{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T02:46:59Z","timestamp":1770518819191,"version":"3.49.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Science and Technology Projects in Guangzhou","award":["2025A03J4169"],"award-info":[{"award-number":["2025A03J4169"]}]},{"name":"Science and Technology Projects in Guangzhou","award":["2023B03J1351"],"award-info":[{"award-number":["2023B03J1351"]}]},{"name":"Science and Technology Projects in Guangzhou","award":["2025A04J3475"],"award-info":[{"award-number":["2025A04J3475"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201437"],"award-info":[{"award-number":["82201437"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Genet Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00438-026-02348-9","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T06:11:04Z","timestamp":1770444664000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circ-FoxO3 alleviates APOE4-induced brain pathology through FoxO3-mediated autophagy"],"prefix":"10.1007","volume":"301","author":[{"given":"Kejing","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houlin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyi","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weilong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keshen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7674-977X","authenticated-orcid":false,"given":"Zhenguo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"key":"2348_CR1","doi-asserted-by":"publisher","unstructured":"Cai W, Wu T, Chen N (2023) The amyloid-beta clearance: from molecular targets to glial and neural cells. Biomolecules 13(2). https:\/\/doi.org\/10.3390\/biom13020313","DOI":"10.3390\/biom13020313"},{"issue":"7","key":"2348_CR2","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/s41556-023-01158-0","volume":"25","author":"I Choi","year":"2023","unstructured":"Choi I, Wang M, Yoo S et al (2023) Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence. Nat Cell Biol 25(7):963\u2013974. https:\/\/doi.org\/10.1038\/s41556-023-01158-0","journal-title":"Nat Cell Biol"},{"issue":"6","key":"2348_CR5","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1093\/nar\/gkw027","volume":"44","author":"WW Du","year":"2016","unstructured":"Du WW, Yang W, Liu E et al (2016) Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res 44(6):2846\u20132858. https:\/\/doi.org\/10.1093\/nar\/gkw027","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"2348_CR3","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/cdd.2016.133","volume":"24","author":"WW Du","year":"2017","unstructured":"Du WW, Fang L, Yang W et al (2017a) Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity. Cell Death Differ 24(2):357\u2013370. https:\/\/doi.org\/10.1038\/cdd.2016.133","journal-title":"Cell Death Differ"},{"issue":"18","key":"2348_CR4","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1093\/eurheartj\/ehw001","volume":"38","author":"WW Du","year":"2017","unstructured":"Du WW, Yang W, Chen Y et al (2017b) Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. Eur Heart J 38(18):1402\u20131412. https:\/\/doi.org\/10.1093\/eurheartj\/ehw001","journal-title":"Eur Heart J"},{"issue":"16","key":"2348_CR6","doi-asserted-by":"publisher","first-page":"e1878","DOI":"10.1212\/wnl.0000000000007323","volume":"92","author":"CM Erickson","year":"2019","unstructured":"Erickson CM, Schultz SA, Oh JM et al (2019) KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD. Neurology 92(16):e1878\u2013e1889. https:\/\/doi.org\/10.1212\/wnl.0000000000007323","journal-title":"Neurology"},{"issue":"2","key":"2348_CR7","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1080\/10409238.2016.1276882","volume":"52","author":"JW Fischer","year":"2017","unstructured":"Fischer JW, Leung AK (2017) CircRNAs: a regulator of cellular stress. Crit Rev Biochem Mol Biol 52(2):220\u2013233. https:\/\/doi.org\/10.1080\/10409238.2016.1276882","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"5","key":"2348_CR8","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1080\/15548627.2021.1883881","volume":"18","author":"S Ghafouri-Fard","year":"2022","unstructured":"Ghafouri-Fard S, Shoorei H, Mohaqiq M et al (2022) Exploring the role of non-coding RNAs in autophagy. Autophagy 18(5):949\u2013970. https:\/\/doi.org\/10.1080\/15548627.2021.1883881","journal-title":"Autophagy"},{"issue":"10","key":"2348_CR9","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.tins.2020.07.007","volume":"43","author":"A Gokool","year":"2020","unstructured":"Gokool A, Loy CT, Halliday GM et al (2020) Circular rnas: the brain transcriptome comes full circle. Trends Neurosci 43(10):752\u2013766. https:\/\/doi.org\/10.1016\/j.tins.2020.07.007","journal-title":"Trends Neurosci"},{"issue":"1","key":"2348_CR10","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.cell.2024.10.027","volume":"188","author":"JL Guo","year":"2025","unstructured":"Guo JL, Braun D, Fitzgerald GA et al (2025) Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes. Cell 188(1):187\u2013206e126. https:\/\/doi.org\/10.1016\/j.cell.2024.10.027","journal-title":"Cell"},{"issue":"3","key":"2348_CR11","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.hest.2024.04.004","volume":"5","author":"L Huang","year":"2024","unstructured":"Huang L, Wang J, Chen S et al (2024) Inspiration for the treatment of intracerebral hemorrhage from the duality of glial scar: the right time point for reactive astrocytes reprogramming. Brain Hemorrhages 5(3):143\u2013146","journal-title":"Brain Hemorrhages"},{"issue":"1","key":"2348_CR12","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.biopsych.2021.09.018","volume":"92","author":"G Karmon","year":"2022","unstructured":"Karmon G, Sragovich S, Hacohen-Kleiman G et al (2022) Novel ADNP syndrome mice reveal dramatic sex-specific peripheral gene expression with brain synaptic and tau pathologies. Biol Psychiatry 92(1):81\u201395. https:\/\/doi.org\/10.1016\/j.biopsych.2021.09.018","journal-title":"Biol Psychiatry"},{"issue":"1","key":"2348_CR13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s13024-024-00740-w","volume":"19","author":"S Kim","year":"2024","unstructured":"Kim S, Chun H, Kim Y et al (2024) Astrocytic autophagy plasticity modulates A\u03b2 clearance and cognitive function in alzheimer\u2019s disease. Mol Neurodegener 19(1):55. https:\/\/doi.org\/10.1186\/s13024-024-00740-w","journal-title":"Mol Neurodegener"},{"issue":"10","key":"2348_CR14","doi-asserted-by":"publisher","first-page":"113183","DOI":"10.1016\/j.celrep.2023.113183","volume":"42","author":"H Lee","year":"2023","unstructured":"Lee H, Cho S, Kim MJ et al (2023) ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes. Cell Rep 42(10):113183. https:\/\/doi.org\/10.1016\/j.celrep.2023.113183","journal-title":"Cell Rep"},{"key":"2348_CR15","doi-asserted-by":"publisher","first-page":"118015","DOI":"10.1016\/j.lfs.2020.118015","volume":"257","author":"F Li","year":"2020","unstructured":"Li F, Long TY, Bi SS et al (2020) circPAN3 exerts a profibrotic role via sponging miR-221 through FoxO3\/ATG7-activated autophagy in a rat model of myocardial infarction. Life Sci 257:118015. https:\/\/doi.org\/10.1016\/j.lfs.2020.118015","journal-title":"Life Sci"},{"issue":"14","key":"2348_CR16","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1038\/s41388-024-02968-8","volume":"43","author":"R Li","year":"2024","unstructured":"Li R, Wang J, Xie Z et al (2024) CircUSP1 as a novel marker promotes gastric cancer progression via stabilizing HuR to upregulate USP1 and vimentin. Oncogene 43(14):1033\u20131049. https:\/\/doi.org\/10.1038\/s41388-024-02968-8","journal-title":"Oncogene"},{"key":"2348_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2025.02.017","author":"Z Li","year":"2025","unstructured":"Li Z, Martens YA, Ren Y et al (2025) APOE genotype determines cell-type-specific pathological landscape of alzheimer\u2019s disease. Neuron. https:\/\/doi.org\/10.1016\/j.neuron.2025.02.017","journal-title":"Neuron"},{"issue":"1","key":"2348_CR18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s13024-022-00516-0","volume":"17","author":"TE Mahan","year":"2022","unstructured":"Mahan TE, Wang C, Bao X et al (2022) Selective reduction of astrocyte apoE3 and apoE4 strongly reduces A\u03b2 accumulation and plaque-related pathology in a mouse model of amyloidosis. Mol Neurodegener 17(1):13. https:\/\/doi.org\/10.1186\/s13024-022-00516-0","journal-title":"Mol Neurodegener"},{"issue":"6","key":"2348_CR19","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.cmet.2007.11.001","volume":"6","author":"C Mammucari","year":"2007","unstructured":"Mammucari C, Milan G, Romanello V et al (2007) FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab 6(6):458\u2013471. https:\/\/doi.org\/10.1016\/j.cmet.2007.11.001","journal-title":"Cell Metab"},{"key":"2348_CR20","doi-asserted-by":"publisher","unstructured":"Margvelani G, Maquera KAA, Welden JR et al (2025) Translation of circular RNAs. Nucleic Acids Res 53(1). https:\/\/doi.org\/10.1093\/nar\/gkae1167","DOI":"10.1093\/nar\/gkae1167"},{"issue":"8","key":"2348_CR21","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1016\/j.neuron.2022.03.004","volume":"110","author":"YA Martens","year":"2022","unstructured":"Martens YA, Zhao N, Liu C-C et al (2022) ApoE cascade hypothesis in the pathogenesis of alzheimer\u2019s disease and related dementias. Neuron 110(8):1304\u20131317","journal-title":"Neuron"},{"issue":"9","key":"2348_CR22","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1001\/jamaneurol.2021.2293","volume":"78","author":"MM Mielke","year":"2021","unstructured":"Mielke MM, Frank RD, Dage JL et al (2021) Comparison of plasma phosphorylated tau species with amyloid and tau positron emission tomography, neurodegeneration, vascular pathology, and cognitive outcomes. JAMA Neurol 78(9):1108\u20131117. https:\/\/doi.org\/10.1001\/jamaneurol.2021.2293","journal-title":"JAMA Neurol"},{"issue":"1","key":"2348_CR23","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.immuni.2023.12.001","volume":"57","author":"A Millet","year":"2024","unstructured":"Millet A, Ledo JH, Tavazoie SF (2024) An exhausted-like microglial population accumulates in aged and APOE4 genotype alzheimer\u2019s brains. Immunity 57(1):153\u2013170e156. https:\/\/doi.org\/10.1016\/j.immuni.2023.12.001","journal-title":"Immunity"},{"issue":"12","key":"2348_CR24","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1038\/s41593-023-01480-8","volume":"26","author":"MR Nelson","year":"2023","unstructured":"Nelson MR, Liu P, Agrawal A et al (2023) The APOE-R136S mutation protects against APOE4-driven tau pathology, neurodegeneration and neuroinflammation. Nat Neurosci 26(12):2104\u20132121. https:\/\/doi.org\/10.1038\/s41593-023-01480-8","journal-title":"Nat Neurosci"},{"issue":"6","key":"2348_CR25","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1080\/15548627.2022.2150003","volume":"19","author":"J Niu","year":"2023","unstructured":"Niu J, Yan T, Guo W et al (2023) The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma. Autophagy 19(6):1693\u20131710. https:\/\/doi.org\/10.1080\/15548627.2022.2150003","journal-title":"Autophagy"},{"issue":"4","key":"2348_CR26","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/s41576-024-00806-x","volume":"26","author":"E O\u2019Leary","year":"2025","unstructured":"O\u2019Leary E, Jiang Y, Kristensen LS et al (2025) The therapeutic potential of circular RNAs. Nat Rev Genet 26(4):230\u2013244. https:\/\/doi.org\/10.1038\/s41576-024-00806-x","journal-title":"Nat Rev Genet"},{"issue":"12","key":"2348_CR27","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.tips.2022.09.010","volume":"43","author":"A Orea-Soufi","year":"2022","unstructured":"Orea-Soufi A, Paik J, Bragan\u00e7a J et al (2022) FOXO transcription factors as therapeutic targets in human diseases. Trends Pharmacol Sci 43(12):1070\u20131084. https:\/\/doi.org\/10.1016\/j.tips.2022.09.010","journal-title":"Trends Pharmacol Sci"},{"issue":"5","key":"2348_CR28","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1080\/15548627.2023.2286116","volume":"20","author":"K Pierzynowska","year":"2024","unstructured":"Pierzynowska K, Podlacha M, Gaffke L et al (2024) Correction of symptoms of huntington disease by genistein through FOXO3-mediated autophagy stimulation. Autophagy 20(5):1159\u20131182. https:\/\/doi.org\/10.1080\/15548627.2023.2286116","journal-title":"Autophagy"},{"issue":"6","key":"2348_CR29","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1093\/hmg\/ddt530","volume":"23","author":"E Pino","year":"2014","unstructured":"Pino E, Amamoto R, Zheng L et al (2014) FOXO3 determines the accumulation of \u03b1-synuclein and controls the fate of dopaminergic neurons in the substantia Nigra. Hum Mol Genet 23(6):1435\u20131452. https:\/\/doi.org\/10.1093\/hmg\/ddt530","journal-title":"Hum Mol Genet"},{"issue":"8","key":"2348_CR30","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1002\/alz.12960","volume":"19","author":"S Puri","year":"2023","unstructured":"Puri S, Hu J, Sun Z et al (2023) Identification of circrnas linked to Alzheimer\u2019s disease and related dementias. Alzheimers Dement 19(8):3389\u20133405. https:\/\/doi.org\/10.1002\/alz.12960","journal-title":"Alzheimers Dement"},{"issue":"5","key":"2348_CR31","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.molcel.2015.03.027","volume":"58","author":"A Rybak-Wolf","year":"2015","unstructured":"Rybak-Wolf A, Stottmeister C, Gla\u017ear P et al (2015) Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed. Mol Cell 58(5):870\u2013885. https:\/\/doi.org\/10.1016\/j.molcel.2015.03.027","journal-title":"Mol Cell"},{"issue":"1","key":"2348_CR32","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12916-019-1299-4","volume":"17","author":"M Safieh","year":"2019","unstructured":"Safieh M, Korczyn AD, Michaelson DM (2019) ApoE4: an emerging therapeutic target for Alzheimer\u2019s disease. BMC Med 17(1):64. https:\/\/doi.org\/10.1186\/s12916-019-1299-4","journal-title":"BMC Med"},{"issue":"6","key":"2348_CR33","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.neuron.2018.08.017","volume":"99","author":"I Sch\u00e4ffner","year":"2018","unstructured":"Sch\u00e4ffner I, Minakaki G, Khan MA et al (2018) FoxO function is essential for maintenance of autophagic flux and neuronal morphogenesis in adult neurogenesis. Neuron 99(6):1188\u20131203e1186. https:\/\/doi.org\/10.1016\/j.neuron.2018.08.017","journal-title":"Neuron"},{"issue":"2","key":"2348_CR34","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/s41418-021-00865-1","volume":"29","author":"C Song","year":"2022","unstructured":"Song C, Zhang Y, Huang W et al (2022) Circular RNA Cwc27 contributes to Alzheimer\u2019s disease pathogenesis by repressing Pur-\u03b1 activity. Cell Death Differ 29(2):393\u2013406. https:\/\/doi.org\/10.1038\/s41418-021-00865-1","journal-title":"Cell Death Differ"},{"issue":"10","key":"2348_CR35","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1016\/j.neuron.2021.03.024","volume":"109","author":"C Wang","year":"2021","unstructured":"Wang C, Xiong M, Gratuze M et al (2021) Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia. Neuron 109(10):1657\u20131674e1657. https:\/\/doi.org\/10.1016\/j.neuron.2021.03.024","journal-title":"Neuron"},{"issue":"9","key":"2348_CR36","doi-asserted-by":"publisher","first-page":"6501","DOI":"10.1007\/s12035-024-03977-0","volume":"61","author":"X Wen","year":"2024","unstructured":"Wen X, Huang C, Xie H et al (2024) The applications of circrna in the diagnosis and treatment of Alzheimer\u2019s disease. Mol Neurobiol 61(9):6501\u20136510. https:\/\/doi.org\/10.1007\/s12035-024-03977-0","journal-title":"Mol Neurobiol"},{"key":"2348_CR37","doi-asserted-by":"publisher","first-page":"652995","DOI":"10.3389\/fgene.2021.652995","volume":"12","author":"T Yang","year":"2021","unstructured":"Yang T, Li Y, Zhao F et al (2021a) Circular RNA Foxo3: a promising cancer-associated biomarker. Front Genet 12:652995. https:\/\/doi.org\/10.3389\/fgene.2021.652995","journal-title":"Front Genet"},{"issue":"10","key":"2348_CR39","doi-asserted-by":"publisher","first-page":"3048","DOI":"10.1080\/15548627.2020.1851897","volume":"17","author":"Z Yang","year":"2021","unstructured":"Yang Z, Lin P, Chen B et al (2021b) Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation of CLDN5 (claudin 5). Autophagy 17(10):3048\u20133067. https:\/\/doi.org\/10.1080\/15548627.2020.1851897","journal-title":"Autophagy"},{"issue":"3","key":"2348_CR38","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/j.ymthe.2021.11.004","volume":"30","author":"Z Yang","year":"2022","unstructured":"Yang Z, Huang C, Wen X et al (2022) Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia\/reperfusion. Mol Ther 30(3):1275\u20131287. https:\/\/doi.org\/10.1016\/j.ymthe.2021.11.004","journal-title":"Mol Ther"},{"issue":"6","key":"2348_CR40","doi-asserted-by":"publisher","first-page":"839","DOI":"10.3892\/ol.2021.13100","volume":"22","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Ge P, Zhou D et al (2021) Circular RNA FOXO3 accelerates glycolysis and improves cisplatin sensitivity in lung cancer cells via the miR-543\/Foxo3 axis. Oncol Lett 22(6):839. https:\/\/doi.org\/10.3892\/ol.2021.13100","journal-title":"Oncol Lett"},{"issue":"11","key":"2348_CR41","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1038\/s41419-022-05390-8","volume":"13","author":"C Zhao","year":"2022","unstructured":"Zhao C, Li X, Sun G et al (2022) CircFOXO3 protects against osteoarthritis by targeting its parental gene FOXO3 and activating PI3K\/AKT-mediated autophagy. Cell Death Dis 13(11):932. https:\/\/doi.org\/10.1038\/s41419-022-05390-8","journal-title":"Cell Death Dis"},{"issue":"9","key":"2348_CR42","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1080\/15548627.2023.2196889","volume":"19","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Liu Y, Kang Z et al (2023) CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy. Autophagy 19(9):2520\u20132537. https:\/\/doi.org\/10.1080\/15548627.2023.2196889","journal-title":"Autophagy"}],"container-title":["Molecular Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-026-02348-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00438-026-02348-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-026-02348-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T06:11:05Z","timestamp":1770444665000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00438-026-02348-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,7]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2348"],"URL":"https:\/\/doi.org\/10.1007\/s00438-026-02348-9","relation":{},"ISSN":["1617-4615","1617-4623"],"issn-type":[{"value":"1617-4615","type":"print"},{"value":"1617-4623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,7]]},"assertion":[{"value":"18 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Animal protocols were reviewed and approved by the Institutional Animal Care and Use Committee of Jinan University, Guangzhou, China.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"37"}}