{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:36:23Z","timestamp":1776468983378,"version":"3.51.2"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["ZYJC21027"],"award-info":[{"award-number":["ZYJC21027"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"crossref","award":["2023HXBH119"],"award-info":[{"award-number":["2023HXBH119"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010822","name":"Chengdu Science and Technology Bureau","doi-asserted-by":"crossref","award":["2022-YF05-01387-SN"],"award-info":[{"award-number":["2022-YF05-01387-SN"]}],"id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010822","name":"Chengdu Science and Technology Bureau","doi-asserted-by":"crossref","award":["2024-YF05-00050-SN"],"award-info":[{"award-number":["2024-YF05-00050-SN"]}],"id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Science and Technology Department of Sichuan Province","award":["2024YFHZ0076"],"award-info":[{"award-number":["2024YFHZ0076"]}]},{"name":"The Science and Technology Department of Sichuan Province","award":["2025ZNSFSC1526"],"award-info":[{"award-number":["2025ZNSFSC1526"]}]},{"name":"The Foundation of National Clinical Research Center for Geriatrics","award":["Z2023LC002"],"award-info":[{"award-number":["Z2023LC002"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Youth Science Foundation of China","doi-asserted-by":"crossref","award":["82301307"],"award-info":[{"award-number":["82301307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Health Care Research Project of Sichuan Province","award":["ZH2025-102"],"award-info":[{"award-number":["ZH2025-102"]}]},{"name":"National Key Research and Development Program of China","award":["2024YFC2418305"],"award-info":[{"award-number":["2024YFC2418305"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Genet Genomics"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00438-025-02281-3","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T08:12:14Z","timestamp":1756627934000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Shared genetics between metabolic traits and sensorineural hearing loss: a large-scale genome-wide cross-trait analysis"],"prefix":"10.1007","volume":"300","author":[{"given":"Xiaoyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendu","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5938-688X","authenticated-orcid":false,"given":"Jianjun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1874-908X","authenticated-orcid":false,"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"issue":"1","key":"2281_CR1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1080\/000164801300006245","volume":"121","author":"E Bachor","year":"2001","unstructured":"Bachor E et al (2001) Vascular variations of the inner ear. Acta Otolaryngol 121(1):35\u201341","journal-title":"Acta Otolaryngol"},{"issue":"2","key":"2281_CR2","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nm.3074","volume":"19","author":"R Baron","year":"2013","unstructured":"Baron R, Kneissel M (2013) WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat Med 19(2):179\u2013192","journal-title":"Nat Med"},{"issue":"21","key":"2281_CR3","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1056\/NEJMoa0706628","volume":"357","author":"PJ Barter","year":"2007","unstructured":"Barter PJ et al (2007) Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med 357(21):2109\u20132122","journal-title":"N Engl J Med"},{"issue":"7675","key":"2281_CR4","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nature24277","volume":"550","author":"A Battle","year":"2017","unstructured":"Battle A et al (2017) Genetic effects on gene expression across human tissues. Nature 550(7675):204\u2013213","journal-title":"Nature"},{"issue":"1\u20132","key":"2281_CR5","first-page":"33","volume":"7","author":"PV Bodine","year":"2006","unstructured":"Bodine PV, Komm BS (2006) Wnt signaling and osteoblastogenesis. Rev Endocr Metab Disord 7(1\u20132):33\u201339","journal-title":"Rev Endocr Metab Disord"},{"issue":"13","key":"2281_CR6","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1056\/NEJMoa1706444","volume":"377","author":"L Bowman","year":"2017","unstructured":"Bowman L et al (2017) Effects of anacetrapib in patients with atherosclerotic vascular disease. N Engl J Med 377(13):1217\u20131227","journal-title":"N Engl J Med"},{"issue":"1","key":"2281_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2022.100316","volume":"64","author":"MR Brodeur","year":"2023","unstructured":"Brodeur MR et al (2023) Dalcetrapib and anacetrapib increase apolipoprotein E-containing HDL in rabbits and humans. J Lipid Res 64(1):100316","journal-title":"J Lipid Res"},{"issue":"7","key":"2281_CR8","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/gepi.21998","volume":"40","author":"S Burgess","year":"2016","unstructured":"Burgess S, Davies NM, Thompson SG (2016) Bias due to participant overlap in two-sample Mendelian randomization. Genet Epidemiol 40(7):597\u2013608","journal-title":"Genet Epidemiol"},{"issue":"6","key":"2281_CR9","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/s41588-021-00852-9","volume":"53","author":"J Chen","year":"2021","unstructured":"Chen J et al (2021) The trans-ancestral genomic architecture of glycemic traits. Nat Genet 53(6):840\u2013860","journal-title":"Nat Genet"},{"issue":"7863","key":"2281_CR10","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/s41586-021-03552-w","volume":"594","author":"J Chiou","year":"2021","unstructured":"Chiou J et al (2021) Interpreting type 1 diabetes risk with genetics and single-cell epigenomics. Nature 594(7863):398\u2013402","journal-title":"Nature"},{"issue":"16","key":"2281_CR11","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1056\/NEJMoa1607948","volume":"375","author":"F Cosman","year":"2016","unstructured":"Cosman F et al (2016) Romosozumab treatment in postmenopausal women with osteoporosis. N Engl J Med 375(16):1532\u20131543","journal-title":"N Engl J Med"},{"issue":"8","key":"2281_CR12","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1056\/NEJMoa0809493","volume":"361","author":"SR Cummings","year":"2009","unstructured":"Cummings SR et al (2009) Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 361(8):756\u2013765","journal-title":"N Engl J Med"},{"issue":"1","key":"2281_CR13","doi-asserted-by":"publisher","first-page":"6877","DOI":"10.1038\/s41467-022-34596-9","volume":"13","author":"S Dehghani-Ghahnaviyeh","year":"2022","unstructured":"Dehghani-Ghahnaviyeh S, Zhao Z, Tajkhorshid E (2022) Lipid-mediated prestin organization in outer hair cell membranes and its implications in sound amplification. Nat Commun 13(1):6877","journal-title":"Nat Commun"},{"issue":"10","key":"2281_CR14","first-page":"897","volume":"39","author":"QQ Fan","year":"2017","unstructured":"Fan QQ et al (2017) Functions of Wnt signaling pathway in hair cell differentiation and regeneration. Yi Chuan 39(10):897\u2013907","journal-title":"Yi Chuan"},{"issue":"4","key":"2281_CR15","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1111\/j.1365-2362.1991.tb01385.x","volume":"21","author":"G Franceschini","year":"1991","unstructured":"Franceschini G, Chiesa G, Sirtori CR (1991) Probucol increases cholesteryl ester transfer protein activity in hypercholesterolaemic patients. Eur J Clin Invest 21(4):384\u2013388","journal-title":"Eur J Clin Invest"},{"issue":"D1","key":"2281_CR16","doi-asserted-by":"publisher","first-page":"D1144","DOI":"10.1093\/nar\/gkaa1084","volume":"49","author":"SL Freshour","year":"2021","unstructured":"Freshour SL et al (2021) Integration of the drug-gene interaction database (DGIdb 4.0) with open crowdsource efforts. Nucleic Acids Res 49(D1):D1144-d1151","journal-title":"Nucleic Acids Res"},{"key":"2281_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59020269","author":"FM Gioacchini","year":"2023","unstructured":"Gioacchini FM et al (2023) Diabetes mellitus and hearing loss: a complex relationship. Medicina (Kaunas). https:\/\/doi.org\/10.3390\/medicina59020269","journal-title":"Medicina (Kaunas)"},{"issue":"11","key":"2281_CR18","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1530\/EC-21-0414","volume":"10","author":"R Gong","year":"2021","unstructured":"Gong R et al (2021) Associations between TG\/HDL ratio and insulin resistance in the US population: a cross-sectional study. Endocr Connect 10(11):1502\u20131512","journal-title":"Endocr Connect"},{"issue":"7890","key":"2281_CR19","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41586-021-04064-3","volume":"600","author":"SE Graham","year":"2021","unstructured":"Graham SE et al (2021) The power of genetic diversity in genome-wide association studies of lipids. Nature 600(7890):675\u2013679","journal-title":"Nature"},{"issue":"1","key":"2281_CR20","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1210\/jc.2012-2119","volume":"98","author":"C Horikawa","year":"2013","unstructured":"Horikawa C et al (2013) Diabetes and risk of hearing impairment in adults: a meta-analysis. J Clin Endocrinol Metab 98(1):51\u201358","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2281_CR21","doi-asserted-by":"publisher","first-page":"64","DOI":"10.15420\/ecr.2015.10.01.64","volume":"10","author":"C Huggins","year":"2015","unstructured":"Huggins C, Charolidi N, Cockerill GW (2015) Cholesteryl ester transfer protein inhibitors - future soon to be revealed. Eur Cardiol 10(1):64\u201367","journal-title":"Eur Cardiol"},{"issue":"4","key":"2281_CR22","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1254\/jphs.13R09CP","volume":"123","author":"M Ito","year":"2013","unstructured":"Ito M, Adachi-Akahane S (2013) Inter-organ communication in the regulation of lipid metabolism: focusing on the network between the liver, intestine, and heart. J Pharmacol Sci 123(4):312\u2013317","journal-title":"J Pharmacol Sci"},{"issue":"23","key":"2281_CR23","doi-asserted-by":"publisher","first-page":"4395","DOI":"10.1242\/dev.080358","volume":"139","author":"BE Jacques","year":"2012","unstructured":"Jacques BE et al (2012) A dual function for canonical Wnt\/beta-catenin signaling in the developing mammalian cochlea. Development 139(23):4395\u20134404","journal-title":"Development"},{"key":"2281_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115694","volume":"215","author":"H Jiang","year":"2023","unstructured":"Jiang H et al (2023) The role of sclerostin in lipid and glucose metabolism disorders. Biochem Pharmacol 215:115694","journal-title":"Biochem Pharmacol"},{"key":"2281_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13050929","author":"CE Kosmas","year":"2023","unstructured":"Kosmas CE et al (2023) The triglyceride\/high-density lipoprotein cholesterol (TG\/HDL-C) ratio as a risk marker for metabolic syndrome and cardiovascular disease. Diagnostics (Basel). https:\/\/doi.org\/10.3390\/diagnostics13050929","journal-title":"Diagnostics (Basel)"},{"issue":"7944","key":"2281_CR26","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","volume":"613","author":"MI Kurki","year":"2023","unstructured":"Kurki MI et al (2023) FinnGen provides genetic insights from a well-phenotyped isolated population. Nature 613(7944):508\u2013518","journal-title":"Nature"},{"issue":"14","key":"2281_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e34100","volume":"10","author":"X Li","year":"2024","unstructured":"Li X, Xu J (2024) Correlation of Apo B\/A1 ratio with hemodynamics and hearing impairment degree in elderly patients with sudden sensorineural hearing loss. Heliyon 10(14):e34100","journal-title":"Heliyon"},{"issue":"20","key":"2281_CR28","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1056\/NEJMoa1609581","volume":"376","author":"AM Lincoff","year":"2017","unstructured":"Lincoff AM et al (2017) Evacetrapib and cardiovascular outcomes in high-risk vascular disease. N Engl J Med 376(20):1933\u20131942","journal-title":"N Engl J Med"},{"issue":"1","key":"2281_CR29","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s12882-020-01810-z","volume":"21","author":"W Liu","year":"2020","unstructured":"Liu W et al (2020) The association between reduced kidney function and hearing loss: a cross-sectional study. BMC Nephrol 21(1):145","journal-title":"BMC Nephrol"},{"issue":"10","key":"2281_CR30","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/s41581-023-00741-w","volume":"19","author":"A Mitrofanova","year":"2023","unstructured":"Mitrofanova A, Merscher S, Fornoni A (2023) Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease. Nat Rev Nephrol 19(10):629\u2013645","journal-title":"Nat Rev Nephrol"},{"issue":"43","key":"2281_CR31","doi-asserted-by":"publisher","first-page":"40722","DOI":"10.1074\/jbc.M206681200","volume":"277","author":"GE Muscat","year":"2002","unstructured":"Muscat GE et al (2002) Regulation of cholesterol homeostasis and lipid metabolism in skeletal muscle by liver X receptors. J Biol Chem 277(43):40722\u201340728","journal-title":"J Biol Chem"},{"key":"2281_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2024.109128","volume":"453","author":"T Ni","year":"2024","unstructured":"Ni T et al (2024) No causal relationship serum lipids on age-related hearing loss based on Mendelian randomized evidence. Hear Res 453:109128","journal-title":"Hear Res"},{"key":"2281_CR33","unstructured":"Odeh OI, K.M., Fasunla AJ, Nwaorgu OG, Sensorineural hearing loss and dyslipidemia Is there any relationship?. West Afr J Med, 2015. 34(\u2460): p. 27\u201331."},{"issue":"6","key":"2281_CR34","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/s41440-018-0034-4","volume":"41","author":"M Ohishi","year":"2018","unstructured":"Ohishi M (2018) Hypertension with diabetes mellitus: physiology and pathology. Hypertens Res 41(6):389\u2013393","journal-title":"Hypertens Res"},{"key":"2281_CR35","unstructured":"Organization, W.H. Deafness and hearing loss (2024) Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/deafness-and-hearing-loss"},{"key":"2281_CR36","unstructured":"Organization, W.H. Hypertension (2024) Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hypertension"},{"issue":"1","key":"2281_CR37","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0378-5955(89)90117-2","volume":"42","author":"RB Patuzzi","year":"1989","unstructured":"Patuzzi RB, Yates GK, Johnstone BM (1989) Outer hair cell receptor current and sensorineural hearing loss. Hear Res 42(1):47\u201372","journal-title":"Hear Res"},{"issue":"1","key":"2281_CR38","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/hmg\/ddy327","volume":"28","author":"SL Pulit","year":"2019","unstructured":"Pulit SL et al (2019) Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. Hum Mol Genet 28(1):166\u2013174","journal-title":"Hum Mol Genet"},{"key":"2281_CR39","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.857600","volume":"13","author":"H Ramatsoma","year":"2022","unstructured":"Ramatsoma H, Patrick SM (2022) Hypertension associated with hearing loss and tinnitus among hypertensive adults at a tertiary hospital in South Africa. Front Neurol 13:857600","journal-title":"Front Neurol"},{"issue":"11","key":"2281_CR40","doi-asserted-by":"publisher","first-page":"3160","DOI":"10.1016\/j.celrep.2019.02.053","volume":"26","author":"PT Ranum","year":"2019","unstructured":"Ranum PT et al (2019) Insights into the Biology of Hearing and Deafness Revealed by Single-Cell RNA Sequencing. Cell Rep 26(11):3160-3171.e3","journal-title":"Cell Rep"},{"issue":"17","key":"2281_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e36717","volume":"10","author":"JW Rhim","year":"2024","unstructured":"Rhim JW et al (2024) A sensorineural hearing loss harboring novel compound heterozygous variant in the TRIOBP gene: a case report. Heliyon 10(17):e36717","journal-title":"Heliyon"},{"issue":"1","key":"2281_CR42","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1086\/499164","volume":"78","author":"S Riazuddin","year":"2006","unstructured":"Riazuddin S et al (2006) Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness. Am J Hum Genet 78(1):137\u2013143","journal-title":"Am J Hum Genet"},{"issue":"1","key":"2281_CR43","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/MOL.0000000000000253","volume":"27","author":"KA Rye","year":"2016","unstructured":"Rye KA, Barter PJ, Cochran BJ (2016) Apolipoprotein A-I interactions with insulin secretion and production. Curr Opin Lipidol 27(1):8\u201313","journal-title":"Curr Opin Lipidol"},{"issue":"Suppl 1","key":"2281_CR44","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s12070-022-03328-2","volume":"75","author":"R Sharma","year":"2023","unstructured":"Sharma R et al (2023) Relationship between lipid profile and sensorineural hearing loss: an institution based study. Indian J Otolaryngol Head Neck Surg 75(Suppl 1):191\u2013196","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"issue":"43","key":"2281_CR45","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102(43):15545\u201315550","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"2281_CR46","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1038\/s41588-020-00713-x","volume":"52","author":"P Surendran","year":"2020","unstructured":"Surendran P et al (2020) Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nat Genet 52(12):1314\u20131332","journal-title":"Nat Genet"},{"issue":"D1","key":"2281_CR47","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D et al (2023) The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res 51(D1):D638-d646","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2281_CR48","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1161\/CIRCRESAHA.117.311978","volume":"122","author":"AR Tall","year":"2018","unstructured":"Tall AR, Rader DJ (2018) Trials and tribulations of CETP inhibitors. Circ Res 122(1):106\u2013112","journal-title":"Circ Res"},{"issue":"2","key":"2281_CR49","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/s41588-017-0009-4","volume":"50","author":"P Turley","year":"2018","unstructured":"Turley P et al (2018) Multi-trait analysis of genome-wide association summary statistics using MTAG. Nat Genet 50(2):229\u2013237","journal-title":"Nat Genet"},{"issue":"8","key":"2281_CR50","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41574-018-0037-x","volume":"14","author":"B Wang","year":"2018","unstructured":"Wang B, Tontonoz P (2018) Liver X receptors in lipid signalling and membrane homeostasis. Nat Rev Endocrinol 14(8):452\u2013463","journal-title":"Nat Rev Endocrinol"},{"key":"2281_CR51","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.cca.2016.11.009","volume":"464","author":"F Wang","year":"2017","unstructured":"Wang F, Han L, Hu D (2017) Fasting insulin, insulin resistance and risk of hypertension in the general population: a meta-analysis. Clin Chim Acta 464:57\u201363","journal-title":"Clin Chim Acta"},{"issue":"1\u20132","key":"2281_CR52","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.heares.2010.05.004","volume":"273","author":"ME Warchol","year":"2011","unstructured":"Warchol ME (2011) Sensory regeneration in the vertebrate inner ear: differences at the levels of cells and species. Hear Res 273(1\u20132):72\u201379","journal-title":"Hear Res"},{"issue":"1","key":"2281_CR53","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","volume":"8","author":"K Watanabe","year":"2017","unstructured":"Watanabe K et al (2017) Functional mapping and annotation of genetic associations with FUMA. Nat Commun 8(1):1826","journal-title":"Nat Commun"},{"issue":"1","key":"2281_CR54","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.1038\/s41467-018-04951-w","volume":"9","author":"A Xue","year":"2018","unstructured":"Xue A et al (2018) Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. Nat Commun 9(1):2941","journal-title":"Nat Commun"},{"key":"2281_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.774585","volume":"15","author":"W Yu","year":"2021","unstructured":"Yu W et al (2021) Role of the stria vascularis in the pathogenesis of sensorineural hearing loss: a narrative review. Front Neurosci 15:774585","journal-title":"Front Neurosci"},{"issue":"1","key":"2281_CR56","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/s41467-017-02317-2","volume":"9","author":"Z Zhu","year":"2018","unstructured":"Zhu Z et al (2018) Causal associations between risk factors and common diseases inferred from GWAS summary data. Nat Commun 9(1):224","journal-title":"Nat Commun"}],"container-title":["Molecular Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-025-02281-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00438-025-02281-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-025-02281-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:23:06Z","timestamp":1756898586000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00438-025-02281-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,31]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2281"],"URL":"https:\/\/doi.org\/10.1007\/s00438-025-02281-3","relation":{},"ISSN":["1617-4615","1617-4623"],"issn-type":[{"value":"1617-4615","type":"print"},{"value":"1617-4623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,31]]},"assertion":[{"value":"14 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study does not involve clinical research or human subjects, and therefore does not require ethical approval from an institutional review board or ethics committee. However, this research utilizes phenotype and genotype data from UK Biobank participants, which has been approved by the UK Biobank Committee (Application Numbers: 69718, 80787). All the other data and materials used in this study are publicly available. The study adheres to ethical standards in research conduct, ensuring integrity, transparency, and respect for all sources of information.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"80"}}