{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:05:09Z","timestamp":1784693109137,"version":"3.55.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Supported by China Agriculture Research System of MOF and MARA","award":["CARS-43-A-1"],"award-info":[{"award-number":["CARS-43-A-1"]}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20231332"],"award-info":[{"award-number":["BK20231332"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018533","name":"Major Scientific and Technological Special Project of Guizhou Province","doi-asserted-by":"publisher","award":["2021C02068-7"],"award-info":[{"award-number":["2021C02068-7"]}],"id":[{"id":"10.13039\/501100018533","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Genet Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00438-026-02486-0","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:44:20Z","timestamp":1784691860000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of TRPV3 gene polymorphisms with wool production traits in Zhexi Angora rabbits"],"prefix":"10.1007","volume":"301","author":[{"given":"Rongrong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9871-0251","authenticated-orcid":false,"given":"Xinsheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"2486_CR1","doi-asserted-by":"publisher","first-page":"2664","DOI":"10.1038\/sj.jid.5700468","volume":"126","author":"M Asakawa","year":"2006","unstructured":"Asakawa M, Yoshioka T, Matsutani T, Hikita I, Suzuki M, Oshima I, Tsukahara K, Arimura A, Horikawa T, Hirasawa T, Sakata T (2006) Association of a mutation in TRPV3 with defective hair growth in rodents. J Investig Dermatol 126:2664\u20132672","journal-title":"J Investig Dermatol"},{"key":"2486_CR2","doi-asserted-by":"publisher","first-page":"ra70","DOI":"10.1126\/scisignal.2000602","volume":"2","author":"AM Ashique","year":"2009","unstructured":"Ashique AM, Choe Y, Karlen M, May SR, Phamluong K, Solloway MJ, Ericson J, Peterson AS (2009) The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis. Sci Signal 2:ra70","journal-title":"Sci Signal"},{"key":"2486_CR3","doi-asserted-by":"crossref","unstructured":"Bai WL, Dang YL, Wang JJ, Yin RH, Wang ZY, Zhu YB, Cong YY, Xue HL, Deng L, Guo D, Wang SQ, Yang SH (2016) Molecular characterization, expression and methylation status analysis of BMP4 gene in skin tissue of Liaoning cashmere goat during hair follicle cycle. Genetica 144:457\u2013\u200967","DOI":"10.1007\/s10709-016-9914-1"},{"key":"2486_CR4","doi-asserted-by":"crossref","unstructured":"Borb\u00edr\u00f3 I, Lisztes E, T\u00f3th B, Czifra G, Ol\u00e1h A, Sz\u00f6ll\u0151si AG, Norbert S, P\u00e9ter PN, Zolt\u00e1n P, Ralf P, L\u00e1szl\u00f3 K, Tam\u00e1s B (2011) Activation of transient receptor potential Vanilloid-3 inhibits human hair growth. J Investig Dermatol 131:1605\u20131614","DOI":"10.1038\/jid.2011.122"},{"key":"2486_CR5","doi-asserted-by":"crossref","unstructured":"Botchkarev VA, Sharov AA (2004) BMP signaling in the control of skin development and hair follicle growth. Differentiation 72:512\u2013526","DOI":"10.1111\/j.1432-0436.2004.07209005.x"},{"key":"2486_CR6","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.3390\/agriculture12111858","volume":"12","author":"J Cai","year":"2022","unstructured":"Cai J, Zhao B, Li J, Bao Z, Chen Y, Liu Y, Wu X (2022) A single nucleotide polymorphism in the WIF1 promoter region regulates the wool length in rabbits. Agriculture 12:1858","journal-title":"Agriculture"},{"key":"2486_CR8","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.4238\/2011.November.4.1","volume":"10","author":"SJ Chen","year":"2011","unstructured":"Chen SJ, Liu T, Liu YJ, Dong B, Huang YT, Gu ZL (2011) Identification of single nucleotide polymorphisms in the CCNA2 gene and its association with wool density in Rex rabbits. Genet Mol Res 10:3365\u20133370","journal-title":"Genet Mol Res"},{"key":"2486_CR7","doi-asserted-by":"publisher","first-page":"E8403","DOI":"10.1073\/pnas.1800949115","volume":"115","author":"B Chen","year":"2018","unstructured":"Chen B, Niu J, Kreuzer J, Zheng B, Jarugumilli GK, Haas W, Wu X (2018) Auto-fatty acylation of transcription factor RFX3 regulates ciliogenesis. Proc Natl Acad Sci USA 115:E8403\u2013e12","journal-title":"Proc Natl Acad Sci USA"},{"key":"2486_CR9","doi-asserted-by":"crossref","unstructured":"Chen Y, Bao Z, Liu M, Li J, Dai Y, Wang F, Zhang X, Zhai P, Zhao B, Wu X (2022) Promoter methylation changes in KRT17: a novel epigenetic marker for wool production in Angora rabbit. Int J Mol Sci 23:6077","DOI":"10.3390\/ijms23116077"},{"key":"2486_CR10","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.ydbio.2011.12.029","volume":"363","author":"MI Chung","year":"2012","unstructured":"Chung MI, Peyrot SM, LeBoeuf S, Park TJ, McGary KL, Marcotte EM, Wallingford JB (2012) RFX2 is broadly required for ciliogenesis during vertebrate development. Dev Biol 363:155\u2013165","journal-title":"Dev Biol"},{"key":"2486_CR11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/age.13024","volume":"52","author":"K Doro\u017cy\u0144ska","year":"2021","unstructured":"Doro\u017cy\u0144ska K, Maj D (2021) Rabbits\u2014their domestication and molecular genetics of hair coat development and quality. Anim Genet 52:10\u201320","journal-title":"Anim Genet"},{"key":"2486_CR12","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1186\/s12864-024-10583-w","volume":"25","author":"S Farhangi","year":"2024","unstructured":"Farhangi S, G\u00f2dia M, Derks MFL, Harlizius B, Dibbits B, Gonz\u00e1lez-Prendes R, Crooijmans R, Madsen O, Groenen MAM (2024) Expression genome-wide association study identifies key regulatory variants enriched with metabolic and immune functions in four porcine tissues. BMC Genomics 25:684","journal-title":"BMC Genomics"},{"key":"2486_CR13","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1186\/s12864-023-09405-2","volume":"24","author":"N Fatima","year":"2023","unstructured":"Fatima N, Jia L, Liu B, Li L, Bai L, Wang W, Zhao S, Wang R, Liu E (2023) A homozygous missense mutation in the fibroblast growth factor 5 gene is associated with the long-hair trait in Angora rabbits. BMC Genomics 24:298","journal-title":"BMC Genomics"},{"key":"2486_CR14","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1096\/fasebj.14.5.752","volume":"14","author":"K Foitzik","year":"2000","unstructured":"Foitzik K, Lindner G, Mueller-Roever S, Maurer M, Botchkareva N, Botchkarev V, Handjiski B, Metz M, Hibino T, Soma T, Dotto GP, Paus R (2000) Control of murine hair follicle regression (catagen) by TGF-beta1 in vivo. Faseb J 14:752\u2013760","journal-title":"Faseb J"},{"key":"2486_CR15","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.stem.2014.09.009","volume":"15","author":"M Genander","year":"2014","unstructured":"Genander M, Cook PJ, Ramsk\u00f6ld D, Keyes BE, Mertz AF, Sandberg R, Fuchs E (2014) BMP signaling and its pSMAD1\/5 target genes differentially regulate hair follicle stem cell lineages. Cell Stem Cell 15:619\u2013633","journal-title":"Cell Stem Cell"},{"key":"2486_CR16","doi-asserted-by":"crossref","unstructured":"Gentile P, Garcovich S (2019) Advances in regenerative stem cell therapy in androgenic alopecia and hair loss: Wnt pathway, growth-factor, and mesenchymal stem cell signaling impact analysis on cell growth and hair follicle development. Cells 8:466","DOI":"10.3390\/cells8050466"},{"key":"2486_CR17","doi-asserted-by":"publisher","first-page":"e52301","DOI":"10.15252\/embr.202052301","volume":"22","author":"A Geueke","year":"2021","unstructured":"Geueke A, Mantellato G, Kuester F, Schettina P, Nelles M, Seeger JM, Kashkar H, Niemann C (2021) The anti-apoptotic Bcl-2 protein regulates hair follicle stem cell function. EMBORep 22:e52301","journal-title":"EMBO Rep"},{"key":"2486_CR18","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/s12935-021-01952-6","volume":"21","author":"J Issac","year":"2021","unstructured":"Issac J, Raveendran PS, Das AV (2021) RFX1: a promising therapeutic arsenal against cancer. Cancer Cell Int 21:253","journal-title":"Cancer Cell Int"},{"key":"2486_CR19","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1248\/bpb.b23-00276","volume":"47","author":"T Iwabuchi","year":"2024","unstructured":"Iwabuchi T, Ogura K, Hagiwara K, Ueno S, Kitamura H, Yamanishi H, Tsunekawa Y, Kiso A (2024) Ginsenosides in Panax ginseng extract promote anagen transition by suppressing BMP4 expression and promote human hair growth by stimulating follicle-cell proliferation. Biol Pharm Bull 47:240\u2013244","journal-title":"Biol Pharm Bull"},{"key":"2486_CR20","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1034\/j.1600-0625.2001.100402.x","volume":"10","author":"CA Jahoda","year":"2001","unstructured":"Jahoda CA, Oliver RF, Reynolds AJ, Forrester JC, Gillespie JW, Cserhalmi-Friedman PB, Christiano AM, Horne KA (2001) Trans-species hair growth induction by human hair follicle dermal papillae. Exp Dermatol 10:229\u2013237","journal-title":"Exp Dermatol"},{"key":"2486_CR21","doi-asserted-by":"publisher","first-page":"79","DOI":"10.5021\/ad.2014.26.1.79","volume":"26","author":"BK Kim","year":"2014","unstructured":"Kim BK, Yoon SK (2014) Expression of sfrp2 is increased in catagen of hair follicles and inhibits keratinocyte proliferation. Ann Dermatol 26:79\u201387","journal-title":"Ann Dermatol"},{"key":"2486_CR22","doi-asserted-by":"publisher","first-page":"6664","DOI":"10.1093\/emboj\/19.24.6664","volume":"19","author":"H Kulessa","year":"2000","unstructured":"Kulessa H, Turk G, Hogan BL (2000) Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle. Embo J 19:6664\u20136674","journal-title":"Embo J"},{"key":"2486_CR23","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3724\/SP.J.1005.2008.00893","volume":"30","author":"CX Li","year":"2008","unstructured":"Li CX, Jiang MS, Chen SY, Lai SJ (2008) Correlation analysis between single nucleotide polymorphism of FGF5 gene and wool yield in rabbits. Yi Chuan 30:893\u2013899","journal-title":"Yi Chuan"},{"key":"2486_CR24","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.gene.2009.11.010","volume":"451","author":"F Li","year":"2010","unstructured":"Li F, Murthy KS, Khalili K, Hu W (2010) Cloning and characterization of rabbit Rgs4 promoter in gut smooth muscle. Gene 451:45\u201353","journal-title":"Gene"},{"key":"2486_CR25","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ghir.2014.03.004","volume":"24","author":"J Li","year":"2014","unstructured":"Li J, Yang Z, Li Z, Gu L, Wang Y, Sung C (2014) Exogenous IGF-1 promotes hair growth by stimulating cell proliferation and down regulating TGF-\u03b21 in C57BL\/6 mice in vivo. Growth Horm IGF Res 24:89\u201394","journal-title":"Growth Horm IGF Res"},{"key":"2486_CR27","doi-asserted-by":"publisher","first-page":"111793","DOI":"10.1016\/j.biopha.2021.111793","volume":"141","author":"S Li","year":"2021","unstructured":"Li S, Chen J, Chen F, Wang C, Guo X, Wang C, Fan Y, Wang Y, Peng Y, Li W (2021) Liposomal honokiol promotes hair growth via activating Wnt3a\/\u03b2-catenin signaling pathway and down regulating TGF-\u03b21 in C57BL\/6\u00a0N mice. Biomed Pharmacother 141:111793","journal-title":"Biomed Pharmacother"},{"key":"2486_CR26","doi-asserted-by":"crossref","unstructured":"Li J, Zhao B, Yao S, Dai Y, Zhang X, Yang N, Bao Z, Cai J, Chen Y, Wu X (2023) Dermal papillacell-derived exosomes regulate hair follicle stem cell proliferation via LEF1. Int J Mol Sci 24:3961","DOI":"10.3390\/ijms24043961"},{"key":"2486_CR28","doi-asserted-by":"crossref","unstructured":"Liang Y, Tang X, Zhang X, Cao C, Yu M, Wan M (2023) Adipose mesenchymal stromal cell-derived exosomes carrying MiR-122-5p antagonize the inhibitory effect of dihydrotestosterone on hair follicles by targeting the TGF-\u03b21\/SMAD3 signaling pathway. Int J Mol Sci 24:5703","DOI":"10.3390\/ijms24065703"},{"key":"2486_CR29","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.jid.2017.01.012","volume":"137","author":"X Ma","year":"2017","unstructured":"Ma X, Tian Y, Song Y, Shi J, Xu J, Xiong K, Li J, Xu W, Zhao Y, Shuai J, Chen L, Plikus MV, Lengner CJ, Ren F, Xue L, Yu Z (2017) Msi2 maintains quiescent state of hair follicle stem cells by directly repressing the Hh signaling pathway. J Investig Dermatol 137:1015\u20131024","journal-title":"J Invest Dermatol"},{"key":"2486_CR30","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1007\/s00403-018-1868-y","volume":"310","author":"J Meephansan","year":"2018","unstructured":"Meephansan J, Pongcharoensuk T, Thummakriengkrai J, Ponnikorn S, Yingmema W, Deenonpoe R (2018) Effect of tofacitinib on the expression of noggin\/BMP-4 and hair growth stimulation in mice. Arch Dermatol Res 310:843\u2013848","journal-title":"Arch Dermatol Res"},{"key":"2486_CR31","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/sj.jidsp.5640228","volume":"4","author":"S M\u00fcller-R\u00f6ver","year":"1999","unstructured":"M\u00fcller-R\u00f6ver S, Rossiter H, Lindner G, Peters EM, Kupper TS, Paus R (1999) Hair follicle apoptosis and Bcl-2. J Investig Dermatol Symp Proc 4:272\u2013277","journal-title":"J Investig Dermatol Symp Proc"},{"key":"2486_CR32","doi-asserted-by":"crossref","unstructured":"Simonson L, Oldham E, Chang H (2022) Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development. Development 149:dev200816","DOI":"10.1242\/dev.200816"},{"key":"2486_CR33","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1016\/j.jid.2020.11.036","volume":"141","author":"Z Song","year":"2021","unstructured":"Song Z, Chen X, Zhao Q, Stanic V, Lin Z, Yang S, Chen T, Chen J, Yang Y (2021) Hair loss caused by gain-of-function mutant TRPV3 is associated with premature differentiation of follicular keratinocytes. J Investig Dermatol 141:1964\u20131974","journal-title":"J Investig Dermatol"},{"key":"2486_CR34","doi-asserted-by":"crossref","unstructured":"Sun H, He Z, Xi Q, Zhao F, Hu J, Wang J, Liu X, Zhao Z, Li M, Luo Y, Li S (2022) Lef1 and Dlx3 may facilitate the maturation of secondary hair follicles in the skin of Gansu Alpine Merino. Genes (Basel) 13:1326","DOI":"10.3390\/genes13081326"},{"key":"2486_CR35","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.canlet.2015.12.013","volume":"374","author":"K Suyama","year":"2016","unstructured":"Suyama K, Onishi H, Imaizumi A, Shinkai K, Umebayashi M, Kubo M, Mizuuchi Y, Oda Y, Tanaka M, Nakamura M, Katano M (2016) CD24 suppresses malignant phenotype by downregulation of SHH transcription through STAT1 inhibition in breast cancer cells. Cancer Lett 374:44\u201353","journal-title":"Cancer Lett"},{"key":"2486_CR36","doi-asserted-by":"crossref","unstructured":"Welle MM (2023) Basic principles of hair follicle structure, morphogenesis, and regeneration. Vet Pathol 60:732\u2009\u2013\u200947","DOI":"10.1177\/03009858231176561"},{"key":"2486_CR37","doi-asserted-by":"crossref","unstructured":"Wen S, Zou R, Du X, Pan R, Li R, Xia J, Xu C, Wang R, Jiang F, Zhou G, Feng J, Zhu M, Wang X, Shen B (2024) Identification of macrophage-related genes correlated with prognosis and immunotherapy efficacy in non-small cell lung cancer. Heliyon 10:e27170","DOI":"10.1016\/j.heliyon.2024.e27170"},{"key":"2486_CR38","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1101\/gad.187401.112","volume":"26","author":"WM Woo","year":"2012","unstructured":"Woo WM, Zhen HH, Oro AE (2012) Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop. Genes Dev 26:1235\u20131246","journal-title":"Genes Dev"},{"key":"2486_CR39","doi-asserted-by":"publisher","first-page":"603","DOI":"10.7150\/ijms.15571","volume":"13","author":"Y Xing","year":"2016","unstructured":"Xing Y, Ma X, Guo H, Deng F, Yang J, Li Y (2016) Wnt5a suppresses \u03b2-catenin signaling during hair follicle regeneration. Int J Med Sci 13:603\u2013610","journal-title":"Int J Med Sci"},{"key":"2486_CR41","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1124\/jpet.119.258087","volume":"370","author":"K Yan","year":"2019","unstructured":"Yan K, Sun X, Wang G, Liu Y, Wang K (2019) Pharmacological activation of thermo-transient receptor potential Vanilloid 3 channels inhibits hair growth by inducing cell death of hair follicle outer root sheath. J Pharmacol Exp Ther 370:299\u2013307","journal-title":"J Pharmacol Exp Ther"},{"key":"2486_CR40","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1089\/dna.2021.0288","volume":"41","author":"H Yan","year":"2022","unstructured":"Yan H, Jin M, Li Y, Gao Y, Ding Q, Wang X, Zeng W, Chen Y (2022) miR-1 regulates differentiation and proliferation of goat hair follicle stem cells by targeting IGF1R and LEF1 genes. DNA Cell Biol 41:190\u2013201","journal-title":"DNA Cell Biol"},{"key":"2486_CR42","doi-asserted-by":"publisher","first-page":"20329","DOI":"10.1002\/jcp.28633","volume":"234","author":"B Zhao","year":"2019","unstructured":"Zhao B, Chen Y, Yang N, Chen Q, Bao Z, Liu M, Hu S, Li J, Wu X (2019) miR-218-5p regulates skin and hair follicle development through Wnt\/\u03b2-catenin signaling pathway by targeting SFRP2. J Cell Physiol 234:20329\u201320341","journal-title":"J Cell Physiol"},{"key":"2486_CR43","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1111\/exd.12539","volume":"23","author":"X Zhu","year":"2014","unstructured":"Zhu X, Wu Y, Huang S, Chen Y, Tao Y, Wang Y, He S, Shen S, Wu J, Guo X, Li B, He L, Ma G (2014) Overexpression of Wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development. Exp Dermatol 23:926\u2013928","journal-title":"Exp Dermatol"}],"container-title":["Molecular Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-026-02486-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00438-026-02486-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-026-02486-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:44:23Z","timestamp":1784691863000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00438-026-02486-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2486"],"URL":"https:\/\/doi.org\/10.1007\/s00438-026-02486-0","relation":{},"ISSN":["1617-4615","1617-4623"],"issn-type":[{"value":"1617-4615","type":"print"},{"value":"1617-4623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"assertion":[{"value":"13 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"No potential conflict of interest was reported by the author(s).","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal study protocol was approved by the Animal Protection and Use Committee of Yangzhou University approved all the animal experimental procedures (No. 202103358). The animals were used in accordance with Laboratory Animal Requirements of Environment and Housing Facilities (GB14925-2001).","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"159"}}