{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:43:43Z","timestamp":1786121023231,"version":"build-2736575974"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Genet Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00438-026-02460-w","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T02:39:27Z","timestamp":1786070367000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lactate derived from CAFs mediates H3K18la in stemness gene promoters, which promotes tumor malignant phenotype formation"],"prefix":"10.1007","volume":"301","author":[{"given":"Jie","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangbin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3655-039X","authenticated-orcid":false,"given":"Haitao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"issue":"8","key":"2460_CR1","doi-asserted-by":"publisher","first-page":"e32899","DOI":"10.1097\/md.0000000000032899","volume":"102","author":"Y Alduais","year":"2023","unstructured":"Alduais Y, Zhang H et al (2023) Non-small cell lung cancer (NSCLC): A review of risk factors, diagnosis, and treatment. Medicine 102(8):e32899. https:\/\/doi.org\/10.1097\/md.0000000000032899","journal-title":"Medicine"},{"issue":"1","key":"2460_CR2","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12935-026-04172-y","volume":"26","author":"H Bi","year":"2026","unstructured":"Bi H, He L et al (2026) SPP1 promotes cancer stemness and reduces osimertinib sensitivity in non-small cell lung cancer through interactions with CD44. Cancer Cell Int 26(1):81. https:\/\/doi.org\/10.1186\/s12935-026-04172-y","journal-title":"Cancer Cell Int"},{"issue":"10","key":"2460_CR4","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1002\/cac2.12359","volume":"42","author":"P Chen","year":"2022","unstructured":"Chen P, Liu Y et al (2022) Non-small cell lung cancer in China. Cancer Commun (London England) 42(10):937\u2013970. https:\/\/doi.org\/10.1002\/cac2.12359","journal-title":"Cancer Commun (London England)"},{"issue":"3","key":"2460_CR3","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.21037\/jgo-24-368","volume":"15","author":"J Chen","year":"2024","unstructured":"Chen J, He G et al (2024) Lactic acid: a narrative review of a promoter of the liver cancer microenvironment. J Gastrointest Oncol 15(3):1282\u20131296. https:\/\/doi.org\/10.21037\/jgo-24-368","journal-title":"J Gastrointest Oncol"},{"issue":"3","key":"2460_CR5","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.ccell.2023.12.021","volume":"42","author":"L Cords","year":"2024","unstructured":"Cords L, Engler S et al (2024) Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer. Cancer Cell 42(3):396\u2013412e395. https:\/\/doi.org\/10.1016\/j.ccell.2023.12.021","journal-title":"Cancer Cell"},{"issue":"12","key":"2460_CR6","doi-asserted-by":"publisher","first-page":"4565","DOI":"10.4251\/wjgo.v16.i12.4565","volume":"16","author":"JY Cui","year":"2024","unstructured":"Cui JY, Ma J et al (2024) Unraveling the role of cancer-associated fibroblasts in colorectal cancer. World J Gastrointest Oncol 16(12):4565\u20134578. https:\/\/doi.org\/10.4251\/wjgo.v16.i12.4565","journal-title":"World J Gastrointest Oncol"},{"issue":"9","key":"2460_CR7","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3779\/j.issn.1009-3419.2014.09.07","volume":"17","author":"H Du","year":"2014","unstructured":"Du H, Che G (2014) [Advancement of relationship between metabolic alteration in cancer-associated fibroblasts and tumor progression in lung cancer]. Zhongguo fei ai za zhi = Chin J lung cancer 17(9):679\u2013684. https:\/\/doi.org\/10.3779\/j.issn.1009-3419.2014.09.07","journal-title":"Zhongguo fei ai za zhi = Chin J lung cancer"},{"issue":"1","key":"2460_CR8","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s13059-024-03308-5","volume":"25","author":"W Fan","year":"2024","unstructured":"Fan W, Zeng S et al (2024) A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis. Genome Biol 25(1):165. https:\/\/doi.org\/10.1186\/s13059-024-03308-5","journal-title":"Genome Biol"},{"key":"2460_CR9","doi-asserted-by":"publisher","unstructured":"Flores Banda JS, Gangane S et al (2025) Current development of therapeutic vaccines in lung cancer. Vaccines 13(2). https:\/\/doi.org\/10.3390\/vaccines13020185","DOI":"10.3390\/vaccines13020185"},{"issue":"1","key":"2460_CR10","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12943-022-01501-3","volume":"21","author":"C Hu","year":"2022","unstructured":"Hu C, Xia R et al (2022) circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF\/STAT3 axis. Mol Cancer 21(1):24. https:\/\/doi.org\/10.1186\/s12943-022-01501-3","journal-title":"Mol Cancer"},{"issue":"9","key":"2460_CR11","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1016\/j.ccell.2023.07.012","volume":"41","author":"Q Huang","year":"2023","unstructured":"Huang Q, Liu L et al (2023) CD44(+) lung cancer stem cell-derived pericyte-like cells cause brain metastases through GPR124-enhanced trans-endothelial migration. Cancer Cell 41(9):1621\u20131636e1628. https:\/\/doi.org\/10.1016\/j.ccell.2023.07.012","journal-title":"Cancer Cell"},{"issue":"8","key":"2460_CR12","doi-asserted-by":"publisher","first-page":"3506","DOI":"10.1038\/s44319-024-00180-z","volume":"25","author":"L Ippolito","year":"2024","unstructured":"Ippolito L, Duatti A et al (2024) Lactate supports cell-autonomous ECM production to sustain metastatic behavior in prostate cancer. EMBO Rep 25(8):3506\u20133531. https:\/\/doi.org\/10.1038\/s44319-024-00180-z","journal-title":"EMBO Rep"},{"key":"2460_CR13","doi-asserted-by":"publisher","first-page":"684505","DOI":"10.3389\/fcell.2021.684505","volume":"9","author":"Z Ji","year":"2021","unstructured":"Ji Z, Tian W et al (2021) Cancer-associated fibroblast-derived interleukin-8 promotes ovarian cancer cell stemness and malignancy through the notch3-mediated signaling. Front cell Dev biology 9:684505. https:\/\/doi.org\/10.3389\/fcell.2021.684505","journal-title":"Front cell Dev biology"},{"issue":"7","key":"2460_CR14","doi-asserted-by":"publisher","first-page":"3014","DOI":"10.7150\/thno.94207","volume":"14","author":"X Jin","year":"2024","unstructured":"Jin X, Deng Q et al (2024) Cancer-associated fibroblast-derived periostin promotes papillary thyroid tumor growth through integrin-FAK-STAT3 signaling. Theranostics 14(7):3014\u20133028. https:\/\/doi.org\/10.7150\/thno.94207","journal-title":"Theranostics"},{"issue":"2","key":"2460_CR15","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1177\/09287329241291432","volume":"33","author":"N Kang","year":"2025","unstructured":"Kang N, Ge W et al (2025) Cancer-associated fibroblasts derived-exosomal circ_0076535 promotes esophageal squamous cell carcinoma progression. Technol health care: official J Eur Soc Eng Med 33(2):1088\u20131098. https:\/\/doi.org\/10.1177\/09287329241291432","journal-title":"Technol health care: official J Eur Soc Eng Med"},{"key":"2460_CR16","doi-asserted-by":"publisher","first-page":"102143","DOI":"10.1016\/j.tranon.2024.102143","volume":"50","author":"X Liu","year":"2024","unstructured":"Liu X, Kong Y et al (2024) Spatial heterogeneity of infiltrating immune cells in the tumor microenvironment of non-small cell lung cancer. Translational Oncol 50:102143. https:\/\/doi.org\/10.1016\/j.tranon.2024.102143","journal-title":"Translational Oncol"},{"issue":"1","key":"2460_CR17","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12943-021-01428-1","volume":"20","author":"X Mao","year":"2021","unstructured":"Mao X, Xu J et al (2021) Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives. Mol Cancer 20(1):131. https:\/\/doi.org\/10.1186\/s12943-021-01428-1","journal-title":"Mol Cancer"},{"key":"2460_CR18","doi-asserted-by":"publisher","unstructured":"P\u00e9rez-Tom\u00e1s R, P\u00e9rez-Guill\u00e9n I (2020) Lactate in the tumor microenvironment: an essential molecule in cancer progression and treatment. Cancers 12(11). https:\/\/doi.org\/10.3390\/cancers12113244","DOI":"10.3390\/cancers12113244"},{"issue":"3","key":"2460_CR19","doi-asserted-by":"publisher","first-page":"3160","DOI":"10.3390\/curroncol30030239","volume":"30","author":"F Petrella","year":"2023","unstructured":"Petrella F, Rizzo S et al (2023) Stage III non-small-cell lung cancer: an overview of treatment options. Curr Oncol (Toronto Ont) 30(3):3160\u20133175. https:\/\/doi.org\/10.3390\/curroncol30030239","journal-title":"Curr Oncol (Toronto Ont)"},{"key":"2460_CR20","doi-asserted-by":"publisher","unstructured":"Qian Y, Gong Z et al (2026) Cancer-associated fibroblasts promote osimertinib resistance in non-small cell lung cancer cells via METTL1-mediated NET1 m(7)G modification. Cell Death Dis 17(1). https:\/\/doi.org\/10.1038\/s41419-026-08505-7","DOI":"10.1038\/s41419-026-08505-7"},{"issue":"28","key":"2460_CR21","doi-asserted-by":"publisher","first-page":"e2307216","DOI":"10.1002\/advs.202307216","volume":"11","author":"J Qiao","year":"2024","unstructured":"Qiao J, Tan Y et al (2024) Histone H3K18 and ezrin lactylation promote renal dysfunction in sepsis-associated acute kidney injury. Advanced science (Weinheim, Baden-Wurttemberg. Germany) 11(28):e2307216. https:\/\/doi.org\/10.1002\/advs.202307216","journal-title":"Germany)"},{"issue":"7","key":"2460_CR22","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1080\/07357907.2023.2237576","volume":"41","author":"N Rastegar-Pouyani","year":"2023","unstructured":"Rastegar-Pouyani N, Montazeri V et al (2023) The impact of cancer-associated fibroblasts on drug resistance, stemness, and epithelial-mesenchymal transition in bladder cancer: a comparison between recurrent and non-recurrent patient-derived CAFs. Cancer Invest 41(7):656\u2013671. https:\/\/doi.org\/10.1080\/07357907.2023.2237576","journal-title":"Cancer Invest"},{"issue":"11","key":"2460_CR23","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1038\/s41590-024-01985-9","volume":"25","author":"D Raychaudhuri","year":"2024","unstructured":"Raychaudhuri D, Singh P et al (2024) Histone lactylation drives CD8(+) T cell metabolism and function. Nat Immunol 25(11):2140\u20132151. https:\/\/doi.org\/10.1038\/s41590-024-01985-9","journal-title":"Nat Immunol"},{"issue":"3","key":"2460_CR24","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/s41568-019-0238-1","volume":"20","author":"E Sahai","year":"2020","unstructured":"Sahai E, Astsaturov I et al (2020) A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer 20(3):174\u2013186. https:\/\/doi.org\/10.1038\/s41568-019-0238-1","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"2460_CR25","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/s13578-023-01158-5","volume":"13","author":"P Samart","year":"2023","unstructured":"Samart P, Heenatigala Palliyage G et al (2023) Musashi-2 in cancer-associated fibroblasts promotes non-small cell lung cancer metastasis through paracrine IL-6-driven epithelial-mesenchymal transition. Cell bioscience 13(1):205. https:\/\/doi.org\/10.1186\/s13578-023-01158-5","journal-title":"Cell bioscience"},{"key":"2460_CR26","doi-asserted-by":"publisher","unstructured":"Schegoleva AA, Khozyainova AA et al (2021) Prognosis of different types of non-small cell lung cancer progression: current state and perspectives. Cell Physiol and Biochem: Int J Exp Cell Physiol Biochem, and Pharmacol 55(S2): 29\u201348. https:\/\/doi.org\/10.33594\/000000340","DOI":"10.33594\/000000340"},{"key":"2460_CR27","doi-asserted-by":"publisher","first-page":"119147","DOI":"10.1016\/j.carbpol.2022.119147","volume":"283","author":"S Shan","year":"2022","unstructured":"Shan S, Xiong Y et al (2022) Effect of an inulin-type fructan from Platycodon grandiflorum on the intestinal microbiota in rats exposed to PM2.5. Carbohydr Polym 283:119147. https:\/\/doi.org\/10.1016\/j.carbpol.2022.119147","journal-title":"Carbohydr Polym"},{"key":"2460_CR28","doi-asserted-by":"publisher","first-page":"111182","DOI":"10.1016\/j.cellsig.2024.111182","volume":"119","author":"Z Sheng","year":"2024","unstructured":"Sheng Z, Wang X et al (2024) Exosomal miRNA-92a derived from cancer-associated fibroblasts promote invasion and metastasis in breast cancer by regulating G3BP2. Cell Signal 119:111182. https:\/\/doi.org\/10.1016\/j.cellsig.2024.111182","journal-title":"Cell Signal"},{"issue":"7","key":"2460_CR29","doi-asserted-by":"publisher","first-page":"e989","DOI":"10.1002\/ctm2.989","volume":"12","author":"L Shi","year":"2022","unstructured":"Shi L, Zhu W et al (2022) Cancer-associated fibroblast-derived exosomal microRNA-20a suppresses the PTEN\/PI3K-AKT pathway to promote the progression and chemoresistance of non-small cell lung cancer. Clin translational Med 12(7):e989. https:\/\/doi.org\/10.1002\/ctm2.989","journal-title":"Clin translational Med"},{"issue":"7","key":"2460_CR30","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.7150\/ijbs.83574","volume":"19","author":"DJ Stravopodis","year":"2023","unstructured":"Stravopodis DJ, Papavassiliou KA et al (2023) Vistas in non-small cell Lung Cancer (NSCLC) treatment: of kinome and signaling networks. Int J Biol Sci 19(7):2002\u20132005. https:\/\/doi.org\/10.7150\/ijbs.83574","journal-title":"Int J Biol Sci"},{"issue":"4","key":"2460_CR33","doi-asserted-by":"publisher","first-page":"696","DOI":"10.3892\/ol.2021.12957","volume":"22","author":"X Sun","year":"2021","unstructured":"Sun X, Chen Z (2021) Cancer-associated fibroblast-derived CCL5 contributes to cisplatin resistance in A549 NSCLC cells partially through upregulation of lncRNA HOTAIR expression. Oncol Lett 22(4):696. https:\/\/doi.org\/10.3892\/ol.2021.12957","journal-title":"Oncol Lett"},{"key":"2460_CR31","doi-asserted-by":"publisher","first-page":"112817","DOI":"10.1016\/j.biopha.2022.112817","volume":"149","author":"J Sun","year":"2022","unstructured":"Sun J, Wu S et al (2022) Lymph node micrometastasis in non-small cell lung cancer. Biomed pharmacotherapy = Biomedecine pharmacotherapie 149:112817. https:\/\/doi.org\/10.1016\/j.biopha.2022.112817","journal-title":"Biomed pharmacotherapy = Biomedecine pharmacotherapie"},{"issue":"1","key":"2460_CR32","doi-asserted-by":"publisher","first-page":"133","DOI":"10.32604\/or.2024.054141","volume":"33","author":"T Sun","year":"2025","unstructured":"Sun T, Song Q et al (2025) CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP\/TLR4-MyD88-NF-\u03baB pathway. Oncol Res 33(1):133\u2013148. https:\/\/doi.org\/10.32604\/or.2024.054141","journal-title":"Oncol Res"},{"key":"2460_CR34","doi-asserted-by":"publisher","first-page":"103627","DOI":"10.1016\/j.ebiom.2021.103627","volume":"73","author":"ZH Wang","year":"2021","unstructured":"Wang ZH, Peng WB et al (2021) Lactate in the tumour microenvironment: From immune modulation to therapy. EBioMedicine 73:103627. https:\/\/doi.org\/10.1016\/j.ebiom.2021.103627","journal-title":"EBioMedicine"},{"issue":"1","key":"2460_CR35","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12943-021-01316-8","volume":"20","author":"L Xia","year":"2021","unstructured":"Xia L, Oyang L et al (2021) The cancer metabolic reprogramming and immune response. Mol Cancer 20(1):28. https:\/\/doi.org\/10.1186\/s12943-021-01316-8","journal-title":"Mol Cancer"},{"issue":"1","key":"2460_CR36","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s12957-024-03482-7","volume":"22","author":"Y Xu","year":"2024","unstructured":"Xu Y, Ren Z et al (2024) Cancer-associated fibroblast-derived WNT5A promotes cell proliferation, metastasis, stemness and glycolysis in gastric cancer via regulating HK2. World J Surg Oncol 22(1):193. https:\/\/doi.org\/10.1186\/s12957-024-03482-7","journal-title":"World J Surg Oncol"},{"issue":"1","key":"2460_CR37","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3233\/tub-200075","volume":"43","author":"B Zarin","year":"2021","unstructured":"Zarin B, Rafiee L et al (2021) A review on the role of CAFs and CAF-derived exosomes in progression and metastasis of digestive system cancers. Tumour biology: J Int Soc Oncodevelopmental Biology Med 43(1):141\u2013157. https:\/\/doi.org\/10.3233\/tub-200075","journal-title":"Tumour biology: J Int Soc Oncodevelopmental Biology Med"},{"issue":"1","key":"2460_CR38","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12943-023-01860-5","volume":"22","author":"H Zhang","year":"2023","unstructured":"Zhang H, Yue X et al (2023) Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials. Mol Cancer 22(1):159. https:\/\/doi.org\/10.1186\/s12943-023-01860-5","journal-title":"Mol Cancer"},{"issue":"1","key":"2460_CR39","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s13578-024-01329-y","volume":"14","author":"S Zhang","year":"2024","unstructured":"Zhang S, Wang J et al (2024) CAFs-derived lactate enhances the cancer stemness through inhibiting the MST1 ubiquitination degradation in OSCC. Cell bioscience 14(1):144. https:\/\/doi.org\/10.1186\/s13578-024-01329-y","journal-title":"Cell bioscience"},{"issue":"1","key":"2460_CR41","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12943-024-01957-5","volume":"23","author":"Y Zhao","year":"2024","unstructured":"Zhao Y, Jia Y et al (2024) circNOX4 activates an inflammatory fibroblast niche to promote tumor growth and metastasis in NSCLC via FAP\/IL-6 axis. Mol Cancer 23(1):47. https:\/\/doi.org\/10.1186\/s12943-024-01957-5","journal-title":"Mol Cancer"},{"key":"2460_CR40","doi-asserted-by":"publisher","first-page":"117097","DOI":"10.1016\/j.bcp.2025.117097","volume":"240","author":"S Zhao","year":"2025","unstructured":"Zhao S, Cheng J et al (2025) Histone lactylation-driven YTHDF2 promotes non-small cell lung cancer cell glycolysis and stemness by recognizing m6A modification of SFRP2. Biochem Pharmacol 240:117097. https:\/\/doi.org\/10.1016\/j.bcp.2025.117097","journal-title":"Biochem Pharmacol"},{"issue":"10","key":"2460_CR42","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1158\/0008-5472.Can-22-2213","volume":"83","author":"J Zhuang","year":"2023","unstructured":"Zhuang J, Shen L et al (2023) Cancer-associated fibroblast-derived miR-146a-5p generates a Niche that promotes bladder cancer stemness and chemoresistance. Cancer Res 83(10):1611\u20131627. https:\/\/doi.org\/10.1158\/0008-5472.Can-22-2213","journal-title":"Cancer Res"}],"container-title":["Molecular Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-026-02460-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00438-026-02460-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-026-02460-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T02:39:30Z","timestamp":1786070370000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00438-026-02460-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2460"],"URL":"https:\/\/doi.org\/10.1007\/s00438-026-02460-w","relation":{},"ISSN":["1617-4615","1617-4623"],"issn-type":[{"value":"1617-4615","type":"print"},{"value":"1617-4623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]},"assertion":[{"value":"31 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study were approved by the Ethics Committee of the First Affiliated Hospital of Soochow University (Ethics Approval Number: 2025289) and were performed in accordance with the National Institutions of Health Guide for Care and Use of Laboratory Animals.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"166"}}