{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:44:52Z","timestamp":1782708292206,"version":"3.54.5"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Hebei Natural Science Foundation","doi-asserted-by":"crossref","award":["H2024206476"],"award-info":[{"award-number":["H2024206476"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Science Research Project of Hebei","award":["20250693"],"award-info":[{"award-number":["20250693"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Genet Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00438-026-02476-2","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:03:09Z","timestamp":1782705789000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HIPK3 silencing promotes M2 macrophage polarization through NF-\u03baB signaling pathway to enhance oral cancer progression"],"prefix":"10.1007","volume":"301","author":[{"given":"Rongxia","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongle","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0381-0233","authenticated-orcid":false,"given":"Chencong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"issue":"5","key":"2476_CR1","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1111\/jop.12643","volume":"47","author":"AM Alves","year":"2018","unstructured":"Alves AM, Diel LF, Lamers ML (2018) Macrophages and prognosis of oral squamous cell carcinoma: a systematic review. J Oral Pathol Med 47(5):460\u2013467","journal-title":"J Oral Pathol Med"},{"key":"2476_CR2","unstructured":"Bangwu C, Xiaowen F, Shujuan L, Aididar N, Hong C, Tianyuan P, Wei W, Huifang L, Qing L, Xiaomei L et al (2025) 5-FU Resistance facilitates immune evasion in esophageal squamous cell carcinoma through ADAM10-mediated PD-L1 shedding and tumour microenvironment remodelling. Immunology 177(1)"},{"key":"2476_CR3","doi-asserted-by":"crossref","unstructured":"Boutilier AJ, Elsawa SF (2021) Macrophage polarization states in the tumor microenvironment. Int J Mol Sci 22(13)","DOI":"10.3390\/ijms22136995"},{"key":"2476_CR4","doi-asserted-by":"publisher","first-page":"229","DOI":"10.12688\/f1000research.22941.1","volume":"9","author":"A Bugshan","year":"2020","unstructured":"Bugshan A, Farooq I (2020) Oral squamous cell carcinoma: metastasis, potentially associated malignant disorders, etiology and recent advancements in diagnosis. F1000Research 9:229","journal-title":"F1000Research"},{"issue":"5","key":"2476_CR5","doi-asserted-by":"publisher","first-page":"C731","DOI":"10.1152\/ajpcell.00366.2018","volume":"316","author":"J Cai","year":"2019","unstructured":"Cai J, Qiao B, Gao N, Lin N, He W (2019) Oral squamous cell carcinoma-derived exosomes promote M2 subtype macrophage polarization mediated by exosome-enclosed miR-29a-3p. Am J Physiol Cell Physiol 316(5):C731\u2013c740","journal-title":"Am J Physiol Cell Physiol"},{"key":"2476_CR6","doi-asserted-by":"publisher","first-page":"1476030","DOI":"10.3389\/fimmu.2024.1476030","volume":"15","author":"Y Cao","year":"2024","unstructured":"Cao Y, Yi Y, Han C, Shi B (2024) NF-\u03baB signaling pathway in tumor microenvironment. Front Immunol 15:1476030","journal-title":"Front Immunol"},{"issue":"1","key":"2476_CR7","doi-asserted-by":"publisher","first-page":"e70","DOI":"10.1038\/emm.2013.135","volume":"46","author":"DI Cho","year":"2014","unstructured":"Cho DI, Kim MR, Jeong HY, Jeong HC, Jeong MH, Yoon SH, Kim YS, Ahn Y (2014) Mesenchymal stem cells reciprocally regulate the M1\/M2 balance in mouse bone marrow-derived macrophages. Exp Mol Med 46(1):e70","journal-title":"Exp Mol Med"},{"issue":"5","key":"2476_CR8","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1111\/j.1398-9995.1992.tb00662.x","volume":"47","author":"G Del Prete","year":"1992","unstructured":"Del Prete G (1992) Human Th1 and Th2 lymphocytes: their role in the pathophysiology of atopy. Allergy 47(5):450\u2013455","journal-title":"Allergy"},{"issue":"6","key":"2476_CR9","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.7150\/ijbs.91519","volume":"20","author":"C Fang","year":"2024","unstructured":"Fang C, Zhong R, Lu S, Yu G, Liu Z, Yan C, Gao J, Tang Y, Wang Y, Zhao Q et al (2024) TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-\u03baB\/CXCL3 axis. Int J Biol Sci 20(6):1992\u20132007","journal-title":"Int J Biol Sci"},{"issue":"1","key":"2476_CR10","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1186\/s12967-023-04449-0","volume":"21","author":"X Feng","year":"2023","unstructured":"Feng X, Zhu S, Qiao J, Ji Z, Zhou B, Xu W (2023) CX3CL1 promotes M1 macrophage polarization and osteoclast differentiation through NF-kappaB signaling pathway in ankylosing spondylitis in vitro. J Transl Med 21(1):573","journal-title":"J Transl Med"},{"key":"2476_CR11","doi-asserted-by":"publisher","first-page":"948098","DOI":"10.1155\/2012\/948098","volume":"2012","author":"NB Hao","year":"2012","unstructured":"Hao NB, Lu MH, Fan YH, Cao YL, Zhang ZR, Yang SM (2012) Macrophages in tumor microenvironments and the progression of tumors. Clin Dev Immunol 2012:948098","journal-title":"Clin Dev Immunol"},{"issue":"1","key":"2476_CR12","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/S0169-328X(00)00042-5","volume":"77","author":"JR Heyen","year":"2000","unstructured":"Heyen JR, Ye S, Finck BN, Johnson RW (2000) Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-kappaB. Brain Res Mol brain Res 77(1):138\u2013147","journal-title":"Brain Res Mol brain Res"},{"key":"2476_CR13","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/978-1-0716-1225-5_11","volume":"2269","author":"MJ Hsu","year":"2021","unstructured":"Hsu MJ, Christ M, Christ B (2021) Co-culture of human mesenchymal stromal cells and primary mouse hepatocytes. Methods Mol Biol 2269:151\u2013165","journal-title":"Methods Mol Biol"},{"key":"2476_CR14","doi-asserted-by":"publisher","first-page":"611115","DOI":"10.3389\/fonc.2021.611115","volume":"11","author":"EM Kalogirou","year":"2021","unstructured":"Kalogirou EM, Tosios KI, Christopoulos PF (2021) The role of macrophages in oral squamous cell carcinoma. Front Oncol 11:611115","journal-title":"Front Oncol"},{"issue":"1","key":"2476_CR15","doi-asserted-by":"publisher","first-page":"15455","DOI":"10.1038\/s41598-021-94671-x","volume":"11","author":"T Katopodi","year":"2021","unstructured":"Katopodi T, Petanidis S, Domvri K, Zarogoulidis P, Anestakis D, Charalampidis C, Tsavlis D, Bai C, Huang H, Freitag L et al (2021) Kras-driven intratumoral heterogeneity triggers infiltration of M2 polarized macrophages via the circHIPK3\/PTK2 immunosuppressive circuit. Sci Rep 11(1):15455","journal-title":"Sci Rep"},{"issue":"11","key":"2476_CR16","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1038\/s41417-024-00811-6","volume":"31","author":"A Khan","year":"2024","unstructured":"Khan A, Zhang Y, Ma N, Shi J, Hou Y (2024) NF-\u03baB role on tumor proliferation, migration, invasion and immune escape. Cancer Gene Ther 31(11):1599\u20131610","journal-title":"Cancer Gene Ther"},{"key":"2476_CR17","doi-asserted-by":"publisher","first-page":"1485174","DOI":"10.3389\/fimmu.2024.1485174","volume":"15","author":"C Li","year":"2024","unstructured":"Li C, Dong X, Li B (2024) Tumor microenvironment in oral squamous cell carcinoma. Front Immunol 15:1485174","journal-title":"Front Immunol"},{"issue":"1","key":"2476_CR18","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s13046-024-03128-2","volume":"43","author":"CX Li","year":"2024","unstructured":"Li CX, Gong ZC, Yu JW (2024) Deliberation concerning the role of M1-type macrophage subset in oral carcinogenesis. J Experim Clin Cancer Res 43(1):220","journal-title":"J Experim Clin Cancer Res"},{"issue":"1","key":"2476_CR19","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12865-020-00355-y","volume":"21","author":"L Liu","year":"2020","unstructured":"Liu L, Guo H, Song A, Huang J, Zhang Y, Jin S, Li S, Zhang L, Yang C, Yang P (2020) Progranulin inhibits LPS-induced macrophage M1 polarization via NF-\u043aB and MAPK pathways. BMC Immunol 21(1):32","journal-title":"BMC Immunol"},{"issue":"1","key":"2476_CR20","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12964-020-00557-2","volume":"18","author":"Q Liu","year":"2020","unstructured":"Liu Q, Yang C, Wang S, Shi D, Wei C, Song J, Lin X, Dou R, Bai J, Xiang Z et al (2020) Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promotes colorectal cancer progression. Cell communication signaling: CCS 18(1):51","journal-title":"Cell communication signaling: CCS"},{"issue":"5","key":"2476_CR22","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s12032-025-02694-5","volume":"42","author":"H Mivehchi","year":"2025","unstructured":"Mivehchi H, Eskandari-Yaghbastlo A, Ghazanfarpour M, Ziaei S, Mesgari H, Faghihinia F, Zokaei Ashtiani N, Afjadi MN (2025) Microenvironment-based immunotherapy in oral cancer: a comprehensive review. Med Oncol (Northwood Lond Engl) 42(5):140","journal-title":"Med Oncol (Northwood Lond Engl)"},{"key":"2476_CR23","doi-asserted-by":"publisher","first-page":"1134661","DOI":"10.3389\/fimmu.2023.1134661","volume":"14","author":"M Mussbacher","year":"2023","unstructured":"Mussbacher M, Derler M, Basilio J, Schmid JA (2023) NF-kappaB in monocytes and macrophages - an inflammatory master regulator in multitalented immune cells. Front Immunol 14:1134661","journal-title":"Front Immunol"},{"key":"2476_CR21","doi-asserted-by":"crossref","unstructured":"Pekarek L, Garrido-Gil MJ, S\u00e1nchez-Cendra A, Cassinello J, Pekarek T, Fraile-Martinez O, Garc\u00eda-Montero C, Lopez-Gonzalez L, Rios-Parra A, \u00c1lvarez-Mon M et al (2023) Emerging histological and serological biomarkers in oral squamous cell carcinoma: applications in diagnosis, prognosis evaluation and personalized therapeutics (Review). Oncol Rep 50(6)","DOI":"10.3892\/or.2023.8650"},{"issue":"11","key":"2476_CR24","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1038\/s41419-020-03178-2","volume":"11","author":"L Peng","year":"2020","unstructured":"Peng L, Wen L, Shi QF, Gao F, Huang B, Meng J, Hu CP, Wang CM (2020) Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-\u03baB\/NLRP3-mediated epithelial-mesenchymal transition and inflammation. Cell Death Dis 11(11):978","journal-title":"Cell Death Dis"},{"issue":"3","key":"2476_CR25","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/s41568-022-00531-9","volume":"23","author":"AT Ruffin","year":"2023","unstructured":"Ruffin AT, Li H, Vujanovic L, Zandberg DP, Ferris RL, Bruno TC (2023) Improving head and neck cancer therapies by immunomodulation of the tumour microenvironment. Nat Rev Cancer 23(3):173\u2013188","journal-title":"Nat Rev Cancer"},{"key":"2476_CR26","doi-asserted-by":"crossref","unstructured":"Shao Q, Huang Y, Zhang C, Gao X, Gao S (2021) Emerging landscape of circHIPK3 and its role in cancer and other diseases (Review). Mol Med Rep 23(6)","DOI":"10.3892\/mmr.2021.12048"},{"key":"2476_CR27","doi-asserted-by":"crossref","unstructured":"Shutao Z, Shuo H, Yan L, Qing L, Tao L, Yiyi T, Tianyuan P, Conggai H, Haidong G, Xiaomei L (2024) NME4 suppresses NF\u03baB2-CCL5 axis, restricting CD8\u2009+\u2009T cell tumour infiltration in oesophageal squamous cell carcinoma. Immunology 173(2)","DOI":"10.1111\/imm.13838"},{"key":"2476_CR28","doi-asserted-by":"crossref","unstructured":"Shutao Z, Yan L, Yiyi T, Lu L, Qing L, Tao L, Xiaomei L (2022) Small tweaks, major changes: post-translational modifications that occur within M2 macrophages in the tumor microenvironment. Cancers (Basel) 14(22)","DOI":"10.3390\/cancers14225532"},{"key":"2476_CR29","doi-asserted-by":"publisher","first-page":"105925","DOI":"10.1016\/j.archoralbio.2024.105925","volume":"161","author":"VP Thakore","year":"2024","unstructured":"Thakore VP, Patel KD, Vora HH, Patel PS, Jain NK (2024) Up-regulation of extracellular-matrix and inflammation related genes in oral squamous cell carcinoma. Arch Oral Biol 161:105925","journal-title":"Arch Oral Biol"},{"key":"2476_CR30","doi-asserted-by":"publisher","first-page":"840029","DOI":"10.3389\/fimmu.2022.840029","volume":"13","author":"S Wang","year":"2022","unstructured":"Wang S, Liu G, Li Y, Pan Y (2022) Metabolic Reprogramming induces macrophage polarization in the tumor microenvironment. Front Immunol 13:840029","journal-title":"Front Immunol"},{"key":"2476_CR31","doi-asserted-by":"crossref","unstructured":"Wang H, Yung MMH, Ngan HYS, Chan KKL, Chan DW (2021) The impact of the tumor microenvironment on macrophage polarization in cancer metastatic progression. Int J Mol Sci 22(12)","DOI":"10.3390\/ijms22126560"},{"key":"2476_CR32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.canlet.2021.03.009","volume":"507","author":"G Wang","year":"2021","unstructured":"Wang G, Zhang M, Cheng M, Wang X, Li K, Chen J, Chen Z, Chen S, Chen J, Xiong G et al (2021) Tumor microenvironment in head and neck squamous cell carcinoma: functions and regulatory mechanisms. Cancer Lett 507:55\u201369","journal-title":"Cancer Lett"},{"issue":"24","key":"2476_CR33","doi-asserted-by":"publisher","first-page":"e2309298","DOI":"10.1002\/advs.202309298","volume":"11","author":"Y Wang","year":"2024","unstructured":"Wang Y, Zhang J, Shi H, Wang M, Yu D, Fu M, Qian Y, Zhang X, Ji R, Wang S et al (2024) M2 tumor-associated macrophages-derived exosomal MALAT1 promotes glycolysis and gastric cancer progression. Adv Sci (Weinh) 11(24):e2309298","journal-title":"Adv Sci (Weinh)"},{"key":"2476_CR35","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.3389\/fimmu.2020.01731","volume":"11","author":"K Wu","year":"2020","unstructured":"Wu K, Lin K, Li X, Yuan X, Xu P, Ni P, Xu D (2020) Redefining tumor-associated macrophage subpopulations and functions in the tumor microenvironment. Front Immunol 11:1731","journal-title":"Front Immunol"},{"key":"2476_CR34","doi-asserted-by":"publisher","first-page":"216643","DOI":"10.1016\/j.canlet.2024.216643","volume":"584","author":"QN Wu","year":"2024","unstructured":"Wu QN, Qi J, Liu ZK, Luo XJ, Yu K, Lu YX, Wang Y, Jin Y, Liu J, Huang LY et al (2024) HIPK3 maintains sensitivity to platinum drugs and prevents disease progression in gastric cancer. Cancer Lett 584:216643","journal-title":"Cancer Lett"},{"issue":"3","key":"2476_CR36","doi-asserted-by":"publisher","first-page":"3536","DOI":"10.18632\/aging.202294","volume":"13","author":"W Xiao","year":"2021","unstructured":"Xiao W, Wang T, Ye Y, Wang X, Chen B, Xing J, Yang H, Zhang X (2021) Identification of HIPK3 as a potential biomarker and an inhibitor of clear cell renal cell carcinoma. Aging 13(3):3536\u20133553","journal-title":"Aging"},{"key":"2476_CR37","doi-asserted-by":"publisher","first-page":"117252","DOI":"10.1016\/j.lfs.2019.117252","volume":"254","author":"Y Xie","year":"2020","unstructured":"Xie Y, Yuan X, Zhou W, Kosiba AA, Shi H, Gu J, Qin Z (2020) The circular RNA HIPK3 (circHIPK3) and its regulation in cancer progression: Review. Life Sci 254:117252","journal-title":"Life Sci"},{"key":"2476_CR38","doi-asserted-by":"publisher","first-page":"116930","DOI":"10.1016\/j.biopha.2024.116930","volume":"177","author":"W Zhang","year":"2024","unstructured":"Zhang W, Wang M, Ji C, Liu X, Gu B, Dong T (2024) Macrophage polarization in the tumor microenvironment: emerging roles and therapeutic potentials. Biomed Pharmacotherapy 177:116930","journal-title":"Biomed Pharmacotherapy"},{"issue":"1","key":"2476_CR39","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1186\/s13287-022-03094-6","volume":"13","author":"K Zheng","year":"2022","unstructured":"Zheng K, Ma Y, Chiu C, Pang Y, Gao J, Zhang C, Du D (2022) Co-culture pellet of human Wharton\u2019s jelly mesenchymal stem cells and rat costal chondrocytes as a candidate for articular cartilage regeneration: in vitro and in vivo study. Stem Cell Res Ther 13(1):386","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"2476_CR40","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s12672-022-00533-x","volume":"13","author":"WH Zhou","year":"2022","unstructured":"Zhou WH, Wang Y, Yan C, Du WD, Al-Aroomi MA, Zheng L, Lin SF, Gao JX, Jiang S, Wang ZX et al (2022) CC chemokine receptor 7 promotes macrophage recruitment and induces M2-polarization through CC chemokine ligand 19&21 in oral squamous cell carcinoma. Discover Oncol 13(1):67","journal-title":"Discover Oncol"},{"issue":"1","key":"2476_CR41","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s40168-024-01907-9","volume":"12","author":"J Zhou","year":"2024","unstructured":"Zhou J, Hu Z, Wang L, Hu Q, Chen Z, Lin T, Zhou R, Cai Y, Wu Z, Zhang Z et al (2024) Tumor-colonized Streptococcus mutans metabolically reprograms tumor microenvironment and promotes oral squamous cell carcinoma. Microbiome 12(1):193","journal-title":"Microbiome"},{"issue":"1","key":"2476_CR42","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s40164-021-00252-z","volume":"10","author":"S Zhu","year":"2021","unstructured":"Zhu S, Yi M, Wu Y, Dong B, Wu K (2021) Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies. Experimental Hematol Oncol 10(1):60","journal-title":"Experimental Hematol Oncol"}],"container-title":["Molecular Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-026-02476-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00438-026-02476-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-026-02476-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:03:20Z","timestamp":1782705800000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00438-026-02476-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2476"],"URL":"https:\/\/doi.org\/10.1007\/s00438-026-02476-2","relation":{},"ISSN":["1617-4615","1617-4623"],"issn-type":[{"value":"1617-4615","type":"print"},{"value":"1617-4623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"assertion":[{"value":"30 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"148"}}