{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:13:00Z","timestamp":1792782780043,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"2024 National College Student Innovation and Entrepreneurship Training Program","award":["202410440038"],"award-info":[{"award-number":["202410440038"]}]},{"name":"2024 National College Student Innovation and Entrepreneurship Training Program","award":["202410440009"],"award-info":[{"award-number":["202410440009"]}]},{"name":"Doctoral Projects of Lishui University","award":["QDZK112023003"],"award-info":[{"award-number":["QDZK112023003"]}],"id":[{"id":"https:\/\/ror.org\/0418kp584","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Genet Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00438-026-02509-w","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:42:42Z","timestamp":1789785762000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The phosphate specific transport system protein PhoU modulates persister cell formation of Klebsiella pneumoniae"],"prefix":"10.1007","volume":"301","author":[{"given":"Yanxin","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenru","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoping","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingcun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimai","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouyan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"2509_CR2","doi-asserted-by":"publisher","first-page":"1141538","DOI":"10.3389\/fpls.2023.1141538","volume":"14","author":"N Ali","year":"2023","unstructured":"Ali N, Swarnkar MK, Veer R, Kaushal P, Pati AM (2023) Temperature-induced modulation of stress-tolerant PGP genes bioprospected from Bacillus sp. IHBT-705 associated with saffron (Crocus sativus) rhizosphere: A natural -treasure trove of microbial biostimulants. Front Plant Sci 14:1141538. https:\/\/doi.org\/10.3389\/fpls.2023.1141538","journal-title":"Front Plant Sci"},{"key":"2509_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ymeth.2019.07.013","volume":"172","author":"OS Alkhnbashi","year":"2020","unstructured":"Alkhnbashi OS, Meier T, Mitrofanov A, Backofen R, Vo\u00df B (2020) CRISPR-Cas bioinformatics. Methods 172:3\u201311. https:\/\/doi.org\/10.1016\/j.ymeth.2019.07.013","journal-title":"Methods"},{"issue":"45","key":"2509_CR1","doi-asserted-by":"publisher","first-page":"34269","DOI":"10.1074\/jbc.M605763200","volume":"281","author":"AM Augustus","year":"2006","unstructured":"Augustus AM, Reardon PN, Heller WT, Spicer LD (2006) Structural basis for the differential regulation of DNA by the methionine repressor MetJ. J Biol Chem 281(45):34269\u201334276. https:\/\/doi.org\/10.1074\/jbc.M605763200","journal-title":"J Biol Chem"},{"issue":"1","key":"2509_CR4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.tim.2014.09.004","volume":"23","author":"M Ayrapetyan","year":"2015","unstructured":"Ayrapetyan M, Williams TC, Oliver JD (2015) Bridging the gap between viable but non-culturable and antibiotic persistent bacteria. Trends Microbiol 23(1):7\u201313. https:\/\/doi.org\/10.1016\/j.tim.2014.09.004","journal-title":"Trends Microbiol"},{"issue":"3","key":"2509_CR5","doi-asserted-by":"publisher","first-page":"e602","DOI":"10.1093\/cid\/ciaa1712","volume":"73","author":"SM Bart","year":"2021","unstructured":"Bart SM, Rubin D, Kim P, Farley JJ, Nambiar S (2021) Trends in Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia Trials. Clin Infect Dis 73(3):e602\u2013e608. https:\/\/doi.org\/10.1093\/cid\/ciaa1712","journal-title":"Clin Infect Dis"},{"issue":"6320","key":"2509_CR6","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0140-6736(00)74210-3","volume":"244","author":"JW Bigger","year":"1944","unstructured":"Bigger JW (1944) Treatment of staphylococcal infections with penicillin by intermittent sterilisation. Lancet 244(6320):497\u2013500. https:\/\/doi.org\/10.1016\/S0140-6736(00)74210-3","journal-title":"Lancet"},{"issue":"9","key":"2509_CR7","doi-asserted-by":"publisher","first-page":"e0164224","DOI":"10.1128\/mbio.01642-24","volume":"15","author":"RE Bruna","year":"2024","unstructured":"Bruna RE, Kendra CG, Pontes MH (2024) An intracellular phosphorus-starvation signal activates the PhoB\/PhoR two-component system in Salmonella enterica. mBio 15(9):e0164224. https:\/\/doi.org\/10.1128\/mbio.01642-24","journal-title":"mBio"},{"key":"2509_CR8","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jpba.2014.12.017","volume":"113","author":"R Bujak","year":"2015","unstructured":"Bujak R, Struck-Lewicka W, Markuszewski MJ, Kaliszan R (2015) Metabolomics for laboratory diagnostics. J Pharm Biomed Anal 113:108\u2013120. https:\/\/doi.org\/10.1016\/j.jpba.2014.12.017","journal-title":"J Pharm Biomed Anal"},{"key":"2509_CR9","unstructured":"Clinical and Laboratory Standards Institute (2025) Performance Standards for Antimicrobial Susceptibility Testing (35th ed., CLSI supplement M100). Clinical and Laboratory Standards Institute"},{"issue":"11","key":"2509_CR10","doi-asserted-by":"publisher","first-page":"6876","DOI":"10.1128\/AEM.01176-06","volume":"72","author":"E Darmon","year":"2006","unstructured":"Darmon E, Dorenbos R, Meens J, Freudl R, Antelmann H, Hecker M, Kuipers OP, Bron S, Quax WJ, Dubois JY, van Dijl JM (2006) A disulfide bond-containing alkaline phosphatase triggers a BdbC-dependent secretion stress response in Bacillus subtilis. Appl Environ Microbiol 72(11):6876\u20136885. https:\/\/doi.org\/10.1128\/AEM.01176-06","journal-title":"Appl Environ Microbiol"},{"key":"2509_CR11","doi-asserted-by":"publisher","first-page":"900848","DOI":"10.3389\/fcimb.2022.900848","volume":"12","author":"W Eisenreich","year":"2022","unstructured":"Eisenreich W, Rudel T, Heesemann J, Goebel W (2022) Link Between Antibiotic Persistence and Antibiotic Resistance in Bacterial Pathogens. Front Cell Infect Microbiol 12:900848. https:\/\/doi.org\/10.3389\/fcimb.2022.900848","journal-title":"Front Cell Infect Microbiol"},{"issue":"Pt 8","key":"2509_CR12","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1099\/mic.0.077826-0","volume":"160","author":"MP Ferla","year":"2014","unstructured":"Ferla MP, Patrick WM (2014) Bacterial methionine biosynthesis. Microbiol (Reading) 160(Pt 8):1571\u20131584. https:\/\/doi.org\/10.1099\/mic.0.077826-0","journal-title":"Microbiol (Reading)"},{"issue":"3","key":"2509_CR16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00203-025-04251-0","volume":"207","author":"T George","year":"2025","unstructured":"George T, Sivam V, Vaiyapuri M, Anandan R, Sivaraman GK, Joseph TC (2025) Standardizing biofilm quantification: harmonizing crystal violet absorbance measurements through extinction coefficient ratio adjustment. Arch Microbiol 207(3):59. https:\/\/doi.org\/10.1007\/s00203-025-04251-0","journal-title":"Arch Microbiol"},{"issue":"4","key":"2509_CR14","first-page":"221","volume":"12","author":"M Ghane","year":"2020","unstructured":"Ghane M, Babaeekhou L, Ketabi SS (2020) Antibiofilm Activity of Kefir Probiotic Lactobacilli Against Uropathogenic Escherichia coli (UPEC). Avicenna J Med Biotechnol 12(4):221\u2013229","journal-title":"Avicenna J Med Biotechnol"},{"issue":"1","key":"2509_CR13","doi-asserted-by":"publisher","first-page":"6877","DOI":"10.1038\/s41467-024-51347-0","volume":"15","author":"DA Gray","year":"2024","unstructured":"Gray DA, Wang B, Sidarta M, Cornejo FA, Wijnheijmer J, Rani R, Gamba P, Turgay K, Wenzel M, Strahl H, Hamoen LW (2024) Membrane depolarization kills dormant Bacillus subtilis cells by generating a lethal dose of ROS. Nat Commun 15(1):6877. https:\/\/doi.org\/10.1038\/s41467-024-51347-0","journal-title":"Nat Commun"},{"issue":"11","key":"2509_CR15","doi-asserted-by":"publisher","first-page":"18572","DOI":"10.1002\/jcb.29201","volume":"120","author":"N Gupta","year":"2019","unstructured":"Gupta N, Maurya S, Verma H, Verma VK (2019) Unraveling the factors and mechanism involved in persistence: Host-pathogen interactions in Helicobacter pylori. J Cell Biochem 120(11):18572\u201318587. https:\/\/doi.org\/10.1002\/jcb.29201","journal-title":"J Cell Biochem"},{"issue":"12","key":"2509_CR17","doi-asserted-by":"publisher","first-page":"e51034","DOI":"10.15252\/embr.202051034","volume":"21","author":"M Huemer","year":"2020","unstructured":"Huemer M, Mairpady Shambat S, Brugger SD, Zinkernagel AS (2020) Antibiotic resistance and persistence-Implications for human health and treatment perspectives. EMBO Rep 21(12):e51034. https:\/\/doi.org\/10.15252\/embr.202051034","journal-title":"EMBO Rep"},{"key":"2509_CR19","doi-asserted-by":"publisher","unstructured":"Jochim A, Shi T, Belikova D, Schwarz S, Peschel A, Heilbronner S (2019) Methionine Limitation Impairs Pathogen Expansion and Biofilm Formation Capacity. Appl Environ Microbiol 85(9). https:\/\/doi.org\/10.1128\/aem.00177-19","DOI":"10.1128\/aem.00177-19"},{"issue":"1","key":"2509_CR20","doi-asserted-by":"publisher","first-page":"2721","DOI":"10.1080\/21505594.2021.1990660","volume":"12","author":"H Joshi","year":"2021","unstructured":"Joshi H, Kandari D, Bhatnagar R (2021) Insights into the molecular determinants involved in Mycobacterium tuberculosis persistence and their therapeutic implications. Virulence 12(1):2721\u20132749. https:\/\/doi.org\/10.1080\/21505594.2021.1990660","journal-title":"Virulence"},{"key":"2509_CR21","doi-asserted-by":"publisher","unstructured":"Jurado-Mart\u00edn I, Sainz-Mej\u00edas M, McClean S (2021) Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors. Int J Mol Sci 22(6). https:\/\/doi.org\/10.3390\/ijms22063128","DOI":"10.3390\/ijms22063128"},{"issue":"3","key":"2509_CR22","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1111\/j.1574-6976.2008.00101.x","volume":"32","author":"MG Lamarche","year":"2008","unstructured":"Lamarche MG, Wanner BL, Cr\u00e9pin S, Harel J (2008) The phosphate regulon and bacterial virulence: a regulatory network connecting phosphate homeostasis and pathogenesis. FEMS Microbiol Rev 32(3):461\u2013473. https:\/\/doi.org\/10.1111\/j.1574-6976.2008.00101.x","journal-title":"FEMS Microbiol Rev"},{"issue":"12","key":"2509_CR28","doi-asserted-by":"publisher","first-page":"6593","DOI":"10.1128\/jb.171.12.6593-6599.1989","volume":"171","author":"TY Lee","year":"1989","unstructured":"Lee TY, Makino K, Shinagawa H, Amemura M, Nakata A (1989) Phosphate regulon in members of the family Enterobacteriaceae: comparison of the phoB-phoR operons of Escherichia coli, Shigella dysenteriae, and Klebsiella pneumoniae. J Bacteriol 171(12):6593\u20136599. https:\/\/doi.org\/10.1128\/jb.171.12.6593-6599.1989","journal-title":"J Bacteriol"},{"issue":"1","key":"2509_CR23","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/nrmicro1557","volume":"5","author":"K Lewis","year":"2007","unstructured":"Lewis K (2007) Persister cells, dormancy and infectious disease. Nat Rev Microbiol 5(1):48\u201356. https:\/\/doi.org\/10.1038\/nrmicro1557","journal-title":"Nat Rev Microbiol"},{"key":"2509_CR24","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1146\/annurev.micro.112408.134306","volume":"64","author":"K Lewis","year":"2010","unstructured":"Lewis K (2010) Persister cells. Annu Rev Microbiol 64:357\u2013372. https:\/\/doi.org\/10.1146\/annurev.micro.112408.134306","journal-title":"Annu Rev Microbiol"},{"issue":"6","key":"2509_CR26","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1128\/aac.00052-07","volume":"51","author":"Y Li","year":"2007","unstructured":"Li Y, Zhang Y (2007) PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. Antimicrob Agents Chemother 51(6):2092\u20132099. https:\/\/doi.org\/10.1128\/aac.00052-07","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"2509_CR25","doi-asserted-by":"publisher","first-page":"20230707","DOI":"10.1515\/med-2023-0707","volume":"18","author":"Y Li","year":"2023","unstructured":"Li Y, Kumar S, Zhang L, Wu H, Wu H (2023) Characteristics of antibiotic resistance mechanisms and genes of Klebsiella pneumoniae. Open Med (Wars) 18(1):20230707. https:\/\/doi.org\/10.1515\/med-2023-0707","journal-title":"Open Med (Wars)"},{"key":"2509_CR27","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.99194","author":"H Liao","year":"2024","unstructured":"Liao H, Yan X, Wang C, Huang C, Zhang W, Xiao L, Jiang J, Bao Y, Huang T, Zhang H, Guo C, Zhang Y, Pu Y (2024) Cyclic di-GMP as an antitoxin regulates bacterial genome stability and antibiotic persistence in biofilms. Elife 13. https:\/\/doi.org\/10.7554\/eLife.99194","journal-title":"Elife 13"},{"issue":"8","key":"2509_CR30","doi-asserted-by":"publisher","first-page":"e1012495","DOI":"10.1371\/journal.ppat.1012495","volume":"20","author":"HLT Mobley","year":"2024","unstructured":"Mobley HLT, Anderson MT, Moricz BS, Severin GB, Holmes CL, Ottosen EN, Eichler T, Gupta S, Paudel S, Sinha R, Mason S, Himpsl SD, Brown AN, Gaca M, Kiser CM, Clarke TH, Fouts DE, DiRita VJ, Bachman MA (2024) Fitness factor genes conserved within the multi-species core genome of Gram-negative Enterobacterales species contribute to bacteremia pathogenesis. PLoS Pathog 20(8):e1012495. https:\/\/doi.org\/10.1371\/journal.ppat.1012495","journal-title":"PLoS Pathog"},{"issue":"24","key":"2509_CR29","doi-asserted-by":"publisher","first-page":"7905","DOI":"10.1128\/AEM.01952-13","volume":"79","author":"EA Mordukhova","year":"2013","unstructured":"Mordukhova EA, Pan JG (2013) Evolved cobalamin-independent methionine synthase (MetE) improves the acetate and thermal tolerance of Escherichia coli. Appl Environ Microbiol 79(24):7905\u20137915. https:\/\/doi.org\/10.1128\/AEM.01952-13","journal-title":"Appl Environ Microbiol"},{"issue":"6058","key":"2509_CR31","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1126\/science.1211037","volume":"334","author":"D Nguyen","year":"2011","unstructured":"Nguyen D, Joshi-Datar A, Lepine F, Bauerle E, Olakanmi O, Beer K, McKay G, Siehnel R, Schafhauser J, Wang Y, Britigan BE, Singh PK (2011) Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria. Science 334(6058):982\u2013986. https:\/\/doi.org\/10.1126\/science.1211037","journal-title":"Science"},{"key":"2509_CR32","doi-asserted-by":"publisher","unstructured":"Oliveira M, Antunes W, Mota S, Madureira-Carvalho \u00c1, Dinis-Oliveira RJ, da Silva D, D (2024) An Overview of the Recent Advances in Antimicrobial Resistance. Microorganisms 12(9). https:\/\/doi.org\/10.3390\/microorganisms12091920","DOI":"10.3390\/microorganisms12091920"},{"key":"2509_CR33","doi-asserted-by":"publisher","unstructured":"Pacios O, Herrera-Espejo S, Arm\u00e1n L, Ibarguren-Quiles C, Blasco L, Bleriot I, Fern\u00e1ndez-Garc\u00eda L, Ortiz-Cartagena C, Paniagua M, Barrio-Pujante A, Aracil B, Cisneros JM, Pach\u00f3n-Ib\u00e1\u00f1ez ME, Tom\u00e1s M (2024) Mitomycin C as an Anti-Persister Strategy against Klebsiella pneumoniae: Toxicity and Synergy Studies. Antibiot (Basel) 13(9). https:\/\/doi.org\/10.3390\/antibiotics13090815","DOI":"10.3390\/antibiotics13090815"},{"key":"2509_CR34","doi-asserted-by":"publisher","unstructured":"Pan X, Sun C, Tang M, You J, Osire T, Zhao Y, Xu M, Zhang X, Shao M, Yang S, Yang T, Rao Z (2020) LysR-Type Transcriptional Regulator MetR Controls Prodigiosin Production, Methionine Biosynthesis, Cell Motility, H(2)O(2) Tolerance, Heat Tolerance, and Exopolysaccharide Synthesis in Serratia marcescens. Appl Environ Microbiol 86(4). https:\/\/doi.org\/10.1128\/aem.02241-19","DOI":"10.1128\/aem.02241-19"},{"issue":"1","key":"2509_CR37","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1128\/jb.166.1.205-211.1986","volume":"166","author":"NN Rao","year":"1986","unstructured":"Rao NN, Wang E, Yashphe J, Torriani A (1986) Nucleotide pool in pho regulon mutants and alkaline phosphatase synthesis in Escherichia coli. J Bacteriol 166(1):205\u2013211. https:\/\/doi.org\/10.1128\/jb.166.1.205-211.1986","journal-title":"J Bacteriol"},{"issue":"10","key":"2509_CR18","doi-asserted-by":"publisher","first-page":"e912","DOI":"10.1002\/cpz1.912","volume":"3","author":"BE Ring","year":"2023","unstructured":"Ring BE, Khadka S, Pariseau DA, Mike LA (2023) Genetic Manipulation of Klebsiella pneumoniae. Curr protocols 3(10):e912. https:\/\/doi.org\/10.1002\/cpz1.912","journal-title":"Curr protocols"},{"issue":"Pt 7","key":"2509_CR35","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1099\/00221287-148-7-2215","volume":"148","author":"AJ Roe","year":"2002","unstructured":"Roe AJ, O\u2019Byrne C, McLaggan D, Booth IR (2002) Inhibition of Escherichia coli growth by acetic acid: a problem with methionine biosynthesis and homocysteine toxicity. Microbiology 148(Pt 7):2215\u20132222. https:\/\/doi.org\/10.1099\/00221287-148-7-2215","journal-title":"Microbiology"},{"issue":"10","key":"2509_CR36","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/s41568-024-00737-z","volume":"24","author":"M Russo","year":"2024","unstructured":"Russo M, Chen M, Mariella E, Peng H, Rehman SK, Sancho E, Sogari A, Toh TS, Balaban NQ, Batlle E, Bernards R, Garnett MJ, Hangauer M, Leucci E, Marine JC, O\u2019Brien CA, Oren Y, Patton EE, Robert C, Bardelli A (2024) Cancer drug-tolerant persister cells: from biological questions to clinical opportunities. Nat Rev Cancer 24(10):694\u2013717. https:\/\/doi.org\/10.1038\/s41568-024-00737-z","journal-title":"Nat Rev Cancer"},{"key":"2509_CR38","doi-asserted-by":"publisher","unstructured":"Schilcher K, Horswill AR (2020) Staphylococcal Biofilm Development: Structure, Regulation, and Treatment Strategies. Microbiol Mol Biol Rev 84(3). https:\/\/doi.org\/10.1128\/mmbr.00026-19","DOI":"10.1128\/mmbr.00026-19"},{"issue":"2","key":"2509_CR39","doi-asserted-by":"publisher","first-page":"28","DOI":"10.15698\/mic2021.02.741","volume":"8","author":"A Schulze","year":"2021","unstructured":"Schulze A, Mitterer F, Pombo JP, Schild S (2021) Biofilms by bacterial human pathogens: Clinical relevance - development, composition and regulation - therapeutical strategies. Microb Cell 8(2):28\u201356. https:\/\/doi.org\/10.15698\/mic2021.02.741","journal-title":"Microb Cell"},{"issue":"16","key":"2509_CR40","doi-asserted-by":"publisher","first-page":"5762","DOI":"10.1128\/JB.00347-06I","volume":"188","author":"TA Seiflein","year":"2006","unstructured":"Seiflein TA, Lawrence JG (2006) Two transsulfurylation pathways in Klebsiella pneumoniae. J Bacteriol 188(16):5762\u20135774. https:\/\/doi.org\/10.1128\/JB.00347-06I","journal-title":"J Bacteriol"},{"issue":"6","key":"2509_CR41","doi-asserted-by":"publisher","first-page":"e0206023","DOI":"10.1128\/spectrum.02060-23","volume":"11","author":"X Tan","year":"2023","unstructured":"Tan X, Cheng X, Xiao J, Liu Q, Du D, Li M, Sun Y, Zhou J, Zhu G (2023) Alkaline phosphatase LapA regulates quorum sensing-mediated virulence and biofilm formation in Pseudomonas aeruginosa PAO1 under phosphate depletion stress. Microbiol Spectr 11(6):e0206023. https:\/\/doi.org\/10.1128\/spectrum.02060-23","journal-title":"Microbiol Spectr"},{"key":"2509_CR42","doi-asserted-by":"publisher","first-page":"904627","DOI":"10.3389\/fmicb.2022.904627","volume":"13","author":"J Tang","year":"2022","unstructured":"Tang J, Chen J, Liu Y, Hu J, Xia Z, Li X, He H, Rang J, Sun Y, Yu Z, Cui J, Xia L (2022) The Global Regulator PhoU Positively Controls Growth and Butenyl-Spinosyn Biosynthesis in Saccharopolyspora pogona. Front Microbiol 13:904627. https:\/\/doi.org\/10.3389\/fmicb.2022.904627","journal-title":"Front Microbiol"},{"issue":"4","key":"2509_CR43","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1111\/jam.13533","volume":"123","author":"C Vuotto","year":"2017","unstructured":"Vuotto C, Longo F, Pascolini C, Donelli G, Balice MP, Libori MF, Tiracchia V, Salvia A, Varaldo PE (2017) Biofilm formation and antibiotic resistance in Klebsiella pneumoniae urinary strains. J Appl Microbiol 123(4):1003\u20131018. https:\/\/doi.org\/10.1111\/jam.13533","journal-title":"J Appl Microbiol"},{"key":"2509_CR47","doi-asserted-by":"publisher","unstructured":"Wang Y, Wang S, Chen W, Song L, Zhang Y, Shen Z, Yu F, Li M, Ji Q (2018) CRISPR-Cas9 and CRISPR-Assisted Cytidine Deaminase Enable Precise and Efficient Genome Editing in Klebsiella pneumoniae. Appl Environ Microbiol 84(23). https:\/\/doi.org\/10.1128\/aem.01834-18","DOI":"10.1128\/aem.01834-18"},{"issue":"4","key":"2509_CR46","doi-asserted-by":"publisher","first-page":"106925","DOI":"10.1016\/j.ijantimicag.2023.106925","volume":"62","author":"X Wang","year":"2023","unstructured":"Wang X, Ma W, Shan J, Chen K, Xu W, Lu Z, Ju Z, Dong Z, Li B, Zhang Y (2023) The phosphotransferase system gene ptsH affects persister formation in Klebsiella pneumoniae by regulating cyclic adenosine monophosphate levels. Int J Antimicrob Agents 62(4):106925. https:\/\/doi.org\/10.1016\/j.ijantimicag.2023.106925","journal-title":"Int J Antimicrob Agents"},{"issue":"1","key":"2509_CR44","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0022-2836(86)90421-3","volume":"191","author":"BL Wanner","year":"1986","unstructured":"Wanner BL (1986) Novel regulatory mutants of the phosphate regulon in Escherichia coli K-12. J Mol Biol 191(1):39\u201358. https:\/\/doi.org\/10.1016\/0022-2836(86)90421-3","journal-title":"J Mol Biol"},{"issue":"7","key":"2509_CR45","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1111\/j.1365-2958.1991.tb01905","volume":"5","author":"H Weissbach","year":"1991","unstructured":"Weissbach H, Brot N (1991) Regulation of methionine synthesis in Escherichia coli. Mol Microbiol 5(7):1593\u20131597. https:\/\/doi.org\/10.1111\/j.1365-2958.1991.tb01905","journal-title":"Mol Microbiol"},{"issue":"1","key":"2509_CR48","doi-asserted-by":"publisher","first-page":"2545559","DOI":"10.1080\/21505594.2025.2545559","volume":"16","author":"J Yang","year":"2025","unstructured":"Yang J, Wang M, Wang Y, Qiang R, Jin Q, Zhao C, Chen Q, Han M, Ma X, Zhang H (2025) Roles of Pho regulon in bacterial pathogenicity. Virulence 16(1):2545559. https:\/\/doi.org\/10.1080\/21505594.2025.2545559","journal-title":"Virulence"},{"issue":"5","key":"2509_CR49","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1080\/14789450.2020.1784731","volume":"17","author":"D Zhang","year":"2020","unstructured":"Zhang D, Hu Y, Zhu Q, Huang J, Chen Y (2020) Proteomic interrogation of antibiotic resistance and persistence in Escherichia coli - progress and potential for medical research. Expert Rev Proteom 17(5):393\u2013409. https:\/\/doi.org\/10.1080\/14789450.2020.1784731","journal-title":"Expert Rev Proteom"}],"container-title":["Molecular Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-026-02509-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00438-026-02509-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-026-02509-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:42:45Z","timestamp":1789785765000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00438-026-02509-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,19]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2509"],"URL":"https:\/\/doi.org\/10.1007\/s00438-026-02509-w","relation":{},"ISSN":["1617-4615","1617-4623"],"issn-type":[{"value":"1617-4615","type":"print"},{"value":"1617-4623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,19]]},"assertion":[{"value":"27 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All authors declare no conflicts of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not required.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"197"}}