{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T22:42:01Z","timestamp":1772232121802,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T00:00:00Z","timestamp":1219363200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Genet"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1007\/s00439-008-0545-1","type":"journal-article","created":{"date-parts":[[2008,8,21]],"date-time":"2008-08-21T10:17:39Z","timestamp":1219313859000},"page":"225-234","source":"Crossref","is-referenced-by-count":26,"title":["Network-based model weighting to detect multiple loci influencing complex diseases"],"prefix":"10.1007","volume":"124","author":[{"given":"Wei","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,8,22]]},"reference":[{"key":"545_CR1","doi-asserted-by":"crossref","first-page":"D418","DOI":"10.1093\/nar\/gki051","volume":"33","author":"C Alfarano","year":"2005","unstructured":"Alfarano C, Andrade CE, Anthony K, Bahroos N, Bajec M, Bantoft K, Betel D, Bobechko B, Boutilier K, Burgess E, Buzadzija K, Cavero R, D\u2019Abreo C, Donaldson I, Dorairajoo D, Dumontier MJ, Dumontier MR, Earles V, Farrall R, Feldman H et\u00a0al (2005) The biomolecular interaction network database and related tools 2005 update. Nucleic Acids Res 33:D418\u2013D424","journal-title":"Nucleic Acids Res"},{"key":"545_CR2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrg1272","volume":"5","author":"AL Barabasi","year":"2004","unstructured":"Barabasi AL, Oltvai ZN (2004) Network biology: understanding the cell\u2019s functional organization. Nat Rev Genet 5:101\u2013113","journal-title":"Nat Rev Genet"},{"key":"545_CR3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B 57:289\u2013300","journal-title":"J R Stat Soc B"},{"key":"545_CR4","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/msb4100180","volume":"3","author":"H-Y Chuang","year":"2007","unstructured":"Chuang H-Y, Lee E, Liu Y-T, Lee D, Ideker T (2007) Network-based classification of breast cancer metastasis. Mol Syst Biol 3:140","journal-title":"Mol Syst Biol"},{"key":"545_CR5","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/msb4100200","volume":"3","author":"Q Cui","year":"2007","unstructured":"Cui Q, Ma Y, Jaramillo M, Bari H, Awan A, Yang S, Zhang S, Liu L, Lu M, O\u2019Connor-McCourt M, Purisima E, Wang E (2007) A map of human cancer signaling. Mol Syst Biol 3:152","journal-title":"Mol Syst Biol"},{"key":"545_CR6","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1600-0854.2005.00299.x","volume":"6","author":"SM Di Pietro","year":"2005","unstructured":"Di Pietro SM, Dell\u2019Angelica EC (2005) The cell biology of Hermansky-Pudlak syndrome: recent advances. Traffic 6:525\u2013533","journal-title":"Traffic"},{"key":"545_CR7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/gepi.20204","volume":"31","author":"D Dinu","year":"2007","unstructured":"Dinu D, Miller P, Zhao H (2007) Evidence for association between multiple complement pathway genes and AMD. Genet Epidemiol 31:224\u2013237","journal-title":"Genet Epidemiol"},{"key":"545_CR9","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.1141634","volume":"316","author":"TM Frayling","year":"2007","unstructured":"Frayling TM et\u00a0al (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889\u2013894","journal-title":"Science"},{"key":"545_CR10","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/ng1747","volume":"38","author":"TKB Gandhi","year":"2006","unstructured":"Gandhi TKB, Zhong J, Mathivanan S, Karthick L, Chandrika KN, Mohan SS, Sharma S, Pinkert S, Nagaraju S, Periaswamy B, Mishra G, Nandakumar K, Shen B, Deshpande N, Nayak R, Sarker M, Boeke JD, Parmigiani G, Schultz J, Bader JS, Pandey A (2006) Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets. Nat Genet 38:285\u2013293","journal-title":"Nat Genet"},{"key":"545_CR11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/biomet\/93.3.509","volume":"93","author":"CR Genovese","year":"2006","unstructured":"Genovese CR, Roeder K, Wasserman L (2006) False discovery control with p-value weighting. Biometrika 93:509\u2013524","journal-title":"Biometrika"},{"key":"545_CR12","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1101\/gr.071852.107","volume":"18","author":"T Ideker","year":"2008","unstructured":"Ideker T, Sharan R (2008) Protein networks in disease. Genome Res 18:644\u2013652","journal-title":"Genome Res"},{"key":"545_CR13","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1086\/519748","volume":"81","author":"I Ionita-Laza","year":"2007","unstructured":"Ionita-Laza I, McQueen MB, Laird NM, Lange C (2007) Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan. Am J Hum Genet 81:607\u2013614","journal-title":"Am J Hum Genet"},{"key":"545_CR14","doi-asserted-by":"crossref","first-page":"D428","DOI":"10.1093\/nar\/gki072","volume":"33","author":"G Joshi-Tope","year":"2005","unstructured":"Joshi-Tope G, Gillespie M, Vastrik I, D\u2019Eustachio P, Schmidt E, de Bono B, Jassal B, Gopinath GR, Wu GR, Matthews L, Lewis S, Birney E, Stein L (2005) Reactome: a knowledgebase of biological pathways. Nucleic Acids Res 33:D428\u2013D432","journal-title":"Nucleic Acids Res"},{"key":"545_CR15","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.cell.2006.03.032","volume":"125","author":"J Lim","year":"2006","unstructured":"Lim J, Hao T, Shaw C, Patel AJ, Szabo G, Rual J-F, Fisk CJ, Li N, Smolyar A, Hill DE, Barabasi A-L, Vidal M, Zoghbi HY (2006) A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell 125:801\u2013814","journal-title":"Cell"},{"key":"545_CR16","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1101\/gr.6431107","volume":"17","author":"J Lin","year":"2007","unstructured":"Lin J, Gan CM, Zhang X, Jones S, Sjoblom T, Wood LD, Parsons DW, Papadopoulos N, Kinzler KW, Vogelstein B, Parmigiani G, Velculescu VE (2007) A multidimensional analysis of genes mutated in breast and colorectal cancers. Genome Res. 17:1304\u20131318","journal-title":"Genome Res"},{"key":"545_CR17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ng1071","volume":"33","author":"KE Lohmueller","year":"2003","unstructured":"Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN (2003) Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33:177\u2013182","journal-title":"Nat Genet"},{"key":"545_CR18","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.biochi.2005.05.003","volume":"87","author":"G Mace","year":"2005","unstructured":"Mace G, Bogliolo M, Guervilly JH, Dugas du Villard JA, Rosselli F (2005) 3R coordination by Fanconi anemia proteins. Biochimie 87:647\u2013658","journal-title":"Biochimie"},{"key":"545_CR19","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/ng1537","volume":"37","author":"J Marchini","year":"2005","unstructured":"Marchini J, Donnelly P, Cardon LR (2005) Genome-wide strategies for detecting multiple loci that influence complex diseases. Nat Genet 37:413\u2013417","journal-title":"Nat Genet"},{"key":"545_CR20","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1136\/jmg.2006.041376","volume":"43","author":"M Oti","year":"2006","unstructured":"Oti M, Snel B, Huynen MA, Brunner HG (2006) Predicting disease genes using protein-protein interactions. J Med Genet 43:691\u2013698","journal-title":"J Med Genet"},{"key":"545_CR21","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1101\/gr.1680803","volume":"13","author":"S Peri","year":"2003","unstructured":"Peri S, Navarro JD, Amanchy R, Kristiansen TZ, Jonnalagadda CK, Surendranath V, Niranjan V, Muthusamy B, Gandhi TK, Gronborg M, Ibarrola N, Deshpande N, Shanker K, Shivashankar HN, Rashmi BP, Ramya MA, Zhao Z, Chandrika KN, Padma N, Harsha HC et\u00a0al (2003) Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res 13:2363\u20132371","journal-title":"Genome Res"},{"key":"545_CR22","doi-asserted-by":"crossref","first-page":"R40","DOI":"10.1186\/gb-2005-6-5-r40","volume":"6","author":"AK Ramani","year":"2005","unstructured":"Ramani AK, Bunescu RC, Mooney RJ, Marcotte EM (2005) Consolidating the set of known human protein-protein interactions in preparation for large-scale mapping of the human interactome. Genome Biol 6:R40","journal-title":"Genome Biol"},{"key":"545_CR23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/gepi.20050","volume":"28","author":"K Roeder","year":"2005","unstructured":"Roeder K, Bacanu SA, Sonpar V, Zhang X, Devlin B (2005) Analysis of single-locus tests to detect gene\/disease associations. Genet Epidemiol 28:207\u2013219","journal-title":"Genet Epidemiol"},{"key":"545_CR24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1086\/500026","volume":"78","author":"K Roeder","year":"2006","unstructured":"Roeder K, Bacanu SA, Wasserman L, Devlin B (2006) Using linkage genome scans to improve power of association in genome scans. Am J Hum Genet 78:243\u2013252","journal-title":"Am J Hum Genet"},{"key":"545_CR25","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/gepi.20237","volume":"31","author":"K Roeder","year":"2007","unstructured":"Roeder K, Devlin B, Wasserman L (2007) Improving power in genome-wide association studies: weights tip the scale. Genet Epidemiol 31:741\u2013747","journal-title":"Genet Epidemiol"},{"key":"545_CR26","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nature04209","volume":"437","author":"JF Rual","year":"2005","unstructured":"Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S et\u00a0al (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437:1173\u20131178","journal-title":"Nature"},{"key":"545_CR27","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.cell.2005.08.029","volume":"122","author":"U Stelzl","year":"2005","unstructured":"Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksoz E, Droege A, Krobitsch S, Korn B et\u00a0al (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell 122:957\u2013968","journal-title":"Cell"},{"key":"545_CR28","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1086\/522374","volume":"81","author":"K Wang","year":"2007","unstructured":"Wang K, Li M, Bucan M (2007) Pathway-based approaches for analysis of genomewide association studies. Am J Hum Genet 81:1278\u20131283","journal-title":"Am J Hum Genet"},{"key":"545_CR29","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1126\/science.1145720","volume":"318","author":"LD Wood","year":"2007","unstructured":"Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, Leary RJ et\u00a0al (2007) The genomic landscapes of human breast and colorectal cancers. Science 318:1108\u20131113","journal-title":"Science"}],"container-title":["Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00439-008-0545-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00439-008-0545-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00439-008-0545-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T16:23:46Z","timestamp":1738340626000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00439-008-0545-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,22]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["545"],"URL":"https:\/\/doi.org\/10.1007\/s00439-008-0545-1","relation":{},"ISSN":["0340-6717","1432-1203"],"issn-type":[{"value":"0340-6717","type":"print"},{"value":"1432-1203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,22]]}}}