{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:45:28Z","timestamp":1790711128395,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2008,5,27]],"date-time":"2008-05-27T00:00:00Z","timestamp":1211846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Genet"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1007\/s00439-008-0518-4","type":"journal-article","created":{"date-parts":[[2008,5,26]],"date-time":"2008-05-26T07:13:11Z","timestamp":1211785991000},"page":"643-653","source":"Crossref","is-referenced-by-count":71,"title":["Sensitivity of RECQL4-deficient fibroblasts from Rothmund\u2013Thomson syndrome patients to genotoxic agents"],"prefix":"10.1007","volume":"123","author":[{"given":"Weidong","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhendu K.","family":"Otta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon E.","family":"Plon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa L.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,5,27]]},"reference":[{"key":"518_CR1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0300-9084(84)90018-X","volume":"66","author":"G Aubel-Sadron","year":"1984","unstructured":"Aubel-Sadron G, Londos-Gagliardi D (1984) Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review. Biochimie 66:333\u2013352","journal-title":"Biochimie"},{"key":"518_CR2","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1097\/00008480-199712000-00010","volume":"9","author":"AD Auerbach","year":"1997","unstructured":"Auerbach AD, Verlander PC (1997) Disorders of DNA replication and repair. Curr Opin Pediatr 9:600\u2013616","journal-title":"Curr Opin Pediatr"},{"key":"518_CR3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00412-007-0142-4","volume":"117","author":"CZ Bachrati","year":"2008","unstructured":"Bachrati CZ, Hickson ID (2008) RecQ helicases: guardian angels of the DNA replication fork. Chromosoma 117:219\u2013233","journal-title":"Chromosoma"},{"key":"518_CR4","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1365-313X.2005.02501.x","volume":"43","author":"MB Bagherieh-Najjar","year":"2005","unstructured":"Bagherieh-Najjar MB, de Vries OM, Hille J, Dijkwel PP (2005) Arabidopsis RecQI4A suppresses homologous recombination and modulates DNA damage responses. Plant J 43:789\u2013798","journal-title":"Plant J"},{"key":"518_CR5","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.dnarep.2004.02.003","volume":"3","author":"A Blank","year":"2004","unstructured":"Blank A, Bobola MS, Gold B, Varadarajan S, Kolstoe D, Meade EH, Rabinovitch PS, Loeb LA, Silber JR (2004) The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function. DNA Repair (Amst) 3:629\u2013638","journal-title":"DNA Repair (Amst)"},{"key":"518_CR6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.gene.2006.11.019","volume":"391","author":"LM Burks","year":"2007","unstructured":"Burks LM, Yin J, Plon SE (2007) Nuclear import and retention domains in the amino terminus of RECQL4. Gene 391:26\u201338","journal-title":"Gene"},{"key":"518_CR7","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1128\/MCB.24.3.1279-1291.2004","volume":"24","author":"SL Davies","year":"2004","unstructured":"Davies SL, North PS, Dart A, Lakin ND, Hickson ID (2004) Phosphorylation of the Bloom\u2019s syndrome helicase and its role in recovery from S-phase arrest. Mol Cell Biol 24:1279\u20131291","journal-title":"Mol Cell Biol"},{"key":"518_CR8","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nsmb1267","volume":"14","author":"SL Davies","year":"2007","unstructured":"Davies SL, North PS, Hickson ID (2007) Role for BLM in replication-fork restart and suppression of origin firing after replicative stress. Nat Struct Mol Biol 14:677\u2013679","journal-title":"Nat Struct Mol Biol"},{"key":"518_CR9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s004390100505","volume":"109","author":"JT Dunnen den","year":"2001","unstructured":"den Dunnen JT, Antonarakis SE (2001) Nomenclature for the description of human sequence variations. Hum Genet 109:121\u2013124","journal-title":"Hum Genet"},{"key":"518_CR10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1474-9726.2006.00260.x","volume":"6","author":"KK Dhillon","year":"2007","unstructured":"Dhillon KK, Sidorova J, Saintigny Y, Poot M, Gollahon K, Rabinovitch PS, Monnat RJ Jr (2007) Functional role of the Werner syndrome RecQ helicase in human fibroblasts. Aging Cell 6:53\u201361","journal-title":"Aging Cell"},{"key":"518_CR11","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s00018-007-6468-5","volume":"64","author":"T Dietschy","year":"2007","unstructured":"Dietschy T, Shevelev I, Stagljar I (2007) The molecular role of the Rothmund\u2013Thomson-, RAPADILINO- and Baller\u2013Gerold-gene product, RECQL4: recent progress. Cell Mol Life Sci 64:796\u2013802","journal-title":"Cell Mol Life Sci"},{"key":"518_CR12","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0092-8674(95)90105-1","volume":"83","author":"NA Ellis","year":"1995","unstructured":"Ellis NA, Groden J, Ye TZ, Straughen J, Lennon DJ, Ciocci S, Proytcheva M, German J (1995) The Bloom\u2019s syndrome gene product is homologous to RecQ helicases. Cell 83:655\u2013666","journal-title":"Cell"},{"key":"518_CR13","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1038\/nprot.2006.339","volume":"1","author":"NA Franken","year":"2006","unstructured":"Franken NA, Rodermond HM, Stap J, Haveman J, van Bree C (2006) Clonogenic assay of cells in vitro. Nat Protoc 1:2315\u20132319","journal-title":"Nat Protoc"},{"key":"518_CR14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1034\/j.1399-0004.2000.580308.x","volume":"58","author":"SG Grant","year":"2000","unstructured":"Grant SG, Wenger SL, Latimer JJ, Thull D, Burke LW (2000) Analysis of genomic instability using multiple assays in a patient with Rothmund\u2013Thomson syndrome. Clin Genet 58:209\u2013215","journal-title":"Clin Genet"},{"key":"518_CR15","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1007\/s00018-007-7121-z","volume":"64","author":"K Hanada","year":"2007","unstructured":"Hanada K, Hickson ID (2007) Molecular genetics of RecQ helicase disorders. Cell Mol Life Sci 64:2306\u20132322","journal-title":"Cell Mol Life Sci"},{"key":"518_CR16","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1200\/JCO.2006.08.4558","volume":"25","author":"MJ Hicks","year":"2007","unstructured":"Hicks MJ, Roth JR, Kozinetz CA, Wang LL (2007) Clinicopathologic features of osteosarcoma in patients with Rothmund\u2013Thomson syndrome. J Clin Oncol 25:370\u2013375","journal-title":"J Clin Oncol"},{"key":"518_CR17","first-page":"2372","volume":"60","author":"FM Hisama","year":"2000","unstructured":"Hisama FM, Chen YH, Meyn MS, Oshima J, Weissman SM (2000) WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts. Cancer Res 60:2372\u20132376","journal-title":"Cancer Res"},{"key":"518_CR18","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1093\/hmg\/ddg254","volume":"12","author":"Y Hoki","year":"2003","unstructured":"Hoki Y, Araki R, Fujimori A, Ohhata T, Koseki H, Fukumura R, Nakamura M, Takahashi H, Noda Y, Kito S, Abe M (2003) Growth retardation and skin abnormalities of the Recql4-deficient mouse. Hum Mol Genet 12:2293\u20132299","journal-title":"Hum Mol Genet"},{"key":"518_CR19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1383-5718(02)00144-4","volume":"520","author":"M Honma","year":"2002","unstructured":"Honma M, Tadokoro S, Sakamoto H, Tanabe H, Sugimoto M, Furuichi Y, Satoh T, Sofuni T, Goto M, Hayashi M (2002) Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients. Mutat Res 520:15\u201324","journal-title":"Mutat Res"},{"key":"518_CR20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/8788","volume":"22","author":"S Kitao","year":"1999","unstructured":"Kitao S, Shimamoto A, Goto M, Miller RW, Smithson WA, Lindor NM, Furuichi Y (1999) Mutations in RECQL4 cause a subset of cases of Rothmund\u2013Thomson syndrome. Nat Genet 22:82\u201384","journal-title":"Nat Genet"},{"key":"518_CR21","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.bbamcr.2007.01.005","volume":"1773","author":"Y Kumata","year":"2007","unstructured":"Kumata Y, Tada S, Yamanada Y, Tsuyama T, Kobayashi T, Dong YP, Ikegami K, Murofushi H, Seki M, Enomoto T (2007) Possible involvement of RecQL4 in the repair of double-strand DNA breaks in Xenopus egg extracts. Biochim Biophys Acta 1773:556\u2013564","journal-title":"Biochim Biophys Acta"},{"key":"518_CR22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.canlet.2005.07.042","volume":"232","author":"L Larizza","year":"2006","unstructured":"Larizza L, Magnani I, Roversi G (2006) Rothmund\u2013Thomson syndrome and RECQL4 defect: splitting and lumping. Cancer Lett 232:107\u2013120","journal-title":"Cancer Lett"},{"key":"518_CR23","doi-asserted-by":"crossref","first-page":"13097","DOI":"10.1073\/pnas.95.22.13097","volume":"95","author":"M Lebel","year":"1998","unstructured":"Lebel M, Leder P (1998) A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci USA 95:13097\u201313102","journal-title":"Proc Natl Acad Sci USA"},{"key":"518_CR24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/(SICI)1096-8628(20000131)90:3<223::AID-AJMG7>3.0.CO;2-Z","volume":"90","author":"NM Lindor","year":"2000","unstructured":"Lindor NM, Furuichi Y, Kitao S, Shimamoto A, Arndt C, Jalal S (2000) Rothmund\u2013Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome. Am J Med Genet 90:223\u2013228","journal-title":"Am J Med Genet"},{"key":"518_CR25","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.dnarep.2005.09.005","volume":"5","author":"MA Macris","year":"2006","unstructured":"Macris MA, Krejci L, Bussen W, Shimamoto A, Sung P (2006) Biochemical characterization of the RECQ4 protein, mutated in Rothmund\u2013Thomson syndrome. DNA Repair (Amst) 5:172\u2013180","journal-title":"DNA Repair (Amst)"},{"key":"518_CR26","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1158\/1078-0432.CCR-07-2238","volume":"14","author":"LP Martin","year":"2008","unstructured":"Martin LP, Hamilton TC, Schilder RJ (2008) Platinum resistance: the role of DNA repair pathways. Clin Cancer Res 14:1291\u20131295","journal-title":"Clin Cancer Res"},{"key":"518_CR27","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.1158\/0008-5472.CAN-05-4471","volume":"66","author":"ZH Miao","year":"2006","unstructured":"Miao ZH, Rao VA, Agama K, Antony S, Kohn KW, Pommier Y (2006) 4-nitroquinoline-1-oxide induces the formation of cellular topoisomerase I-DNA cleavage complexes. Cancer Res 66:6540\u20136545","journal-title":"Cancer Res"},{"key":"518_CR28","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/(SICI)1097-0215(19980812)77:4<504::AID-IJC5>3.0.CO;2-Y","volume":"77","author":"M Miozzo","year":"1998","unstructured":"Miozzo M, Castorina P, Riva P, Dalpra L, Fuhrman Conti AM, Volpi L, Hoe TS, Khoo A, Wiegant J, Rosenberg C, Larizza L (1998) Chromosomal instability in fibroblasts and mesenchymal tumors from 2 sibs with Rothmund\u2013Thomson syndrome. Int J Cancer 77:504\u2013510","journal-title":"Int J Cancer"},{"key":"518_CR29","first-page":"3250","volume":"53","author":"T Nunoshiba","year":"1993","unstructured":"Nunoshiba T, Demple B (1993) Potent intracellular oxidative stress exerted by the carcinogen 4-nitroquinoline-N-oxide. Cancer Res 53:3250\u20133252","journal-title":"Cancer Res"},{"key":"518_CR30","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1089\/dna.2006.25.696","volume":"25","author":"SJ Park","year":"2006","unstructured":"Park SJ, Lee YJ, Beck BD, Lee SH (2006) A positive involvement of RecQL4 in UV-induced S-phase arrest. DNA Cell Biol 25:696\u2013703","journal-title":"DNA Cell Biol"},{"key":"518_CR31","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1242\/jcs.02556","volume":"118","author":"M Petkovic","year":"2005","unstructured":"Petkovic M, Dietschy T, Freire R, Jiao R, Stagljar I (2005) The human Rothmund\u2013Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability. J Cell Sci 118:4261\u20134269","journal-title":"J Cell Sci"},{"key":"518_CR32","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1096\/fj.01-0906fje","volume":"16","author":"M Poot","year":"2002","unstructured":"Poot M, Gollahon KA, Emond MJ, Silber JR, Rabinovitch PS (2002a) Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype. FASEB J 16:757\u2013758","journal-title":"FASEB J"},{"key":"518_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cyto.10101","volume":"48","author":"M Poot","year":"2002","unstructured":"Poot M, Silber JR, Rabinovitch PS (2002b) A novel flow cytometric technique for drug cytotoxicity gives results comparable to colony-forming assays. Cytometry 48:1\u20135","journal-title":"Cytometry"},{"key":"518_CR34","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s004399900078","volume":"105","author":"PR Prince","year":"1999","unstructured":"Prince PR, Ogburn CE, Moser MJ, Emond MJ, Martin GM, Monnat RJ Jr (1999) Cell fusion corrects the 4-nitroquinoline 1-oxide sensitivity of Werner syndrome fibroblast cell lines. Hum Genet 105:132\u2013138","journal-title":"Hum Genet"},{"key":"518_CR35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1089\/rej.2006.0503","volume":"10","author":"AM Rodriguez-Lopez","year":"2007","unstructured":"Rodriguez-Lopez AM, Whitby MC, Borer CM, Bachler MA, Cox LS (2007) Correction of proliferation and drug sensitivity defects in the progeroid Werner\u2019s Syndrome by Holliday junction resolution. Rejuvenation Res 10:27\u201340","journal-title":"Rejuvenation Res"},{"key":"518_CR36","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.cell.2005.05.015","volume":"121","author":"MN Sangrithi","year":"2005","unstructured":"Sangrithi MN, Bernal JA, Madine M, Philpott A, Lee J, Dunphy WG, Venkitaraman AR (2005) Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund\u2013Thomson syndrome. Cell 121:887\u2013898","journal-title":"Cell"},{"key":"518_CR37","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1001\/archderm.1993.01680240072009","volume":"129","author":"A Shinya","year":"1993","unstructured":"Shinya A, Nishigori C, Moriwaki S, Takebe H, Kubota M, Ogino A, Imamura S (1993) A case of Rothmund\u2013Thomson syndrome with reduced DNA repair capacity. Arch Dermatol 129:332\u2013336","journal-title":"Arch Dermatol"},{"key":"518_CR38","doi-asserted-by":"crossref","first-page":"796","DOI":"10.4161\/cc.7.6.5566","volume":"7","author":"JM Sidorova","year":"2008","unstructured":"Sidorova JM, Li N, Folch A, Monnat RJ Jr (2008) The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest. Cell Cycle 7:796\u2013807","journal-title":"Cell Cycle"},{"key":"518_CR39","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1093\/hmg\/ddg306","volume":"12","author":"HA Siitonen","year":"2003","unstructured":"Siitonen HA, Kopra O, Kaariainen H, Haravuori H, Winter RM, Saamanen AM, Peltonen L, Kestila M (2003) Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases. Hum Mol Genet 12:2837\u20132844","journal-title":"Hum Mol Genet"},{"key":"518_CR40","first-page":"511","volume":"41","author":"PJ Smith","year":"1981","unstructured":"Smith PJ, Paterson MC (1981) Abnormal responses to mid-ultraviolet light of cultured fibroblasts from patients with disorders featuring sunlight sensitivity. Cancer Res 41:511\u2013518","journal-title":"Cancer Res"},{"key":"518_CR41","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0027-5107(82)90183-X","volume":"94","author":"PJ Smith","year":"1982","unstructured":"Smith PJ, Paterson MC (1982) Enhanced radiosensitivity and defective DNA repair in cultured fibroblasts derived from Rothmund Thomson syndrome patients. Mutat Res 94:213\u2013228","journal-title":"Mutat Res"},{"key":"518_CR42","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/088800102753541314","volume":"19","author":"RY Tamminga","year":"2002","unstructured":"Tamminga RY, Dolsma WV, Leeuw JA, Kampinga HH (2002) Chemo- and radiosensitivity testing in a patient with ataxia telangiectasia and Hodgkin disease. Pediatr Hematol Oncol 19:163\u2013171","journal-title":"Pediatr Hematol Oncol"},{"key":"518_CR43","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1136\/jmg.2005.031781","volume":"43","author":"L Maldergem Van","year":"2006","unstructured":"Van Maldergem L, Siitonen HA, Jalkh N, Chouery E, De RM, Delague V, Muenke M, Jabs EW, Cai J, Wang LL, Plon SE, Fourneau C, Kestila M, Gillerot Y, Megarbane A, Verloes A (2006) Revisiting the craniosynostosis-radial ray hypoplasia association: Baller\u2013Gerold syndrome caused by mutations in the RECQL4 gene. J Med Genet 43:148\u2013152","journal-title":"J Med Genet"},{"key":"518_CR44","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1080\/000155599750011417","volume":"79","author":"F Vasseur","year":"1999","unstructured":"Vasseur F, Delaporte E, Zabot MT, Sturque MN, Barrut D, Savary JB, Thomas L, Thomas P (1999) Excision repair defect in Rothmund Thomson syndrome. Acta Derm Venereol 79:150\u2013152","journal-title":"Acta Derm Venereol"},{"key":"518_CR46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/1096-8628(20010722)102:1<11::AID-AJMG1413>3.0.CO;2-A","volume":"102","author":"LL Wang","year":"2001","unstructured":"Wang LL, Levy ML, Lewis RA, Chintagumpala MM, Lev D, Rogers M, Plon SE (2001) Clinical manifestations in a cohort of 41 Rothmund\u2013Thomson syndrome patients. Am J Med Genet 102:11\u201317","journal-title":"Am J Med Genet"},{"key":"518_CR45","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/jnci\/95.9.669","volume":"95","author":"LL Wang","year":"2003","unstructured":"Wang LL, Gannavarapu A, Kozinetz CA, Levy ML, Lewis RA, Chintagumpala MM, Ruiz-Maldanado R, Contreras-Ruiz J, Cunniff C, Erickson RP, Lev D, Rogers M, Zackai EH, Plon SE (2003) Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund\u2013Thomson syndrome. J Natl Cancer Inst 95:669\u2013674","journal-title":"J Natl Cancer Inst"},{"key":"518_CR47","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.bbrc.2006.04.093","volume":"345","author":"SR Werner","year":"2006","unstructured":"Werner SR, Prahalad AK, Yang J, Hock JM (2006) RECQL4-deficient cells are hypersensitive to oxidative stress\/damage: insights for osteosarcoma prevalence and heterogeneity in Rothmund\u2013Thomson syndrome. Biochem Biophys Res Commun 345:403\u2013409","journal-title":"Biochem Biophys Res Commun"},{"key":"518_CR48","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1016\/j.yexcr.2006.07.023","volume":"312","author":"LL Woo","year":"2006","unstructured":"Woo LL, Futami K, Shimamoto A, Furuichi Y, Frank KM (2006) The Rothmund\u2013Thomson gene product RECQL4 localizes to the nucleolus in response to oxidative stress. Exp Cell Res 312:3443\u20133457","journal-title":"Exp Cell Res"},{"key":"518_CR49","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1126\/science.272.5259.258","volume":"272","author":"CE Yu","year":"1996","unstructured":"Yu CE, Oshima J, Fu YH, Wijsman EM, Hisama F, Alisch R, Matthews S, Nakura J, Miki T, Ouais S, Martin GM, Mulligan J, Schellenberg GD (1996) Positional cloning of the Werner\u2019s syndrome gene. Science 272:258\u2013262","journal-title":"Science"},{"key":"518_CR50","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0027-5107(80)90027-5","volume":"70","author":"B Zelle","year":"1980","unstructured":"Zelle B, Bootsma D (1980) Repair of DNA damage after exposure to 4-nitroquinoline-1-oxide in heterokaryons derived from xeroderma pigmentosum cells. Mutat Res 70:373\u2013381","journal-title":"Mutat Res"}],"container-title":["Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00439-008-0518-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00439-008-0518-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00439-008-0518-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T19:25:58Z","timestamp":1559071558000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00439-008-0518-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,27]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["518"],"URL":"https:\/\/doi.org\/10.1007\/s00439-008-0518-4","relation":{},"ISSN":["0340-6717","1432-1203"],"issn-type":[{"value":"0340-6717","type":"print"},{"value":"1432-1203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,27]]}}}