"},{"key":"2215_CR53","doi-asserted-by":"publisher","first-page":"103673","DOI":"10.1016\/j.jprot.2020.103673","volume":"216","author":"G Liu","year":"2020","unstructured":"Liu G, Lu T, Li Y, Liu Y, Ji X, Jia W et al (2020) Exosomal proteome from the serum, bone marrow, and palm and toe pustular skin tissues of a single patient with SAPHO syndrome. J Proteom 216:103673","journal-title":"J Proteom"},{"key":"2215_CR81","doi-asserted-by":"publisher","first-page":"695957","DOI":"10.3389\/fphar.2021.695957","volume":"12","author":"M Liu","year":"2021","unstructured":"Liu M, Wu K, Lin J, Xie Q, Liu Y, Huang Y et al (2021) Emerging Biological Functions of IL-17A: A New Target in Chronic Obstructive Pulmonary Disease? Front Pharmacol 12:695957","journal-title":"Front Pharmacol"},{"key":"2215_CR55","doi-asserted-by":"crossref","unstructured":"Liu G, Li F, Chen M, Luo Y, Dai Y, Hou P (2022) SNRPD1\/E\/F\/G Serve as Potential Prognostic Biomarkers in Lung Adenocarcinoma. Front Genet.;13","DOI":"10.3389\/fgene.2022.813285"},{"issue":"1","key":"2215_CR26","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s12931-019-1123-x","volume":"20","author":"Y Ma","year":"2019","unstructured":"Ma Y, Tong H, Zhang X, Wang M, Yang J, Wu M et al (2019) Chronic obstructive pulmonary disease in rheumatoid arthritis: a systematic review and meta-analysis. Respir Res 20(1):144","journal-title":"Respir Res"},{"key":"2215_CR45","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.msard.2016.05.009","volume":"8","author":"RA Marrie","year":"2016","unstructured":"Marrie RA, Patten S, Tremlett H, Svenson LW, Wolfson C, Yu BN et al (2016) Chronic lung disease and multiple sclerosis: incidence, prevalence, and temporal trends. Multiple Scler Relat Disorders 8:86\u201392","journal-title":"Multiple Scler Relat Disorders"},{"issue":"10","key":"2215_CR23","doi-asserted-by":"publisher","first-page":"e2302","DOI":"10.1002\/brb3.2302","volume":"11","author":"A Mehmood","year":"2021","unstructured":"Mehmood A, Ali W, Song S, Din ZU, Guo RY, Shah W et al (2021) Optical coherence tomography monitoring and diagnosing retinal changes in multiple sclerosis. Brain Behav 11(10):e2302","journal-title":"Brain Behav"},{"issue":"8","key":"2215_CR3","doi-asserted-by":"publisher","first-page":"4071","DOI":"10.1007\/s10571-023-01432-7","volume":"43","author":"A Mehmood","year":"2023","unstructured":"Mehmood A, Shah S, Guo RY, Haider A, Shi M, Ali H et al (2023a) Methyl-CpG-Binding Protein 2 Emerges as a Central Player in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders. Cell Mol Neurobiol 43(8):4071\u20134101","journal-title":"Cell Mol Neurobiol"},{"issue":"5","key":"2215_CR10","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/iep.12488","volume":"104","author":"A Mehmood","year":"2023","unstructured":"Mehmood A, Song S, Du X, Yan H, Wang X, Guo L et al (2023b) mRNA expression profile reveals differentially expressed genes in splenocytes of experimental autoimmune encephalomyelitis model. Int J Exp Pathol 104(5):247\u2013257","journal-title":"Int J Exp Pathol"},{"issue":"1","key":"2215_CR43","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/acn3.51244","volume":"8","author":"S Menascu","year":"2021","unstructured":"Menascu S, Khavkin Y, Zilkha-Falb R, Dolev M, Magalashvili D, Achiron A et al (2021) Clinical and transcriptional recovery profiles in pediatric and adult multiple sclerosis patients. Ann Clin Transl Neurol 8(1):81\u201394","journal-title":"Ann Clin Transl Neurol"},{"key":"2215_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.imlet.2020.02.012","volume":"222","author":"M Mimpen","year":"2020","unstructured":"Mimpen M, Smolders J, Hupperts R, Damoiseaux J (2020) Natural killer cells in multiple sclerosis: a review. Immunol Lett 222:1\u201311","journal-title":"Immunol Lett"},{"issue":"1","key":"2215_CR35","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12931-022-02077-8","volume":"23","author":"M Moll","year":"2022","unstructured":"Moll M, Hobbs BD, Menon A, Ghosh AJ, Putman RK, Hino T et al (2022) Blood gene expression risk profiles and interstitial lung abnormalities: COPDGene and ECLIPSE cohort studies. Respir Res 23(1):157","journal-title":"Respir Res"},{"issue":"5","key":"2215_CR71","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1080\/08820139.2021.1909616","volume":"51","author":"A Mosarrezaii Aghdam","year":"2022","unstructured":"Mosarrezaii Aghdam A, Rezaei S, Zarza Nalivan F, Babaie F, Amiri Nikpour MR, Torkamandi S (2022) Downregulation of miR-125a-5p and miR-218-5p in Peripheral Blood Mononuclear Cells of Patients with Relapsing-Remitting Multiple Sclerosis. Immunol Invest 51(5):1149\u20131161","journal-title":"Immunol Invest"},{"issue":"2","key":"2215_CR67","first-page":"1427","volume":"19","author":"K Nong","year":"2020","unstructured":"Nong K, Zhang D, Chen C, Yang Y, Yang Y, Liu S et al (2020) MicroRNA\u2013519 inhibits hypoxia\u2013induced tumorigenesis of pancreatic cancer by regulating immune checkpoint PD\u2013L1. Oncol Lett 19(2):1427\u20131433","journal-title":"Oncol Lett"},{"issue":"8","key":"2215_CR28","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.3390\/medicina58081030","volume":"58","author":"SS Park","year":"2022","unstructured":"Park SS, Perez Perez JL, Perez Gandara B, Agudelo CW, Rodriguez Ortega R, Ahmed H et al (2022) Mechanisms linking COPD to type 1 and 2 diabetes mellitus: is there a relationship between diabetes and COPD? Medicina 58(8):1030","journal-title":"Medicina"},{"issue":"1","key":"2215_CR8","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12931-020-1323-4","volume":"21","author":"S Pascual-Guardia","year":"2020","unstructured":"Pascual-Guardia S, Ataya M, Ram\u00edrez-Mart\u00ednez I, Y\u00e9lamos J, Chalela R, Bellido S et al (2020) Adaptive NKG2C\u2009+\u2009natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients. Respir Res 21(1):63","journal-title":"Respir Res"},{"issue":"3","key":"2215_CR54","first-page":"455","volume":"36","author":"W Peng","year":"2018","unstructured":"Peng W, Liang X, Zhong Y, Zhou Y, Hu L, Wang W (2018) Increased levels of serum histone H4 and activated protein C in patients with active rheumatoid arthritis. Clin Exp Rheumatol 36(3):455\u2013461","journal-title":"Clin Exp Rheumatol"},{"key":"2215_CR37","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s12885-016-2223-3","volume":"16","author":"AL Pineda","year":"2016","unstructured":"Pineda AL, Ogoe HA, Balasubramanian JB, Rangel Escare\u00f1o C, Visweswaran S, Herman JG et al (2016) On Predicting lung cancer subtypes using \u2018omic\u2019 data from tumor and tumor-adjacent histologically-normal tissue. BMC Cancer 16:184","journal-title":"BMC Cancer"},{"issue":"4","key":"2215_CR18","doi-asserted-by":"publisher","first-page":"L687","DOI":"10.1152\/ajplung.00304.2016","volume":"311","author":"F Polverino","year":"2016","unstructured":"Polverino F, Seys LJ, Bracke KR, Owen CA (2016) B cells in chronic obstructive pulmonary disease: moving to center stage. Am J Physiology-Lung Cell Mol Physiol 311(4):L687\u2013L95","journal-title":"Am J Physiology-Lung Cell Mol Physiol"},{"key":"2215_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-017-0978-3","volume":"14","author":"CK Prajeeth","year":"2017","unstructured":"Prajeeth CK, Kronisch J, Khorooshi R, Knier B, Toft-Hansen H, Gudi V et al (2017) Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties. J Neuroinflamm 14:1\u201314","journal-title":"J Neuroinflamm"},{"key":"2215_CR19","doi-asserted-by":"publisher","first-page":"666045","DOI":"10.3389\/fimmu.2021.666045","volume":"12","author":"Y Rao","year":"2021","unstructured":"Rao Y, Le Y, Xiong J, Pei Y, Sun Y (2021) NK Cells in the Pathogenesis of Chronic Obstructive Pulmonary Disease. Front Immunol 12:666045","journal-title":"Front Immunol"},{"issue":"7","key":"2215_CR79","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1007\/s11010-022-04610-1","volume":"478","author":"O Razi","year":"2023","unstructured":"Razi O, Teixeira AM, Tartibian B, Zamani N, Knechtle B (2023) Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise. Mol Cell Biochem 478(7):1533\u20131559","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"2215_CR68","first-page":"1567","volume":"19","author":"L Ren","year":"2020","unstructured":"Ren L, Li Y, Zhao Q, Fan L, Tan B, Zang A et al (2020) miR-519 regulates the proliferation of breast cancer cells via targeting human antigen R. Oncol Lett 19(2):1567\u20131576","journal-title":"Oncol Lett"},{"issue":"7","key":"2215_CR36","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W et al (2015) limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43(7):e47\u2013e","journal-title":"Nucleic Acids Res"},{"key":"2215_CR58","doi-asserted-by":"publisher","first-page":"e2775","DOI":"10.7717\/peerj.2775","volume":"4","author":"N Safari-Alighiarloo","year":"2016","unstructured":"Safari-Alighiarloo N, Rezaei-Tavirani M, Taghizadeh M, Tabatabaei SM, Namaki S (2016) Network-based analysis of differentially expressed genes in cerebrospinal fluid (CSF) and blood reveals new candidate genes for multiple sclerosis. PeerJ 4:e2775","journal-title":"PeerJ"},{"key":"2215_CR46","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1007\/s12031-021-01878-8","volume":"71","author":"Z Salehi","year":"2021","unstructured":"Salehi Z, Talebi S, Maleknia S, Palizban F, Naser Moghadasi A, Kavousi K et al (2021) RNA Sequencing of CD4\u2009+\u2009T cells in relapsing\u2013remitting multiple sclerosis patients at relapse: Deciphering the involvement of novel genes and pathways. J Mol Neurosci 71:2628\u20132645","journal-title":"J Mol Neurosci"},{"issue":"11","key":"2215_CR38","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D et al (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498\u20132504","journal-title":"Genome Res"},{"key":"2215_CR32","doi-asserted-by":"publisher","first-page":"105953","DOI":"10.1016\/j.nbd.2022.105953","volume":"176","author":"E Shavit","year":"2023","unstructured":"Shavit E, Menascu S, Achiron A, Gurevich M (2023) Age-related blood transcriptional regulators affect disease progression in pediatric multiple sclerosis. Neurobiol Dis 176:105953","journal-title":"Neurobiol Dis"},{"issue":"3","key":"2215_CR25","doi-asserted-by":"publisher","first-page":"e91821","DOI":"10.1371\/journal.pone.0091821","volume":"9","author":"T-C Shen","year":"2014","unstructured":"Shen T-C, Lin C-L, Chen C-H, Tu C-Y, Hsia T-C, Shih C-M et al (2014) Increased risk of chronic obstructive pulmonary disease in patients with systemic lupus erythematosus: a population-based cohort study. PLoS ONE 9(3):e91821","journal-title":"PLoS ONE"},{"issue":"11","key":"2215_CR20","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1016\/j.ebiom.2015.10.021","volume":"2","author":"D Singh","year":"2015","unstructured":"Singh D (2015) Chronic Obstructive Pulmonary Disease, Neutrophils and Bacterial Infection: A Complex Web Involving IL-17 and IL-22 Unravels. EBioMedicine 2(11):1580\u20131581","journal-title":"EBioMedicine"},{"issue":"9","key":"2215_CR33","doi-asserted-by":"publisher","first-page":"e107381","DOI":"10.1371\/journal.pone.0107381","volume":"9","author":"D Singh","year":"2014","unstructured":"Singh D, Fox SM, Tal-Singer R, Bates S, Riley JH, Celli B (2014) Altered gene expression in blood and sputum in COPD frequent exacerbators in the ECLIPSE cohort. PLoS ONE 9(9):e107381","journal-title":"PLoS ONE"},{"issue":"13","key":"2215_CR74","first-page":"4319","volume":"22","author":"J Song","year":"2018","unstructured":"Song J, Wang Q, Zou S (2018) Role of microRNA-218-5p in the pathogenesis of chronic obstructive pulmonary disease. Eur Rev Med Pharmacol Sci 22(13):4319\u20134324","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"3","key":"2215_CR5","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/cns.13791","volume":"28","author":"S Song","year":"2022","unstructured":"Song S, Guo R, Mehmood A, Zhang L, Yin B, Yuan C et al (2022) Liraglutide attenuate central nervous inflammation and demyelination through AMPK and pyroptosis-related NLRP3 pathway. CNS Neurosci Ther 28(3):422\u2013434","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"2215_CR50","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1111\/jcmm.14852","volume":"24","author":"X Sun","year":"2020","unstructured":"Sun X, Shang J, Wu A, Xia J, Xu F (2020) Identification of dynamic signatures associated with smoking-related squamous cell lung cancer and chronic obstructive pulmonary disease. J Cell Mol Med 24(2):1614\u20131625","journal-title":"J Cell Mol Med"},{"issue":"3","key":"2215_CR77","doi-asserted-by":"publisher","first-page":"782","DOI":"10.3390\/v15030782","volume":"15","author":"B Sundaresan","year":"2023","unstructured":"Sundaresan B, Shirafkan F, Ripperger K, Rattay K (2023) The role of viral infections in the onset of autoimmune diseases. Viruses 15(3):782","journal-title":"Viruses"},{"issue":"D1","key":"2215_CR39","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R et al (2023) The STRING database in 2023: protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res 51(D1):D638\u2013D46","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"2215_CR1","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1002\/acn3.51401","volume":"8","author":"BA t Hart","year":"2021","unstructured":"t Hart BA, Luchicchi A, Schenk GJ, Stys PK, Geurts JJG (2021) Mechanistic underpinning of an inside-out concept for autoimmunity in multiple sclerosis. Ann Clin Transl Neurol 8(8):1709\u20131719","journal-title":"Ann Clin Transl Neurol"},{"issue":"1","key":"2215_CR75","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12974-017-0832-7","volume":"14","author":"F Talebi","year":"2017","unstructured":"Talebi F, Ghorbani S, Chan WF, Boghozian R, Masoumi F, Ghasemi S et al (2017) MicroRNA-142 regulates inflammation and T cell differentiation in an animal model of multiple sclerosis. J Neuroinflamm 14(1):55","journal-title":"J Neuroinflamm"},{"key":"2215_CR49","doi-asserted-by":"publisher","first-page":"102952","DOI":"10.1016\/j.dnarep.2020.102952","volume":"95","author":"MA Uddin","year":"2020","unstructured":"Uddin MA, Barabutis N (2020) P53 in the impaired lungs. DNA Repair (Amst) 95:102952","journal-title":"DNA Repair (Amst)"},{"key":"2215_CR7","doi-asserted-by":"publisher","first-page":"1071623","DOI":"10.3389\/fimmu.2023.1071623","volume":"14","author":"AG Vakrakou","year":"2023","unstructured":"Vakrakou AG, Paschalidis N, Pavlos E, Giannouli C, Karathanasis D, Tsipota X et al (2023) Specific myeloid signatures in peripheral blood differentiate active and rare clinical phenotypes of multiple sclerosis. Front Immunol 14:1071623","journal-title":"Front Immunol"},{"issue":"5","key":"2215_CR56","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.3390\/nano11051283","volume":"11","author":"S Van Den Broucke","year":"2021","unstructured":"Van Den Broucke S, Vanoirbeek JAJ, Derua R, Hoet PHM, Ghosh M (2021) Effect of Graphene and Graphene Oxide on Airway Barrier and Differential Phosphorylation of Proteins in Tight and Adherens Junction Pathways. Nanomaterials 11(5):1283","journal-title":"Nanomaterials"},{"key":"2215_CR9","doi-asserted-by":"crossref","unstructured":"van Langelaar J, Rijvers L, Smolders J, van Luijn MM (2020) B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers. Front Immunol.;11","DOI":"10.3389\/fimmu.2020.00760"},{"key":"2215_CR76","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.2147\/COPD.S130416","volume":"12","author":"R Wang","year":"2017","unstructured":"Wang R, Xu J, Liu H, Zhao Z (2017) Peripheral leukocyte microRNAs as novel biomarkers for COPD. Int J Chron Obstruct Pulmon Dis 12:1101\u20131112","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"2","key":"2215_CR64","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1002\/jcb.26659","volume":"120","author":"Y Wang","year":"2019","unstructured":"Wang Y, Zheng F, Gao G, Yan S, Zhang L, Wang L et al (2019) MiR-548a\u20103p regulates inflammatory response via TLR4\/NF\u2010\u03baB signaling pathway in rheumatoid arthritis. J Cell Biochem 120(2):1133\u20131140","journal-title":"J Cell Biochem"},{"issue":"1","key":"2215_CR72","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12967-024-04881-w","volume":"22","author":"D Wang","year":"2024","unstructured":"Wang D, Gao H, Qin Q, Li J, Zhao J, Qu Y et al (2024) MicroRNA-218-5p-Ddx41 axis restrains microglia-mediated neuroinflammation through downregulating type I interferon response in a mouse model of Parkinson\u2019s disease. J Translational Med 22(1):63","journal-title":"J Translational Med"},{"key":"2215_CR42","doi-asserted-by":"crossref","unstructured":"Wickham H, Wickham H (2016) Data analysis: Springer","DOI":"10.1007\/978-3-319-24277-4_9"},{"key":"2215_CR16","doi-asserted-by":"publisher","first-page":"107035","DOI":"10.1016\/j.rmed.2022.107035","volume":"205","author":"J Wu","year":"2022","unstructured":"Wu J, Zhao X, Xiao C, Xiong G, Ye X, Li L et al (2022) The role of lung macrophages in chronic obstructive pulmonary disease. Respir Med 205:107035","journal-title":"Respir Med"},{"issue":"48","key":"2215_CR59","doi-asserted-by":"publisher","first-page":"e27667","DOI":"10.1097\/MD.0000000000027667","volume":"100","author":"ZB Xu","year":"2021","unstructured":"Xu ZB, Feng X, Zhu WN, Qiu ML (2021) Identification of key genes and microRNAs for multiple sclerosis using bioinformatics analysis. Med (Baltim) 100(48):e27667","journal-title":"Med (Baltim)"},{"issue":"5","key":"2215_CR41","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang L-G, Han Y, He Q-Y (2012) clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16(5):284\u2013287","journal-title":"OMICS"},{"key":"2215_CR69","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.lfs.2017.03.010","volume":"175","author":"G Yu","year":"2017","unstructured":"Yu G, Zhang T, Jing Y, Bao Q, Tang Q, Zhang Y (2017) miR-519 suppresses nasopharyngeal carcinoma cell proliferation by targeting oncogene URG4\/URGCP. Life Sci 175:47\u201351","journal-title":"Life Sci"},{"key":"2215_CR2","doi-asserted-by":"crossref","unstructured":"Zeng X, Zhang K, Liang M, Yu B, Zhang P, Mehmood A et al (2024) NAD(+) affects differentially expressed genes-MBOAT2-SLC25A21-SOX6 in experimental autoimmune encephalomyelitis model. Int J Neurosci.:1\u20138","DOI":"10.1080\/00207454.2024.2313022"},{"issue":"1","key":"2215_CR66","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2298\/ABS220201008Z","volume":"74","author":"L Zhang","year":"2022","unstructured":"Zhang L, Liu X, Zheng Y, Du F, He G (2022) MiR-548ar-3p increases cigarette smoke extractinduced chronic obstructive pulmonary disease (COPD) injury through solute carrier family 17 member 9 (SLC17A9). Archives Biol Sci 74(1):97\u2013105","journal-title":"Archives Biol Sci"},{"issue":"12","key":"2215_CR51","doi-asserted-by":"publisher","first-page":"995","DOI":"10.3390\/toxics11120995","volume":"11","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Sheng Y, Gao Y, Lin Y, Cheng B, Li H et al (2023) Exploration of the Pathogenesis of Chronic Obstructive Pulmonary Disease Caused by Smoking\u2014Based on Bioinformatics Analysis and In Vitro Experimental Evidence. Toxics 11(12):995","journal-title":"Toxics"}],"container-title":["Molecular Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-024-02215-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00438-024-02215-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-024-02215-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T05:02:23Z","timestamp":1735275743000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00438-024-02215-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,27]]},"references-count":81,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2215"],"URL":"https:\/\/doi.org\/10.1007\/s00438-024-02215-5","relation":{},"ISSN":["1617-4615","1617-4623"],"issn-type":[{"value":"1617-4615","type":"print"},{"value":"1617-4623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,27]]},"assertion":[{"value":"16 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The author declares no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8"}}