{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T07:07:31Z","timestamp":1788937651285,"version":"build-2803163510"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Genet Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00438-026-02511-2","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:51:18Z","timestamp":1788936678000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ACE2 and Parkinsonism\u2011related bone metabolic alterations: signaling pathways and hub gene analysis"],"prefix":"10.1007","volume":"301","author":[{"given":"Tingting","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuheng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianshe","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"2511_CR1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ejphar.2017.04.031","volume":"807","author":"HM Abuohashish","year":"2017","unstructured":"Abuohashish HM, Ahmed MM, Sabry D, Khattab MM, Al-Rejaie SS (2017) The ACE-2\/Ang1-7\/Mas cascade enhances bone structure and metabolism following angiotensin-II type 1 receptor blockade. Eur J Pharmacol 807:44\u201355. https:\/\/doi.org\/10.1016\/j.ejphar.2017.04.031","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"2511_CR2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s11914-015-0264-1","volume":"13","author":"AD Bakker","year":"2015","unstructured":"Bakker AD, Jaspers RT (2015) IL-6 and IGF-1 Signaling Within and Between Muscle and Bone: How Important is the mTOR Pathway for Bone Metabolism? Curr Osteoporos Rep 13(3):131\u2013139. https:\/\/doi.org\/10.1007\/s11914-015-0264-1","journal-title":"Curr Osteoporos Rep"},{"issue":"3","key":"2511_CR3","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1111\/apt.15895","volume":"52","author":"G Bertoldi","year":"2020","unstructured":"Bertoldi G, Gianesello L, Cal\u00f2 LA (2020) Letter: ACE2, Rho kinase inhibition and the potential role of vitamin D against COVID-19. Aliment Pharmacol Ther 52(3):577\u2013578. https:\/\/doi.org\/10.1111\/apt.15895","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"2511_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02223-0","volume":"18","author":"I Castilla-Cort\u00e1zar","year":"2020","unstructured":"Castilla-Cort\u00e1zar I, Aguirre GA, Femat-Rold\u00e1n G, Mart\u00edn-Estal I, Espinosa L (2020) Is insulin-like growth factor-1 involved in Parkinson\u2019s disease development? J Transl Med 18(1):70. https:\/\/doi.org\/10.1186\/s12967-020-02223-0","journal-title":"J Transl Med"},{"issue":"7032","key":"2511_CR5","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/nature03398","volume":"434","author":"F Elefteriou","year":"2005","unstructured":"Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X et al (2005) Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434(7032):514\u201320. https:\/\/doi.org\/10.1038\/nature03398","journal-title":"Nature"},{"issue":"10","key":"2511_CR6","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","volume":"14","author":"C Franceschi","year":"2018","unstructured":"Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A (2018) Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol 14(10):576\u2013590. https:\/\/doi.org\/10.1038\/s41574-018-0059-4","journal-title":"Nat Rev Endocrinol"},{"issue":"21","key":"2511_CR7","doi-asserted-by":"publisher","first-page":"13304","DOI":"10.18632\/aging.206028","volume":"16","author":"Q Gao","year":"2024","unstructured":"Gao Q, Li X, Huang T, Gao L, Wang S, Deng Y, Wang F, Xue X, Duan R (2024) Angiotensin-(1\u20137) relieves behavioral defects and \u03b1-synuclein expression through NEAT1\/miR-153-3p axis in Parkinson\u2019s disease. Aging 16(21):13304\u201313322. https:\/\/doi.org\/10.18632\/aging.206028","journal-title":"Aging"},{"issue":"5","key":"2511_CR8","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.3390\/biomedicines12051074","volume":"12","author":"A Gathings","year":"2024","unstructured":"Gathings A, Zaman V, Banik NL, Haque A (2024) Insights into Calpain Activation and Rho-ROCK Signaling in Parkinson\u2019s Disease and Aging. Biomedicines 12(5):1074. https:\/\/doi.org\/10.3390\/biomedicines12051074","journal-title":"Biomedicines"},{"key":"2511_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.590480","volume":"11","author":"A Glasnovi\u0107","year":"2020","unstructured":"Glasnovi\u0107 A, O\u2019Mara N, Kova\u010di\u0107 N, Gr\u010devi\u0107 D, Gajovi\u0107 S (2020) RANK\/RANKL\/OPG signaling in the brain: a systematic review of the literature. Front Neurol 11:590480. https:\/\/doi.org\/10.3389\/fneur.2020.590480","journal-title":"Front Neurol"},{"issue":"10","key":"2511_CR10","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1021\/acschemneuro.1c00797","volume":"13","author":"S Gupta","year":"2022","unstructured":"Gupta S, Tiwari V, Tiwari P, Parul, Mishra A, Hanif K et al (2022) Angiotensin-Converting Enzyme 2 Activation Mitigates Behavioral Deficits and Neuroinflammatory Burden in 6-OHDA Induced Experimental Models of Parkinson\u2019s Disease. ACS Chem Neurosci 13(10):1491\u20131504. https:\/\/doi.org\/10.1021\/acschemneuro.1c00797","journal-title":"ACS Chem Neurosci"},{"issue":"12","key":"2511_CR11","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1016\/j.cell.2022.05.008","volume":"185","author":"E Hallacli","year":"2022","unstructured":"Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S et al (2022) The Parkinson\u2019s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability. Cell 185(12):2035-2056e.e33. https:\/\/doi.org\/10.1016\/j.cell.2022.05.008","journal-title":"Cell"},{"issue":"2","key":"2511_CR12","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1002\/path.1570","volume":"203","author":"I Hamming","year":"2004","unstructured":"Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H (2004) Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 203(2):631\u2013637. https:\/\/doi.org\/10.1002\/path.1570","journal-title":"J Pathol"},{"issue":"1","key":"2511_CR13","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s40168-020-00988-6","volume":"9","author":"YF Hou","year":"2021","unstructured":"Hou YF, Shan C, Zhuang SY, Zhuang QQ, Ghosh A, Zhu KC et al (2021) Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson\u2019s disease. Microbiome 9(1):34. https:\/\/doi.org\/10.1186\/s40168-020-00988-6","journal-title":"Microbiome"},{"issue":"1","key":"2511_CR14","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41413-024-00342-8","volume":"12","author":"L Hu","year":"2024","unstructured":"Hu L, Chen W, Qian A, Li YP (2024) Wnt\/\u03b2-catenin signaling components and mechanisms in bone formation, homeostasis, and disease. Bone Res 12(1):39. https:\/\/doi.org\/10.1038\/s41413-024-00342-8","journal-title":"Bone Res"},{"key":"2511_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2022.105389","volume":"159","author":"YL Huang","year":"2022","unstructured":"Huang YL, Zhang JN, Hou TZ, Gu L, Yang HM, Zhang H (2022) Inhibition of Wnt\/\u03b2-catenin signaling attenuates axonal degeneration in models of Parkinson\u2019s disease. Neurochem Int 159:105389. https:\/\/doi.org\/10.1016\/j.neuint.2022.105389","journal-title":"Neurochem Int"},{"issue":"4","key":"2511_CR16","doi-asserted-by":"publisher","first-page":"645","DOI":"10.18632\/aging.101419","volume":"10","author":"T Jiang","year":"2018","unstructured":"Jiang T, Xue LJ, Yang Y, Wang QG, Xue X, Ou Z, Gao Q, Shi JQ, Wu L, Zhang YD (2018) AVE0991, a nonpeptide analogue of Ang-(1\u20137), attenuates aging-related neuroinflammation. Aging 10(4):645\u2013657. https:\/\/doi.org\/10.18632\/aging.101419","journal-title":"Aging"},{"issue":"2","key":"2511_CR17","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/jnc.15135","volume":"157","author":"A John","year":"2021","unstructured":"John A, Ng-Cordell E, Hanna N, Brkic D, Baker K (2021) The neurodevelopmental spectrum of synaptic vesicle cycling disorders. J Neurochem 157(2):208\u2013228. https:\/\/doi.org\/10.1111\/jnc.15135","journal-title":"J Neurochem"},{"issue":"5","key":"2511_CR18","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1002\/ana.25221","volume":"83","author":"M Jonikas","year":"2018","unstructured":"Jonikas M, Madill M, Mathy A, Zekoll T, Zois CE, Wigfield S et al (2018) Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1. Ann Neurol 83(5):915\u2013925. https:\/\/doi.org\/10.1002\/ana.25221","journal-title":"Ann Neurol"},{"key":"2511_CR19","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9:559. https:\/\/doi.org\/10.1186\/1471-2105-9-559","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"2511_CR20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s40249-020-00662-x","volume":"9","author":"MY Li","year":"2020","unstructured":"Li MY, Li L, Zhang Y, Wang XS (2020) Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues. Infect Dis Poverty 9(1):45. https:\/\/doi.org\/10.1186\/s40249-020-00662-x","journal-title":"Infect Dis Poverty"},{"issue":"23","key":"2511_CR21","doi-asserted-by":"publisher","first-page":"12842","DOI":"10.3390\/ijms252312842","volume":"25","author":"T Liu","year":"2024","unstructured":"Liu T, Wu H, Li J, Zhu C, Wei J (2024a) Unraveling the bone-brain axis: A new frontier in Parkinson\u2019s disease research. Int J Mol Sci 25(23):12842. https:\/\/doi.org\/10.3390\/ijms252312842","journal-title":"Int J Mol Sci"},{"key":"2511_CR22","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.neuroscience.2024.06.024","volume":"553","author":"T Liu","year":"2024","unstructured":"Liu T, Li J, Sun L, Zhu C, Wei J (2024b) The role of ACE2 in RAS axis on microglia activation in Parkinson\u2019s disease. Neuroscience 553:128\u2013144. https:\/\/doi.org\/10.1016\/j.neuroscience.2024.06.024","journal-title":"Neuroscience"},{"key":"2511_CR23","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.2147\/JIR.S460161","volume":"17","author":"T Liu","year":"2024","unstructured":"Liu T, Wu H, Sun L, Wei J (2024c) Role of inflammation in the development of COVID-19 to Parkinson\u2019s disease. J Inflamm Res 17:3259\u20133282. https:\/\/doi.org\/10.2147\/JIR.S460161","journal-title":"J Inflamm Res"},{"issue":"6","key":"2511_CR24","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.neurol.2020.07.015","volume":"177","author":"M Louvois","year":"2021","unstructured":"Louvois M, Ferrero S, Barnetche T, Roux CH, Breuil V (2021) High risk of osteoporotic fracture in Parkinson\u2019s disease: meta-analysis, pathophysiology and management. Rev Neurol (Paris) 177(6):660\u2013669. https:\/\/doi.org\/10.1016\/j.neurol.2020.07.015","journal-title":"Rev Neurol (Paris)"},{"issue":"5","key":"2511_CR25","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1007\/s00774-023-01446-7","volume":"41","author":"C Ma","year":"2023","unstructured":"Ma C, Yu R, Li J, Wang X, Guo J, Xiao E, Liu P (2023) Association of serum uric acid levels with bone mineral density and the presence of osteoporosis in Chinese patients with Parkinson\u2019s disease: a cross-sectional study. J Bone Min Metab 41(5):714\u2013726. https:\/\/doi.org\/10.1007\/s00774-023-01446-7","journal-title":"J Bone Min Metab"},{"issue":"12","key":"2511_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123743","volume":"19","author":"B Marchetti","year":"2018","unstructured":"Marchetti B (2018) Wnt\/\u03b2-catenin signaling pathway governs a full program for dopaminergic neuron survival, neurorescue and regeneration in the MPTP mouse model of Parkinson\u2019s disease. Int J Mol Sci 19(12):3743. https:\/\/doi.org\/10.3390\/ijms19123743","journal-title":"Int J Mol Sci"},{"issue":"6","key":"2511_CR27","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1007\/s00774-020-01132-y","volume":"38","author":"C Mo","year":"2020","unstructured":"Mo C, Ke J, Zhao D, Zhang B (2020) Role of the renin-angiotensin-aldosterone system in bone metabolism. J Bone Min Metab 38(6):772\u2013779. https:\/\/doi.org\/10.1007\/s00774-020-01132-y","journal-title":"J Bone Min Metab"},{"issue":"7","key":"2511_CR28","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1111\/ejn.14894","volume":"53","author":"C Moore","year":"2021","unstructured":"Moore C, Xu M, Bohlen JK, Meshul CK (2021) Differential ultrastructural alterations in the Vglut2 glutamatergic input to the substantia nigra pars compacta\/pars reticulata following nigrostriatal dopamine loss in a progressive mouse model of Parkinson\u2019s disease. Eur J Neurosci 53(7):2061\u20132077. https:\/\/doi.org\/10.1111\/ejn.14894","journal-title":"Eur J Neurosci"},{"issue":"9","key":"2511_CR29","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1080\/00207454.2016.1248240","volume":"127","author":"A Noor","year":"2017","unstructured":"Noor A, Zahid S (2017) A review of the role of synaptosomal-associated protein 25 (SNAP-25) in neurological disorders. Int J Neurosci 127(9):805\u2013811. https:\/\/doi.org\/10.1080\/00207454.2016.1248240","journal-title":"Int J Neurosci"},{"issue":"2","key":"2511_CR30","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.ymthe.2022.09.018","volume":"31","author":"WT Oh","year":"2023","unstructured":"Oh WT, Yang YS, Xie J, Ma H, Kim JM, Park KH et al (2023) WNT-modulating gene silencers as a gene therapy for osteoporosis, bone fracture, and critical-sized bone defects. Mol Ther 31(2):435\u2013453. https:\/\/doi.org\/10.1016\/j.ymthe.2022.09.018","journal-title":"Mol Ther"},{"issue":"1","key":"2511_CR31","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.cell.2013.08.042","volume":"155","author":"F Oury","year":"2013","unstructured":"Oury F, Khrimian L, Denny CA, Gardin A, Chamouni A, Goeden N et al (2013) Maternal and offspring pools of osteocalcin influence brain development and functions. Cell 155(1):228\u2013241. https:\/\/doi.org\/10.1016\/j.cell.2013.08.042","journal-title":"Cell"},{"issue":"11","key":"2511_CR32","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1152\/physiolgenomics.00089.2020","volume":"52","author":"CA Pollard","year":"2020","unstructured":"Pollard CA, Morran MP, Nestor-Kalinoski AL (2020) The COVID-19 pandemic: a global health crisis. Physiol Genomics 52(11):549\u2013557. https:\/\/doi.org\/10.1152\/physiolgenomics.00089.2020","journal-title":"Physiol Genomics"},{"issue":"22","key":"2511_CR33","doi-asserted-by":"publisher","first-page":"8191","DOI":"10.1073\/pnas.1400544111","volume":"111","author":"M Shimamura","year":"2014","unstructured":"Shimamura M, Nakagami H, Osako MK, Kurinami H, Koriyama H, Zhengda P, Tomioka H, Tenma A, Wakayama K, Morishita R (2014) OPG\/RANKL\/RANK axis is a critical inflammatory signaling system in ischemic brain in mice. Proc Natl Acad Sci U S A 111(22):8191\u20138196. https:\/\/doi.org\/10.1073\/pnas.1400544111","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"2511_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2023.167992","volume":"435","author":"T Sohrabi","year":"2023","unstructured":"Sohrabi T, Mirzaei-Behbahani B, Zadali R, Pirhaghi M, Morozova-Roche LA, Meratan AA (2023) Common mechanisms underlying \u03b1-synuclein-induced mitochondrial dysfunction in Parkinson\u2019s disease. J Mol Biol 435(12):167992. https:\/\/doi.org\/10.1016\/j.jmb.2023.167992","journal-title":"J Mol Biol"},{"issue":"D1","key":"2511_CR35","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R et al (2023) The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res 51(D1):D638\u2013D646. https:\/\/doi.org\/10.1093\/nar\/gkac1000","journal-title":"Nucleic Acids Res"},{"key":"2511_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2024.103953","volume":"130","author":"P Tiwari","year":"2024","unstructured":"Tiwari P, Mueed S, Abdulkareem AO, Hanif K (2024) Activation of angiotensin converting enzyme 2 promotes hippocampal neurogenesis via activation of Wnt\/\u03b2-catenin signaling in hypertension. Mol Cell Neurosci 130:103953. https:\/\/doi.org\/10.1016\/j.mcn.2024.103953","journal-title":"Mol Cell Neurosci"},{"key":"2511_CR37","doi-asserted-by":"publisher","DOI":"10.4161\/sgtp.28119","volume":"5","author":"H Touaitahuata","year":"2014","unstructured":"Touaitahuata H, Blangy A, Vives V (2014) Modulation of osteoclast differentiation and bone resorption by Rho GTPases. Small GTPases 5:e28119. https:\/\/doi.org\/10.4161\/sgtp.28119","journal-title":"Small GTPases"},{"key":"2511_CR38","doi-asserted-by":"publisher","first-page":"102078","DOI":"10.1016\/j.redox.2021.102078","volume":"46","author":"R Valenzuela","year":"2021","unstructured":"Valenzuela R, Rodriguez-Perez AI, Costa-Besada MA, Rivas-Santisteban R, Garrido-Gil P, Lopez-Lopez A et al (2021) An ACE2\/Mas-related receptor MrgE axis in dopaminergic neuron mitochondria. Redox Biol 46:102078. https:\/\/doi.org\/10.1016\/j.redox.2021.102078","journal-title":"Redox Biol"},{"issue":"4","key":"2511_CR39","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1172\/JCI71812","volume":"124","author":"Y Wang","year":"2014","unstructured":"Wang Y, Lei R, Zhuang X, Zhang N, Pan H, Li G, Hu J, Pan X, Tao Q, Fu D, Xiao J, Chin YE, Kang Y, Yang Q, Hu G (2014) DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis. J Clin Invest 124(4):1646\u20131659. https:\/\/doi.org\/10.1172\/JCI71812","journal-title":"J Clin Invest"},{"issue":"1","key":"2511_CR40","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S1474-4422(21)00330-6","volume":"21","author":"D Weintraub","year":"2022","unstructured":"Weintraub D, Aarsland D, Chaudhuri KR, Dobkin RD, Leentjens AF, Rodriguez-Violante M et al (2022) The neuropsychiatry of Parkinson\u2019s disease: advances and challenges. Lancet Neurol 21(1):89\u2013102. https:\/\/doi.org\/10.1016\/S1474-4422(21)00330-6","journal-title":"Lancet Neurol"},{"issue":"1","key":"2511_CR41","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41413-025-00404-5","volume":"13","author":"J Yu","year":"2025","unstructured":"Yu J, Ji L, Liu Y, Wang X, Wang J, Liu C (2025) Bone-brain interaction: mechanisms and potential intervention strategies of biomaterials. Bone Res 13(1):38. https:\/\/doi.org\/10.1038\/s41413-025-00404-5","journal-title":"Bone Res"}],"container-title":["Molecular Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-026-02511-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00438-026-02511-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00438-026-02511-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:51:20Z","timestamp":1788936680000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00438-026-02511-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2511"],"URL":"https:\/\/doi.org\/10.1007\/s00438-026-02511-2","relation":{},"ISSN":["1617-4615","1617-4623"],"issn-type":[{"value":"1617-4615","type":"print"},{"value":"1617-4623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]},"assertion":[{"value":"4 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there is no conflict of interest regarding the publication of this paper.","order":1,"name":"Ethics","label":"<b>Conflict of interest<\/b>","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of Henan University (No. HUSOM2021-161).","order":2,"name":"Ethics","label":"<b>Ethical approval and consent to participate<\/b>","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"<b>Consent for publication<\/b>","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"185"}}