{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:21:21Z","timestamp":1791321681773,"version":"4.3.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Genet"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1007\/s00439-010-0812-9","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T07:18:57Z","timestamp":1269933537000},"page":"669-674","source":"Crossref","is-referenced-by-count":74,"title":["Heritability of chronic venous disease"],"prefix":"10.1007","volume":"127","author":[{"given":"Andreas","family":"Fiebig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Krusche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Krawczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitt","family":"Timm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Nikolaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Frings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,31]]},"reference":[{"key":"812_CR1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1136\/jech.35.3.213","volume":"35","author":"JH Abramson","year":"1981","unstructured":"Abramson JH, Hopp C, Epstein LM (1981) The epidemiology of varicose veins. A survey in western Jerusalem. J Epidemiol Community Health 35:213\u2013217","journal-title":"J Epidemiol Community Health"},{"key":"812_CR2","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1086\/301844","volume":"62","author":"L Almasy","year":"1998","unstructured":"Almasy L, Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198\u20131211","journal-title":"Am J Hum Genet"},{"key":"812_CR3","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0749-3797(18)31203-0","volume":"4","author":"FN Brand","year":"1988","unstructured":"Brand FN, Dannenberg AL, Abbott RD, Kannel WB (1988) The epidemiology of varicose veins: the Framingham Study. Am J Prev Med 4:96\u2013101","journal-title":"Am J Prev Med"},{"key":"812_CR4","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1067\/mva.2003.147","volume":"37","author":"PH Carpentier","year":"2003","unstructured":"Carpentier PH, Cornu-Thenard A, Uhl JF, Partsch H, Antignani PL (2003) Appraisal of the information content of the C classes of CEAP clinical classification of chronic venous disorders: a multicenter evaluation of 872 patients. J Vasc Surg 37:827\u2013833","journal-title":"J Vasc Surg"},{"issue":"4","key":"812_CR5","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.jvs.2004.07.025","volume":"40","author":"PH Carpentier","year":"2004","unstructured":"Carpentier PH, Maricq HR, Biro C, Pon\u00e7ot-Makinen CO, Franco A (2004) Prevalence, risk factors, and clinical patterns of chronic venous disorders of lower limbs: a population-based study in France. J Vasc Surg 40(4):650\u2013659","journal-title":"J Vasc Surg"},{"key":"812_CR6","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1161\/01.CIR.48.4.839","volume":"48","author":"WW Coon","year":"1973","unstructured":"Coon WW, Willis PW 3rd, Keller JB (1973) Venous thrombo-embolism and other venous disease in the Tecumseh community health study. Circulation 48:839\u2013846","journal-title":"Circulation"},{"key":"812_CR7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1177\/000331979704800703","volume":"48","author":"G Backer De","year":"1997","unstructured":"De Backer G (1997) Epidemiology of chronic venous insufficiency. Angiology 48:569\u2013576","journal-title":"Angiology"},{"key":"812_CR8","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.jvs.2004.09.027","volume":"40","author":"B Eklof","year":"2004","unstructured":"Eklof B, Rutherford RB, Bergan JJ, Carpentier PH, Gloviczki P, Kistner RL, Meissner MH, Moneta GL, Myers K, Padberg FT, Perrin M, Ruckley CV, Smith PC, Wakefield TW (2004) Revision of the CEAP classification for chronic venous disorders: consensus statement. J Vasc Surg 40:1248\u20131252","journal-title":"J Vasc Surg"},{"key":"812_CR9","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.jvs.2008.09.014","volume":"49","author":"B Eklof","year":"2009","unstructured":"Eklof B, Perrin M, Delis KT, Rutherford RB, Gloviczki P (2009) Updated terminology of chronic venous disorders: the VEIN-TERM transatlantic interdisciplinary consensus document. J Vasc Surg 49:498\u2013501","journal-title":"J Vasc Surg"},{"key":"812_CR10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/jech.53.3.149","volume":"53","author":"CJ Evans","year":"1999","unstructured":"Evans CJ, Fowkes FG, Ruckley CV, Lee AJ (1999) Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein Study. J Epidemiol Community Health 53:149\u2013153","journal-title":"J Epidemiol Community Health"},{"key":"812_CR11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1017\/S0080456800012163","volume":"52","author":"R Fisher","year":"1918","unstructured":"Fisher R (1918) The correlation between relatives on the supposition of Mendelian inheritance. Trans Roy Soc Edin 52:399\u2013433","journal-title":"Trans Roy Soc Edin"},{"key":"812_CR12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/0003319701052001S02","volume":"52","author":"FG Fowkes","year":"1999","unstructured":"Fowkes FG, Evans CJ, Lee AJ (1999) Prevalence and risk factors of chronic venous insufficiency. Angiology 52:5\u201315","journal-title":"Angiology"},{"key":"812_CR13","first-page":"149","volume":"158","author":"PJ Franks","year":"1992","unstructured":"Franks PJ, Wright DD, Fletcher AE, Moffatt CJ (1992) A questionnaire to assess risk factors, quality of life, and use of health resources in patients with venous disease. Eur J Surg 158:149\u2013155","journal-title":"Eur J Surg"},{"key":"812_CR14","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1159\/000022863","volume":"49","author":"R Guerra","year":"1999","unstructured":"Guerra R, Wan Y, Jia A, Amos CI, Cohen JC (1999) Testing for linkage under robust genetic models. Hum Hered 49:146\u2013153","journal-title":"Hum Hered"},{"key":"812_CR15","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4065\/71.4.338","volume":"71","author":"RL Kistner","year":"1996","unstructured":"Kistner RL, Eklof B, Masuda EM (1996) Diagnosis of chronic venous disease of the lower extremities: the \u201cCEAP\u201d classification. Mayo Clin Proc 71:338\u2013345","journal-title":"Mayo Clin Proc"},{"key":"812_CR16","first-page":"130","volume":"40","author":"N Labropoulos","year":"2003","unstructured":"Labropoulos N (2003) Hemodynamic changes according to the CEAP classification. Phlebolymphology 40:130\u2013136","journal-title":"Phlebolymphology"},{"key":"812_CR17","first-page":"126","volume":"15","author":"G Madar","year":"1986","unstructured":"Madar G, Widmer LK, Zemp E, Maggs M (1986) Varicose veins and chronic venous insufficiency disorder or disease? A critical epidemiological review. Vasa 15:126\u2013134","journal-title":"Vasa"},{"key":"812_CR23","unstructured":"Meissner MH (2004) Pathophysiology of varicose veins and chronic venous insufficiency. In: Hallett JW, Mills JL, Earnshaw JJ, Reekers JA (eds) Comprehensive: vascular and endovascular surgery, chap 39, sect 10. Mosby, Edinburgh, 571\u2013589, ISBN: 0723432325"},{"key":"812_CR24","volume-title":"Eine Studie \u00fcber den Erblichkeitsgrad bei 89 Hautkrankheiten nach Untersuchung von 370 Zwillingspaaren","author":"H Niermann","year":"1964","unstructured":"Niermann H (1964) Eine Studie \u00fcber den Erblichkeitsgrad bei 89 Hautkrankheiten nach Untersuchung von 370 Zwillingspaaren. Springer, NY"},{"key":"812_CR18","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0741-5214(95)70195-8","volume":"21","author":"JM Porter","year":"1995","unstructured":"Porter JM, Moneta MG (1995) Reporting standards in venous disease: an update. International Consensus Committee on Chronic Venous Disease. J Vasc Surg 21:635\u2013645","journal-title":"J Vasc Surg"},{"key":"812_CR19","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1067\/mva.2002.126547","volume":"36","author":"CV Ruckley","year":"2002","unstructured":"Ruckley CV, Evans CJ, Allan PL, Lee AJ, Fowkes FG (2002) Chronic venous insufficiency: clinical and duplex correlations. The Edinburgh Vein Study of venous disorders in the general population. J Vasc Surg 36:520\u2013525","journal-title":"J Vasc Surg"},{"key":"812_CR20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-0037-1617353","volume":"32","author":"E Rabe","year":"2003","unstructured":"Rabe E, Pannier-Fischer F, Bromen K, Schuldt K, Stang A, Poncar C, Wittehorst M, Bock E, Weber S, J\u00f6ckel K-H (2003) Bonner Venenstudie der Gesellschaft f\u00fcr Phlebologie. Phlebologie 32:1\u201314","journal-title":"Phlebologie"},{"key":"812_CR21","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1042\/CS20060170","volume":"112","author":"P Sansilvestri-Morel","year":"2007","unstructured":"Sansilvestri-Morel P, Fioretti F, Rupin A, Senni K, Fabiani JN, Godeau G, Verbeuren TJ (2007) Comparison of extracellular matrix in skin and saphenous veins from patients with varicose veins: does the skin reflect venous matrix changes? Clin Sci (Lond) 112:229\u2013239","journal-title":"Clin Sci (Lond)"},{"key":"812_CR22","first-page":"405","volume":"161","author":"T Sisto","year":"1995","unstructured":"Sisto T, Reunanen A, Laurikka J, Impivaara O, Heliovaara M, Knekt P, Aromaa A (1995) Prevalence and risk factors of varicose veins in lower extremities: mini-Finland health survey. Eur J Surg 161:405\u2013414","journal-title":"Eur J Surg"},{"key":"812_CR25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrg2322","volume":"9","author":"PM Visscher","year":"2008","unstructured":"Visscher PM, Hill WG, Wray NR (2008) Heritability in the genomics era\u2014concepts and misconceptions. Nat Rev Genet 9:255\u2013266","journal-title":"Nat Rev Genet"}],"container-title":["Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s00439-010-0812-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T18:03:37Z","timestamp":1551290617000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00439-010-0812-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,31]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["812"],"URL":"https:\/\/doi.org\/10.1007\/s00439-010-0812-9","relation":{},"ISSN":["0340-6717","1432-1203"],"issn-type":[{"value":"0340-6717","type":"print"},{"value":"1432-1203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,31]]}}}